James A. Hamilton, PhD
Professor
Boston University School of Medicine
Dept of Physiology & Biophysics

PhD, Indiana University Bloomington



Research in our group is aimed at providing fundamental information relating to heart disease, diabetes, obesity, and diseases related to fatty acid metabolism. An overall goal to is to develop novel approaches to biomedical issues by integrating physical-chemical and physiological/biochemical approaches. In our newer research this is achieved by assembling multi-disciplinary teams to translate basic research into clinical applications. We use physical and instrumental methods (including solution state 13C NMR spectroscopy, solid state and magic angle spinning multinuclear NMR, multidimensional NMR, MR imaging, and fluorescence) that are tailored to the specific questions we are addressing. These techniques are complemented with molecular modeling, molecular biology and other cell biology methods.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences


Professor
Boston University School of Medicine
Radiology


Research Associate Professor
Boston University School of Medicine
Biochemistry


Research Associate Professor
Boston University School of Medicine
Medicine
General Internal Medicine Section

Boston Medical Center




How CD36 and Caveloin-1 Affect Fatty Acid Uptake
01/01/2011 - 12/31/2013 (PI)
American Diabetes Association

NMR and MR Imaging Studies of Plaque Rupture
08/08/2000 - 03/31/2010 (PI)
NIH/National Heart, Lung, and Blood Institute
5 R01 HL61825 04

Investigation of Pepducin Membrane “Flip-Flop” -- Effects of Peptide Sequence and Lipid Composition
01/01/2009 - 12/31/2009 (PI)
Ascent Therapeutics

Transport and Metabolism of Fatty Acids in Adipocytes
04/16/2001 - 03/31/2007 (PI)
NIH/National Heart, Lung, and Blood Institute
5 R01 HL67188 04

NMR Studies of Lipids in Disease
12/08/1997 - 11/30/2000 (PI)
NIH/National Heart, Lung, and Blood Institute
5 R01 HL41904 08




Yr Title Project-Sub Proj Pubs
2010 Imaging the Vascular Consequences of Lipid Deposition 5P50HL083801-05-3 54
2009 Imaging the Vascular Consequences of Lipid Deposition 5P50HL083801-04-3 54
2008 Imaging the Vascular Consequences of Lipid Deposition 5P50HL083801-03-3 54
2007 Imaging the Vascular Consequences of Lipid Deposition 5P50HL083801-02-3 54
2006 Imaging the Vascular Consequences of Lipid Deposition 1P50HL083801-01-3 54
2005 FATTY ACID TRANSPORT--STRUCTURAL AND CELL BIOLOGY 5P01HL026335-25-7 225
2004 FATTY ACID TRANSPORT--STRUCTURAL AND CELL BIOLOGY 5P01HL026335-24-7 225
2004 Transport and Metabolism of Fatty Acids in Adipocytes 5R01HL067188-04 8
2003 Transport and Metabolism of Fatty Acids in Adipocytes 5R01HL067188-03 8
2003 NMR AND MR IMAGING STUDIES OF PLAQUE RUPTURE 5R01HL061825-04 5
Showing 10 of 33 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Stein-Merlob AF, Hara T, McCarthy JR, Mauskapf A, Hamilton JA, Ntziachristos V, Libby P, Jaffer FA. Atheroma Susceptible to Thrombosis Exhibit Impaired Endothelial Permeability In Vivo as Assessed by Nanoparticle-Based Fluorescence Molecular Imaging. Circ Cardiovasc Imaging. 2017 May; 10(5). PMID: 28487316.
  2. Jay AG, Hamilton JA. Disorder Amidst Membrane Order: Standardizing Laurdan Generalized Polarization and Membrane Fluidity Terms. J Fluoresc. 2017 Jan; 27(1):243-249.View Related Profiles. PMID: 27738919; DOI: 10.1007/s10895-016-1951-8;.
  3. Jay AG, Hamilton JA. The enigmatic membrane fatty acid transporter CD36: New insights into fatty acid binding and their effects on uptake of oxidized LDL. Prostaglandins Leukot Essent Fatty Acids. 2016 May 20.View Related Profiles. PMID: 27288302; DOI: 10.1016/j.plefa.2016.05.005;.
  4. Pham TA, Hua N, Phinikaridou A, Killiany R, Hamilton J. Early in vivo discrimination of vulnerable atherosclerotic plaques that disrupt: A serial MRI study. Atherosclerosis. 2016 Jan; 244:101-7.View Related Profiles. PMID: 26606442; DOI: 10.1016/j.atherosclerosis.2015.11.013;.
  5. Hua N, Baik F, Pham T, Phinikaridou A, Giordano N, Friedman B, Whitney M, Nguyen QT, Tsien RY, Hamilton JA. Identification of High-Risk Plaques by MRI and Fluorescence Imaging in a Rabbit Model of Atherothrombosis. PLoS One. 2015; 10(10):e0139833.View Related Profiles. PMID: 26448434; PMCID: PMC4598148; DOI: 10.1371/journal.pone.0139833;.
  6. Hasturk H, Abdallah R, Kantarci A, Nguyen D, Giordano N, Hamilton J, Van Dyke TE. Resolvin E1 (RvE1) Attenuates Atherosclerotic Plaque Formation in Diet and Inflammation-Induced Atherogenesis. Arterioscler Thromb Vasc Biol. 2015 May; 35(5):1123-33.View Related Profiles. PMID: 25792445; PMCID: PMC4415167; DOI: 10.1161/ATVBAHA.115.305324;.
  7. Jay AG, Chen AN, Paz MA, Hung JP, Hamilton JA. CD36 binds oxidized low density lipoprotein (LDL) in a mechanism dependent upon fatty acid binding. J Biol Chem. 2015 Feb 20; 290(8):4590-603.View Related Profiles. PMID: 25555908; PMCID: PMC4335201; DOI: 10.1074/jbc.M114.627026;.
  8. Papadopoulos G, Kramer CD, Slocum CS, Weinberg EO, Hua N, Gudino CV, Hamilton JA, Genco CA. A mouse model for pathogen-induced chronic inflammation at local and systemic sites. J Vis Exp. 2014; (90):e51556.View Related Profiles. PMID: 25146644; DOI: 10.3791/51556;.
  9. Slocum C, Coats SR, Hua N, Kramer C, Papadopoulos G, Weinberg EO, Gudino CV, Hamilton JA, Darveau RP, Genco CA. Distinct lipid a moieties contribute to pathogen-induced site-specific vascular inflammation. PLoS Pathog. 2014 Jul; 10(7):e1004215.View Related Profiles. PMID: 25010102; PMCID: PMC4092147; DOI: 10.1371/journal.ppat.1004215;.
  10. Hua N, Chen Z, Phinikaridou A, Pham T, Qiao Y, LaValley MP, Bigornia SJ, Ruth MR, Apovian CM, Ruberg FL, Hamilton JA. The influence of pericardial fat upon left ventricular function in obese females: evidence of a site-specific effect. J Cardiovasc Magn Reson. 2014; 16:37.View Related Profiles. PMID: 24884541; PMCID: PMC4046092; DOI: 10.1186/1532-429X-16-37;.
Showing 10 of 135 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 135 publications over 31 distinct years, with a maximum of 14 publications in 2007

YearPublications
19871
19884
19893
19901
19912
19922
19933
19943
19957
19965
19972
19984
19993
20003
20014
20026
20037
20045
20054
20067
200714
20086
20097
20105
20115
20123
20136
20146
20154
20162
20171
Contact for Mentoring:


700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
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