Adrienne Cupples, PhD
Professor
Boston University School of Public Health
Dept of Biostatistics

MA, Boston University
PhD, Boston University



L. Adrienne Cupples, Ph.D. is Professor of Biostatistics and of Epidemiology. She has a long standing interest in statistical methods for epidemiologic studies, for survival data analysis and for genetic epidemiology. She has taught for thirty years at both the introductory and advanced levels. She developed several of the courses in the Biostatistics curriculum, including Statistical Methods for Epidemiology (BS852) and has received numerous teaching awards, including the Norman A Scotch Award for Excellence in Teaching at the School of Public Health. For her efforts in research she received the BUSPH Faculty Career Award in Research & Scholarship as the First Recipient. And she received the Janet L. Norwood Award for Outstanding Achievement by a Woman in the Statistical Sciences as the ninth recipient in 2010 and the 2012 L. Adrienne Cupples Award for Excellence in Teaching, Research and Service in Biostatistics. She has collaborated in the Framingham Heart Study for more than 30 years on a variety of topics from risk factors for sudden death, nutritional epidemiology and most recently the genetic etiology of cardiovascular disease and its risk factors. She is Co-Principal Investigator of the NHLBI Contract to Boston University for the Framingham Heart Study and Co-Chair of the Framingham Genetics Steering Committee. She has a long history with the study of the genetic etiology of Alzheimer’s disease in the MIRAGE Study (Multi-Institutional Research of Alzheimer’s Genetic Epidemiology) and of Huntington disease. She has been actively involved in genetic risk prediction and evaluation of how people interpret and respond to such predictions, particularly in the context of Alzheimer's disease through the REVEAL (Risk Evaluation and Education for Alzheimer's Disease) Study.

Professor
Boston University School of Public Health
Epidemiology


Framingham Heart Study


Boston Medical Center



2014 American Heart Association: EPI/NPAM 2014 Richard Remington Lecturer
2012 Boston University, Department of Biostatistics, School of Public Health: L. Adrienne Cupples Award for Excellence in Teaching, Research, and Service in Biostatistics
2010 Boston University School of Public Health: Faculty Career Award in Research & Scholarship, First Recipient
2010 University of Alabama: Janet L. Norwood Award for Outstanding Achievement by a Woman in the Statistical Sciences, 9th award
2006 University of Leeds, UK: Visiting Professor
1995 Boston University School of Public Health: Norman Scotch Award for Excellence in Teaching


Impact of Disclosing Amyloid Imaging Results to Cognitively Normal Individuals(REVEAL 5)
08/20/2015 - 07/31/2017 (PI)
The Brigham and Women's Hospital, Inc. NIH NIA
1RF1AG047866-01A1

Genetic Architecture of Adiposity in Multiple Large Cohorts
09/19/2014 - 06/30/2017 (PI)
Washington University NIH NIDDK
5R01DK089256-07

Mechanism and Clinical Importance of Hyperkyphosis: The Framingham Study
09/30/2011 - 05/31/2017 (PI)
Hebrew Rehabilitation Center For Aged, Inc. NIH NIA
5R01AG041658-04

DCC Supplement for Rare Variants and NHLBI Traits
04/01/2015 - 03/31/2017 (PI)
University of Washington NIH NHLBI
5R01HL120393-03

Whole Genome Sequence Imputation in Families for Echocardiographic Traits
09/20/2013 - 07/31/2016 (PI)
NIH/National Heart, Lung, and Blood Institute
5R21HL121589-02

Rare Variants and NHLBI Traits in Deeply Phenotyped Cohorts
04/01/2015 - 03/31/2016 (PI)
University of Washington NIH NHLBI
5R01HL120393-02

A Multi-Ethnic Study of Gene-Lifestyle Interactions in Cardiovascular Traits
01/01/2015 - 12/31/2015 (PI)
Washington University NIH NHLBI
5R01HL118305-02

Interdisciplinary Training for Biostatisticians
07/01/2010 - 06/30/2015 (PI of Sub-Project / SP)
PI: Paola Sebastiani, PhD
NIH/National Institute of General Medical Sciences
5T32GM074905-10

The Role of Eicosanoids in Renal Function Project 5: Human Hypertension and P450 Omega/Omega-1 Hydroxylases and Epoxygenases
07/01/2009 - 06/30/2015 (PI)
Vanderbilt University NIH NIDDK
P01DK038226

Rare Variants and NHLBI Traits in Deeply Phenotyped Cohorts
04/01/2014 - 03/31/2015 (PI)
University of Washington NIH NHLBI
1R01HL120393-01A1

Showing 10 of 31 results. Show All Results



Yr Title Project-Sub Proj Pubs
2016 Genetic Architecture of Adiposity in Multiple Large Cohorts 5R01DK089256-07 28
2015 Genetic Architecture of Adiposity in Multiple Large Cohorts 5R01DK089256-06 28
2014 Whole Genome Sequence Imputation in Families for Echocardioagraphic Traits 5R21HL121589-02
2014 Genetic Architecture of Adiposity in Multiple Large Cohorts 2R01DK089256-05 28
2013 Whole Genome Sequence Imputation in Families for Echocardioagraphic Traits 1R21HL121589-01
2013 Genetic Architecture of Adiposity in Multiple Large Cohorts 5R01DK089256-04 28
2012 Genetic Architecture of Adiposity in Multiple Large Cohorts 5R01DK089256-03 28
2011 Genetic Architecture of Adiposity in Multiple Large Cohorts 5R01DK089256-02 28
2011 Interdisciplinary Training for Biostatisticians 5T32GM074905-07 58
2010 Genetic Architecture of Adiposity in Multiple Large Cohorts 1R01DK089256-01 28
Showing 10 of 17 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Afshar M, Luk K, Do R, Dufresne L, Owens DS, Harris TB, Peloso GM, Kerr KF, Wong Q, Smith AV, Budoff MJ, Rotter JI, Cupples LA, Rich SS, Engert JC, Gudnason V, O''Donnell CJ, Post WS, Thanassoulis G. Association of Triglyceride-Related Genetic Variants With Mitral Annular Calcification. J Am Coll Cardiol. 2017 Jun 20; 69(24):2941-2948.View Related Profiles. PMID: 28619195.
  2. Shungin D, Deng WQ, Varga TV, Luan J, Mihailov E, Metspalu A, Morris AP, Forouhi NG, Lindgren C, Magnusson PKE, Pedersen NL, Hallmans G, Chu AY, Justice AE, Graff M, Winkler TW, Rose LM, Langenberg C, Cupples LA, Ridker PM, Wareham NJ, Ong KK, Loos RJF, Chasman DI, Ingelsson E, Kilpeläinen TO, Scott RA, Mägi R, Paré G, Franks PW. Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions. PLoS Genet. 2017 Jun 14; 13(6):e1006812. PMID: 28614350.
  3. Rao DC, Sung YJ, Winkler TW, Schwander K, Borecki I, Cupples LA, Gauderman WJ, Rice K, Munroe PB, Psaty BM. Multiancestry Study of Gene-Lifestyle Interactions for Cardiovascular Traits in 610 475 Individuals From 124 Cohorts: Design and Rationale. Circ Cardiovasc Genet. 2017 Jun; 10(3). PMID: 28620071.
  4. Lorbergs AL, O''Connor GT, Zhou Y, Travison TG, Kiel DP, Cupples LA, Rosen H, Samelson EJ. Severity of Kyphosis and Decline in Lung Function: The Framingham Study. J Gerontol A Biol Sci Med Sci. 2017 May 01; 72(5):689-694.View Related Profiles. PMID: 27341855; DOI: 10.1093/gerona/glw124;.
  5. Graff M, Scott RA, Justice AE, Young KL, Feitosa MF, Barata L, Winkler TW, Chu AY, Mahajan A, Hadley D, Xue L, Workalemahu T, Heard-Costa NL, den Hoed M, Ahluwalia TS, Qi Q, Ngwa JS, Renström F, Quaye L, Eicher JD, Hayes JE, Cornelis M, Kutalik Z, Lim E, Luan J, Huffman JE, Zhang W, Zhao W, Griffin PJ, Haller T, Ahmad S, Marques-Vidal PM, Bien S, Yengo L, Teumer A, Smith AV, Kumari M, Harder MN, Justesen JM, Kleber ME, Hollensted M, Lohman K, Rivera NV, Whitfield JB, Zhao JH, Stringham HM, Lyytikäinen LP, Huppertz C, Willemsen G, Peyrot WJ, Wu Y, Kristiansson K, Demirkan A, Fornage M, Hassinen M, Bielak LF, Cadby G, Tanaka T, Mägi R, van der Most PJ, Jackson AU, Bragg-Gresham JL, Vitart V, Marten J, Navarro P, Bellis C, Pasko D, Johansson Å, Snitker S, Cheng YC, Eriksson J, Lim U, Aadahl M, Adair LS, Amin N, Balkau B, Auvinen J, Beilby J, Bergman RN, Bergmann S, Bertoni AG, Blangero J, Bonnefond A, Bonnycastle LL, Borja JB, Brage S, Busonero F, Buyske S, Campbell H, Chines PS, Collins FS, Corre T, Smith GD, Delgado GE, Dueker N, Dörr M, Ebeling T, Eiriksdottir G, Esko T, Faul JD, Fu M, Færch K, Gieger C, Gläser S, Gong J, Gordon-Larsen P, Grallert H, Grammer TB, Grarup N, van Grootheest G, Harald K, Hastie ND, Havulinna AS, Hernandez D, Hindorff L, Hocking LJ, Holmens OL, Holzapfel C, Hottenga JJ, Huang J, Huang T, Hui J, Huth C, Hutri-Kähönen N, James AL, Jansson JO, Jhun MA, Juonala M, Kinnunen L, Koistinen HA, Kolcic I, Komulainen P, Kuusisto J, Kvaløy K, Kähönen M, Lakka TA, Launer LJ, Lehne B, Lindgren CM, Lorentzon M, Luben R, Marre M, Milaneschi Y, Monda KL, Montgomery GW, De Moor MHM, Mulas A, Müller-Nurasyid M, Musk AW, Männikkö R, Männistö S, Narisu N, Nauck M, Nettleton JA, Nolte IM, Oldehinkel AJ, Olden M, Ong KK, Padmanabhan S, Paternoster L, Perez J, Perola M, Peters A, Peters U, Peyser PA, Prokopenko I, Puolijoki H, Raitakari OT, Rankinen T, Rasmussen-Torvik LJ, Rawal R, Ridker PM, Rose LM, Rudan I, Sarti C, Sarzynski MA, Savonen K, Scott WR, Sanna S, Shuldiner AR, Sidney S, Silbernagel G, Smith BH, Smith JA, Snieder H, Stancáková A, Sternfeld B, Swift AJ, Tammelin T, Tan ST, Thorand B, Thuillier D, Vandenput L, Vestergaard H, van Vliet-Ostaptchouk JV, Vohl MC, Völker U, Waeber G, Walker M, Wild S, Wong A, Wright AF, Zillikens MC, Zubair N, Haiman CA, Lemarchand L, Gyllensten U, Ohlsson C, Hofman A, Rivadeneira F, Uitterlinden AG, Pérusse L, Wilson JF, Hayward C, Polasek O, Cucca F, Hveem K, Hartman CA, Tönjes A, Bandinelli S, Palmer LJ, Kardia SLR, Rauramaa R, Sørensen TIA, Tuomilehto J, Salomaa V, Penninx BWJH, de Geus EJC, Boomsma DI, Lehtimäki T, Mangino M, Laakso M, Bouchard C, Martin NG, Kuh D, Liu Y, Linneberg A, März W, Strauch K, Kivimäki M, Harris TB, Gudnason V, Völzke H, Qi L, Järvelin MR, Chambers JC, Kooner JS, Froguel P, Kooperberg C, Vollenweider P, Hallmans G, Hansen T, Pedersen O, Metspalu A, Wareham NJ, Langenberg C, Weir DR, Porteous DJ, Boerwinkle E, Chasman DI, Abecasis GR, Barroso I, McCarthy MI, Frayling TM, O''Connell JR, van Duijn CM, Boehnke M, Heid IM, Mohlke KL, Strachan DP, Fox CS, Liu CT, Hirschhorn JN, Klein RJ, Johnson AD, Borecki IB, Franks PW, North KE, Cupples LA, Loos RJF, Kilpeläinen TO. Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults. PLoS Genet. 2017 Apr; 13(4):e1006528.View Related Profiles. PMID: 28448500.
  6. Ng MCY, Graff M, Lu Y, Justice AE, Mudgal P, Liu CT, Young K, Yanek LR, Feitosa MF, Wojczynski MK, Rand K, Brody JA, Cade BE, Dimitrov L, Duan Q, Guo X, Lange LA, Nalls MA, Okut H, Tajuddin SM, Tayo BO, Vedantam S, Bradfield JP, Chen G, Chen WM, Chesi A, Irvin MR, Padhukasahasram B, Smith JA, Zheng W, Allison MA, Ambrosone CB, Bandera EV, Bartz TM, Berndt SI, Bernstein L, Blot WJ, Bottinger EP, Carpten J, Chanock SJ, Chen YI, Conti DV, Cooper RS, Fornage M, Freedman BI, Garcia M, Goodman PJ, Hsu YH, Hu J, Huff CD, Ingles SA, John EM, Kittles R, Klein E, Li J, McKnight B, Nayak U, Nemesure B, Ogunniyi A, Olshan A, Press MF, Rohde R, Rybicki BA, Salako B, Sanderson M, Shao Y, Siscovick DS, Stanford JL, Stevens VL, Stram A, Strom SS, Vaidya D, Witte JS, Yao J, Zhu X, Ziegler RG, Zonderman AB, Adeyemo A, Ambs S, Cushman M, Faul JD, Hakonarson H, Levin AM, Nathanson KL, Ware EB, Weir DR, Zhao W, Zhi D, Arnett DK, Grant SFA, Kardia SLR, Oloapde OI, Rao DC, Rotimi CN, Sale MM, Williams LK, Zemel BS, Becker DM, Borecki IB, Evans MK, Harris TB, Hirschhorn JN, Li Y, Patel SR, Psaty BM, Rotter JI, Wilson JG, Bowden DW, Cupples LA, Haiman CA, Loos RJF, North KE. Discovery and fine-mapping of adiposity loci using high density imputation of genome-wide association studies in individuals of African ancestry: African Ancestry Anthropometry Genetics Consortium. PLoS Genet. 2017 Apr; 13(4):e1006719.View Related Profiles. PMID: 28430825; DOI: 10.1371/journal.pgen.1006719;.
  7. Desikan RS, Fan CC, Wang Y, Schork AJ, Cabral HJ, Cupples LA, Thompson WK, Besser L, Kukull WA, Holland D, Chen CH, Brewer JB, Karow DS, Kauppi K, Witoelar A, Karch CM, Bonham LW, Yokoyama JS, Rosen HJ, Miller BL, Dillon WP, Wilson DM, Hess CP, Pericak-Vance M, Haines JL, Farrer LA, Mayeux R, Hardy J, Goate AM, Hyman BT, Schellenberg GD, McEvoy LK, Andreassen OA, Dale AM. Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score. PLoS Med. 2017 Mar; 14(3):e1002258.View Related Profiles. PMID: 28323831; DOI: 10.1371/journal.pmed.1002258;.
  8. Eicher JD, Chen MH, Pitsillides AN, Lin H, Veeraraghavan N, Brody JA, Metcalf GA, Muzny DM, Gibbs RA, Becker DM, Becker LC, Faraday N, Mathias RA, Yanek LR, Boerwinkle E, Cupples LA, Johnson AD. Whole exome sequencing in the Framingham Heart Study identifies rare variation in HYAL2 that influences platelet aggregation. Thromb Haemost. 2017 Jun 02; 117(6):1083-1092.View Related Profiles. PMID: 28300864; DOI: 10.1160/TH16-09-0677;.
  9. Ikezaki H, Ai M, Schaefer EJ, Otokozawa S, Asztalos BF, Nakajima K, Zhou Y, Liu CT, Jacques PF, Cupples LA, Furusyo N. Cardiovascular disease prevalence and insulin resistance in the Kyushu-Okinawa Population Study and the Framingham Offspring Study. J Clin Lipidol. 2017 Mar - Apr; 11(2):348-356.View Related Profiles. PMID: 28502490.
  10. Hedman ÅK, Mendelson MM, Marioni RE, Gustafsson S, Joehanes R, Irvin MR, Zhi D, Sandling JK, Yao C, Liu C, Liang L, Huan T, McRae AF, Demissie S, Shah S, Starr JM, Cupples LA, Deloukas P, Spector TD, Sundström J, Krauss RM, Arnett DK, Deary IJ, Lind L, Levy D, Ingelsson E. Epigenetic Patterns in Blood Associated With Lipid Traits Predict Incident Coronary Heart Disease Events and Are Enriched for Results From Genome-Wide Association Studies. Circ Cardiovasc Genet. 2017 Jan; 10(1).View Related Profiles. PMID: 28213390; DOI: 10.1161/CIRCGENETICS.116.001487;.
Showing 10 of 498 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 498 publications over 31 distinct years, with a maximum of 42 publications in 2010

YearPublications
19872
19885
19895
19904
19918
19926
19936
19944
19954
19968
19973
19983
19995
20004
20015
200218
200329
200422
200530
200620
200732
200829
200934
201042
201133
201227
201322
201431
201520
201627
201710
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801 Massachusetts Ave Crosstown Center
Boston MA 02118
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