Tsuneya Ikezu, MD, PhD
Professor
Boston University School of Medicine
Dept of Pharmacology & Experimental Therapeutics

MD, Tokyo Medical and Dental University
PhD, Tokyo Medical and Dental University



My expertise is biomedical research on neurodegenerative disorders, neuroinflammation, and molecular pharmacologic interventions. Specifically, I have been studying the therapeutic potentials of select anti-inflammatory and neurotrophic factors on animal models of Alzheimer's disease and frontotemporal dementia using virus-mediated gene delivery system. The virus systems include adeno-associated virus, adenovirus, and lentivirus. I have also been investigating the role of innate immunity, more specifically the functions of macrophages and microglia, on HIV-1 infection and neuroinflammation in the context of HIV-associated neurocognitive dysfunction and Alzheimer's disease.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences


Professor
Boston University School of Medicine
Neurology




Exosome-mediated propagation of pathogenic tau protein
09/30/2016 - 06/30/2021 (PI)
NIH/National Institute on Aging
1RF1AG054199-01

Therapeutic evaluation of novel tau kinase inhibitors in Alzheimer's disease
07/01/2017 - 06/30/2019 (PI)
Coins for Alzheimer's Research Trust

Novel TREM2 Reporter Platform for Drug Discovery
07/01/2016 - 06/30/2019 (PI)
Bright Focus Foundation

Development of cell-based shRNA screening platform for targeting exosome pathway
03/01/2017 - 02/28/2019 (PI)
Ono Pharmaceutical Co Ltd (Japan)

Abbvie-BU Collaborative Proposal
12/13/2016 - 12/12/2018 (PI)
AbbVie

Evaluation of STX6 silencing on the novel AAV-based PSP model
09/01/2016 - 08/31/2018 (PI)
CurePSP

Characterization of Microglial Wnt Signaling in Maternal Immune Activation-Related Autism
04/01/2015 - 03/31/2018 (PI)
Landreth Family Foundation

Characterization of Microglial Wnt Signaling in Maternal Immune Activation-Related Autism
04/01/2015 - 03/31/2018 (PI)
The Nancy Lurie Marks Family Foundation

Exosome Pathway as a Novel Therapeutic Target of Tauopathy
10/01/2014 - 09/30/2017 (PI)
Alzheimer's Association

Proteomic and RNA profiling of Exosomes in CTE biospecimens
08/01/2016 - 07/31/2017 (PI)
Aethlon Medical, Inc.

Showing 10 of 15 results. Show All Results



Yr Title Project-Sub Proj Pubs
2016 Exosome-mediated propagation of pathogenic tau protein 1RF1AG054199-01
2012 Cells and Tissue Core 5P01NS043985-10-9003 195
2011 Cells and Tissue Core 5P01NS043985-09-9003 195
2011 Cells and Tissue Core 5P01NS043985-09-9003 195
2010 In Vivo Reconstitution Models for NeuroAIDS and Beta-Amyloidosis 7R01MH083523-03 6
2010 Anti-inflammatory regulation of beta-amyloidosis 7R21AG032600-03 11
2010 Anti-inflammatory regulation of beta-amyloidosis 5R21AG032600-02 11
2010 Cells and Tissue Core 5P01NS043985-08-9003 195
2009 In Vivo Reconstitution Models for NeuroAIDS and Beta-Amyloidosis 1R01MH083523-01 6
2009 Anti-inflammatory regulation of beta-amyloidosis 1R21AG032600-01A1 11
Showing 10 of 21 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Varnum MM, Clayton KA, Yoshii-Kitahara A, Yonemoto G, Koro L, Ikezu S, Ikezu T. A split-luciferase complementation, real-time reporting assay enables monitoring of the disease-associated transmembrane protein TREM2 in live cells. J Biol Chem. 2017 Jun 23; 292(25):10651-10663.View Related Profiles. PMID: 28490631.
  2. Fujioka S, Curry SE, Kennelly KD, Tacik P, Heckman MG, Tsuboi Y, Strongosky AJ, van Gerpen JA, Uitti RJ, Ross OA, Ikezu T, Wszolek ZK. Occurrence of Crohn''s disease with Parkinson''s disease. Parkinsonism Relat Disord. 2017 Apr; 37:116-117. PMID: 28215729; DOI: 10.1016/j.parkreldis.2017.01.013;.
  3. Wolozin B, Ikezu T. Corrigendum to "Syk and ye shall find" [EBioMedicine 2 (11) (2015) 190-1591]. EBioMedicine. 2016 Jun; 8:349.View Related Profiles. PMID: 27428444; DOI: 10.1016/j.ebiom.2016.05.033;.
  4. Zhou Q, Yen A, Rymarczyk G, Asai H, Trengrove C, Aziz N, Kirber MT, Mostoslavsky G, Ikezu T, Wolozin B, Bolotina VM. Impairment of PARK14-dependent Ca(2+) signalling is a novel determinant of Parkinson''s disease. Nat Commun. 2016; 7:10332.View Related Profiles. PMID: 26755131; PMCID: PMC4729940; DOI: 10.1038/ncomms10332;.
  5. Stern RA, Tripodis Y, Baugh CM, Fritts NG, Martin BM, Chaisson C, Cantu RC, Joyce JA, Shah S, Ikezu T, Zhang J, Gercel-Taylor C, Taylor DD. Preliminary Study of Plasma Exosomal Tau as a Potential Biomarker for Chronic Traumatic Encephalopathy. J Alzheimers Dis. 2016; 51(4):1099-109.View Related Profiles. PMID: 26890775; PMCID: PMC4833534; DOI: 10.3233/JAD-151028;.
  6. Sapkota K, Mao Z, Synowicki P, Lieber D, Liu M, Ikezu T, Gautam V, Monaghan DT. GluN2D N-Methyl-d-Aspartate Receptor Subunit Contribution to the Stimulation of Brain Activity and Gamma Oscillations by Ketamine: Implications for Schizophrenia. J Pharmacol Exp Ther. 2016 Mar; 356(3):702-11. PMID: 26675679; PMCID: PMC4767398; DOI: 10.1124/jpet.115.230391;.
  7. Wolozin B, Ikezu T. Syk and Yea Shall Find. EBioMedicine. 2015 Nov; 2(11):1590-1.View Related Profiles. PMID: 26870779; PMCID: PMC4740329; DOI: 10.1016/j.ebiom.2015.11.012;.
  8. Asai H, Ikezu S, Tsunoda S, Medalla M, Luebke J, Haydar T, Wolozin B, Butovsky O, Kügler S, Ikezu T. Depletion of microglia and inhibition of exosome synthesis halt tau propagation. Nat Neurosci. 2015 Nov; 18(11):1584-93.View Related Profiles. PMID: 26436904; PMCID: PMC4694577; DOI: 10.1038/nn.4132;.
  9. Woodbury ME, Freilich RW, Cheng CJ, Asai H, Ikezu S, Boucher JD, Slack F, Ikezu T. miR-155 Is Essential for Inflammation-Induced Hippocampal Neurogenic Dysfunction. J Neurosci. 2015 Jul 1; 35(26):9764-81.View Related Profiles. PMID: 26134658; PMCID: PMC4571507; DOI: 10.1523/JNEUROSCI.4790-14.2015;.
  10. Jun G, Asai H, Zeldich E, Drapeau E, Chen C, Chung J, Park JH, Kim S, Haroutunian V, Foroud T, Kuwano R, Haines JL, Pericak-Vance MA, Schellenberg GD, Lunetta KL, Kim JW, Buxbaum JD, Mayeux R, Ikezu T, Abraham CR, Farrer LA. PLXNA4 is associated with Alzheimer disease and modulates tau phosphorylation. Ann Neurol. 2014 Sep; 76(3):379-92.View Related Profiles. PMID: 25043464; DOI: 10.1002/ana.24219;.
Showing 10 of 78 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 78 publications over 24 distinct years, with a maximum of 11 publications in 2008

YearPublications
19922
19931
19941
19951
19961
19974
19983
19993
20021
20032
20044
20051
20064
20075
200811
20094
20105
20115
20125
20133
20143
20154
20163
20172

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Contact for Mentoring:


72 E. Concord St Instructional (L)
Boston MA 02118
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