Olga Gursky, PhD
Professor
Boston University School of Medicine
Dept of Physiology & Biophysics

PhD, Brandeis University
MS, Moscow State University



Our research focus is on protein folding, structure and stability. It includes the analysis of the energetic-structure-function relationship and folding pathways in proteins and peptides by circular dichroism spectroscopy, differential scanning calorimetry, fluorescence, x-ray crystallography, and site-directed mutagenesis.

Our on-going NIH-funded work is aimed at understanding the energetic and structural basis for the conformational plasticity of apolipoproteins. These are protein constituents of lipoproteins that mediate lipid transport and metabolism and are central in the pathogenesis of atherosclerosis, stroke, and certain forms of amyloidosis. Apolipoproteins are distinct in their structural adaptability to various lipoprotein particles and to plasma. We try to understand in molecular detail the energetic and structural basis for this adaptability.

A major focus of our research is on the molecular mechanisms of lipoprotein stabilization and fusion. In 2002 we revealed that lipoprotein stability is determined by kinetic barriers. Similar barriers may modulate in-vivo lipoprotein transformations. Our goal is to obtain key molecular determinants for these energy barriers.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences




Structural Stability and Functional Remodeling of High-density Lipoproteins
07/01/2016 - 06/30/2017 (PI)
NIH/National Institute of General Medical Sciences
4R01GM067260-14

Structural Stability and Functional Remodeling of High-density Lipoproteins
09/01/2013 - 06/30/2016 (PI)
NIH/National Institute of General Medical Sciences
3R01GM067260-13S1

Structural Thermodynamics of Human Apolipoprotein C-1
12/20/2002 - 05/31/2008 (PI)
NIH/National Institute of General Medical Sciences
3 R01 GM67260 08S1

Structural Thermodynamics of Human Apolipoprotein C-1
12/15/1998 - 11/30/2002 (PI)
NIH/National Heart, Lung, and Blood Institute
5 R29 HL61429 04




Yr Title Project-Sub Proj Pubs
2016 Structural stability and functional remodeling of high-density lipoproteins 4R01GM067260-14 36
2014 Structural stability and functional remodeling of high-density lipoproteins 5R01GM067260-12 36
2013 Structural stability and functional remodeling of high-density lipoproteins 2R01GM067260-11A1 36
2010 Structural stability and fusion of high- and very-low-density lipoproteins contai 5R01GM067260-10 36
2010 Energetics-Structure-Function Relationship in Lipoproteins 5P01HL026335-30-9 225
2009 Structural stability and fusion of high- and very-low-density lipoproteins contai 2R01GM067260-09A1 36
2007 Structural Thermodynamics of Human Apolipoprotein C-1 3R01GM067260-08S1 36
2006 Energetics-Structure-Function Relationship in Lipoproteins 2P01HL026335-26-9 225
2006 Structural Thermodynamics of Human Apolipoprotein C-1 5R01GM067260-08 36
2005 Structural Thermodynamics of Human Apolipoprotein C-1 5R01GM067260-07 36
Showing 10 of 16 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Das M, Wilson CJ, Mei X, Wales T, Engen JR, Gursky O. Structural stability and local dynamics in disease-causing mutants of human apolipoprotein a-I: what makes the protein amyloidogenic? Amyloid. 2017 Mar; 24(sup1):11-12.View Related Profiles. PMID: 28042708; DOI: 10.1080/13506129.2016.1269737;.
  2. Frame NM, Gursky O. Structure of serum amyloid A suggests a mechanism for selective lipoprotein binding and functions: SAA as a hub in macromolecular interaction networks. Amyloid. 2017 Mar; 24(sup1):13-14.View Related Profiles. PMID: 28042712; DOI: 10.1080/13506129.2016.1270930;.
  3. Jayaraman S, Sánchez-Quesada JL, Gursky O. Triglyceride increase in the core of high-density lipoproteins augments apolipoprotein dissociation from the surface: Potential implications for treatment of apolipoprotein deposition diseases. Biochim Biophys Acta. 2017 Jan; 1863(1):200-210.View Related Profiles. PMID: 27768903; DOI: 10.1016/j.bbadis.2016.10.010;.
  4. Jayaraman S, Haupt C, Gursky O. Paradoxical effects of SAA on lipoprotein oxidation suggest a new antioxidant function for SAA. J Lipid Res. 2016 Dec; 57(12):2138-2149.View Related Profiles. PMID: 27744369.
  5. Rull A, Jayaraman S, Gantz DL, Rivas-Urbina A, Pérez-Cuellar M, Ordóñez-Llanos J, Sánchez-Quesada JL, Gursky O. Thermal stability of human plasma electronegative low-density lipoprotein: A paradoxical behavior of low-density lipoprotein aggregation. Biochim Biophys Acta. 2016 Sep; 1861(9 Pt A):1015-24.View Related Profiles. PMID: 27233433; DOI: 10.1016/j.bbalip.2016.05.008;.
  6. Frame NM, Gursky O. Structure of serum amyloid A suggests a mechanism for selective lipoprotein binding and functions: SAA as a hub in macromolecular interaction networks. FEBS Lett. 2016 Mar; 590(6):866-79.View Related Profiles. PMID: 26918388; PMCID: PMC4805461; DOI: 10.1002/1873-3468.12116;.
  7. Das M, Wilson CJ, Mei X, Wales TE, Engen JR, Gursky O. Structural Stability and Local Dynamics in Disease-Causing Mutants of Human Apolipoprotein A-I: What Makes the Protein Amyloidogenic? J Mol Biol. 2016 Jan 29; 428(2 Pt B):449-62.View Related Profiles. PMID: 26562506; PMCID: PMC4744490; DOI: 10.1016/j.jmb.2015.10.029;.
  8. Jayaraman S, Haupt C, Gursky O. Thermal transitions in serum amyloid A in solution and on the lipid: implications for structure and stability of acute-phase HDL. J Lipid Res. 2015 Aug; 56(8):1531-42.View Related Profiles. PMID: 26022803; PMCID: PMC4513994; DOI: 10.1194/jlr.M059162;.
  9. Gursky O. Structural stability and functional remodeling of high-density lipoproteins. FEBS Lett. 2015 Sep 14; 589(19 Pt A):2627-39. PMID: 25749369; PMCID: PMC4561042; DOI: 10.1016/j.febslet.2015.02.028;.
  10. Das M, Gursky O. Amyloid-Forming Properties of Human Apolipoproteins: Sequence Analyses and Structural Insights. Adv Exp Med Biol. 2015; 855:175-211.View Related Profiles. PMID: 26149931; DOI: 10.1007/978-3-319-17344-3_8;.
Showing 10 of 61 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 61 publications over 22 distinct years, with a maximum of 6 publications in 2016

YearPublications
19922
19942
19962
19981
19991
20002
20011
20021
20034
20041
20055
20062
20075
20083
20092
20103
20114
20124
20133
20142
20155
20166
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

calorimetry
energy landscapes
lipoproteins
protein spectroscopy
protein stability
protein structure-function
thermodynamics and kinetics

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Career Mentor
  • Co-Mentor or Peer Mentor
  • Research / Scholarly Mentor
Contact for Mentoring:


700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
Google Map


Gursky's Networks
Click the "See All" links for more information and interactive visualizations
Concepts
_
Co-Authors
_
Similar People
_
Same Department