Conan Kornetsky, PhD
Emeritus Professor
Boston University School of Medicine
Dept of Psychiatry
General Psychiatry Section

PhD, University of Kentucky
MS, University of Kentucky



Research Interests: Neuronal Bases for the Rewarding Effects of Abused Substances

Research in the behavioral pharmacology laboratory is directed toward the determination of neuronal mechanisms involved in the behavioral effects of drugs. Much of this research is focused on the brain’s motivational systems. Changes in these systems are directly related to the rewarding effects associated with the action of the abused psychomotor stimulants, e.g., cocaine and opioids, e.g., heroin. There is reason to believe that these same systems are also affected, albeit in opposite ways, in clinical depression and anxiety. The research of graduate students in this laboratory will continue to study the mechanisms involved in the rewarding actions of these abused substances using the following techniques and procedures: stereotaxic surgery for implanting intercerebral stimulating electrodes and/or cannulae directly into specific brain sites, the use of psychophysical methods for determining thresholds for various types of intracerebral electrical stimulation (e.g., appetitive, aversive), the use of an intravenous drug self-administration model in rats, the use of the quantitative 2-[14C] deoxyglucose method for determining cerebral metabolic rates of glucose in specific brain areas, and the evaluation of brain-stimulation reward in knockout mice models.

2011 University of Maine Alumni Association: Bernard Lown Humanitarian Award
2010 University of Kentucky: Distinguished Alumnus, Department of Psychology
2005 College on Problems of Drug Dependence: Nathan B. Eddy Award for Excellence in Drug Abuse Research
2002 College of Problems of Drug Dependence: Mentorship Award
1997-1998 University of Kentucky: Distinguished Alumnus, Department of Psychology
1990 American Association for the Advancement of Science: Fellow
1985-1986 Division of Psychopharmacology of The American Psychological Association: President


Brain Stimulation Models of Drug Abuse
12/10/1993 - 12/31/2008 (PI)
NIH/National Institute on Drug Abuse
5 K05 DA00099 25

Ethanol: Protracted Changes in Brain Glucose Metabolism
09/26/2002 - 08/31/2006 (PI)
NIH/National Institute on Alcohol Abuse and Alcoholism
5 R21 AA13425 03

Drugs of Abuse and Brain Stimulation Reward in the Mouse
04/15/2001 - 03/31/2005 (PI)
NIH/National Institute on Drug Abuse
5 R21 DA14184 03

Opiate Abuse, Reward and Aging
08/15/2001 - 06/30/2004 (PI)
NIH/National Institute on Drug Abuse
5 R21 DA13678 02

Structural Brain Mapping Cocaine Action
09/25/1999 - 06/30/2004 (PI)
Massachusetts General Hospital NIH NIDA

The Role of Calcium in Behavioral Sensitization to Cocaine
07/01/1999 - 12/31/2002 (Dept Sponsor)
National Alliance for Research on Schizophrenia and Depressi

Drugs of Abuse and Brain Stimulation Reward
12/01/1979 - 06/30/2001 (PI)
NIH/National Institute on Drug Abuse
3 R01 DA02326 20S1




Yr Title Project-Sub Proj Pubs
2010 Interactions Between the Brain Reward and Pain Systems. 5R21DA025586-02 1
2009 Interactions Between the Brain Reward and Pain Systems. 1R21DA025586-01 1
2008 BRAIN STIMULATION MODELS OF DRUG ABUSE 5K05DA000099-25 26
2007 BRAIN STIMULATION MODELS OF DRUG ABUSE 5K05DA000099-24 26
2006 BRAIN STIMULATION MODELS OF DRUG ABUSE 5K05DA000099-23 26
2005 BRAIN STIMULATION MODELS OF DRUG ABUSE 5K05DA000099-22 26
2004 Ethanol: Protracted Changes in Brain Glucose Metabolism 5R21AA013425-03 1
2004 BRAIN STIMULATION MODELS OF DRUG ABUSE 2K05DA000099-21 26
2003 Ethanol: Protracted Changes in Brain Glucose Metabolism 5R21AA013425-02 1
2003 DRUGS OF ABUSE AND BRAIN STIMULATION REWARD IN THE MOUSE 5R21DA014184-03 1
Showing 10 of 64 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Iemolo A, Valenza M, Tozier L, Knapp CM, Kornetsky C, Steardo L, Sabino V, Cottone P. Withdrawal from chronic, intermittent access to a highly palatable food induces depressive-like behavior in compulsive eating rats. Behav Pharmacol. 2012 Sep; 23(5-6):593-602.View Related Profiles. PMID: 22854309; DOI: 10.1097/FBP.0b013e328357697f;.
  2. Kornetsky C, Knapp CM, Tozier L, Pak A. Medial forebrain stimulation enhances intracranial nociception and attenuates morphine analgesia suggesting the existence of an endogenous opioid antagonist. Pharmacol Biochem Behav. 2010 May; 95(3):273-7.View Related Profiles. PMID: 20149816; PMCID: PMC2859829; DOI: 10.1016/j.pbb.2010.01.015;.
  3. Knapp CM, Tozier L, Pak A, Ciraulo DA, Kornetsky C. Deep brain stimulation of the nucleus accumbens reduces ethanol consumption in rats. Pharmacol Biochem Behav. 2009 May; 92(3):474-9.View Related Profiles. PMID: 19463262; PMCID: PMC2716656; DOI: 10.1016/j.pbb.2009.01.017;.
  4. Knapp CM, Kornetsky C. Neural Basis of Pleasure and Reward, In Handbook of Neuroscience for the behavioral Scientist. Berston G (Ed). John Wiley and Sons. 2009.
  5. Vassoler FM, Schmidt HD, Gerard ME, Famous KR, Ciraulo DA, Kornetsky C, Knapp CM, Pierce RC. Deep brain stimulation of the nucleus accumbens shell attenuates cocaine priming-induced reinstatement of drug seeking in rats. J Neurosci. 2008 Aug 27; 28(35):8735-9.View Related Profiles. PMID: 18753374; PMCID: PMC2585378; DOI: 10.1523/JNEUROSCI.5277-07.2008;.
  6. Kornetsky C. A walk through the history of research in drug abuse trends and fads. The Nathan B. Eddy Award address given at CPDD 2005: part II. Drug Alcohol Depend. 2007 Oct 8; 90(2-3):312-6. PMID: 17944026.
  7. Knapp CM, Mercado M, Markley TL, Crosby S, Ciraulo DA, Kornetsky C. Zonisamide decreases ethanol intake in rats and mice. Pharmacol Biochem Behav. 2007 May; 87(1):65-72.View Related Profiles. PMID: 17482246; PMCID: PMC2867456.
  8. Kornetsky C. A walk through the history of research in drug abuse, trends and fads, The Nathan B. Eddy award address given at CPDD 2005: Part I. Drug and Alcohol Dependence. 2007; 88:96-103.
  9. Knapp CM, Datta S, Ciraulo DA, Kornetsky C. Effects of low dose cocaine on REM sleep in the freely moving rat. Sleep Biol Rhythms. 2007 Jan; 5(1):55-62.View Related Profiles. PMID: 18568092; DOI: 10.1111/j.1479-8425.2006.00247.x;.
  10. Crosby SJ, Knapp CM, Kornetsky C. Nociceptive threshold and analgesic response to morphine in aged and young adult rats as determined by thermal radiation and intracerebral electrical stimulation. Pharmacol Biochem Behav. 2006 May; 84(1):148-57.View Related Profiles. PMID: 16759686.
Showing 10 of 206 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 114 publications over 32 distinct years, with a maximum of 8 publications in 1990

YearPublications
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20121
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72 E. Concord St Instructional (L)
Boston MA 02118
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