Rachel Fearns, PhD
Associate Professor
Boston University School of Medicine
Dept of Microbiology

PhD, University of St Andrews

Expertise in paramyxovirus genome transcription and replication mechanisms.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences

Development of an in ivtro assay for paramyxovirus polymerases
05/16/2014 - 05/15/2018 (PI)
Alios BioPharma, Inc.

The B cell repertoire as a window into the nature and impact of the lung virome
05/01/2017 - 04/30/2018 (Co-PI)
PI: Thomas Kepler, PhD
NIH/National Heart, Lung, and Blood Inst

Treating Respiratory Syncytial Virus Infection by Targeting a Virus-Associated Kinase
04/01/2015 - 03/31/2018 (PI)
The Hartwell Foundation

Development of a non-radioactive assay for the RSV polymerase
11/12/2015 - 11/11/2017 (PI)
Merck, Sharp & Dohme Corp

A structure analysis of the intact viron and replicative complexes of human respiratory syncytial virus
11/30/2014 - 08/31/2017 (PI)
University Glasgow Medical Resrch Coun

Initiation and regulation of RSV mRNA transcription and genome replication
08/07/2014 - 07/31/2017 (PI)
NIH/National Institute of Allergy & Infe

The development of respiratory syncytial virus polymerase assay and mechanism of action studies
07/15/2013 - 09/15/2015 (PI)

Respiratory Syncytial Virus Polymerase Protein and Promoter Interactions
09/30/2008 - 08/31/2013 (PI)
NIH/National Institute of Allergy & Infe

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Fearns R, Plemper RK. Polymerases of paramyxoviruses and pneumoviruses. Virus Res. 2017 Apr 15; 234:87-102. PMID: 28104450; DOI: 10.1016/j.virusres.2017.01.008;.
  2. Fearns R, Deval J. New antiviral approaches for respiratory syncytial virus and other mononegaviruses: Inhibiting the RNA polymerase. Antiviral Res. 2016 Oct; 134:63-76. PMID: 27575793; DOI: 10.1016/j.antiviral.2016.08.006;.
  3. Aljabr W, Touzelet O, Pollakis G, Wu W, Munday DC, Hughes M, Hertz-Fowler C, Kenny J, Fearns R, Barr JN, Matthews DA, Hiscox JA. Investigating the Influence of Ribavirin on Human Respiratory Syncytial Virus RNA Synthesis by Using a High-Resolution Transcriptome Sequencing Approach. J Virol. 2016 May 15; 90(10):4876-88. PMID: 26656699; PMCID: PMC4859727; DOI: 10.1128/JVI.02349-15;.
  4. Duvall JR, VerPlank L, Ludeke B, McLeod SM, Lee MD, Vishwanathan K, Mulrooney CA, Le Quement S, Yu Q, Palmer MA, Fleming P, Fearns R, Foley MA, Scherer CA. Novel diversity-oriented synthesis-derived respiratory syncytial virus inhibitors identified via a high throughput replicon-based screen. Antiviral Res. 2016 Jul; 131:19-25. PMID: 27059228; PMCID: PMC4937797; DOI: 10.1016/j.antiviral.2016.03.015;.
  5. Warren TK, Jordan R, Lo MK, Ray AS, Mackman RL, Soloveva V, Siegel D, Perron M, Bannister R, Hui HC, Larson N, Strickley R, Wells J, Stuthman KS, Van Tongeren SA, Garza NL, Donnelly G, Shurtleff AC, Retterer CJ, Gharaibeh D, Zamani R, Kenny T, Eaton BP, Grimes E, Welch LS, Gomba L, Wilhelmsen CL, Nichols DK, Nuss JE, Nagle ER, Kugelman JR, Palacios G, Doerffler E, Neville S, Carra E, Clarke MO, Zhang L, Lew W, Ross B, Wang Q, Chun K, Wolfe L, Babusis D, Park Y, Stray KM, Trancheva I, Feng JY, Barauskas O, Xu Y, Wong P, Braun MR, Flint M, McMullan LK, Chen SS, Fearns R, Swaminathan S, Mayers DL, Spiropoulou CF, Lee WA, Nichol ST, Cihlar T, Bavari S. Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys. Nature. 2016 Mar 17; 531(7594):381-5. PMID: 26934220; DOI: 10.1038/nature17180;.
  6. McCutcheon KM, Jordan R, Mawhorter ME, Noton SL, Powers JG, Fearns R, Cihlar T, Perron M. The Interferon Type I/III Response to Respiratory Syncytial Virus Infection in Airway Epithelial Cells Can Be Attenuated or Amplified by Antiviral Treatment. J Virol. 2016 Feb; 90(4):1705-17.View Related Profiles. PMID: 26608311; PMCID: PMC4733981; DOI: 10.1128/JVI.02417-15;.
  7. Deval J, Hong J, Wang G, Taylor J, Smith LK, Fung A, Stevens SK, Liu H, Jin Z, Dyatkina N, Prhavc M, Stoycheva AD, Serebryany V, Liu J, Smith DB, Tam Y, Zhang Q, Moore ML, Fearns R, Chanda SM, Blatt LM, Symons JA, Beigelman L. Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2''-Fluoro-4''-Chloromethyl-Cytidine Triphosphate. PLoS Pathog. 2015 Jun; 11(6):e1004995. PMID: 26098424; PMCID: PMC4476725; DOI: 10.1371/journal.ppat.1004995;.
  8. Noton SL, Nagendra K, Dunn EF, Mawhorter ME, Yu Q, Fearns R. Respiratory Syncytial Virus Inhibitor AZ-27 Differentially Inhibits Different Polymerase Activities at the Promoter. J Virol. 2015 Aug; 89(15):7786-98.View Related Profiles. PMID: 25995255; PMCID: PMC4505683; DOI: 10.1128/JVI.00530-15;.
  9. Dickey LL, Duncan JK, Hanley TM, Fearns R. Decapping protein 1 phosphorylation modulates IL-8 expression during respiratory syncytial virus infection. Virology. 2015 Jul; 481:199-209. PMID: 25796077; PMCID: PMC4437874; DOI: 10.1016/j.virol.2015.02.043;.
  10. Noton SL, Fearns R. Initiation and regulation of paramyxovirus transcription and replication. Virology. 2015 May; 479-480:545-54.View Related Profiles. PMID: 25683441; PMCID: PMC4424093; DOI: 10.1016/j.virol.2015.01.014;.
Showing 10 of 36 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 36 publications over 18 distinct years, with a maximum of 5 publications in 2015

In addition to these self-described keywords below, a list of MeSH based concepts is available here.

processing bodies
RNA dependent RNA polymerase
stress granules

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Research / Scholarly Mentor
Contact for Mentoring:

72 E. Concord St Housman (R)
Boston MA 02118
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