Erdjan Salih, PhD
Associate Professor
Boston University Henry M. Goldman School of Dental Medicine
Dept of Molecular & Cell Biology

PhD, University of London



Dr. Salih’s research expertise and interests are in several areas of biomedical sciences. These include regulation of biomineralization and modulation of bone remodeling stages such as bone resorption and formation utilizing both cell culture and mouse calvarial bone organ culture systems. Such studies are coupled with extensive protein structure-function analysis of bone extracellular matrix (ECM) components specifically the phosphoproteins and protein kinases that phosphorylate them. Development and use of novel chemistries for qualitative and quantitative determination of the precise phosphorylation sites and their topographical distribution on phosphoproteins using both N-terminal automated amino-acid sequencing and mass spectrometric (MS) technologies. Application of the state-of-the-art MS instrumentations such as MALDI-TOF-MS/MS and LTQ-LC-ESI-MS/MS for large-scale proteome and phosphoproteome studies in general cell biology and bone biology. These MS based approaches have been utilized in conjunction with specific new chemistries for quantitative proteomics and phosphoproteomics in both general cell biology and clinical samples, saliva and gingival crevicular fluid from patients with periodontal disease for diagnostic/predictive biomarker discovery. Further extensive studies have been carried out in the field of tissue engineering by design and use of bioactive composites of bone ECM phosphoproteins and native collagen as a carrier in in vivo models of bone regeneration and reparative dentinogenesis studies. Additional major interests and research areas are development and use of novel three-dimensional cancer-bone metastasis model using ex-vivo mouse calvarial bone organ cultures. This novel model developed by Dr Salih has been more recently utilized to evaluate effects of clinically used bisphosphonates on cancer-bone interactions as well as establish why and how patients who are treated with bisphosphonates for osteoporosis and cancer treatment are at high risk for “bisphosphonate induced-osteonecrosis of jaw bone”.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences



Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Salih E. Qualitative and Quantitative Proteome Analysis of Oral Fluids in Health and Periodontal Disease by Mass Spectrometry. Methods Mol Biol. 2017; 1537:37-60. PMID: 27924587.
  2. Alasmari A, Lin SC, Dibart S, Salih E. Bone microenvironment-mediated resistance of cancer cells to bisphosphonates and impact on bone osteocytes/stem cells. Clin Exp Metastasis. 2016 Aug; 33(6):563-88. PMID: 27155840; DOI: 10.1007/s10585-016-9798-6;.
  3. Dibart S, Alasmari A, Zanni O, Salih E. Effect of Corticotomies with Different Instruments on Cranial Bone Biology Using an Ex Vivo Calvarial Bone Organ Culture Model System. Int J Periodontics Restorative Dent. 2016; 36 Suppl:s123-36.View Related Profiles. PMID: 27031627; DOI: 10.11607/prd.2701;.
  4. Carneiro LG, Nouh H, Salih E. Quantitative gingival crevicular fluid proteome in health and periodontal disease using stable isotope chemistries and mass spectrometry. J Clin Periodontol. 2014 Aug; 41(8):733-47.View Related Profiles. PMID: 24738839; PMCID: PMC4128226; DOI: 10.1111/jcpe.12262;.
  5. Liu J, Czernick D, Lin SC, Alasmari A, Serge D, Salih E. Novel bioactivity of phosvitin in connective tissue and bone organogenesis revealed by live calvarial bone organ culture models. Dev Biol. 2013 Sep 1; 381(1):256-75.View Related Profiles. PMID: 23791550; DOI: 10.1016/j.ydbio.2013.06.005;.
  6. Czernick D, Liu J, Serge D, Salih E. Topographical distribution of phosphorylation sites of phosvitins by mass spectrometry. J Proteomics. 2013 May 27; 83:76-98.View Related Profiles. PMID: 23474079; DOI: 10.1016/j.jprot.2013.02.016;.
  7. Curtin P, Youm H, Salih E. Three-dimensional cancer-bone metastasis model using ex-vivo co-cultures of live calvarial bones and cancer cells. Biomaterials. 2012 Feb; 33(4):1065-78. PMID: 22071100; PMCID: PMC3221840; DOI: 10.1016/j.biomaterials.2011.10.046;.
  8. Carneiro LG, Venuleo C, Oppenheim FG, Salih E. Proteome data set of human gingival crevicular fluid from healthy periodontium sites by multidimensional protein separation and mass spectrometry. J Periodontal Res. 2012 Apr; 47(2):248-62.View Related Profiles. PMID: 22029670; PMCID: PMC3272151; DOI: 10.1111/j.1600-0765.2011.01429.x;.
  9. Wang Z, Salih E, Burke PA. Quantitative analysis of cytokine-induced hepatocyte nuclear factor-4a phosphorylation by mass spectrometry. Biochemistry. 2011 Jun 14; 50(23):5292-300.View Related Profiles. PMID: 21598922; PMCID: PMC3115757; DOI: 10.1021/bi200540w;.
  10. Komatsu T, Salih E, Helmerhorst EJ, Offner GD, Oppenheim FG. Influence of histatin 5 on Candida albicans mitochondrial protein expression assessed by quantitative mass spectrometry. J Proteome Res. 2011 Feb 4; 10(2):646-55.View Related Profiles. PMID: 21080726; PMCID: PMC3033980; DOI: 10.1021/pr100861k;.
Showing 10 of 90 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 90 publications over 33 distinct years, with a maximum of 8 publications in 2004

YearPublications
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Contact for Mentoring:


700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
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