Valentina Perissi, PhD
Assistant Professor
Boston University School of Medicine
Dept of Biochemistry

PhD, University of California at San Diego



The major goal of the Perissi lab is to investigate the transcriptional and non-transcriptional functions of various cofactors with a particular focus on their misregulation during disease states such as cancer, diabetes and other inflammatory disorders. We have been interested for a long time in the regulation of transcriptional events by corepressor and coactivator complexes and in particular we have focused on the NCoR/SMRT corepressors and its associated proteins HDAC3, TBL1 and TBLR1. More recently, based on the finding that another component of the same complex, GPS2, was required for the adipogenic differentiation of 3T3-L1 cells, we began investigating the mechanism of its actions in adipogenesis and uncovered a critical, non-transcriptional role for GPS2 in regulating the enzymatic activity of the TRAF2/CIAP1/Ubc13 ubiquitin conjugating complex and therefore inhibiting the pro-inflammatory TNFalpha pathway. Our goal now is to investigate, both in vitro and in vivo, in tissue-specific mouse models, how the different components of the NCoR complex contribute to broadly regulate the cellular responses to external stimulation by acting in different cellular compartments to modulate hormonal and inflammatory pathways. Ongoing projects aim at: i) determining GPS2 role in the regulation of K63 ubiquitin chain formation within inflammatory responses regulated by Toll-like receptors and TNFalpha in macrophages and B-cells; ii) dissecting the molecular mechanism of GPS2 role in nuclear receptor-mediated transcriptional regulation in differentiating and mature adipocytes; iii) understanding how GPS2 sub-cellular localization and specific functions are regulated by post-translational modifications in different cell types.

Opportunities:

Please contact Dr. Perissi by e-mail for more information about open positions for postdoctoral fellows and graduate students.

Research Themes:

Metabolism, Obesity/Diabetes

Signal Transduction and Cancer

2012-2015 Boston University: Peter Paul Professor


Coordinated regulation of breast cancer cell growth and metabolism though inhibition of non-proteolytic K63 ubiquitination
02/01/2017 - 09/30/2022 (PI)
Department of Defense

Ubiquitin-dependent Regulation of Inflammation and Insulin Resistance
04/15/2014 - 03/31/2018 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5R01DK100422-04

Expansion of the Diabetes Research Center's Pilot and Feasibility Program
09/14/2012 - 06/30/2016 (SP Co-PI of Sub-Project / SP)
Joslin Diabetes Center NIH NIDDK
5P30DK036836-29

Ubiquitin regulation in PPARgamma-mediated trascriptional regulation
04/01/2012 - 03/31/2014 (PI)
Boston Medical Center Corporation NIH NIDDK
5P30DK046200-20

Role of the NCoR Corepressor Complex in the Development of Insulin Resistance
09/25/2010 - 06/30/2013 (PI)
NIH/National Diabetes & Digestive & Kidney Diseases
5R00DK078756-05



Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Lentucci C, Belkina AC, Cederquist CT, Chan M, Johnson HE, Prasad S, Lopacinski A, Nikolajczyk BS, Monti S, Snyder-Cappione J, Tanasa B, Cardamone MD, Perissi V. Inhibition of Ubc13-mediated Ubiquitination by GPS2 Regulates Multiple Stages of B Cell Development. J Biol Chem. 2017 Feb 17; 292(7):2754-2772.View Related Profiles. PMID: 28039360; DOI: 10.1074/jbc.M116.755132;.
  2. Cederquist CT, Lentucci C, Martinez-Calejman C, Hayashi V, Orofino J, Guertin D, Fried SK, Lee MJ, Cardamone MD, Perissi V. Systemic insulin sensitivity is regulated by GPS2 inhibition of AKT ubiquitination and activation in adipose tissue. Molecular Metabolism. 2016; 1(6):125-137. View Publication
  3. Cederquist CT, Lentucci C, Martinez-Calejman C, Hayashi V, Orofino J, Guertin D, Fried SK, Lee MJ, Cardamone MD, Perissi V. Systemic insulin sensitivity is regulated by GPS2 inhibition of AKT ubiquitination and activation in adipose tissue. Mol Metab. 2017 Jan; 6(1):125-137.View Related Profiles. PMID: 28123943; DOI: 10.1016/j.molmet.2016.10.007;.
  4. Huang J, Cardamone MD, Johnson HE, Neault M, Chan M, Floyd ZE, Mallette FA, Perissi V. Exchange Factor TBL1 and Arginine Methyltransferase PRMT6 Cooperate in Protecting G Protein Pathway Suppressor 2 (GPS2) from Proteasomal Degradation. J Biol Chem. 2015 Jul 31; 290(31):19044-54.View Related Profiles. PMID: 26070566; PMCID: PMC4521029; DOI: 10.1074/jbc.M115.637660;.
  5. Cardamone MD, Tanasa B, Chan M, Cederquist CT, Andricovich J, Rosenfeld MG, Perissi V. GPS2/KDM4A pioneering activity regulates promoter-specific recruitment of PPAR?. Cell Rep. 2014 Jul 10; 8(1):163-76.View Related Profiles. PMID: 24953653; PMCID: PMC4104678; DOI: 10.1016/j.celrep.2014.05.041;.
  6. Scafoglio C, Smolka M, Zhou H, Perissi V, Rosenfeld MG. The co-repressor SMRT delays DNA damage-induced caspase activation by repressing pro-apoptotic genes and modulating the dynamics of checkpoint kinase 2 activation. PLoS One. 2013; 8(5):e59986. PMID: 23690919; PMCID: PMC3656868; DOI: 10.1371/journal.pone.0059986;.
  7. Cardamone MD, Krones A, Tanasa B, Taylor H, Ricci L, Ohgi KA, Glass CK, Rosenfeld MG, Perissi V. A protective strategy against hyperinflammatory responses requiring the nontranscriptional actions of GPS2. Mol Cell. 2012 Apr 13; 46(1):91-104.View Related Profiles. PMID: 22424771; PMCID: PMC3327812; DOI: 10.1016/j.molcel.2012.01.025;.
  8. Perissi V, Jepsen K, Glass CK, Rosenfeld MG. Deconstructing repression: evolving models of co-repressor action. Nat Rev Genet. 2010 Feb; 11(2):109-23. PMID: 20084085; DOI: 10.1038/nrg2736;.
  9. Huang W, Ghisletti S, Perissi V, Rosenfeld MG, Glass CK. Transcriptional integration of TLR2 and TLR4 signaling at the NCoR derepression checkpoint. Mol Cell. 2009 Jul 10; 35(1):48-57. PMID: 19595715; PMCID: PMC2759189; DOI: 10.1016/j.molcel.2009.05.023;.
  10. Perissi V, Scafoglio C, Zhang J, Ohgi KA, Rose DW, Glass CK, Rosenfeld MG. TBL1 and TBLR1 phosphorylation on regulated gene promoters overcomes dual CtBP and NCoR/SMRT transcriptional repression checkpoints. Mol Cell. 2008 Mar 28; 29(6):755-66. PMID: 18374649; PMCID: PMC2364611; DOI: 10.1016/j.molcel.2008.01.020;.
Showing 10 of 21 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 21 publications over 15 distinct years, with a maximum of 3 publications in 2016

YearPublications
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In addition to these self-described keywords below, a list of MeSH based concepts is available here.

chromatin remodelling
genomics
inflammation
metabolism
nuclear receptors
transcription
ubiquitin
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72 E. Concord St Silvio Conte (K)
Boston MA 02118
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