C. James McKnight, PhD
Associate Professor
Boston University School of Medicine
Dept of Physiology & Biophysics

MA, University of Delaware
PhD, University of Texas Southwestern Medical



My expertise is in protein structure, function, dynamics and folding and chemistry. Methods used include molecular biology, chromatography, NMR spectroscopy, X-ray crystallography, UV/Vis and circular dichroism spectroscopy, electron microscopy, molecular modeling and dynamics. We look at actin binding proteins (especially those containing villin-type headpiece domains) and lipid binding proteins including apolipoprotein B, the essential protein component of low density lipoprotein (LDL, the bad cholesterol) whose elevated levels are correlated with atherosclerosis, stroke, heart and cardiovascular disease.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences



2011-2011 The Protein Society: I was elected to the Nominating Committee of the Protein Society by in a competitive election by the


A Console Upgrade and Cryogenic Probe for a 500 MHz System for Biomedical Research
07/05/2013 - 11/30/2014 (PI)
NIH/Office of the Director
1S10OD011941-01A1

Localizing and Modeling Headpiece Domains on F-Actin
03/01/2002 - 02/28/2007 (PI)
NIH/National Institute of General Medical Sciences
5 R01 GM62886 05




Yr Title Project-Sub Proj Pubs
2013 A Console Upgrade and Cryogenic Probe for a 500 MHz NMR System for Biomedical Res 1S10OD011941-01A1
2011 25th Annual Symposium of The Protein Society 1R13GM099353-01
2010 Early Events in Lipoprotein Assembly 5R01HL094510-02 1
2010 Physical Equipment Facilities 5P01HL026335-30-9001 225
2009 Early Events in Lipoprotein Assembly 1R01HL094510-01A1 1
2006 Physical Equipment Facilities 2P01HL026335-26-9001 225
2006 Localizing and Modeling Headpiece Domains on F-Actin 5R01GM062886-05 19
2005 Localizing and Modeling Headpiece Domains on F-Actin 5R01GM062886-04 19
2004 Localizing and Modeling Headpiece Domains on F-Actin 5R01GM062886-03 19
2003 Localizing and Modeling Headpiece Domains on F-Actin 5R01GM062886-02 19
Showing 10 of 16 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Chin SL, Lu Q, Dane EL, Dominguez L, McKnight CJ, Straub JE, Grinstaff MW. Combined Molecular Dynamics Simulations and Experimental Studies of the Structure and Dynamics of Poly-Amido-Saccharides. J Am Chem Soc. 2016 May 25; 138(20):6532-40.View Related Profiles. PMID: 27119983; DOI: 10.1021/jacs.6b01837;.
  2. Harpole KW, O'Brien ES, Clark MA, McKnight CJ, Vugmeyster L, Wand AJ. The unusual internal motion of the villin headpiece subdomain. Protein Sci. 2016 Feb; 25(2):423-32. PMID: 26473993; PMCID: PMC4815346; DOI: 10.1002/pro.2831;.
  3. Raina D, Agarwal P, Lee J, Bharti A, McKnight CJ, Sharma P, Kharbanda S, Kufe D. Characterization of the MUC1-C Cytoplasmic Domain as a Cancer Target. PLoS One. 2015; 10(8):e0135156.View Related Profiles. PMID: 26267657; PMCID: PMC4534190; DOI: 10.1371/journal.pone.0135156;.
  4. Chen L, Brown JW, Mok YF, Hatters DM, McKnight CJ. The allosteric mechanism induced by protein kinase A (PKA) phosphorylation of dematin (band 4.9). J Biol Chem. 2015 Jul 17; 290(29):17808. PMID: 26188045; PMCID: PMC4505031; DOI: 10.1074/jbc.A112.438861;.
  5. Brown JW, Bullitt E, Sriswasdi S, Harper S, Speicher DW, McKnight CJ. The Physiological Molecular Shape of Spectrin: A Compact Supercoil Resembling a Chinese Finger Trap. PLoS Comput Biol. 2015 Jun; 11(6):e1004302.View Related Profiles. PMID: 26067675; PMCID: PMC4466138; DOI: 10.1371/journal.pcbi.1004302;.
  6. Jiang ZG, Wu Y, Csizmadia E, Feldbrügge L, Enjyoji K, Tigges J, Toxavidis V, Stephan H, Müller CE, Müller CE, McKnight CJ, Moss A, Robson SC. Characterization of circulating microparticle-associated CD39 family ecto-nucleotidases in human plasma. Purinergic Signal. 2014 Dec; 10(4):611-8. PMID: 25165006; PMCID: PMC4272360; DOI: 10.1007/s11302-014-9423-6;.
  7. Miller SA, Burnett JR, Leonis MA, McKnight CJ, van Bockxmeer FM, Hooper AJ. Novel missense MTTP gene mutations causing abetalipoproteinemia. Biochim Biophys Acta. 2014 Oct; 1842(10):1548-54. PMID: 25108285; DOI: 10.1016/j.bbalip.2014.08.001;.
  8. Mitsche MA, Packer LE, Brown JW, Jiang ZG, Small DM, McKnight CJ. Surface tensiometry of apolipoprotein B domains at lipid interfaces suggests a new model for the initial steps in triglyceride-rich lipoprotein assembly. J Biol Chem. 2014 Mar 28; 289(13):9000-12.View Related Profiles. PMID: 24515109; PMCID: PMC3979410; DOI: 10.1074/jbc.M113.540955;.
  9. Fedechkin SO, Brockerman J, Pfaff DA, Burns L, Webb T, Nelson A, Zhang F, Sabantsev AV, Melnikov AS, McKnight CJ, Smirnov SL. Gelsolin-like activation of villin: calcium sensitivity of the long helix in domain 6. Biochemistry. 2013 Nov 12; 52(45):7890-900. PMID: 24070253; DOI: 10.1021/bi400699s;.
  10. Farelli JD, Gumbart JC, Akey IV, Hempstead A, Amyot W, Head JF, McKnight CJ, Isberg RR, Akey CW. IcmQ in the Type 4b secretion system contains an NAD+ binding domain. Structure. 2013 Aug 6; 21(8):1361-73.View Related Profiles. PMID: 23850453; PMCID: PMC3816012; DOI: 10.1016/j.str.2013.05.017;.
Showing 10 of 63 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 63 publications over 23 distinct years, with a maximum of 7 publications in 2009

YearPublications
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Contact for Mentoring:


700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
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