Keywords
Last Name

Jose Cacicedo, PhD

TitleInstructor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionEndocrinology, Diabetes & Nutrition
Address650 Albany St Evans Biomed Research Ctr
Boston MA 02118
Phone(617) 638-7033
ORCID ORCID Icon0000-0001-8417-9754
Other Positions
InstitutionBoston Medical Center

 Research Expertise & Professional Interests
Dr. Cacicedo’s research interests are two-fold 1) the study of macro- and micro-vascular complications caused by diabetes and obesity and 2) the actions of exercise on the vascular wall. Low grade vascular inflammation is an underlying cause of atherosclerotic cardiovascular disease (ASCVD) and physical exercise has been demonstrated to prevent and improve ASCVD and vascular function in patients with and without diabetes. This is evident even in the absence of overt weight loss. Exercise can also help in the control and maintenance of blood glucose levels which is key to the prevention of diabetic microvascular complications such as retinopathy. Thus, an overarching theme to his research is to discover the mechanism(s) of exercise-induced anti-inflammatory actions on the vasculature and determine whether they can be replicated pharmacologically. Discoveries of this nature could serve as critical therapeutics or preventative therapies for vascular disorders associated with diabetes and obesity.

Dr. Cacicedo earned his PhD in the Department of Pathology and Laboratory Medicine at Boston University School of Medicine (BUSM) and is currently a newly appointed Instructor in the Department of Medicine at BUSM.


 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Weikel KA, Cacicedo J, Ruderman NB, Ido Y. Glucose and Palmitate Uncouple AMPK from Autophagy in Human Aortic Endothelial Cells. Am J Physiol Cell Physiol. 2014 Oct 29; ajpcell.00265.2014.
    View in: PubMed
  2. Krasner NM, Ido Y, Ruderman NB, Cacicedo JM. Glucagon-Like Peptide-1 (GLP-1) Analog Liraglutide Inhibits Endothelial Cell Inflammation through a Calcium and AMPK Dependent Mechanism. PLoS One. 2014; 9(5):e97554.
    View in: PubMed
  3. Ruderman NB, Carling D, Prentki M, Cacicedo JM. AMPK, insulin resistance, and the metabolic syndrome. J Clin Invest. 2013 Jul 1; 123(7):2764-72.
    View in: PubMed
  4. Ido Y, Duranton A, Lan F, Cacicedo JM, Chen TC, Breton L, Ruderman NB. Acute activation of AMP-activated protein kinase prevents H2O2-induced premature senescence in primary human keratinocytes. PLoS One. 2012; 7(4):e35092.
    View in: PubMed
  5. Nelson LE, Valentine RJ, Cacicedo JM, Gauthier MS, Ido Y, Ruderman NB. A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose-exposed HepG2 cells. Am J Physiol Cell Physiol. 2012 Jul 1; 303(1):C4-C13.
    View in: PubMed
  6. Xu XJ, Gauthier MS, Hess DT, Apovian CM, Cacicedo JM, Gokce N, Farb M, Valentine RJ, Ruderman NB. Insulin sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue. J Lipid Res. 2012 Apr; 53(4):792-801.
    View in: PubMed
  7. Cacicedo JM, Gauthier MS, Lebrasseur NK, Jasuja R, Ruderman NB, Ido Y. Acute exercise activates AMPK and eNOS in the mouse aorta. Am J Physiol Heart Circ Physiol. 2011 Oct; 301(4):H1255-65.
    View in: PubMed
  8. Cacicedo JM, Benjachareonwong S, Chou E, Yagihashi N, Ruderman NB, Ido Y. Activation of AMP-activated protein kinase prevents lipotoxicity in retinal pericytes. Invest Ophthalmol Vis Sci. 2011 May; 52(6):3630-9.
    View in: PubMed
  9. Gauthier MS, O''Brien EL, Bigornia S, Mott M, Cacicedo JM, Xu XJ, Gokce N, Apovian C, Ruderman N. Decreased AMP-activated protein kinase activity is associated with increased inflammation in visceral adipose tissue and with whole-body insulin resistance in morbidly obese humans. Biochem Biophys Res Commun. 2011 Jan 7; 404(1):382-7.
    View in: PubMed
  10. Ruderman NB, Xu XJ, Nelson L, Cacicedo JM, Saha AK, Lan F, Ido Y. AMPK and SIRT1: a long-standing partnership? Am J Physiol Endocrinol Metab. 2010 Apr; 298(4):E751-60.
    View in: PubMed
  11. Lan F, Cacicedo JM, Ruderman N, Ido Y. SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation. J Biol Chem. 2008 Oct 10; 283(41):27628-35.
    View in: PubMed
  12. Gauthier MS, Miyoshi H, Souza SC, Cacicedo JM, Saha AK, Greenberg AS, Ruderman NB. AMP-activated protein kinase is activated as a consequence of lipolysis in the adipocyte: potential mechanism and physiological relevance. J Biol Chem. 2008 Jun 13; 283(24):16514-24.
    View in: PubMed
  13. Cacicedo JM, Benjachareowong S, Chou E, Ruderman NB, Ido Y. Palmitate-induced apoptosis in cultured bovine retinal pericytes: roles of NAD(P)H oxidase, oxidant stress, and ceramide. Diabetes. 2005 Jun; 54(6):1838-45.
    View in: PubMed
  14. Cacicedo JM, Yagihashi N, Keaney JF, Ruderman NB, Ido Y. AMPK inhibits fatty acid-induced increases in NF-kappaB transactivation in cultured human umbilical vein endothelial cells. Biochem Biophys Res Commun. 2004 Nov 26; 324(4):1204-9.
    View in: PubMed
  15. Ruderman NB, Cacicedo JM, Itani S, Yagihashi N, Saha AK, Ye JM, Chen K, Zou M, Carling D, Boden G, Cohen RA, Keaney J, Kraegen EW, Ido Y. Malonyl-CoA and AMP-activated protein kinase (AMPK): possible links between insulin resistance in muscle and early endothelial cell damage in diabetes. Biochem Soc Trans. 2003 Feb; 31(Pt 1):202-6.
    View in: PubMed
Jose's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts
_
BU Co-Authors
_
Similar BU People
_
Same Department