Mark E. McComb, PhD
Research Associate Professor
Boston University School of Medicine
Dept of Biochemistry

PhD, University Manitoba
MSc, University Manitoba



Dr. McComb is a Research Associate Professor of Biochemistry at Boston University School of Medicine (BUSM), is the Director of the NHLBI Cardiovascular Proteomics Center (CPC) Core Research Laboratory at BUSM and is a Faculty Member of the BUSM Center for Biomedical Mass Spectrometry (CBMS). Dr. McComb has authored/co-authored more than 50 peer-review publications, reviews and textbook chapters and has over 200 conference proceedings including many as invited speaker. Dr. McComb has served as a panel member on several National committees, has served on several NIH peer review study sections and is an expert reviewer for NIH, NCI and other organizations. Dr. McComb is an active member of the Human Proteome Organization (HUPO) whose mission is to characterize the human proteome. Dr. McComb’s research aims are directed towards the identification and characterization of differentially expressed proteins and differentially observed peptides and post-translational modifications (PTMs) associated with human disease. His laboratory focuses on applying mass spectrometry and proteomics technologies for the identification and characterization of proteins which may be perturbed by disease with the aim to identify patterns of changes in order to gain a global comprehensive understanding of disease progression. Identification of specific proteins and PTMs which change as a function of disease will lead to the development of diagnostic and prognostic biomarkers which will have tremendous clinical utility. Specific biomedical applications of research include cancer, Alzheimer’s disease, systemic amyloidosis, prion diseases, and cardiovascular disease.

2000-2002 Boston University: National Sciences and Engineering Research Council of Canada Fellowship


Protein biomarkers of pulmonary hypertension in sickle cell disease
01/01/2012 - 12/31/2014 (PI)
NIH/National Heart, Lung, and Blood Inst
5R21HL107993-02

Radiation Induced Cardiovascular Oxidative Stress: Thiol Modification of Proteins and Novel and Sensitive Biomarkers
10/01/2012 - 09/30/2013 (PI)
National Space Biomedical Research Insti NASA



Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Saito Â, Souza EE, Costa FC, Meirelles GV, Gonçalves KA, Santos MT, Bressan GC, McComb ME, Costello CE, Whelan SA, Kobarg J. Human Regulatory Protein Ki-1/57 Is a Target of SUMOylation and Affects PML Nuclear Body Formation. J Proteome Res. 2017 Sep 01; 16(9):3147-3157.View Related Profiles. PMID: 28695742.
  2. Khatri K, Klein JA, Haserick JR, Leon DR, Costello CE, McComb ME, Zaia J. Microfluidic Capillary Electrophoresis-Mass Spectrometry for Analysis of Monosaccharides, Oligosaccharides, and Glycopeptides. Anal Chem. 2017 Jun 20; 89(12):6645-6655.View Related Profiles. PMID: 28530388.
  3. Ma J, Banerjee P, Whelan SA, Liu T, Wei AC, Ramirez-Correa G, McComb ME, Costello CE, O''Rourke B, Murphy A, Hart GW. Comparative Proteomics Reveals Dysregulated Mitochondrial O-GlcNAcylation in Diabetic Hearts. J Proteome Res. 2016 Jul 01; 15(7):2254-64.View Related Profiles. PMID: 27213235; DOI: 10.1021/acs.jproteome.6b00250;.
  4. Lucena MC, Carvalho-Cruz P, Donadio JL, Oliveira IA, de Queiroz RM, Marinho-Carvalho MM, Sola-Penna M, de Paula IF, Gondim KC, McComb ME, Costello CE, Whelan SA, Todeschini AR, Dias WB. Epithelial Mesenchymal Transition Induces Aberrant Glycosylation through Hexosamine Biosynthetic Pathway Activation. J Biol Chem. 2016 Jun 17; 291(25):12917-29.View Related Profiles. PMID: 27129262; PMCID: PMC4933211; DOI: 10.1074/jbc.M116.729236;.
  5. Yao C, Behring JB, Shao D, Sverdlov AL, Whelan SA, Elezaby A, Yin X, Siwik DA, Seta F, Costello CE, Cohen RA, Matsui R, Colucci WS, McComb ME, Bachschmid MM. Overexpression of Catalase Diminishes Oxidative Cysteine Modifications of Cardiac Proteins. PLoS One. 2015; 10(12):e0144025.View Related Profiles. PMID: 26642319; PMCID: PMC4671598; DOI: 10.1371/journal.pone.0144025;.
  6. Zaarur N, Xu X, Lestienne P, Meriin AB, McComb M, Costello CE, Newnam GP, Ganti R, Romanova NV, Shanmugasundaram M, Silva ST, Bandeiras TM, Matias PM, Lobachev KS, Lednev IK, Chernoff YO, Sherman MY. RuvbL1 and RuvbL2 enhance aggresome formation and disaggregate amyloid fibrils. EMBO J. 2015 Sep 14; 34(18):2363-82.View Related Profiles. PMID: 26303906; PMCID: PMC4570522; DOI: 10.15252/embj.201591245;.
  7. Théberge R, Dikler S, Heckendorf C, Chui DH, Costello CE, McComb ME. MALDI-ISD Mass Spectrometry Analysis of Hemoglobin Variants: a Top-Down Approach to the Characterization of Hemoglobinopathies. J Am Soc Mass Spectrom. 2015 Aug; 26(8):1299-310.View Related Profiles. PMID: 26002792; PMCID: PMC4496427; DOI: 10.1007/s13361-015-1164-4;.
  8. Yao C, Yu J, Taylor L, Polgar P, McComb ME, Costello CE. Protein Expression by Human Pulmonary Artery Smooth Muscle Cells Containing a BMPR2 Mutation and the Action of ET-1 as Determined by Proteomic Mass Spectrometry. Int J Mass Spectrom. 2015 Feb 15; 378:347-359.View Related Profiles. PMID: 25866469.
  9. de Souza EE, Meirelles GV, Godoy BB, Perez AM, Smetana JH, Doxsey SJ, McComb ME, Costello CE, Whelan SA, Kobarg J. Characterization of the human NEK7 interactome suggests catalytic and regulatory properties distinct from those of NEK6. J Proteome Res. 2014 Sep 5; 13(9):4074-90.View Related Profiles. PMID: 25093993; PMCID: PMC4156247; DOI: 10.1021/pr500437x;.
  10. Behring JB, Kumar V, Whelan SA, Chauhan P, Siwik DA, Costello CE, Colucci WS, Cohen RA, McComb ME, Bachschmid MM. Does reversible cysteine oxidation link the Western diet to cardiac dysfunction? FASEB J. 2014 May; 28(5):1975-87.View Related Profiles. PMID: 24469991; PMCID: PMC4046179; DOI: 10.1096/fj.13-233445;.
Showing 10 of 58 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 58 publications over 20 distinct years, with a maximum of 5 publications in 2009

YearPublications
19974
19982
19994
20003
20012
20022
20033
20043
20064
20074
20082
20095
20101
20114
20121
20134
20142
20154
20162
20172
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

bioinformatics
biomarkers
mass spectrometry
proteomics

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
  • Career Mentor
  • Co-Mentor or Peer Mentor
  • Project Mentor
  • Research / Scholarly Mentor
Contact for Mentoring:


670 Albany St Biosquare III
Boston MA 02118
Google Map


McComb's Networks
Click the "See All" links for more information and interactive visualizations
Concepts
_
Co-Authors
_
Similar People
_
Same Department