Jesus Fernando Garcia-Diaz, PhD
Associate Professor
Boston University School of Medicine
Dept of Physiology & Biophysics

PhD, Universidad de Málaga
MS, Indiana University Bloomington



Research in my lab centers on the regulation of ion channel expression during neuronal differentiation and on the modulation of ion channel activity by certain neurotransmitters. We use cell culture techniques, electrophysiology and fluorescence microscopy to analyze the expression pattern and regulation of ion channels in cochlear ganglion (CG) neurons during development. Spiral or cochlear ganglion neurons are responsible for the faithful transmission of sound information from the hair cells in the organ of Corti (the sound transducing elements) to the cochlear nucleus in the brain and, thus, are endowed with a set of fast activating voltage-gated ion channels. We have analyzed the temporal pattern of expression of voltage-gated sodium, calcium and potassium channels in chick embryo CG neurons and found functionally relevant correlations between the development of membrane currents and the innervation pattern of the cochlea (Garcia-Diaz et al., 1998; Garcia-Diaz, 1999). We are also investigating whether certain members of the nerve growth factor family of proteins (neurotrophins), released by the target cells of neurons, regulate the expression of ion channels during embryonic development (Jimenez et al., 1997; Garcia-Diaz, 1999). On the other hand, efferent innervation acting through muscarinic and purinergic receptors modulates the firing response of CG neurons to sound information. We are presently investigating whether the activation of these receptors, and the ensuing signaling events, modulate a cloned non-inactivating potassium channel transfected in a heterologous system.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences







Yr Title Project-Sub Proj Pubs
1990 ANALYSIS OF BASOLATERAL ION CHANNELS IN SKIN 5R01DK039214-03 1
1989 ANALYSIS OF BASOLATERAL ION CHANNELS IN SKIN 5R01DK039214-02 1
1988 ANALYSIS OF BASOLATERAL ION CHANNELS IN SKIN 1R01DK039214-01A1 1
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. García-Díaz JF. Development of a fast transient potassium current in chick cochlear ganglion neurons. Hear Res. 1999 Sep; 135(1-2):124-34. PMID: 10491961.
  2. Jiménez C, Giréldez F, Represa J, García-Díaz JF. Calcium currents in dissociated cochlear neurons from the chick embryo and their modification by neurotrophin-3. Neuroscience. 1997 Apr; 77(3):673-82. PMID: 9070744.
  3. Gaposchkin CG, Garcia-Diaz JF. Modulation of cultured brain, adrenal, and aortic endothelial cell glucose transport. Biochim Biophys Acta. 1996 Dec 4; 1285(2):255-66. PMID: 8972710.
  4. Klemperer G, Garcia-Diaz JF, Nagel W, Essig A. Basolateral membrane potential and conductance in frog skin exposed to high serosal potassium. J Membr Biol. 1986; 90(1):89-96. PMID: 3486296.
  5. García-Díaz JF, Klemperer G, Baxendale LM, Essig A. Cell sodium activity and sodium pump function in frog skin. J Membr Biol. 1986; 92(1):37-46. PMID: 3489101.
  6. Garcia-Diaz JF, Essig A. Capacitative transients in voltage-clamped epithelia. Biophys J. 1985 Sep; 48(3):519-23. PMID: 4041541; PMCID: PMC1329365; DOI: 10.1016/S0006-3495(85)83807-8;.
  7. Garcia-Diaz JF, Essig A. Time-dependent phenomena in voltage-clamped epithelia. J Membr Biol. 1985; 87(2):173-6. PMID: 4078885.
  8. García-Díaz JF, Baxendale LM, Klemperer G, Essig A. Cell K activity in frog skin in the presence and absence of cell current. J Membr Biol. 1985; 85(2):143-58. PMID: 3874286.
  9. Garcia-Diaz JF, Stump S, Armstrong WM. Electronic device for microelectrode recordings in epithelial cells. Am J Physiol. 1984 Mar; 246(3 Pt 1):C339-46. PMID: 6703048.
  10. Nagel W, Garcia-Diaz JF, Essig A. Contribution of junctional conductance to the cellular voltage-divider ratio in frog skins. Pflugers Arch. 1983 Dec; 399(4):336-41. PMID: 6607457.
Showing 10 of 22 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 18 publications over 9 distinct years, with a maximum of 4 publications in 1983

YearPublications
19802
19813
19834
19841
19853
19862
19961
19971
19991
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Electrophysiology
Epithelial ion transport
Regulation of ion channels
Contact for Mentoring:


700 Albany St Ctr for Adv Biomed Res
Boston MA 02118
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