Jianlin Gong, MD
Professor
Boston University School of Medicine
Dept of Medicine
Hematology & Medical Oncology Section

MD, Zhejiang University



I have expertise in generation of dendritic cells (DC), development of tumor vaccine including DC-tumor cell fusion and heat shock proteins, animal models for translational research and preclinical research using human cancer samples.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences




Extracellular Hsp70 and Hypothermia in Tumor Therapy
09/01/2012 - 06/30/2017 (PI)
Beth Israel Deaconess Medical Center, Inc NIH NCI
5R01CA119045-09

Extracellular HSP70 and Hyperthermia in Tumor Therapy
09/21/2007 - 07/31/2012 (PI)
Beth Israel Deaconess Medical Center, Inc NIH NCI
5R01CA119045-05

Telomeres in Breast Cancer Cells, A Target and Biomarker for Radiotherapy
01/01/2010 - 12/31/2010 (PI)
Susan G. Komen Breast Cancer Foundation

Combined Telomerase Inhibition and Immunotherapy in the Prevention and Treatment of Mammary Carcinomas
01/15/2006 - 01/14/2010 (PI)
Department of Defense/Army

Development of HSP70-based Vaccine From Fusion Cells for Clinical Use
01/01/2007 - 12/31/2009 (PI)
Ellison Medical Foundation

Role of Telomerase and Telomeres in the Tumorigenesis of Breast Cancer
05/01/2005 - 04/30/2007 (PI)
Susan G. Komen Breast Cancer Foundation

Dendritic/Leukemic Fusion Cell Vaccine Therapy for AML Patients in First Remission: A Phase I Clinical Trial
12/31/2003 - 12/30/2006 (PI)
Leukemia & Lymphoma Society

Antitumor Immunity Induced by Fusion Cells Vaccination
08/01/2000 - 07/31/2005 (PI)
NIH/National Cancer Institute
5 R01 CA87057 04

Fusion of Human Leukemia and Dendritic Cells as a Novel Anti-Leukemia Vaccine
04/16/2002 - 12/30/2004 (PI)
Leukemia & Lymphoma Society

Development of a Novel Vaccine with Fusions of Dendritic and Ovarian Cancer Cells from Patients
04/16/2002 - 07/31/2004 (PI)
Department of Defense/Army

Showing 10 of 11 results. Show All Results


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Calderwood SK, Gong J, Murshid A. Extracellular HSPs: The Complicated Roles of Extracellular HSPs in Immunity. Front Immunol. 2016; 7:159. PMID: 27199984; DOI: 10.3389/fimmu.2016.00159;.
  2. Calderwood SK, Gong J. Heat Shock Proteins Promote Cancer: It''s a Protection Racket. Trends Biochem Sci. 2016 Apr; 41(4):311-23. PMID: 26874923; PMCID: PMC4911230; DOI: 10.1016/j.tibs.2016.01.003;.
  3. Koido S, Homma S, Kan S, Takakura K, Namiki Y, Kobayashi H, Ito Z, Uchiyama K, Kajihara M, Arihiro S, Arakawa H, Okamoto M, Ohkusa T, Gong J, Tajiri H. Induction of antigen-specific cytotoxic T lymphocytes by fusion cells generated from allogeneic plasmacytoid dendritic and tumor cells. Int J Oncol. 2015 Jun; 46(6):2679. PMID: 25846893; DOI: 10.3892/ijo.2015.2954;.
  4. Murshid A, Gong J, Prince T, Borges TJ, Calderwood SK. Scavenger receptor SREC-I mediated entry of TLR4 into lipid microdomains and triggered inflammatory cytokine release in RAW 264.7 cells upon LPS activation. PLoS One. 2015; 10(4):e0122529. PMID: 25836976; PMCID: PMC4383338; DOI: 10.1371/journal.pone.0122529;.
  5. Takakura K, Kajihara M, Ito Z, Ohkusa T, Gong J, Koido S. Dendritic-tumor fusion cells in cancer immunotherapy. Discov Med. 2015 Mar; 19(104):169-74. PMID: 25828520.
  6. Gong J, Weng D, Eguchi T, Murshid A, Sherman MY, Song B, Calderwood SK. Targeting the hsp70 gene delays mammary tumor initiation and inhibits tumor cell metastasis. Oncogene. 2015 Oct; 34(43):5460-71.View Related Profiles. PMID: 25659585; DOI: 10.1038/onc.2015.1;.
  7. Koido S, Gong J. Cell fusion between dendritic cells and whole tumor cells. Methods Mol Biol. 2015; 1313:185-91. PMID: 25947665; DOI: 10.1007/978-1-4939-2703-6_13;.
  8. Murshid A, Gong J, Ahmad R, Borges TJ, Calderwood SK. Scavenger receptor SREC-I promotes double stranded RNA-mediated TLR3 activation in human monocytes. Immunobiology. 2015 Jun; 220(6):823-32. PMID: 25641411; PMCID: PMC4424133; DOI: 10.1016/j.imbio.2014.12.011;.
  9. Koido S, Homma S, Okamoto M, Takakura K, Gong J, Sugiyama H, Ohkusa T, Tajiri H. Chemoimmunotherapy targeting Wilms'' tumor 1 (WT1)-specific cytotoxic T lymphocyte and helper T cell responses for patients with pancreatic cancer. Oncoimmunology. 2014 Nov; 3(10):e958950. PMID: 25941581.
  10. Koido S, Kan S, Yoshida K, Yoshizaki S, Takakura K, Namiki Y, Tsukinaga S, Odahara S, Kajihara M, Okamoto M, Ito M, Yusa S, Gong J, Sugiyama H, Ohkusa T, Homma S, Tajiri H. Immunogenic modulation of cholangiocarcinoma cells by chemoimmunotherapy. Anticancer Res. 2014 Nov; 34(11):6353-61. PMID: 25368235.
Showing 10 of 91 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 91 publications over 15 distinct years, with a maximum of 11 publications in 2013

YearPublications
20022
20033
20047
200510
20063
20076
20089
20095
20106
20116
20127
201311
20149
20155
20162
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Cytotoxic T lymphocytes
DC-tumor cell fusion
Dendritic cells (DC)
Heat shock proteins

Available to Mentor as: (Review Mentor Role Definitions):
  • Advisor
Contact for Mentoring:


650 Albany St Evans Biomed Research Ctr
Boston MA 02118
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