XiaoYong Tong, MD, PhD
Assistant Professor
Boston University School of Medicine
Dept of Medicine
Cardiovascular Medicine Section

MD, Harbin Medical University
PhD, Shanghai Institute of Materia Medica
MS, Harbin Medical University



Diabetic patients have much higher morbidity and mortality of cardiovascular diseases including atherosclerosis and restenosis compared with other populations. Vascular smooth muscle cell (SMC) migration contributes significantly to these pathological processes. Generally SMCs stay quiescent in vasculature. When the endothelium layer is disrupted, the underlying SMCs migrate from media to intima and form the neointima. This process is accelerated in diabetes mellitus (DM). Nitric oxide (NO), the biologically active component of endothelium-derived relaxing factor, has critical roles in the maintenance of vascular homeostasis. Previous studies showed that NO reduces intracellular calcium, which causes relaxation and inhibits SMC growth and proliferation in native smooth muscle. Sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) plays a very important role in maintaining intracellular calcium level by uptaking calcium into SR/ER. Our previous studies showed that NO upregulated SERCA activity by S-glutathiolation of the most reactive thiol on cysteine-674 (C674) and inhibited SMC migration. My major focus is to study the mechanisms of cardiovascular dysfunction in diabetes, mainly focus on SERCA, NADPH oxidase and smooth muscle cell migration. Those studies can also be expanded to obesity, insulin resistance and metabolic symptoms.

Boston Medical Center




Nox4 Oxidizes SERCA and Induces Vasculature Dysfunction in a Prediabetic Model
01/01/2010 - 12/31/2012 (PI)
American Diabetes Association


The effects of WuQing on Vascular function and atherosclerosis in LDLR deficient mice
05/01/2013 - 04/30/2014 (PI)
Zhimingde International Group



Yr Title Project-Sub Proj Pubs
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Cohen RA, Murdoch CE, Watanabe Y, Bolotina VM, Evangelista AM, Haeussler DJ, Smith MD, Mei Y, Tong X, Han J, Behring JB, Bachschmid MM, Matsui R. Endothelial Cell Redox Regulation of Ischemic Angiogenesis. J Cardiovasc Pharmacol. 2016 Jun; 67(6):458-64.View Related Profiles. PMID: 26927696; PMCID: PMC4899292; DOI: 10.1097/FJC.0000000000000381;.
  2. Tong X, Khandelwal AR, Qin Z, Wu X, Chen L, Ago T, Sadoshima J, Cohen RA. Role of smooth muscle Nox4-based NADPH oxidase in neointimal hyperplasia. J Mol Cell Cardiol. 2015 Dec; 89(Pt B):185-94.View Related Profiles. PMID: 26582463; DOI: 10.1016/j.yjmcc.2015.11.013;.
  3. Mei Y, Thompson MD, Shiraishi Y, Cohen RA, Tong X. Sarcoplasmic/endoplasmic reticulum Ca2+ ATPase C674 promotes ischemia- and hypoxia-induced angiogenesis via coordinated endothelial cell and macrophage function. J Mol Cell Cardiol. 2014 Nov; 76:275-82.View Related Profiles. PMID: 25260714; PMCID: PMC4250384; DOI: 10.1016/j.yjmcc.2014.09.018;.
  4. Thompson MD, Mei Y, Weisbrod RM, Silver M, Shukla PC, Bolotina VM, Cohen RA, Tong X. Glutathione adducts on sarcoplasmic/endoplasmic reticulum Ca2+ ATPase Cys-674 regulate endothelial cell calcium stores and angiogenic function as well as promote ischemic blood flow recovery. J Biol Chem. 2014 Jul 18; 289(29):19907-16.View Related Profiles. PMID: 24920669; PMCID: PMC4106311; DOI: 10.1074/jbc.M114.554451;.
  5. Mei Y, Thompson MD, Cohen RA, Tong X. Autophagy and oxidative stress in cardiovascular diseases. Biochim Biophys Acta. 2015 Feb; 1852(2):243-51.View Related Profiles. PMID: 24834848; PMCID: PMC4231019; DOI: 10.1016/j.bbadis.2014.05.005;.
  6. Qin Z, Hou X, Weisbrod RM, Seta F, Cohen RA, Tong X. Nox2 mediates high fat high sucrose diet-induced nitric oxide dysfunction and inflammation in aortic smooth muscle cells. J Mol Cell Cardiol. 2014 Jul; 72:56-63.View Related Profiles. PMID: 24631774; PMCID: PMC4037381; DOI: 10.1016/j.yjmcc.2014.02.019;.
  7. Mei Y, Thompson MD, Cohen RA, Tong X. Endoplasmic Reticulum Stress and Related Pathological Processes. J Pharmacol Biomed Anal. 2013 Nov 15; 1(2):1000107.View Related Profiles. PMID: 24611136.
  8. Qin F, Siwik DA, Lancel S, Zhang J, Kuster GM, Luptak I, Wang L, Tong X, Kang YJ, Cohen RA, Colucci WS. Hydrogen peroxide-mediated SERCA cysteine 674 oxidation contributes to impaired cardiac myocyte relaxation in senescent mouse heart. J Am Heart Assoc. 2013 Aug; 2(4):e000184.View Related Profiles. PMID: 23963753; PMCID: PMC3828801; DOI: 10.1161/JAHA.113.000184;.
  9. Evangelista AM, Thompson MD, Bolotina VM, Tong X, Cohen RA. Nox4- and Nox2-dependent oxidant production is required for VEGF-induced SERCA cysteine-674 S-glutathiolation and endothelial cell migration. Free Radic Biol Med. 2012 Dec 15; 53(12):2327-34.View Related Profiles. PMID: 23089226; PMCID: PMC3568680; DOI: 10.1016/j.freeradbiomed.2012.10.546;.
  10. Evangelista AM, Thompson MD, Weisbrod RM, Pimental DR, Tong X, Bolotina VM, Cohen RA. Redox regulation of SERCA2 is required for vascular endothelial growth factor-induced signaling and endothelial cell migration. Antioxid Redox Signal. 2012 Oct 15; 17(8):1099-108.View Related Profiles. PMID: 22472004; PMCID: PMC3423867; DOI: 10.1089/ars.2011.4022;.
Showing 10 of 23 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 23 publications over 11 distinct years, with a maximum of 4 publications in 2010 and 2014

YearPublications
20041
20052
20061
20073
20092
20104
20122
20132
20144
20151
20161
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Biotin-IAM label of SERCA
Rat and mouse aorta smooth muscle cell primary culture
Rat common carotid artery injury
Smooth muscle cell migration

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
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650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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