Keywords
Last Name

Victoria L.M. Herrera, MD

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionCardiovascular Medicine
Address700 Albany St
Boston MA 02118
Phone(617) 638-4020
ORCID ORCID Icon0000-0001-8991-2134
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Graduate Medical Sciences

 Research Expertise & Professional Interests
Expertise includes: Transgenic Rat model development and analysis; Ultrasound Micro-Imaging; Ultrasound Contrast-enhanced Molecular Imaging; Ultrasound-Enhanced Gene Transfer; Nanotheranostics.

 Self-Described Keywords
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Herrera VL, Decano JL, Tan GA, Moran AM, Pasion KA, Matsubara Y, Ruiz-Opazo N. DEspR Roles in Tumor Vasculo-Angiogenesis, Invasiveness, CSC-Survival and Anoikis Resistance: A ''Common Receptor Coordinator'' Paradigm. PLoS One. 2014 Jan 21; 9(1):e85821.
    View in: PubMed
  2. Glorioso N, Herrera VL, Didishvili T, Ortu MF, Zaninello R, Fresu G, Argiolas G, Troffa C, Ruiz-Opazo N. Sex-Specific Effects of NLRP6/AVR and ADM Loci on Susceptibility to Essential Hypertension in a Sardinian Population. PLoS One. 2013; 8(10):e77562.
    View in: PubMed
  3. Herrera VL, Ponce LR, Ruiz-Opazo N. Multiple susceptibility loci for radiation-induced mammary tumorigenesis in F2[Dahl S x R]-intercross rats. PLoS One. 2013; 8(8):e72143.
    View in: PubMed
  4. Herrera VL, Pasion KA, Tan GA, Moran AM, Ruiz-Opazo N. Sex-specific effects on spatial learning and memory, and sex-independent effects on blood pressure of a <3.3 Mbp rat chromosome 2 QTL region in Dahl salt-sensitive rats. PLoS One. 2013; 8(7):e67673.
    View in: PubMed
  5. Herrera VL, Pasion KA, Tan GA, Ruiz-Opazo N. Dahl (S × R) rat congenic strain analysis confirms and defines a chromosome 17 spatial navigation quantitative trait locus to <10 Mbp. PLoS One. 2013; 8(2):e58280.
    View in: PubMed
  6. Herrera VL, Pasion KA, Moran AM, Ruiz-Opazo N. Worse renal disease in postmenopausal F2[Dahl S x R]-intercross rats: detection of novel QTLs affecting hypertensive kidney disease. PLoS One. 2013; 8(2):e56096.
    View in: PubMed
  7. Decano JL, Moran AM, Giordano N, Ruiz-Opazo N, Herrera VL. Analysis of CD45- [CD34+/KDR+] endothelial progenitor cells as juvenile protective factors in a rat model of ischemic-hemorrhagic stroke. PLoS One. 2013; 8(1):e55222.
    View in: PubMed
  8. Herrera VL, Pasion KA, Moran AM, Ruiz-Opazo N. Differential genetic basis for pre-menopausal and post-menopausal salt-sensitive hypertension. PLoS One. 2012; 7(8):e43160.
    View in: PubMed
  9. Herrera VL, Matsubara Y, Ponce LR, Ruiz-Opazo N. Distinct QTLs cosegregate with worse hypertension and renal disease in ovariectomized F2[Dahl S × R]-intercross rats. J Hypertens. 2012 Aug; 30(8):1572-80.
    View in: PubMed
  10. Herrera VL, Pasion KA, Moran AM, Ruiz-Opazo N. Dahl (S x R) congenic strain analysis confirms and defines a chromosome 5 female-specific blood pressure quantitative trait locus to <7 Mbp. PLoS One. 2012; 7(7):e42214.
    View in: PubMed
  11. Yohe ST, Herrera VL, Colson YL, Grinstaff MW. 3D superhydrophobic electrospun meshes as reinforcement materials for sustained local drug delivery against colorectal cancer cells. J Control Release. 2012 Aug 20; 162(1):92-101.
    View in: PubMed
  12. Decano JL, Moran AM, Ruiz-Opazo N, Herrera VL. Molecular imaging of vasa vasorum neovascularization via DEspR-targeted contrast-enhanced ultrasound micro-imaging in transgenic atherosclerosis rat model. Mol Imaging Biol. 2011 Dec; 13(6):1096-106.
    View in: PubMed
  13. Glorioso N, Herrera VL, Didishvili T, Argiolas G, Troffa C, Bulla P, Bulla E, Ruiz-Opazo N. DEspR T/CATAAAA-box promoter variant decreases DEspR transcription and is associated with increased BP in Sardinian males. Physiol Genomics. 2011 Nov 7; 43(21):1219-25.
    View in: PubMed
  14. Bergerat A, Decano J, Wu CJ, Choi H, Nesvizhskii AI, Moran AM, Ruiz-Opazo N, Steffen M, Herrera VL. Prestroke proteomic changes in cerebral microvessels in stroke-prone, transgenic[hCETP]-Hyperlipidemic, Dahl salt-sensitive hypertensive rats. Mol Med. 2011; 17(7-8):588-98.
    View in: PubMed
  15. Karajanagi SS, Lopez-Guerra G, Park H, Kobler JB, Galindo M, Aanestad J, Mehta DD, Kumai Y, Giordano N, d'Almeida A, Heaton JT, Langer R, Herrera VL, Faquin W, Hillman RE, Zeitels SM. Assessment of canine vocal fold function after injection of a new biomaterial designed to treat phonatory mucosal scarring. Ann Otol Rhinol Laryngol. 2011 Mar; 120(3):175-84.
    View in: PubMed
  16. Herrera VL, Bagamasbad P, Decano JL, Ruiz-Opazo N. AVR/NAVR deficiency lowers blood pressure and differentially affects urinary concentrating ability, cognition, and anxiety-like behavior in male and female mice. Physiol Genomics. 2011 Jan 7; 43(1):32-42.
    View in: PubMed
  17. Kumai Y, Kobler JB, Herrera VL, Zeitels SM. Perspectives on adipose-derived stem/stromal cells as potential treatment for scarred vocal folds: opportunity and challenges. Curr Stem Cell Res Ther. 2010 Jun; 5(2):175-81.
    View in: PubMed
  18. Kumai Y, Kobler JB, Park H, Galindo M, Herrera VL, Zeitels SM. Modulation of vocal fold scar fibroblasts by adipose-derived stem/stromal cells. Laryngoscope. 2010 Feb; 120(2):330-7.
    View in: PubMed
  19. Herrera VL, Viereck JC, Lopez-Guerra G, Kumai Y, Kobler J, Karajanagi S, Park H, Hillman R, Zeitels SM. 11.7 Tesla magnetic resonance microimaging of laryngeal tissue architecture. Laryngoscope. 2009 Nov; 119(11):2187-94.
    View in: PubMed
  20. Kumai Y, Kobler JB, Park H, Lopez-Guerra G, Karajanagi S, Herrera VL, Zeitels SM. Crosstalk between adipose-derived stem/stromal cells and vocal fold fibroblasts in vitro. Laryngoscope. 2009 Apr; 119(4):799-805.
    View in: PubMed
  21. Decano JL, Viereck JC, McKee AC, Hamilton JA, Ruiz-Opazo N, Herrera VL. Early-life sodium exposure unmasks susceptibility to stroke in hyperlipidemic, hypertensive heterozygous Tg25 rats transgenic for human cholesteryl ester transfer protein. Circulation. 2009 Mar 24; 119(11):1501-9.
    View in: PubMed
  22. Herrera VL, Decano JL, Steffen M, Ruiz-Opazo N. Autophagy: insights from DEspR-deficiency and haploinsufficiency. Autophagy. 2009 Feb; 5(2):259-62.
    View in: PubMed
  23. Herrera VL, Decano JL, Bagamasbad P, Kufahl T, Steffen M, Ruiz-Opazo N. Sex-specific hippocampus-dependent cognitive deficits and increased neuronal autophagy in DEspR haploinsufficiency in mice. Physiol Genomics. 2008 Nov 12; 35(3):316-29.
    View in: PubMed
  24. Herrera VL, Bagamasbad P, Didishvili T, Decano JL, Ruiz-Opazo N. Overlapping genes in Nalp6/PYPAF5 locus encode two V2-type vasopressin isoreceptors: angiotensin-vasopressin receptor (AVR) and non-AVR. Physiol Genomics. 2008 Jun 12; 34(1):65-77.
    View in: PubMed
  25. Herrera VL, Ponce LR, Ruiz-Opazo N. Genome-wide scan for interacting loci affecting human cholesteryl ester transfer protein-induced hypercholesterolemia in transgenic human cholesteryl ester transfer protein F2-intercross rats. J Hypertens. 2007 Aug; 25(8):1608-12.
    View in: PubMed
  26. Glorioso N, Herrera VL, Bagamasbad P, Filigheddu F, Troffa C, Argiolas G, Bulla E, Decano JL, Ruiz-Opazo N. Association of ATP1A1 and dear single-nucleotide polymorphism haplotypes with essential hypertension: sex-specific and haplotype-specific effects. Circ Res. 2007 May 25; 100(10):1522-9.
    View in: PubMed
  27. Kotlo K, Hughes DE, Herrera VL, Ruiz-Opazo N, Costa RH, Robey RB, Danziger RS. Functional polymorphism of the Anpep gene increases promoter activity in the Dahl salt-resistant rat. Hypertension. 2007 Mar; 49(3):467-72.
    View in: PubMed
  28. Herrera VL, Tsikoudakis A, Ponce LR, Matsubara Y, Ruiz-Opazo N. Sex-specific QTLs and interacting loci underlie salt-sensitive hypertension and target organ complications in Dahl S/jrHS hypertensive rats. Physiol Genomics. 2006 Aug 16; 26(3):172-9.
    View in: PubMed
  29. Herrera VL, Ponce LR, Bagamasbad PD, VanPelt BD, Didishvili T, Ruiz-Opazo N. Embryonic lethality in Dear gene-deficient mice: new player in angiogenesis. Physiol Genomics. 2005 Nov 17; 23(3):257-68.
    View in: PubMed
  30. Funari VA, Herrera VL, Freeman D, Tolan DR. Genes required for fructose metabolism are expressed in Purkinje cells in the cerebellum. Brain Res Mol Brain Res. 2005 Dec 14; 142(2):115-22.
    View in: PubMed
  31. Kaneko Y, Cloix JF, Herrera VL, Ruiz-Opazo N. Corroboration of Dahl S Q276L alpha1Na,K-ATPase protein sequence: impact on affinities for ligands and on E1 conformation. J Hypertens. 2005 Apr; 23(4):745-52.
    View in: PubMed
  32. Herrera VL, Ruiz-Opazo N. Genetic studies in rat models: insights into cardiovascular disease. Curr Opin Lipidol. 2005 Apr; 16(2):179-91.
    View in: PubMed
  33. Kaneko Y, Herrera VL, Didishvili T, Ruiz-Opazo N. Sex-specific effects of dual ET-1/ANG II receptor (Dear) variants in Dahl salt-sensitive/resistant hypertension rat model. Physiol Genomics. 2005 Jan 20; 20(2):157-64.
    View in: PubMed
  34. Herrera VL, Tsikoudakis A, Didishvili T, Ponce LR, Bagamasbad P, Gantz D, Herscovitz H, Van Tol A, Ruiz-Opazo N. Analysis of gender-specific atherosclerosis susceptibility in transgenic[hCETP]25DS rat model. Atherosclerosis. 2004 Nov; 177(1):9-18.
    View in: PubMed
  35. Herrera VL, Didishvili T, Lopez LV, Myers RH, Ruiz-Opazo N. Genome-wide scan identifies novel QTLs for cholesterol and LDL levels in F2[Dahl RxS]-intercross rats. Circ Res. 2004 Mar 5; 94(4):446-52.
    View in: PubMed
  36. Ruiz-Opazo N, Kosik KS, Lopez LV, Bagamasbad P, Ponce LR, Herrera VL. Attenuated hippocampus-dependent learning and memory decline in transgenic TgAPPswe Fischer-344 rats. Mol Med. 2004 Jan-Jun; 10(1-6):36-44.
    View in: PubMed
  37. Nguyen GH, Bouchard J, Boselli MG, Tolstoi LG, Keith L, Baldwin C, Nguyen NC, Schultz M, Herrera VL, Smith CL. DNA stability and schizophrenia in twins. Am J Med Genet B Neuropsychiatr Genet. 2003 Jul 1; 120B(1):1-10.
    View in: PubMed
  38. Herrera VL, Shen L, Lopez LV, Didishvili T, Zhang YX, Ruiz-Opazo N. Chlamydia pneumoniae accelerates coronary artery disease progression in transgenic hyperlipidemia-genetic hypertension rat model. Mol Med. 2003 May-Aug; 9(5-8):135-42.
    View in: PubMed
  39. Herrera VL, Traverse S, Lopez LV, Ruiz-Opazo N. X-linked locus associated with hypertensive renal disease susceptibility in Dahl rats. J Hypertens. 2003 Jan; 21(1):67-71.
    View in: PubMed
  40. Herrera VM, Didishvili T, Lopez LV, Ruiz-Opazo N. Differential regulation of functional gene clusters in overt coronary artery disease in a transgenic atherosclerosis-hypertensive rat model. Mol Med. 2002 Jul; 8(7):367-75.
    View in: PubMed
  41. Ruiz-Opazo N, Lopez LV, Herrera VL. The dual AngII/AVP receptor gene N119S/C163R variant exhibits sodium-induced dysfunction and cosegregates with salt-sensitive hypertension in the Dahl salt-sensitive hypertensive rat model. Mol Med. 2002 Jan; 8(1):24-32.
    View in: PubMed
  42. Herrera VM, Didishvili T, Lopez LV, Zander K, Traverse S, Gantz D, Herscovitz H, Ruiz-Opazo N. Hypertension exacerbates coronary artery disease in transgenic hyperlipidemic Dahl salt-sensitive hypertensive rats. Mol Med. 2001 Dec; 7(12):831-44.
    View in: PubMed
  43. Song Y, Herrera VL, Filigheddu F, Troffa C, Lopez LV, Glorioso N, Ruiz-Opazo N. Non-association of the thiazide-sensitive Na,Cl-cotransporter gene with polygenic hypertension in both rats and humans. J Hypertens. 2001 Sep; 19(9):1547-51.
    View in: PubMed
  44. Glorioso N, Filigheddu F, Troffa C, Soro A, Parpaglia PP, Tsikoudakis A, Myers RH, Herrera VL, Ruiz-Opazo N. Interaction of alpha(1)-Na,K-ATPase and Na,K,2Cl-cotransporter genes in human essential hypertension. Hypertension. 2001 Aug; 38(2):204-9.
    View in: PubMed
  45. Herrera VL, Ruiz-Opazo N. Identification of a novel V1-type AVP receptor based on the molecular recognition theory. Mol Med. 2001 Jul; 7(7):499-506.
    View in: PubMed
  46. Herrera VL, Lopez LV, Ruiz-Opazo N. Alpha1 Na,K-ATPase and Na,K,2Cl-cotransporte/D3mit3 loci interact to increase susceptibility to salt-sensitive hypertension in Dahl S(HSD) rats. Mol Med. 2001 Feb; 7(2):125-34.
    View in: PubMed
  47. Herrera VL, Makrides SC, Xie HX, Adari H, Krauss RM, Ryan US, Ruiz-Opazo N. Spontaneous combined hyperlipidemia, coronary heart disease and decreased survival in Dahl salt-sensitive hypertensive rats transgenic for human cholesteryl ester transfer protein. Nat Med. 1999 Dec; 5(12):1383-9.
    View in: PubMed
  48. Herrera VL, Xie HX, Lopez LV, Schork NJ, Ruiz-Opazo N. The alpha1 Na,K-ATPase gene is a susceptibility hypertension gene in the Dahl salt-sensitiveHSD rat. J Clin Invest. 1998 Sep 15; 102(6):1102-11.
    View in: PubMed
  49. Taccioli GE, Amatucci AG, Beamish HJ, Gell D, Xiang XH, Torres Arzayus MI, Priestley A, Jackson SP, Marshak Rothstein A, Jeggo PA, Herrera VL. Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity. Immunity. 1998 Sep; 9(3):355-66.
    View in: PubMed
  50. Tonkiss J, Trzcinska M, Galler JR, Ruiz-Opazo N, Herrera VL. Prenatal malnutrition-induced changes in blood pressure: dissociation of stress and nonstress responses using radiotelemetry. Hypertension. 1998 Jul; 32(1):108-14.
    View in: PubMed
  51. Ruiz-Opazo N, Hirayama K, Akimoto K, Herrera VL. Molecular characterization of a dual endothelin-1/Angiotensin II receptor. Mol Med. 1998 Feb; 4(2):96-108.
    View in: PubMed
  52. Ruiz-Opazo N, Cloix JF, Melis MG, Xiang XH, Herrera VL. Characterization of a sodium-response transcriptional mechanism. Hypertension. 1997 Aug; 30(2 Pt 1):191-8.
    View in: PubMed
  53. Gonzalez CB, Herrera VL, Ruiz-Opazo N. Renal immunocytochemical distribution and pharmacological properties of the dual angiotensin II/AVP receptor. Hypertension. 1997 Apr; 29(4):957-61.
    View in: PubMed
  54. Ruiz-Opazo N, Xiang XH, Herrera VL. Pressure-overload deinduction of human alpha 2 Na,K-ATPase gene expression in transgenic rats. Hypertension. 1997 Feb; 29(2):606-12.
    View in: PubMed
  55. Ruiz-Opazo N, Akimoto K, Herrera VL. Identification of a novel dual angiotensin II/vasopressin receptor on the basis of molecular recognition theory. Nat Med. 1995 Oct; 1(10):1074-81.
    View in: PubMed
  56. Ruiz-Opazo N, Barany F, Hirayama K, Herrera VL. Confirmation of mutant alpha 1 Na,K-ATPase gene and transcript in Dahl salt-sensitive/JR rats. Hypertension. 1994 Sep; 24(3):260-70.
    View in: PubMed
  57. Herrera VL, Ruiz-Opazo N. Beyond genetic markers: hypertension genes. J Hypertens. 1994 Aug; 12(8):847-56.
    View in: PubMed
  58. Herrera VL, Cova T, Sassoon D, Ruiz-Opazo N. Developmental cell-specific regulation of Na(+)-K(+)-ATPase alpha 1-, alpha 2-, and alpha 3-isoform gene expression. Am J Physiol. 1994 May; 266(5 Pt 1):C1301-12.
    View in: PubMed
  59. Sweadner KJ, Herrera VL, Amato S, Moellmann A, Gibbons DK, Repke KR. Immunologic identification of Na+,K(+)-ATPase isoforms in myocardium. Isoform change in deoxycorticosterone acetate-salt hypertension. Circ Res. 1994 Apr; 74(4):669-78.
    View in: PubMed
  60. Herrera VL, Ruiz-Opazo N. Genetic analysis of hypertension in animal models and human hypertensive patients. J Hypertens Suppl. 1994; 12(7):S47-55.
    View in: PubMed
  61. Ruiz-Opazo N, Cloix JF, Herrera VL. Differential interaction of the dual alpha tropomyosin/N5 enhancer with multiple DNA binding proteins: N5 is a putative novel z-ZIP DNA binding protein. Cell Mol Biol Res. 1994; 40(4):265-72.
    View in: PubMed
  62. Canessa M, Romero JR, Ruiz-Opazo N, Herrera VL. The alpha 1 Na(+)-K+ pump of the Dahl salt-sensitive rat exhibits altered Na+ modulation of K+ transport in red blood cells. J Membr Biol. 1993 Jun; 134(2):107-22.
    View in: PubMed
  63. Ruiz-Opazo N, Herrera VL. Analysis of Na+ pump genes. Hypertension. 1992 May; 19(5):495-6.
    View in: PubMed
  64. Herrera VL, Ruiz-Opazo N. Genetics of hypertension A multidisciplinary challenge. Trends Cardiovasc Med. 1991 Jul-Aug; 1(5):185-9.
    View in: PubMed
  65. Herrera VL, Ruiz-Opazo N. Alteration of alpha 1 Na+,K(+)-ATPase 86Rb+ influx by a single amino acid substitution. Science. 1990 Aug 31; 249(4972):1023-6.
    View in: PubMed
  66. Herrera VL, Ruiz-Opazo N. Regulation of alpha-tropomyosin and N5 genes by a shared enhancer. Modular structure and hierarchical organization. J Biol Chem. 1990 Jun 5; 265(16):9555-62.
    View in: PubMed
  67. Herrera VL, Chobanian AV, Ruiz-Opazo N. Isoform-specific modulation of Na+, K+-ATPase alpha-subunit gene expression in hypertension. Science. 1988 Jul 8; 241(4862):221-3.
    View in: PubMed
  68. Claffey KP, Herrera VL, Brecher P, Ruiz-Opazo N. Cloning and tissue distribution of rat heart fatty acid binding protein mRNA: identical forms in heart and skeletal muscle. Biochemistry. 1987 Dec 1; 26(24):7900-4.
    View in: PubMed
  69. Herrera VL, Emanuel JR, Ruiz-Opazo N, Levenson R, Nadal-Ginard B. Three differentially expressed Na,K-ATPase alpha subunit isoforms: structural and functional implications. J Cell Biol. 1987 Oct; 105(4):1855-65.
    View in: PubMed
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