Adrienne Cupples, PhD
Professor
Boston University School of Public Health
Dept of Biostatistics

PhD, Boston University
MA, Boston University



L. Adrienne Cupples, Ph.D. is Professor of Biostatistics and of Epidemiology. She has a long standing interest in statistical methods for epidemiologic studies, for survival data analysis and for genetic epidemiology. She has taught for thirty years at both the introductory and advanced levels. She developed several of the courses in the Biostatistics curriculum, including Statistical Methods for Epidemiology (BS852) and has received numerous teaching awards, including the Norman A Scotch Award for Excellence in Teaching at the School of Public Health. For her efforts in research she received the BUSPH Faculty Career Award in Research & Scholarship as the First Recipient. And she received the Janet L. Norwood Award for Outstanding Achievement by a Woman in the Statistical Sciences as the ninth recipient in 2010 and the 2012 L. Adrienne Cupples Award for Excellence in Teaching, Research and Service in Biostatistics. She has collaborated in the Framingham Heart Study for more than 30 years on a variety of topics from risk factors for sudden death, nutritional epidemiology and most recently the genetic etiology of cardiovascular disease and its risk factors. She is Co-Principal Investigator of the NHLBI Contract to Boston University for the Framingham Heart Study and Co-Chair of the Framingham Genetics Steering Committee. She has a long history with the study of the genetic etiology of Alzheimer’s disease in the MIRAGE Study (Multi-Institutional Research of Alzheimer’s Genetic Epidemiology) and of Huntington disease. She has been actively involved in genetic risk prediction and evaluation of how people interpret and respond to such predictions, particularly in the context of Alzheimer's disease through the REVEAL (Risk Evaluation and Education for Alzheimer's Disease) Study.

Professor
Boston University School of Public Health
Epidemiology


Framingham Heart Study


Boston Medical Center



2014 American Heart Association: EPI/NPAM 2014 Richard Remington Lecturer
2012 Boston University, Department of Biostatistics, School of Public Health: L. Adrienne Cupples Award for Excellence in Teaching, Research, and Service in Biostatistics
2010 Boston University School of Public Health: Faculty Career Award in Research & Scholarship, First Recipient
2010 University of Alabama: Janet L. Norwood Award for Outstanding Achievement by a Woman in the Statistical Sciences, 9th award
2006 University of Leeds, UK: Visiting Professor
1995 Boston University School of Public Health: Norman Scotch Award for Excellence in Teaching


Impact of Disclosing Amyloid Imaging Results to Cognitively Normal Individuals(REVEAL 5)
08/20/2015 - 07/31/2017 (PI)
The Brigham and Women's Hospital, Inc. NIH NIA
1RF1AG047866-01A1

Mechanism and Clinical Importance of Hyperkyphosis: The Framingham Study
09/30/2011 - 05/31/2017 (PI)
Hebrew Rehabilitation Center For Aged, I NIH NIA
5R01AG041658-04

DCC Supplement for Rare Variants and NHLBI Traits
04/01/2015 - 03/31/2017 (PI)
University of Washington NIH NHLBI
5R01HL120393-03

Whole Genome Sequence Imputation in Families for Echocardiographic Traits
09/20/2013 - 07/31/2016 (PI)
NIH/National Heart, Lung, and Blood Inst
5R21HL121589-02

Rare Variants and NHLBI Traits in Deeply Phenotyped Cohorts
04/01/2015 - 03/31/2016 (PI)
University of Washington NIH NHLBI
5R01HL120393-02

A Multi-Ethnic Study of Gene-Lifestyle Interactions in Cardiovascular Traits
01/01/2015 - 12/31/2015 (PI)
Washington University NIH NHLBI
5R01HL118305-02

Interdisciplinary Training for Biostatisticians
07/01/2010 - 06/30/2015 (PI of Sub-Project / SP)
PI: Paola Sebastiani, PhD
NIH/National Institute of General Medica
5T32GM074905-10

The Role of Eicosanoids in Renal Function Project 5: Human Hypertension and P450 Omega/Omega-1 Hydroxylases and Epoxygenases
07/01/2009 - 06/30/2015 (PI)
Vanderbilt University NIH NIDDK
P01DK038226

Rare Variants and NHLBI Traits in Deeply Phenotyped Cohorts
04/01/2014 - 03/31/2015 (PI)
University of Washington NIH NHLBI
1R01HL120393-01A1

A Multi-Ethnic Study of Gene-Lifestyle Interactions in Cardiovascular Traits
01/15/2014 - 12/31/2014 (PI)
Washington University NIH NHLBI
1R01HL118305-01A1

Showing 10 of 30 results. Show All Results



Yr Title Project-Sub Proj Pubs
2016 Genetic Architecture of Adiposity in Multiple Large Cohorts 5R01DK089256-07 28
2015 Genetic Architecture of Adiposity in Multiple Large Cohorts 5R01DK089256-06 28
2014 Whole Genome Sequence Imputation in Families for Echocardioagraphic Traits 5R21HL121589-02
2014 Genetic Architecture of Adiposity in Multiple Large Cohorts 2R01DK089256-05 28
2013 Whole Genome Sequence Imputation in Families for Echocardioagraphic Traits 1R21HL121589-01
2013 Genetic Architecture of Adiposity in Multiple Large Cohorts 5R01DK089256-04 28
2012 Genetic Architecture of Adiposity in Multiple Large Cohorts 5R01DK089256-03 28
2011 Genetic Architecture of Adiposity in Multiple Large Cohorts 5R01DK089256-02 28
2011 Interdisciplinary Training for Biostatisticians 5T32GM074905-07 58
2010 Genetic Architecture of Adiposity in Multiple Large Cohorts 1R01DK089256-01 28
Showing 10 of 17 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Kent ST, Rosenson RS, Avery CL, Chen YI, Correa A, Cummings SR, Cupples LA, Cushman M, Evans DS, Gudnason V, Harris TB, Howard G, Irvin MR, Judd SE, Jukema JW, Lange L, Levitan EB, Li X, Liu Y, Post WS, Postmus I, Psaty BM, Rotter JI, Safford MM, Sitlani CM, Smith AV, Stewart JD, Trompet S, Sun F, Vasan RS, Woolley JM, Whitsel EA, Wiggins KL, Wilson JG, Muntner P. PCSK9 Loss-of-Function Variants, Low-Density Lipoprotein Cholesterol, and Risk of Coronary Heart Disease and Stroke: Data From 9 Studies of Blacks and Whites. Circ Cardiovasc Genet. 2017 Aug; 10(4):e001632. PMID: 28768753.
  2. Winkler TW, Justice AE, Cupples LA, Kronenberg F, Kutalik Z, Heid IM. Approaches to detect genetic effects that differ between two strata in genome-wide meta-analyses: Recommendations based on a systematic evaluation. PLoS One. 2017; 12(7):e0181038. PMID: 28749953.
  3. Sims R, van der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J, Kunkle BW, Boland A, Raybould R, Bis JC, Martin ER, Grenier-Boley B, Heilmann-Heimbach S, Chouraki V, Kuzma AB, Sleegers K, Vronskaya M, Ruiz A, Graham RR, Olaso R, Hoffmann P, Grove ML, Vardarajan BN, Hiltunen M, Nöthen MM, White CC, Hamilton-Nelson KL, Epelbaum J, Maier W, Choi SH, Beecham GW, Dulary C, Herms S, Smith AV, Funk CC, Derbois C, Forstner AJ, Ahmad S, Li H, Bacq D, Harold D, Satizabal CL, Valladares O, Squassina A, Thomas R, Brody JA, Qu L, Sánchez-Juan P, Morgan T, Wolters FJ, Zhao Y, Garcia FS, Denning N, Fornage M, Malamon J, Naranjo MCD, Majounie E, Mosley TH, Dombroski B, Wallon D, Lupton MK, Dupuis J, Whitehead P, Fratiglioni L, Medway C, Jian X, Mukherjee S, Keller L, Brown K, Lin H, Cantwell LB, Panza F, McGuinness B, Moreno-Grau S, Burgess JD, Solfrizzi V, Proitsi P, Adams HH, Allen M, Seripa D, Pastor P, Cupples LA, Price ND, Hannequin D, Frank-García A, Levy D, Chakrabarty P, Caffarra P, Giegling I, Beiser AS, Giedraitis V, Hampel H, Garcia ME, Wang X, Lannfelt L, Mecocci P, Eiriksdottir G, Crane PK, Pasquier F, Boccardi V, Henández I, Barber RC, Scherer M, Tarraga L, Adams PM, Leber M, Chen Y, Albert MS, Riedel-Heller S, Emilsson V, Beekly D, Braae A, Schmidt R, Blacker D, Masullo C, Schmidt H, Doody RS, Spalletta G, Jr WTL, Fairchild TJ, Bossù P, Lopez OL, Frosch MP, Sacchinelli E, Ghetti B, Yang Q, Huebinger RM, Jessen F, Li S, Kamboh MI, Morris J, Sotolongo-Grau O, Katz MJ, Corcoran C, Dunstan M, Braddel A, Thomas C, Meggy A, Marshall R, Gerrish A, Chapman J, Aguilar M, Taylor S, Hill M, Fairén MD, Hodges A, Vellas B, Soininen H, Kloszewska I, Daniilidou M, Uphill J, Patel Y, Hughes JT, Lord J, Turton J, Hartmann AM, Cecchetti R, Fenoglio C, Serpente M, Arcaro M, Caltagirone C, Orfei MD, Ciaramella A, Pichler S, Mayhaus M, Gu W, Lleó A, Fortea J, Blesa R, Barber IS, Brookes K, Cupidi C, Maletta RG, Carrell D, Sorbi S, Moebus S, Urbano M, Pilotto A, Kornhuber J, Bosco P, Todd S, Craig D, Johnston J, Gill M, Lawlor B, Lynch A, Fox NC, Hardy J, Albin RL, Apostolova LG, Arnold SE, Asthana S, Atwood CS, Baldwin CT, Barnes LL, Barral S, Beach TG, Becker JT, Bigio EH, Bird TD, Boeve BF, Bowen JD, Boxer A, Burke JR, Burns JM, Buxbaum JD, Cairns NJ, Cao C, Carlson CS, Carlsson CM, Carney RM, Carrasquillo MM, Carroll SL, Diaz CC, Chui HC, Clark DG, Cribbs DH, Crocco EA, DeCarli C, Dick M, Duara R, Evans DA, Faber KM, Fallon KB, Fardo DW, Farlow MR, Ferris S, Foroud TM, Galasko DR, Gearing M, Geschwind DH, Gilbert JR, Graff-Radford NR, Green RC, Growdon JH, Hamilton RL, Harrell LE, Honig LS, Huentelman MJ, Hulette CM, Hyman BT, Jarvik GP, Abner E, Jin LW, Jun G, Karydas A, Kaye JA, Kim R, Kowall NW, Kramer JH, LaFerla FM, Lah JJ, Leverenz JB, Levey AI, Li G, Lieberman AP, Lunetta KL, Lyketsos CG, Marson DC, Martiniuk F, Mash DC, Masliah E, McCormick WC, McCurry SM, McDavid AN, McKee AC, Mesulam M, Miller BL, Miller CA, Miller JW, Morris JC, Murrell JR, Myers AJ, O''Bryant S, Olichney JM, Pankratz VS, Parisi JE, Paulson HL, Perry W, Peskind E, Pierce A, Poon WW, Potter H, Quinn JF, Raj A, Raskind M, Reisberg B, Reitz C, Ringman JM, Roberson ED, Rogaeva E, Rosen HJ, Rosenberg RN, Sager MA, Saykin AJ, Schneider JA, Schneider LS, Seeley WW, Smith AG, Sonnen JA, Spina S, Stern RA, Swerdlow RH, Tanzi RE, Thornton-Wells TA, Trojanowski JQ, Troncoso JC, Van Deerlin VM, Van Eldik LJ, Vinters HV, Vonsattel JP, Weintraub S, Welsh-Bohmer KA, Wilhelmsen KC, Williamson J, Wingo TS, Woltjer RL, Wright CB, Yu CE, Yu L, Garzia F, Golamaully F, Septier G, Engelborghs S, Vandenberghe R, De Deyn PP, Fernadez CM, Benito YA, Thonberg H, Forsell C, Lilius L, Kinhult-Stählbom A, Kilander L, Brundin R, Concari L, Helisalmi S, Koivisto AM, Haapasalo A, Dermecourt V, Fievet N, Hanon O, Dufouil C, Brice A, Ritchie K, Dubois B, Himali JJ, Keene CD, Tschanz J, Fitzpatrick AL, Kukull WA, Norton M, Aspelund T, Larson EB, Munger R, Rotter JI, Lipton RB, et al. RarView Related Profiles. PMID: 28714976.
  4. Rao DC, Sung YJ, Winkler TW, Schwander K, Borecki I, Cupples LA, Gauderman WJ, Rice K, Munroe PB, Psaty BM. Multiancestry Study of Gene-Lifestyle Interactions for Cardiovascular Traits in 610 475 Individuals From 124 Cohorts: Design and Rationale. Circ Cardiovasc Genet. 2017 Jun; 10(3). PMID: 28620071.
  5. Lorbergs AL, O''Connor GT, Zhou Y, Travison TG, Kiel DP, Cupples LA, Rosen H, Samelson EJ. Severity of Kyphosis and Decline in Lung Function: The Framingham Study. J Gerontol A Biol Sci Med Sci. 2017 May 01; 72(5):689-694.View Related Profiles. PMID: 27341855; DOI: 10.1093/gerona/glw124;.
  6. Desikan RS, Fan CC, Wang Y, Schork AJ, Cabral HJ, Cupples LA, Thompson WK, Besser L, Kukull WA, Holland D, Chen CH, Brewer JB, Karow DS, Kauppi K, Witoelar A, Karch CM, Bonham LW, Yokoyama JS, Rosen HJ, Miller BL, Dillon WP, Wilson DM, Hess CP, Pericak-Vance M, Haines JL, Farrer LA, Mayeux R, Hardy J, Goate AM, Hyman BT, Schellenberg GD, McEvoy LK, Andreassen OA, Dale AM. Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score. PLoS Med. 2017 Mar; 14(3):e1002258.View Related Profiles. PMID: 28323831; DOI: 10.1371/journal.pmed.1002258;.
  7. Eicher JD, Chen MH, Pitsillides AN, Lin H, Veeraraghavan N, Brody JA, Metcalf GA, Muzny DM, Gibbs RA, Becker DM, Becker LC, Faraday N, Mathias RA, Yanek LR, Boerwinkle E, Cupples LA, Johnson AD. Whole exome sequencing in the Framingham Heart Study identifies rare variation in HYAL2 that influences platelet aggregation. Thromb Haemost. 2017 Jun 02; 117(6):1083-1092.View Related Profiles. PMID: 28300864; DOI: 10.1160/TH16-09-0677;.
  8. Ikezaki H, Ai M, Schaefer EJ, Otokozawa S, Asztalos BF, Nakajima K, Zhou Y, Liu CT, Jacques PF, Cupples LA, Furusyo N. Cardiovascular disease prevalence and insulin resistance in the Kyushu-Okinawa Population Study and the Framingham Offspring Study. J Clin Lipidol. 2017 Mar - Apr; 11(2):348-356.View Related Profiles. PMID: 28502490.
  9. Hedman ÅK, Mendelson MM, Marioni RE, Gustafsson S, Joehanes R, Irvin MR, Zhi D, Sandling JK, Yao C, Liu C, Liang L, Huan T, McRae AF, Demissie S, Shah S, Starr JM, Cupples LA, Deloukas P, Spector TD, Sundström J, Krauss RM, Arnett DK, Deary IJ, Lind L, Levy D, Ingelsson E. Epigenetic Patterns in Blood Associated With Lipid Traits Predict Incident Coronary Heart Disease Events and Are Enriched for Results From Genome-Wide Association Studies. Circ Cardiovasc Genet. 2017 Jan; 10(1).View Related Profiles. PMID: 28213390; DOI: 10.1161/CIRCGENETICS.116.001487;.
  10. Noordam R, Sitlani CM, Avery CL, Stewart JD, Gogarten SM, Wiggins KL, Trompet S, Warren HR, Sun F, Evans DS, Li X, Li J, Smith AV, Bis JC, Brody JA, Busch EL, Caulfield MJ, Chen YI, Cummings SR, Cupples LA, Duan Q, Franco OH, Méndez-Giráldez R, Harris TB, Heckbert SR, van Heemst D, Hofman A, Floyd JS, Kors JA, Launer LJ, Li Y, Li-Gao R, Lange LA, Lin HJ, de Mutsert R, Napier MD, Newton-Cheh C, Poulter N, Reiner AP, Rice KM, Roach J, Rodriguez CJ, Rosendaal FR, Sattar N, Sever P, Seyerle AA, Slagboom PE, Soliman EZ, Sotoodehnia N, Stott DJ, Stürmer T, Taylor KD, Thornton TA, Uitterlinden AG, Wilhelmsen KC, Wilson JG, Gudnason V, Jukema JW, Laurie CC, Liu Y, Mook-Kanamori DO, Munroe PB, Rotter JI, Vasan RS, Psaty BM, Stricker BH, Whitsel EA. A genome-wide interaction analysis of tricyclic/tetracyclic antidepressants and RR and QT intervals: a pharmacogenomics study from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium. J Med Genet. 2017 May; 54(5):313-323.View Related Profiles. PMID: 28039329; DOI: 10.1136/jmedgenet-2016-104112;.
Showing 10 of 494 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 494 publications over 31 distinct years, with a maximum of 42 publications in 2010

YearPublications
19872
19885
19895
19904
19918
19926
19936
19944
19954
19968
19973
19983
19995
20004
20015
200218
200329
200422
200530
200620
200730
200829
200934
201042
201133
201227
201322
201431
201520
201626
20179
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801 Massachusetts Ave Crosstown Center
Boston MA 02118
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