Adrienne Cupples, PhD
Professor
Boston University School of Public Health
Dept of Biostatistics

PhD, Boston University
MA, Boston University



L. Adrienne Cupples, Ph.D. is Professor of Biostatistics and of Epidemiology. She has a long standing interest in statistical methods for epidemiologic studies, for survival data analysis and for genetic epidemiology. She has taught for thirty years at both the introductory and advanced levels. She developed several of the courses in the Biostatistics curriculum, including Statistical Methods for Epidemiology (BS852) and has received numerous teaching awards, including the Norman A Scotch Award for Excellence in Teaching at the School of Public Health. For her efforts in research she received the BUSPH Faculty Career Award in Research & Scholarship as the First Recipient. And she received the Janet L. Norwood Award for Outstanding Achievement by a Woman in the Statistical Sciences as the ninth recipient in 2010 and the 2012 L. Adrienne Cupples Award for Excellence in Teaching, Research and Service in Biostatistics. She has collaborated in the Framingham Heart Study for more than 30 years on a variety of topics from risk factors for sudden death, nutritional epidemiology and most recently the genetic etiology of cardiovascular disease and its risk factors. She is Co-Principal Investigator of the NHLBI Contract to Boston University for the Framingham Heart Study and Co-Chair of the Framingham Genetics Steering Committee. She has a long history with the study of the genetic etiology of Alzheimer’s disease in the MIRAGE Study (Multi-Institutional Research of Alzheimer’s Genetic Epidemiology) and of Huntington disease. She has been actively involved in genetic risk prediction and evaluation of how people interpret and respond to such predictions, particularly in the context of Alzheimer's disease through the REVEAL (Risk Evaluation and Education for Alzheimer's Disease) Study.

Professor
Boston University School of Public Health
Department of Epidemiology


Framingham Heart Study


Boston Medical Center



2014 American Heart Association: EPI/NPAM 2014 Richard Remington Lecturer
2012 Boston University, Department of Biostatistics, School of Public Health: L. Adrienne Cupples Award for Excellence in Teaching, Research, and Service in Biostatistics
2010 Boston University School of Public Health: Faculty Career Award in Research & Scholarship, First Recipient
2010 University of Alabama: Janet L. Norwood Award for Outstanding Achievement by a Woman in the Statistical Sciences, 9th award
2006 University of Leeds, UK: Visiting Professor
1995 Boston University School of Public Health: Norman Scotch Award for Excellence in Teaching


Impact of Disclosing Amyloid Imaging Results to Cognitively Normal Individuals(REVEAL 5)
08/20/2015 - 07/31/2017 (PI)
The Brigham and Women's Hospital, Inc. NIH NIA
1RF1AG047866-01A1

Genetic Architecture of Adiposity in Multiple Large Cohorts
09/19/2014 - 06/30/2017 (PI)
Washington University NIH NIDDK
5R01DK089256-07

Mechanism and Clinical Importance of Hyperkyphosis: The Framingham Study
09/30/2011 - 05/31/2017 (PI)
Hebrew Rehabilitation Center For Aged, Inc. NIH NIA
5R01AG041658-04

DCC Supplement for Rare Variants and NHLBI Traits
04/01/2015 - 03/31/2017 (PI)
University of Washington NIH NHLBI
5R01HL120393-03

Whole Genome Sequence Imputation in Families for Echocardiographic Traits
09/20/2013 - 07/31/2016 (PI)
NIH/National Heart, Lung, and Blood Institute
5R21HL121589-02

Rare Variants and NHLBI Traits in Deeply Phenotyped Cohorts
04/01/2015 - 03/31/2016 (PI)
University of Washington NIH NHLBI
5R01HL120393-02

A Multi-Ethnic Study of Gene-Lifestyle Interactions in Cardiovascular Traits
01/01/2015 - 12/31/2015 (PI)
Washington University NIH NHLBI
5R01HL118305-02

Interdisciplinary Training for Biostatisticians
07/01/2010 - 06/30/2015 (PI of Sub-Project / SP)
PI: Paola Sebastiani, PhD
NIH/National Institute of General Medical Sciences
5T32GM074905-10

The Role of Eicosanoids in Renal Function Project 5: Human Hypertension and P450 Omega/Omega-1 Hydroxylases and Epoxygenases
07/01/2009 - 06/30/2015 (PI)
Vanderbilt University NIH NIDDK
P01DK038226

Rare Variants and NHLBI Traits in Deeply Phenotyped Cohorts
04/01/2014 - 03/31/2015 (PI)
University of Washington NIH NHLBI
1R01HL120393-01A1

Showing 10 of 31 results. Show All Results



Yr Title Project-Sub Proj Pubs
2016 Genetic Architecture of Adiposity in Multiple Large Cohorts 5R01DK089256-07 28
2015 Genetic Architecture of Adiposity in Multiple Large Cohorts 5R01DK089256-06 28
2014 Whole Genome Sequence Imputation in Families for Echocardioagraphic Traits 5R21HL121589-02
2014 Genetic Architecture of Adiposity in Multiple Large Cohorts 2R01DK089256-05 28
2013 Whole Genome Sequence Imputation in Families for Echocardioagraphic Traits 1R21HL121589-01
2013 Genetic Architecture of Adiposity in Multiple Large Cohorts 5R01DK089256-04 28
2012 Genetic Architecture of Adiposity in Multiple Large Cohorts 5R01DK089256-03 28
2011 Genetic Architecture of Adiposity in Multiple Large Cohorts 5R01DK089256-02 28
2011 Interdisciplinary Training for Biostatisticians 5T32GM074905-07 58
2010 Genetic Architecture of Adiposity in Multiple Large Cohorts 1R01DK089256-01 28
Showing 10 of 17 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Lorbergs AL, O''Connor GT, Zhou Y, Travison TG, Kiel DP, Cupples LA, Rosen H, Samelson EJ. Severity of Kyphosis and Decline in Lung Function: The Framingham Study. J Gerontol A Biol Sci Med Sci. 2017 May 01; 72(5):689-694.View Related Profiles. PMID: 27341855; DOI: 10.1093/gerona/glw124;.
  2. Desikan RS, Fan CC, Wang Y, Schork AJ, Cabral HJ, Cupples LA, Thompson WK, Besser L, Kukull WA, Holland D, Chen CH, Brewer JB, Karow DS, Kauppi K, Witoelar A, Karch CM, Bonham LW, Yokoyama JS, Rosen HJ, Miller BL, Dillon WP, Wilson DM, Hess CP, Pericak-Vance M, Haines JL, Farrer LA, Mayeux R, Hardy J, Goate AM, Hyman BT, Schellenberg GD, McEvoy LK, Andreassen OA, Dale AM. Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score. PLoS Med. 2017 Mar; 14(3):e1002258.View Related Profiles. PMID: 28323831; DOI: 10.1371/journal.pmed.1002258;.
  3. Eicher JD, Chen MH, Pitsillides AN, Lin H, Veeraraghavan N, Brody JA, Metcalf GA, Muzny DM, Gibbs RA, Becker DM, Becker LC, Faraday N, Mathias RA, Yanek LR, Boerwinkle E, Cupples LA, Johnson AD. Whole exome sequencing in the Framingham Heart Study identifies rare variation in HYAL2 that influences platelet aggregation. Thromb Haemost. 2017 Mar 16.View Related Profiles. PMID: 28300864; DOI: 10.1160/TH16-09-0677;.
  4. Ikezaki H, Ai M, Schaefer EJ, Otokozawa S, Asztalos BF, Nakajima K, Zhou Y, Liu CT, Jacques PF, Cupples LA, Furusyo N. Cardiovascular disease prevalence and insulin resistance in the Kyushu-Okinawa Population Study and the Framingham Offspring Study. J Clin Lipidol. 2017 Mar - Apr; 11(2):348-356.View Related Profiles. PMID: 28502490.
  5. Hedman ÅK, Mendelson MM, Marioni RE, Gustafsson S, Joehanes R, Irvin MR, Zhi D, Sandling JK, Yao C, Liu C, Liang L, Huan T, McRae AF, Demissie S, Shah S, Starr JM, Cupples LA, Deloukas P, Spector TD, Sundström J, Krauss RM, Arnett DK, Deary IJ, Lind L, Levy D, Ingelsson E. Epigenetic Patterns in Blood Associated With Lipid Traits Predict Incident Coronary Heart Disease Events and Are Enriched for Results From Genome-Wide Association Studies. Circ Cardiovasc Genet. 2017 Jan; 10(1).View Related Profiles. PMID: 28213390; DOI: 10.1161/CIRCGENETICS.116.001487;.
  6. Noordam R, Sitlani CM, Avery CL, Stewart JD, Gogarten SM, Wiggins KL, Trompet S, Warren HR, Sun F, Evans DS, Li X, Li J, Smith AV, Bis JC, Brody JA, Busch EL, Caulfield MJ, Chen YI, Cummings SR, Cupples LA, Duan Q, Franco OH, Méndez-Giráldez R, Harris TB, Heckbert SR, van Heemst D, Hofman A, Floyd JS, Kors JA, Launer LJ, Li Y, Li-Gao R, Lange LA, Lin HJ, de Mutsert R, Napier MD, Newton-Cheh C, Poulter N, Reiner AP, Rice KM, Roach J, Rodriguez CJ, Rosendaal FR, Sattar N, Sever P, Seyerle AA, Slagboom PE, Soliman EZ, Sotoodehnia N, Stott DJ, Stürmer T, Taylor KD, Thornton TA, Uitterlinden AG, Wilhelmsen KC, Wilson JG, Gudnason V, Jukema JW, Laurie CC, Liu Y, Mook-Kanamori DO, Munroe PB, Rotter JI, Vasan RS, Psaty BM, Stricker BH, Whitsel EA. A genome-wide interaction analysis of tricyclic/tetracyclic antidepressants and RR and QT intervals: a pharmacogenomics study from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. J Med Genet. 2017 May; 54(5):313-323.View Related Profiles. PMID: 28039329; DOI: 10.1136/jmedgenet-2016-104112;.
  7. van Rooij FJ, Qayyum R, Smith AV, Zhou Y, Trompet S, Tanaka T, Keller MF, Chang LC, Schmidt H, Yang ML, Chen MH, Hayes J, Johnson AD, Yanek LR, Mueller C, Lange L, Floyd JS, Ghanbari M, Zonderman AB, Jukema JW, Hofman A, van Duijn CM, Desch KC, Saba Y, Ozel AB, Snively BM, Wu JY, Schmidt R, Fornage M, Klein RJ, Fox CS, Matsuda K, Kamatani N, Wild PS, Stott DJ, Ford I, Slagboom PE, Yang J, Chu AY, Lambert AJ, Uitterlinden AG, Franco OH, Hofer E, Ginsburg D, Hu B, Keating B, Schick UM, Brody JA, Li JZ, Chen Z, Zeller T, Guralnik JM, Chasman DI, Peters LL, Kubo M, Becker DM, Li J, Eiriksdottir G, Rotter JI, Levy D, Grossmann V, Patel KV, Chen CH. Genome-wide Trans-ethnic Meta-analysis Identifies Seven Genetic Loci Influencing Erythrocyte Traits and a Role for RBPMS in Erythropoiesis. Am J Hum Genet. 2017 Jan 05; 100(1):51-63. PMID: 28017375; DOI: 10.1016/j.ajhg.2016.11.016;.
  8. Chu AY, Deng X, Fisher VA, Drong A, Zhang Y, Feitosa MF, Liu CT, Weeks O, Choh AC, Duan Q, Dyer TD, Eicher JD, Guo X, Heard-Costa NL, Kacprowski T, Kent JW, Lange LA, Liu X, Lohman K, Lu L, Mahajan A, O''Connell JR, Parihar A, Peralta JM, Smith AV, Zhang Y, Homuth G, Kissebah AH, Kullberg J, Laqua R, Launer LJ, Nauck M, Olivier M, Peyser PA, Terry JG, Wojczynski MK, Yao J, Bielak LF, Blangero J, Borecki IB, Bowden DW, Carr JJ, Czerwinski SA, Ding J, Friedrich N, Gudnason V, Harris TB, Ingelsson E, Johnson AD, Kardia SL, Langefeld CD, Lind L, Liu Y, Mitchell BD, Morris AP, Mosley TH, Rotter JI, Shuldiner AR, Towne B, Völzke H, Wallaschofski H, Wilson JG, Allison M, Lindgren CM, Goessling W, Cupples LA, Steinhauser ML, Fox CS. Multiethnic genome-wide meta-analysis of ectopic fat depots identifies loci associated with adipocyte development and differentiation. Nat Genet. 2017 Jan; 49(1):125-130.View Related Profiles. PMID: 27918534; DOI: 10.1038/ng.3738;.
  9. Ried JS, Jeff M J, Chu AY, Bragg-Gresham JL, van Dongen J, Huffman JE, Ahluwalia TS, Cadby G, Eklund N, Eriksson J, Esko T, Feitosa MF, Goel A, Gorski M, Hayward C, Heard-Costa NL, Jackson AU, Jokinen E, Kanoni S, Kristiansson K, Kutalik Z, Lahti J, Luan J, Mägi R, Mahajan A, Mangino M, Medina-Gomez C, Monda KL, Nolte IM, Pérusse L, Prokopenko I, Qi L, Rose LM, Salvi E, Smith MT, Snieder H, Stancáková A, Ju Sung Y, Tachmazidou I, Teumer A, Thorleifsson G, van der Harst P, Walker RW, Wang SR, Wild SH, Willems SM, Wong A, Zhang W, Albrecht E, Couto Alves A, Bakker SJ, Barlassina C, Bartz TM, Beilby J, Bellis C, Bergman RN, Bergmann S, Blangero J, Blüher M, Boerwinkle E, Bonnycastle LL, Bornstein SR, Bruinenberg M, Campbell H, Chen YI, Chiang CW, Chines PS, Collins FS, Cucca F, Cupples LA, D''Avila F, de Geus EJ, Dedoussis G, Dimitriou M, Döring A, Eriksson JG, Farmaki AE, Farrall M, Ferreira T, Fischer K, Forouhi NG, Friedrich N, Gjesing AP, Glorioso N, Graff M, Grallert H, Grarup N, Gräßler J, Grewal J, Hamsten A, Harder MN, Hartman CA, Hassinen M, Hastie N, Hattersley AT, Havulinna AS, Heliövaara M, Hillege H, Hofman A, Holmen O, Homuth G, Hottenga JJ, Hui J, Husemoen LL, Hysi PG, Isaacs A, Ittermann T, Jalilzadeh S, James AL, Jørgensen T, Jousilahti P, Jula A, Marie Justesen J, Justice AE, Kähönen M, Karaleftheri M, Tee Khaw K, Keinanen-Kiukaanniemi SM, Kinnunen L, Knekt PB, Koistinen HA, Kolcic I, Kooner IK, Koskinen S, Kovacs P, Kyriakou T, Laitinen T, Langenberg C, Lewin AM, Lichtner P, Lindgren CM, Lindström J, Linneberg A, Lorbeer R, Lorentzon M, Luben R, Lyssenko V, Männistö S, Manunta P, Leach IM, McArdle WL, Mcknight B, Mohlke KL, Mihailov E, Milani L, Mills R, Montasser ME, Morris AP, Müller G, Musk AW, Narisu N, Ong KK, Oostra BA, Osmond C, Palotie A, Pankow JS, Paternoster L, Penninx BW, Pichler I, Pilia MG, Polašek O, Pramstaller PP, Raitakari OT, Rankinen T, Rao DC, Rayner NW, Ribel-Madsen R, Rice TK, Richards M, Ridker PM, Rivadeneira F, Ryan KA, Sanna S, Sarzynski MA, Scholtens S, Scott RA, Sebert S, Southam L, Sparsø TH, Steinthorsdottir V, Stirrups K, Stolk RP, Strauch K, Stringham HM, Swertz MA, Swift AJ, Tönjes A, Tsafantakis E, van der Most PJ, Van Vliet-Ostaptchouk JV, Vandenput L, Vartiainen E, Venturini C, Verweij N, Viikari JS, Vitart V, Vohl MC, Vonk JM, Waeber G, Widén E, Willemsen G, Wilsgaard T, Winkler TW, Wright AF, Yerges-Armstrong LM, Hua Zhao J, Zillikens MC, Boomsma DI, Bouchard C, Chambers JC, Chasman DI, Cusi D, Gansevoort RT, Gieger C, Hansen T, Hicks AA, Hu F, Hveem K, Jarvelin MR, Kajantie E, Kooner JS, Kuh D, Kuusisto J, Laakso M, Lakka TA, Lehtimäki T, Metspalu A, Njølstad I, Ohlsson C, Oldehinkel AJ, Palmer LJ, Pedersen O, Perola M, Peters A, Psaty BM, Puolijoki H, Rauramaa R, Rudan I, Salomaa V, Schwarz PE, Shudiner AR, Smit JH, Sørensen TI, Spector TD, Stefansson K, Stumvoll M, Tremblay A, Tuomilehto J, Uitterlinden AG, Uusitupa M, Völker U, Vollenweider P, Wareham NJ, Watkins H, Wilson JF, Zeggini E, Abecasis GR, Boehnke M, Borecki IB, Deloukas P, van Duijn CM, Fox C, Groop LC, Heid IM, Hunter DJ, Kaplan RC, McCarthy MI, North KE, O''Connell JR, Schlessinger D, Thorsteinsdottir U, Strachan DP, Frayling T, Hirschhorn JN, Müller-Nurasyid M, Loos RJ. A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape. Nat Commun. 2016 11 23; 7:13357.View Related Profiles. PMID: 27876822; DOI: 10.1038/ncomms13357;.
  10. Natarajan P, Bis JC, Bielak LF, Cox AJ, Dörr M, Feitosa MF, Franceschini N, Guo X, Hwang SJ, Isaacs A, Jhun MA, Kavousi M, Li-Gao R, Lyytikäinen LP, Marioni RE, Schminke U, Stitziel NO, Tada H, van Setten J, Smith AV, Vojinovic D, Yanek LR, Yao J, Yerges-Armstrong LM, Amin N, Baber U, Borecki IB, Carr JJ, Chen YI, Cupples LA, de Jong PA, de Koning H, de Vos BD, Demirkan A, Fuster V, Franco OH, Goodarzi MO, Harris TB, Heckbert SR, Heiss G, Hoffmann U, Hofman A, Išgum I, Jukema JW, Kähönen M, Kardia SL, Kral BG, Launer LJ, Massaro J, Mehran R, Mitchell BD, Mosley TH, de Mutsert R, Newman AB, Nguyen KD, North KE, O''Connell JR, Oudkerk M, Pankow JS, Peloso GM, Post W, Province MA, Raffield LM, Raitakari OT, Reilly DF, Rivadeneira F, Rosendaal F, Sartori S, Taylor KD, Teumer A, Trompet S, Turner ST, Uitterlinden AG, Vaidya D, van der Lugt A, Völker U, Wardlaw JM, Wassel CL, Weiss S, Wojczynski MK, Becker DM, Becker LC, Boerwinkle E, Bowden DW, Deary IJ, Dehghan A, Felix SB, Gudnason V, Lehtimäki T, Mathias R, Mook-Kanamori DO, Psaty BM, Rader DJ, Rotter JI, Wilson JG, van Duijn CM, Völzke H, Kathiresan S, Peyser PA, O''Donnell CJ. Multiethnic Exome-Wide Association Study of Subclinical Atherosclerosis. Circ Cardiovasc Genet. 2016 Dec; 9(6):511-520.View Related Profiles. PMID: 27872105; DOI: 10.1161/CIRCGENETICS.116.001572;.
Showing 10 of 493 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 493 publications over 31 distinct years, with a maximum of 42 publications in 2010

YearPublications
19872
19885
19895
19904
19918
19926
19936
19944
19954
19968
19973
19983
19995
20004
20015
200218
200329
200422
200530
200620
200732
200829
200934
201042
201133
201227
201322
201431
201520
201627
20175
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Boston MA 02118
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