Vickery Trinkaus-Randall, PhD
Professor
Boston University School of Medicine
Dept of Biochemistry

PhD, University of Wisconsin-Madison



Our laboratory is interested in the wound response and repair of epithelium, neurons and extracellular matrix. 1. In the healthy cornea there are no blood vessels and thus the tissue provides an excellent model to study the communication between nerves and epithelium following injury. Primary neurons are co-cultured with epithelial cells to ask how signaling pathways communicate. These include but are not limited to glutamatergic and purinergic receptor-mediated calcium transients. 2. In addition to these signaling events we have found that when epithelial cells are injured nucleotides are released immediately and cause a distinct phosphorylation of EGF receptor residues that ultimately affect the ability of a cell to migrate. 3. To study controlling factors on extracellular matrix or stromal formation we have developed scaffold-free long-term cultures and these have recently enabled us to study the role of hypoxia, which occurs in a diurnal pattern in this tissue as one sleeps. Our experiments are conducted using a number of organ culture and cell models and use biochemical, cell and molecular techniques. 4. Last but not least we are interested in the role of long sugar chains or glycosaminoglycans on the formation of oligomers and fibrils in light chain amyloid disease using atomic force microscopy, negative staining and biochemical technologies.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences


Professor
Boston University School of Medicine
Ophthalmology



2013 GMS Faculty Recognition Award
2010 Gold Fellow of ARVO (Association for Research in Vision and Ophthalmology)


Multicellular Regulation of Corneal Wound Healing
12/01/2014 - 11/30/2017 (PI)
NIH/National Eye Institute
5R21EY024392-02

Corneal Epithelial Adhesion: Morphology and Biochemistry
08/01/2014 - 06/30/2017 (PI)
NIH/National Eye Institute
5R01EY006000-29

Projects for the Massachusetts Lions Eye Research Fund
07/01/2014 - 06/30/2017 (PI of Sub-Project / SP)
PI: Stephen P. Christiansen, MD
Massachusetts Lions Eye Research Fund, Inc.

Corneal Epithelial Adhesion: Morphology & Biochemistry
06/01/1986 - 05/31/2014 (PI)
NIH/National Eye Institute
5R01EY006000-26

Engineering Biomimetric Corneal Constructs
09/30/2009 - 09/29/2011 (PI)
Northeastern University NIH NEI
2 R01EY015500

Purchase of a New Confocal Zeiss LSM 510v3.2
09/01/2005 - 08/31/2006 (PI)
NIH/National Center for Health Research Resources
1 S10 RR17967 01A2

Role of Growth Factors on Epidermal and Neuronal Injury
09/30/2000 - 08/31/2003 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5 R21 DK59753 02

Regulation of Extracellular Matrix in the Corneal Stroma
08/01/1996 - 07/31/2000 (Co-PI)
PI: Matthew A. Nugent, PhD
NIH/National Eye Institute
5 R01 EY11004 04




Yr Title Project-Sub Proj Pubs
2016 Multicellular regulation of corneal wound healing 5R21EY024392-02
2016 Corneal Epithelial Adhesion: Morphology and Biochemistry 5R01EY006000-29 25
2015 Multicellular regulation of corneal wound healing 1R21EY024392-01A1
2014 Corneal Epithelial Adhesion: Morphology and Biochemistry 2R01EY006000-27A1 25
2012 Corneal epithelial adhesion:morphology and biochemistry 5R01EY006000-26 25
2011 AFM AND MS TO MONITOR FIBRIL FORMATION FROM AMYLOID IG LIGHT CHAINS AND GAGS 5P41RR010888-15-5123 236
2011 ENRICHMENT AND DETECTION METHODOLOGIES FOR EGFR PHOSPHOPEPTIDES 5P41RR010888-15-5139 236
2011 Corneal epithelial adhesion:morphology and biochemistry 5R01EY006000-25 25
2010 AFM AND MS TO MONITOR FIBRIL FORMATION FROM AMYLOID IG LIGHT CHAINS AND GAGS 5P41RR010888-14-6825 236
2010 ENRICHMENT AND DETECTION METHODOLOGIES FOR EGFR PHOSPHOPEPTIDES 5P41RR010888-14-6844 236
Showing 10 of 51 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Barrios J, Patel KR, Aven L, Achey R, Minns MS, Lee Y, Trinkaus-Randall VE, Ai X. Early life allergen-induced mucus overproduction requires augmented neural stimulation of pulmonary neuroendocrine cell secretion. FASEB J. 2017 May 31.View Related Profiles. PMID: 28566470.
  2. Minns MS, Trinkaus-Randall V. Purinergic Signaling in Corneal Wound Healing: A Tale of 2 Receptors. J Ocul Pharmacol Ther. 2016 Oct; 32(8):498-503.View Related Profiles. PMID: 27643999.
  3. Minns MS, Teicher G, Rich CB, Trinkaus-Randall V. Purinoreceptor P2X7 Regulation of Ca(2+) Mobilization and Cytoskeletal Rearrangement Is Required for Corneal Reepithelialization after Injury. Am J Pathol. 2016 Feb; 186(2):285-96.View Related Profiles. PMID: 26683661; PMCID: PMC4729273; DOI: 10.1016/j.ajpath.2015.10.006;.
  4. Derricks KE, Trinkaus-Randall V, Nugent MA. Extracellular matrix stiffness modulates VEGF calcium signaling in endothelial cells: individual cell and population analysis. Integr Biol (Camb). 2015 Sep; 7(9):1011-25.View Related Profiles. PMID: 26183123; PMCID: PMC4558347; DOI: 10.1039/c5ib00140d;.
  5. Sanderson J, Dartt DA, Trinkaus-Randall V, Pintor J, Civan MM, Delamere NA, Fletcher EL, Salt TE, Grosche A, Mitchell CH. Purines in the eye: recent evidence for the physiological and pathological role of purines in the RPE, retinal neurons, astrocytes, Müller cells, lens, trabecular meshwork, cornea and lacrimal gland. Exp Eye Res. 2014 Oct; 127:270-9. PMID: 25151301; PMCID: PMC4175147; DOI: 10.1016/j.exer.2014.08.009;.
  6. Karamichos D, Hutcheon AE, Rich CB, Trinkaus-Randall V, Asara JM, Zieske JD. In vitro model suggests oxidative stress involved in keratoconus disease. Sci Rep. 2014; 4:4608. PMID: 24714342; PMCID: PMC3980225; DOI: 10.1038/srep04608;.
  7. Lee A, Derricks K, Minns M, Ji S, Chi C, Nugent MA, Trinkaus-Randall V. Hypoxia-induced changes in Ca(2+) mobilization and protein phosphorylation implicated in impaired wound healing. Am J Physiol Cell Physiol. 2014 May 15; 306(10):C972-85.View Related Profiles. PMID: 24671101; PMCID: PMC4024710; DOI: 10.1152/ajpcell.00110.2013;.
  8. Stepp MA, Zieske JD, Trinkaus-Randall V, Kyne BM, Pal-Ghosh S, Tadvalkar G, Pajoohesh-Ganji A. Wounding the cornea to learn how it heals. Exp Eye Res. 2014 Apr; 121:178-93. PMID: 24607489; PMCID: PMC4072315; DOI: 10.1016/j.exer.2014.02.007;.
  9. Karamichos D, Rich CB, Zareian R, Hutcheon AE, Ruberti JW, Trinkaus-Randall V, Zieske JD. TGF-ß3 stimulates stromal matrix assembly by human corneal keratocyte-like cells. Invest Ophthalmol Vis Sci. 2013 Oct; 54(10):6612-9. PMID: 24022012; PMCID: PMC3803138; DOI: 10.1167/iovs.13-12861;.
  10. Kehasse A, Rich CB, Lee A, McComb ME, Costello CE, Trinkaus-Randall V. Epithelial wounds induce differential phosphorylation changes in response to purinergic and EGF receptor activation. Am J Pathol. 2013 Dec; 183(6):1841-52.View Related Profiles. PMID: 24095926; DOI: 10.1016/j.ajpath.2013.08.015;.
Showing 10 of 92 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 90 publications over 33 distinct years, with a maximum of 8 publications in 1998

YearPublications
19811
19821
19841
19852
19871
19883
19892
19902
19913
19931
19945
19952
19977
19988
19992
20005
20016
20022
20032
20042
20053
20061
20073
20083
20091
20102
20115
20123
20133
20144
20152
20161
20171
Contact for Mentoring:


72 E. Concord St Instructional (L)
Boston MA 02118
Google Map


Trinkaus-Randall's Networks
Click the "See All" links for more information and interactive visualizations
Concepts
_
Co-Authors
_
Similar People
_
Same Department