Lindsay Farrer, PhD
Professor
Boston University School of Medicine
Dept of Medicine
Biomedical Genetics Section

PhD, Indiana University School of Medicine



Dr. Lindsay Farrer is a medical geneticist at Boston University Schools of Medicine and Public Health where he is Chief of Biomedical Genetics and a Professor of Medicine, Neurology, Ophthalmology, Genetics & Genomics, Epidemiology, and Biostatistics. Dr. Farrer is a graduate of the University of North Carolina in Chapel Hill, received his Ph.D. from the Indiana University School of Medicine, and gained additional training in genetic epidemiology at Yale University. He holds adjunct faculty positions at Harvard Medical School, Massachusetts General Hospital, and the Veterans Administration Medical Center in Bedford, Massachusetts. He is a Founding Fellow of the American College of Medical Genetics. Dr. Farrer teaches several courses in human genetics and genetic epidemiology at Boston University, directs Boston University’s Molecular Genetics Core Facility which offers DNA genotyping and sequencing services to investigators at the Boston Medical Center, and provides genetic counseling and testing to patients with a variety of inherited conditions.

Dr. Farrer’s research has lead to more than 300 publications on genetic risk factors for several familial neurodegenerative and other chronic diseases. In collaboration with other laboratories worldwide, his group has localized genes causing a variety of rare and common disorders including Alzheimer disease (AD), Wilson disease, Machado-Joseph disease, Waardenburg syndrome, hypertension, sensorineural deafness, and osteoarthritis. His group identified a functional genetic variant in the complement factor H gene which accounts for more than 30% of the attributable risk for age-related macular degeneration (AMD), the leading cause of progressive vision loss and blindness in the elderly. In collaboration with other researchers, Dr. Farrer is conducting genome wide association studies (GWAS) for several disorders including AD, substance dependence (cocaine, opiates, nicotine and alcohol), AMD and vasculitis. Dr. Farrer’s team is also developing methods for locating genes that influence the natural history of complex diseases and pharmacogenetic response.

Under Dr. Farrer’s leadership, the MIRAGE Project, a multi-center study of AD funded since 1991 by the National Institute on Aging, has made several important contributions to our understanding of the interactions between genetic and environmental factors for the disorder. This study has a particular emphasis on the genetics of AD in African Americans. Thus far, detailed family histories, risk factor data, and DNA specimens from more than 2,500 AD families have been collected as a part of this program. MIRAGE was the first study to demonstrate that genetic factors have a major role in the development of AD and that APOE e4 is more weakly associated with disease in men and persons older than 75 years. Dr. Farrer co-directed the international effort which demonstrated that SORL1 is genetically and functionally associated with AD, thus implicating intracellular protein trafficking as integral pathway in AD. His laboratory conducted genome wide association studies (GWAS) for AD in several populations including African Americans and an inbred Israeli-Arab community. Dr. Farrer serves on the Executive Committee of the national Alzheimer Disease Genetics Consortium and co-directs the data analysis effort for this large NIH-funded project. He and his colleagues recently discovered four new Alzheimer genes in the largest GWAS of AD to date.

Section Chief
Boston University School of Medicine
Medicine
Biomedical Genetics Section

Boston University Distinguished Professor of Genetics
Boston University School of Medicine
Medicine
Biomedical Genetics Section

Professor
Boston University School of Medicine
Ophthalmology


Professor
Boston University School of Medicine
Neurology


Professor
Boston University School of Public Health
Biostatistics


Professor
Boston University School of Public Health
Epidemiology


Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences


Member
Boston University
Bioinformatics Graduate Program




Institutional Program Unifying Population and Laboratory Based Sciences Award
02/01/2013 - 01/31/2019 (PI)
Burroughs Wellcome Fund

Consortium for Alzheimer Sequencing and Analysis (CASA)
06/15/2014 - 05/31/2018 (PI)
Trustees of the University of Pennsylvania NIH NIA
1UF1AG047133-01

Alzheimer's Disease Genetics Consortium
06/15/2015 - 03/31/2018 (PI)
Trustees of the University of Pennsylvania NIH NIA
5U01AG032984-07

Coordinating Center for Genetics and Genomics of Alzheimer's Disease
04/15/2016 - 02/28/2018 (PI)
Trustees of the University of Pennsylvania NIH NIA
5U54AG052427-02

Coordinating Center for Genetics and Genomics of Alzheimer's Disease
04/15/2016 - 02/28/2018 (PI)
Trustees of the University of Pennsylvania NIH NIA
5U54AG052427-02

Alzheimer Disease Genetic Architecture in African Americans
02/15/2015 - 01/31/2018 (PI)
NIH/National Institute on Aging
5R01AG048927-03

Genetics of Opioid Dependence
09/01/2016 - 08/31/2017 (PI)
Yale University NIH NIDA
4R01DA012690-14

Analysis of Genetic Data for refractive error and Myopia
05/01/2014 - 04/30/2017 (PI)
Trustees of the University of Pennsylvania NIH NEI
5R01EY024233-03

Genetics of Opioid Dependence
09/30/2013 - 08/31/2016 (PI)
Yale University NIH NIDA
5R01DA012690-13

Alzheimer's Disease Genetics Consortium
04/01/2009 - 09/30/2015 (PI)
Trustees of the University of Pennsylvania NIH NIA
5U01AG032984-05

Showing 10 of 28 results. Show All Results



Yr Title Project-Sub Proj Pubs
2017 Alzheimer Disease Genetic Architecture in African Americans 5R01AG048927-03 1
2016 Alzheimer Disease Genetic Architecture in African Americans 5R01AG048927-02 1
2016 Alzheimer Disease Genetic Architecture in African Americans 3R01AG048927-02S1 1
2015 Alzheimer Disease Genetic Architecture in African Americans 1R01AG048927-01 1
2014 Consortium for Alzheimers Sequence Analysis (CASA) 1UF1AG047133-01 2
2010 Multi-ethnic Genome-wide Alzheimer association study 5R01AG025259-05 42
2009 Multi-ethnic genome-wide Alzheimer association study 5R01AG025259-04 42
2008 Multi-ethnic genome-wide Alzheimer's association study 5R01AG025259-03 42
2007 GENETIC EPIDEMIOLOGICAL STUDIES OF ALZHEIMER'S DISEASE 2M01RR000533-39-8138 429
2007 Multi-ethnic genome-wide Alzheimer's association study 5R01AG025259-02 42
Showing 10 of 44 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Adkins AE, Hack LM, Bigdeli TB, Williamson VS, McMichael GO, Mamdani M, Edwards AC, Aliev F, Chan RF, Bhandari P, Raabe RC, Alaimo JT, Blackwell GG, Moscati A, Poland RS, Rood B, Patterson DG, Walsh D, Whitfield JB, Zhu G, Montgomery GW, Henders AK, Martin NG, Heath AC, Madden PAF, Frank J, Ridinger M, Wodarz N, Soyka M, Zill P, Ising M, Nöthen MM, Kiefer F, Rietschel M, Gelernter J, Sherva R, Koesterer R, Almasy L, Zhao H, Kranzler HR, Farrer LA, Maher BS, Prescott CA, Dick DM, Bacanu SA, Mathies LD, Davies AG, Vladimirov VI, Grotewiel M, Bowers MS, Bettinger JC, Webb BT, Miles MF, Kendler KS, Riley BP. Genomewide Association Study of Alcohol Dependence Identifies Risk Loci Altering Ethanol-Response Behaviors in Model Organisms. Alcohol Clin Exp Res. 2017 May; 41(5):911-928.View Related Profiles. PMID: 28226201; DOI: 10.1111/acer.13362;.
  2. Desikan RS, Fan CC, Wang Y, Schork AJ, Cabral HJ, Cupples LA, Thompson WK, Besser L, Kukull WA, Holland D, Chen CH, Brewer JB, Karow DS, Kauppi K, Witoelar A, Karch CM, Bonham LW, Yokoyama JS, Rosen HJ, Miller BL, Dillon WP, Wilson DM, Hess CP, Pericak-Vance M, Haines JL, Farrer LA, Mayeux R, Hardy J, Goate AM, Hyman BT, Schellenberg GD, McEvoy LK, Andreassen OA, Dale AM. Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score. PLoS Med. 2017 Mar; 14(3):e1002258.View Related Profiles. PMID: 28323831; DOI: 10.1371/journal.pmed.1002258;.
  3. Deming Y, Li Z, Kapoor M, Harari O, Del-Aguila JL, Black K, Carrell D, Cai Y, Fernandez MV, Budde J, Ma S, Saef B, Howells B, Huang KL, Bertelsen S, Fagan AM, Holtzman DM, Morris JC, Kim S, Saykin AJ, De Jager PL, Albert M, Moghekar A, O''Brien R, Riemenschneider M, Petersen RC, Blennow K, Zetterberg H, Minthon L, Van Deerlin VM, Lee VM, Shaw LM, Trojanowski JQ, Schellenberg G, Haines JL, Mayeux R, Pericak-Vance MA, Farrer LA, Peskind ER, Li G, Di Narzo AF, Kauwe JS, Goate AM, Cruchaga C. Genome-wide association study identifies four novel loci associated with Alzheimer''s endophenotypes and disease modifiers. Acta Neuropathol. 2017 May; 133(5):839-856. PMID: 28247064; DOI: 10.1007/s00401-017-1685-y;.
  4. Jun GR, Chung J, Mez J, Barber R, Beecham GW, Bennett DA, Buxbaum JD, Byrd GS, Carrasquillo MM, Crane PK, Cruchaga C, De Jager P, Ertekin-Taner N, Evans D, Fallin MD, Foroud TM, Friedland RP, Goate AM, Graff-Radford NR, Hendrie H, Hall KS, Hamilton-Nelson KL, Inzelberg R, Kamboh MI, Kauwe JS, Kukull WA, Kunkle BW, Kuwano R, Larson EB, Logue MW, Manly JJ, Martin ER, Montine TJ, Mukherjee S, Naj A, Reiman EM, Reitz C, Sherva R, St George-Hyslop PH, Thornton T, Younkin SG, Vardarajan BN, Wang LS, Wendlund JR, Winslow AR, Haines J, Mayeux R, Pericak-Vance MA, Schellenberg G, Lunetta KL, Farrer LA. Transethnic genome-wide scan identifies novel Alzheimer''s disease loci. Alzheimers Dement. 2017 Feb 07.View Related Profiles. PMID: 28183528; DOI: 10.1016/j.jalz.2016.12.012;.
  5. Smith AH, Jensen KP, Li J, Nunez Y, Farrer LA, Hakonarson H, Cook-Sather SD, Kranzler HR, Gelernter J. Genome-wide association study of therapeutic opioid dosing identifies a novel locus upstream of OPRM1. Mol Psychiatry. 2017 Mar; 22(3):346-352. PMID: 28115739; DOI: 10.1038/mp.2016.257;.
  6. Haddick PC, Larson JL, Rathore N, Bhangale TR, Phung QT, Srinivasan K, Hansen DV, Lill JR, Pericak-Vance MA, Haines J, Farrer LA, Kauwe JS, Schellenberg GD, Cruchaga C, Goate AM, Behrens TW, Watts RJ, Graham RR, Kaminker JS, van der Brug M. A Common Variant of IL-6R is Associated with Elevated IL-6 Pathway Activity in Alzheimer''s Disease Brains. J Alzheimers Dis. 2017; 56(3):1037-1054. PMID: 28106546; DOI: 10.3233/JAD-160524;.
  7. Wachman EM, Hayes MJ, Sherva R, Brown MS, Shrestha H, Logan BA, Heller NA, Nielsen DA, Farrer LA. Association of maternal and infant variants in PNOC and COMT genes with neonatal abstinence syndrome severity. Am J Addict. 2017 Jan; 26(1):42-49.View Related Profiles. PMID: 27983768; DOI: 10.1111/ajad.12483;.
  8. Mez J, Chung J, Jun G, Kriegel J, Bourlas AP, Sherva R, Logue MW, Barnes LL, Bennett DA, Buxbaum JD, Byrd GS, Crane PK, Ertekin-Taner N, Evans D, Fallin MD, Foroud T, Goate A, Graff-Radford NR, Hall KS, Kamboh MI, Kukull WA, Larson EB, Manly JJ, Haines JL, Mayeux R, Pericak-Vance MA, Schellenberg GD, Lunetta KL, Farrer LA. Two novel loci, COBL and SLC10A2, for Alzheimer''s disease in African Americans. Alzheimers Dement. 2017 Feb; 13(2):119-129.View Related Profiles. PMID: 27770636; DOI: 10.1016/j.jalz.2016.09.002;.
  9. Wang Q, Polimanti R, Kranzler HR, Farrer LA, Zhao H, Gelernter J. Genetic factor common to schizophrenia and HIV infection is associated with risky sexual behavior: antagonistic vs. synergistic pleiotropic SNPs enriched for distinctly different biological functions. Hum Genet. 2017 Jan; 136(1):75-83. PMID: 27752767; DOI: 10.1007/s00439-016-1737-8;.
  10. Vathipadiekal V, Farrell JJ, Wang S, Edward HL, Shappell H, Al-Rubaish AM, Al-Muhanna F, Naserullah Z, Alsuliman A, Qutub HO, Simkin I, Farrer LA, Jiang Z, Luo HY, Huang S, Mostoslavsky G, Murphy GJ, Patra PK, Chui DH, Alsultan A, Al-Ali AK, Sebastiani P, Steinberg MH. A candidate transacting modulator of fetal hemoglobin gene expression in the Arab-Indian haplotype of sickle cell anemia. Am J Hematol. 2016 Nov; 91(11):1118-1122.View Related Profiles. PMID: 27501013; DOI: 10.1002/ajh.24527;.
Showing 10 of 401 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 401 publications over 34 distinct years, with a maximum of 28 publications in 2011 and 2013

YearPublications
19841
19857
19865
198710
19886
19898
19906
19918
199212
19939
199411
199511
199610
19978
199811
19999
20007
20018
20026
200311
20045
200520
200616
200713
200811
200916
201013
201128
201220
201328
201420
201526
201615
20176
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

age-related macular degeneration
Alzheimer disease
gene mapping
genetic epidemiology
illicit drug dependence

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  • Co-Mentor or Peer Mentor
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Contact for Mentoring:


72 E. Concord St Instructional (L)
Boston MA 02118
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