Jean-Jacques Soghomonian, PhD
Associate Professor
Boston University School of Medicine
Dept of Anatomy & Neurobiology

PhD, Université de Montréal



Research focuses on the functional neuroanatomy of the basal ganglia and the neurobiological basis of motor control, sensorimotor integration and learning. We are particularly interested in the mechanisms of regulation of GABAergic neurons in the basal ganglia of normal animals and experimental models of Parkinson's disease. Experimental approaches include analysis of protein/peptide expression by quantitative in situ hybridization histochemistry, immunohistochemistry and Western-blotting and analysis of behavioral activity.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences




Quantitative Neurochemical Analysis of the Basal Ganglia in ASC Impacting Motor, Limbic, and Cognitive Regions and their Interactions with Thalmo-cortical and Cerebellar Projections
01/15/2015 - 04/30/2017 (PI)
The John P. Hussman Foundation

Role of Gad1 in I-DOPA- Induced Dyskinesa
09/01/2011 - 12/31/2013 (PI)
Michael J. Fox Foundation for Parkinson's Research

Behavioral Sensitization and Parkinson’s Disease
03/01/2002 - 08/31/2008 (PI)
NIH/National Institute of Neurological Disorders & Stroke
5 R01 NS40783 05

Levodopa-Induced Plasticity in the Basal Ganglia
04/01/2002 - 03/31/2004 (Dept Sponsor)
NIH/National Institute of Neurological Disorders & Stroke
5 F31 NS42499 02

Effects of Intermittent vs Continuous L-DOPA on GABAergic Neurons of the Basal Ganglia
07/01/2000 - 06/30/2001 (PI)
Parkinson's Disease Foundation



Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Zhang K, Chammas C, Soghomonian JJ. Loss of glutamic acid decarboxylase (Gad67) in striatal neurons expressing the Drdr1a dopamine receptor prevents L-DOPA-induced dyskinesia in 6-hydroxydopamine-lesioned mice. Neuroscience. 2015 Sep 10; 303:586-94. PMID: 26188284; DOI: 10.1016/j.neuroscience.2015.07.032;.
  2. Zhang K, Hill K, Labak S, Blatt GJ, Soghomonian JJ. Loss of glutamic acid decarboxylase (Gad67) in Gpr88-expressing neurons induces learning and social behavior deficits in mice. Neuroscience. 2014 Sep 5; 275:238-47.View Related Profiles. PMID: 24952328; DOI: 10.1016/j.neuroscience.2014.06.020;.
  3. Lanoue AC, Blatt GJ, Soghomonian JJ. Decreased parvalbumin mRNA expression in dorsolateral prefrontal cortex in Parkinson''s disease. Brain Res. 2013 Sep 19; 1531:37-47.View Related Profiles. PMID: 23891794; PMCID: PMC3816277; DOI: 10.1016/j.brainres.2013.07.025;.
  4. Lanoue AC, Dumitriu A, Myers RH, Soghomonian JJ. Decreased glutamic acid decarboxylase mRNA expression in prefrontal cortex in Parkinson's disease. Exp Neurol. 2010 Nov; 226(1):207-17.View Related Profiles. PMID: 20832408; PMCID: PMC3108022; DOI: 10.1016/j.expneurol.2010.09.001;.
  5. Soghomonian JJ, Sethares C, Peters A. Effects of age on axon terminals forming axosomatic and axodendritic inhibitory synapses in prefrontal cortex. Neuroscience. 2010 Jun 16; 168(1):74-81. PMID: 20302918; PMCID: PMC2873101; DOI: 10.1016/j.neuroscience.2010.03.020;.
  6. Yamamoto N, Soghomonian JJ. Metabotropic glutamate mGluR5 receptor blockade opposes abnormal involuntary movements and the increases in glutamic acid decarboxylase mRNA levels induced by l-DOPA in striatal neurons of 6-hydroxydopamine-lesioned rats. Neuroscience. 2009 Nov 10; 163(4):1171-80. PMID: 19660528; PMCID: PMC2760628; DOI: 10.1016/j.neuroscience.2009.07.060;.
  7. Yip J, Soghomonian JJ, Blatt GJ. Decreased GAD65 mRNA levels in select subpopulations of neurons in the cerebellar dentate nuclei in autism: an in situ hybridization study. Autism Res. 2009 Feb; 2(1):50-9.View Related Profiles. PMID: 19358307; PMCID: PMC2724747; DOI: 10.1002/aur.62;.
  8. Yamamoto N, Soghomonian JJ. Time-course of SKF-81297-induced increase in glutamic acid decarboxylase 65 and 67 mRNA levels in striatonigral neurons and decrease in GABA(A) receptor alpha1 subunit mRNA levels in the substantia nigra, pars reticulata, in adult rats with a unilateral 6-hydroxydopamine lesion. Neuroscience. 2008 Jun 26; 154(3):1088-99. PMID: 18495353; PMCID: PMC2483836; DOI: 10.1016/j.neuroscience.2008.04.015;.
  9. Yip J, Soghomonian JJ, Blatt GJ. Increased GAD67 mRNA expression in cerebellar interneurons in autism: implications for Purkinje cell dysfunction. J Neurosci Res. 2008 Feb 15; 86(3):525-30.View Related Profiles. PMID: 17918742.
  10. Hatzipetros T, Raudensky JG, Soghomonian JJ, Yamamoto BK. Haloperidol treatment after high-dose methamphetamine administration is excitotoxic to GABA cells in the substantia nigra pars reticulata. J Neurosci. 2007 May 30; 27(22):5895-902. PMID: 17537960.
Showing 10 of 56 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 56 publications over 25 distinct years, with a maximum of 5 publications in 1992

YearPublications
19821
19861
19871
19892
19902
19911
19925
19933
19944
19954
19964
19974
19982
19993
20032
20042
20051
20062
20073
20082
20092
20102
20131
20141
20151
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Basal Ganglia
Chemical and Functional Neuroanatomy
GABAergic neurons
Gene Expression
Monoaminergic neurons
Neurotransmitters
Parkinson's disease

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Project Mentor
  • Research / Scholarly Mentor
Contact for Mentoring:


72 E. Concord St Instructional (L)
Boston MA 02118
Google Map


Soghomonian's Networks
Click the "See All" links for more information and interactive visualizations
Concepts
_
Co-Authors
_
Similar People
_
Same Department