David M. Center, MD
Associate Provost of Translational Research
Boston University Medical Campus

MD, Boston University School of Medicine



Dr. Center is Boston University’s Associate Provost for Translational Research and the Director of the Clinical and Translational Research Institute funded by the NIH. He directs Boston University’s efforts to facilitate translational research and advance team science, with a focus on the use of innovative methods for drug and device discovery and delivery and developing creative tools to expedite and retool traditional research processes.

His own laboratory is interested in two major themes which revolve around roles for Interleukin-16, co-discovered with Bill Cruikshank in 1982. The first theme relates to the functions of IL-16 as a immunomodulatory cytokine. Over the past several years, in collaboration with Bill Cruikshank, he has studied the role of IL-16 in recruitment and development of Regulatory T cells and demonstrated that it plays a key role in tolerance to airborne allergens. Utilizing transgenic knockout and overexpressing mice his laboratory is involved in demonstrating the patterns of CD4+ T cell trafficking through lymph nodes and lung parenchymal in normal and immunologically challenged lungs and identifying potential therapeutic implications of altering recruitment patterns of Regulatory T cells.

The second major emphasis of his laboratory relates to the functional properties of the precursor protein for IL-16, Pro-IL-16 as a tumor suppressor gene. In these studies, along with Yujun Zhang he has shown that Interleukin-16 is synthesized as a precursor which is present in cytoplasm and nucleus of resting T cells. It contains a phosphorylation regulated nuclear localization motif and binds a nuclear chaperone hsc70 which is essential for transport to the nucleus where its presence induces arrest of the cell cycle at G0/G1. It inhibits the cell cycle by acting as a scaffolding protein that assembles a histone deacetylase complex targeted via binding to GA-BP to the Skp2 promoter using intermolecular PDZ binding motifs. Skp2 is an essential member of the ubiquitin ligase protein degradation pathway responsive for degrading the cell cycle cyclin dependent kinase inhibitor p27. In the presence of pro-IL-16, the complex inhibits Skp2 transcription, which in turn decreases p27 degradation resulting in rises in p27 levels and arrest of the cell cycle in G1. Current studies are directed at identifying mutations in Pro-IL-16 that predispose to T cell malignancies and determining its role is permissive exit from G1 in normal T cell activation and proliferation following antigen stimulation.

Gordon and Ruth Snider Chair
Boston University School of Medicine
Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine Section

Gordon and Ruth Snider Professor of Pulmonary Medicine
Boston University School of Medicine
Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine Section

Professor
Boston University School of Medicine
Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine Section

Research Professor
Boston University School of Medicine
Biochemistry


Section Chief
Boston University School of Medicine
Medicine
Pulmonary, Allergy, Sleep & Critical Care Medicine Section

Mentor for Graduate Medical Students
Boston University School of Medicine, Division of Graduate Medical Sciences



2012-2012 American Thoracic Society: Edward Livingston Trudeau Medal
2011-2011 Society for Clinical and Translational Science: Elected Treasurer
2009-2012 Best of Boston, Pulmonary Physicians
2008 Massachusetts Thoracic Society: Chadwick Medal
2003-2007 Best of Boston, Pulmonary Physicians
2002 Boston University School of Medicine: Distinguished Alumnus Award
2002-2012 Best Physicians in America
2002-2006 NHLBI Board of Extramural Advisors
1996 Association of American Physicians: Elected Member
1990 Boston University: AOA
1989 American Society for Clinical Investigation: Elected Member
1987-1988 A.F.C.R.: Elected National Secretary/Treasurer


Biology of the Lung: A Multidisciplinary Program
07/01/2016 - 06/30/2017 (PI)
NIH/National Heart, Lung, and Blood Institute
2T32HL007035-41A1

The Boston University Clinical and Transitional Science Institute (All Components)
04/01/2016 - 03/31/2017 (PI)
NIH/National Center for Advancing Translational Sciences
5UL1TR001430-2

Biology of the Lung: A Multidisciplinary Program
07/01/2011 - 06/30/2016 (PI)
NIH/National Heart, Lung, and Blood Institute
5T32HL007035-40

Boston University Clinical and Translational Science Institute (U Cooperative Agreement)
08/13/2015 - 03/31/2016 (PI)
NIH/National Center for Advancing Translational Sciences
1UL1TR001430-01

Boston University Clinical and Translational Science Institute - U Program
08/20/2014 - 08/19/2015 (PI)
NIH/National Center for Advancing Translational Sciences
1U54TR001012-01

Boston University Clinical and Translational Science Award (CTSA) Program UL1
05/01/2012 - 04/30/2014 (PI)
NIH/National Center for Health Research Resources
8UL1TR000157-05

Boston University Clinical and Translational Science Award (CTSA) Program KL2
05/01/2012 - 04/30/2014 (PI)
NIH/National Center for Health Research Resources
3KL2TR000158-05S1

KL2 Boston University Clinical and Translational Science Institute (CTSA)
05/01/2009 - 04/30/2012 (PI)
NIH/National Center for Health Research Resources
5KL2RR025770-04

BOSTON UNIVERSITY CLINICAL AND TRANSITIONAL SCIENCE AWARD (CTSA) PROGRAM TL1
05/01/2008 - 04/30/2012 (PI)
NIH/National Center for Health Research Resources
5TL1RR025769-04

Boston University Clinical and Translational Science Award (CTSA) Program UL1
05/01/2008 - 04/30/2012 (PI)
NIH/National Center for Health Research Resources
3UL1RR025771-04

Showing 10 of 20 results. Show All Results



Yr Title Project-Sub Proj Pubs
2016 Boston University Clinical and Translational Science Institute 5UL1TR001430-02 6
2016 Biology of the Lung: A Multidisciplinary Program 2T32HL007035-41A1 53
2015 Boston University Clinical and Translational Science Institute 1UL1TR001430-01 6
2014 Boston University Clinical and Translational Science Institute - U Program 1U54TR001012-01 10
2014 Boston University Clinical and Translational Science Institute - U Program 3U54TR001012-01S1 10
2014 Biology of the Lung: A Multidisciplinary Program 5T32HL007035-39 53
2013 Boston University Clinical and Translational Science Award (CTSA) Program KL2 3KL2TR000158-05S1 2
2013 Boston University Clinical and Translational Science Award (CTSA) Program UL1 3UL1TR000157-05S1 15
2013 Biology of the Lung: A Multidisciplinary Program 5T32HL007035-38 53
2012 Boston University Clinical and Translational Science Award (CTSA) Program UL1 8UL1TR000157-05 15
Showing 10 of 121 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Richmond J, Tuzova M, Cruikshank W, Center D. Regulation of cellular processes by interleukin-16 in homeostasis and cancer. J Cell Physiol. 2014 Feb; 229(2):139-47.View Related Profiles. PMID: 23893766; DOI: 10.1002/jcp.24441;.
  2. Center DM, Schwartz DA, Solway J, Gail D, Laposky AD, Lin QS, Gan W. Genomic medicine and lung diseases. Am J Respir Crit Care Med. 2012 Aug 1; 186(3):280-5. PMID: 22652029; PMCID: PMC3423454; DOI: 10.1164/rccm.201203-0569WS;.
  3. Shamoon H, Center D, Davis P, Tuchman M, Ginsberg H, Califf R, Stephens D, Mellman T, Verbalis J, Nadler L, Shekhar A, Ford D, Rizza R, Shaker R, Brady K, Murphy B, Cronstein B, Hochman J, Greenland P, Orwoll E, Sinoway L, Greenberg H, Jackson R, Coller B, Topol E, Guay-Woodford L, Runge M, Clark R, McClain D, Selker H, Lowery C, Dubinett S, Berglund L, Cooper D, Firestein G, Johnston SC, Solway J, Heubi J, Sokol R, Nelson D, Tobacman L, Rosenthal G, Aaronson L, Barohn R, Kern P, Sullivan J, Shanley T, Blazar B, Larson R, FitzGerald G, Reis S, Pearson T, Buchanan T, McPherson D, Brasier A, Toto R, Disis M, Drezner M, Bernard G, Clore J, Evanoff B, Imperato-McGinley J, Sherwin R, Pulley J. Preparedness of the CTSA's structural and scientific assets to support the mission of the National Center for Advancing Translational Sciences (NCATS). Clin Transl Sci. 2012 Apr; 5(2):121-9. PMID: 22507116; PMCID: PMC3335735; DOI: 10.1111/j.1752-8062.2012.00401.x;.
  4. Curiel-Lewandrowski C, Yamasaki H, Si CP, Jin X, Zhang Y, Richmond J, Tuzova M, Wilson K, Sullivan B, Jones D, Ryzhenko N, Little F, Kupper TS, Center DM, Cruikshank WW. Loss of nuclear pro-IL-16 facilitates cell cycle progression in human cutaneous T cell lymphoma. J Clin Invest. 2011 Dec; 121(12):4838-49.View Related Profiles. PMID: 22080865; PMCID: PMC3225985; DOI: 10.1172/JCI41769;.
  5. Granada M, Wilk JB, Tuzova M, Strachan DP, Weidinger S, Albrecht E, Gieger C, Heinrich J, Himes BE, Hunninghake GM, Celedón JC, Weiss ST, Cruikshank WW, Farrer LA, Center DM, O'Connor GT. A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study. J Allergy Clin Immunol. 2012 Mar; 129(3):840-845.e21.View Related Profiles. PMID: 22075330; PMCID: PMC3293994; DOI: 10.1016/j.jaci.2011.09.029;.
  6. Bauchner H, Felson D, Center D. Creating a K-community of investigators. Acad Med. 2010 Dec; 85(12):1814.View Related Profiles. PMID: 21107029; DOI: 10.1097/ACM.0b013e3181fa3a80;.
  7. Green DS, Center DM, Cruikshank WW. Human immunodeficiency virus type 1 gp120 reprogramming of CD4+ T-cell migration provides a mechanism for lymphadenopathy. J Virol. 2009 Jun; 83(11):5765-72.View Related Profiles. PMID: 19297493; PMCID: PMC2681967; DOI: 10.1128/JVI.00130-09;.
  8. Zhang Y, Tuzova M, Xiao ZX, Cruikshank WW, Center DM. Pro-IL-16 recruits histone deacetylase 3 to the Skp2 core promoter through interaction with transcription factor GABP. J Immunol. 2008 Jan 1; 180(1):402-8.View Related Profiles. PMID: 18097041.
  9. McFadden C, Morgan R, Rahangdale S, Green D, Yamasaki H, Center D, Cruikshank W. Preferential migration of T regulatory cells induced by IL-16. J Immunol. 2007 Nov 15; 179(10):6439-45.View Related Profiles. PMID: 17982032.
  10. Morgan RK, McAllister B, Cross L, Green DS, Kornfeld H, Center DM, Cruikshank WW. Histamine 4 receptor activation induces recruitment of FoxP3+ T cells and inhibits allergic asthma in a murine model. J Immunol. 2007 Jun 15; 178(12):8081-9.View Related Profiles. PMID: 17548646.
Showing 10 of 149 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 144 publications over 34 distinct years, with a maximum of 14 publications in 1996

YearPublications
19801
19812
19823
19837
19847
19859
19864
19873
19883
19891
19903
19913
19921
19932
19942
19958
199614
19979
19989
19998
20009
20014
20026
20038
20042
20052
20063
20073
20081
20091
20101
20112
20122
20141
In addition to these self-described keywords below, a list of MeSH based concepts is available here.

Chemotaxis
Interleukin 16
T Cell Immunology
Translational Research
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Boston MA 02118
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