Sayon Roy, PhD
Professor
Boston University School of Medicine
Dept of Medicine
Endocrinology, Diabetes & Nutrition Section

PhD, Boston University
MS, University of Kalyani



My expertise is in understanding the pathogenesis of diabetic microvascular complications. In particular, studying the effect of high glucose in retinal endothelial cells, pericytes, and Muller cell gene expression.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences


Professor
Boston University School of Medicine
Department of Ophthalmology


Boston Medical Center




Thickening of Basement Membrane in Diabetic Retinopathy
01/01/2004 - 12/31/2009 (PI)
NIH/National Eye Institute
3 R01 EY14702 04S1

Towards Development of a Primate Model of Diabetic Retinopathy
03/31/2006 - 03/31/2008 (PI)
Pearl Vision Foundation

Role of Basement Membrane Thickening in Vascular Complications of Diabetes
07/01/2002 - 06/30/2006 (PI)
American Diabetes Association

Basement Membrane Thickening in Diabetic Retinopathy
04/01/1999 - 06/30/2004 (PI)
NIH/National Eye Institute
5 R29 EY11990 06

Gene Delivery and Regulation of Abnormal Gene Expression in Diabetes
02/01/2000 - 02/28/2002 (PI)
National Medical Technology Testbed

Role of Extracellular Matrix Accumulation in the Vascular Complications of Diabetes
04/01/1999 - 12/31/2001 (PI)
American Diabetes Association


Role of Abnormal lysyl oxidase in the pathogenesis of diabetic retinopathy
04/01/2016 - 03/31/2020 (PI)
NIH-NEI
1R01EY025528-02

Novel Therapies to inhibit diabetic retinopathy
04/01/2015 - 03/31/2020 (PI)
Case Western Reserve University NIH-NEI

Assessment of Therapeutic Potential of Danegaptide/Rotigaptide in Diabetic Retinopathy
08/29/2014 - 04/30/2017 (PI)
Zealand Pharma

Role of Intercellular Communication in Pathogenesis of Diabetic Retinopathy
01/01/2009 - 12/31/2014 (PI)
NIH-NEI
5R01 EY018218-05

Diabetic mamoset, a potential non-human primate model of diabetic retinopathy
03/01/2008 - 02/28/2010 (PI)
Juvenile Diab Fdtn

Effect of Insulin against High Glucose-induced apoptosis in retinal vascular cells
06/01/2006 - 08/31/2006 (PI)
Fight for Sight



Yr Title Project-Sub Proj Pubs
2017 Role of Abnormal lysyl oxidase in the pathogenesis of diabetic retinopathy 5R01EY025528-03
2016 Role of Abnormal lysyl oxidase in the pathogenesis of diabetic retinopathy 5R01EY025528-02
2015 Role of Abnormal lysyl oxidase in the pathogenesis of diabetic retinopathy 1R01EY025528-01
2013 Role of intercellular communication in pathogenesis of diabetic retinopathy 5R01EY018218-05 12
2012 Role of intercellular communication in pathogenesis of diabetic retinopathy 5R01EY018218-04 12
2011 DEVELOPMENT OF A NON-HUMAN PRIMATE MODEL OF DIABETIC RETINOPATHY 5P51RR000168-50-7604 243
2011 Role of intercellular communication in pathogenesis of diabetic retinopathy 5R01EY018218-03 12
2011 Role of intercellular communication in pathogenesis of diabetic retinopathy 5R01EY018218-03 12
2011 Role of intercellular communication in pathogenesis of diabetic retinopathy 3R01EY018218-03S1 12
2010 DEVELOPMENT OF A NON-HUMAN PRIMATE MODEL OF DIABETIC RETINOPATH 5P51RR000168-49-8748 243
Showing 10 of 26 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Roy S, Kern TS, Song B, Stuebe C. Mechanistic Insights into Pathological Changes in the Diabetic Retina: Implications for Targeting Diabetic Retinopathy. Am J Pathol. 2017 Jan; 187(1):9-19. PMID: 27846381; DOI: 10.1016/j.ajpath.2016.08.022;.
  2. Hymowitz MB, Chang D, Feinberg EB, Roy S. Increased Intraocular Pressure and Hyperglycemic Level in Diabetic Patients. PLoS One. 2016; 11(3):e0151833.View Related Profiles. PMID: 27002725; PMCID: PMC4803191; DOI: 10.1371/journal.pone.0151833;.
  3. Roy S, Amin S, Roy S. Retinal fibrosis in diabetic retinopathy. Exp Eye Res. 2016 Jan; 142:71-5. PMID: 26675403; PMCID: PMC4683353; DOI: 10.1016/j.exer.2015.04.004;.
  4. Tien T, Muto T, Zhang J, Sohn EH, Mullins RF, Roy S. Association of reduced Connexin 43 expression with retinal vascular lesions in human diabetic retinopathy. Exp Eye Res. 2016 May; 146:103-6.View Related Profiles. PMID: 26738943; DOI: 10.1016/j.exer.2015.12.011;.
  5. Roy S, Kim D, Hernández C, Simó R, Roy S. Beneficial effects of fenofibric acid on overexpression of extracellular matrix components, COX-2, and impairment of endothelial permeability associated with diabetic retinopathy. Exp Eye Res. 2015 Nov; 140:124-9. PMID: 26297615; PMCID: PMC4646846; DOI: 10.1016/j.exer.2015.08.010;.
  6. Roy S, Bae E, Amin S, Kim D. Extracellular matrix, gap junctions, and retinal vascular homeostasis in diabetic retinopathy. Exp Eye Res. 2015 Apr; 133:58-68. PMID: 25819455; DOI: 10.1016/j.exer.2014.08.011;.
  7. Chronopoulos A, Roy S, Beglova E, Mansfield K, Wachtman L, Roy S. Hyperhexosemia-Induced Retinal Vascular Pathology in a Novel Primate Model of Diabetic Retinopathy. Diabetes. 2015 Jul; 64(7):2603-8. PMID: 25732190; PMCID: PMC4477345; DOI: 10.2337/db14-0866;.
  8. Muto T, Tien T, Kim D, Sarthy VP, Roy S. High glucose alters Cx43 expression and gap junction intercellular communication in retinal Müller cells: promotes Müller cell and pericyte apoptosis. Invest Ophthalmol Vis Sci. 2014 Jul; 55(7):4327-37.View Related Profiles. PMID: 24938518; PMCID: PMC4098057; DOI: 10.1167/iovs.14-14606;.
  9. Tien T, Muto T, Barrette K, Challyandra L, Roy S. Downregulation of Connexin 43 promotes vascular cell loss and excess permeability associated with the development of vascular lesions in the diabetic retina. Mol Vis. 2014; 20:732-41.View Related Profiles. PMID: 24940027; PMCID: PMC4043608.
  10. Roy S, Trudeau K, Roy S, Tien T, Barrette KF. Mitochondrial dysfunction and endoplasmic reticulum stress in diabetic retinopathy: mechanistic insights into high glucose-induced retinal cell death. Curr Clin Pharmacol. 2013 Nov; 8(4):278-84.View Related Profiles. PMID: 23173958.
Showing 10 of 42 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 42 publications over 15 distinct years, with a maximum of 7 publications in 2013

YearPublications
20022
20033
20041
20052
20061
20071
20083
20092
20106
20114
20121
20137
20142
20154
20163
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Diabetic microangiopathy
Contact for Mentoring:


650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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