Keywords
Last Name

Barbara A. Corkey, PhD

TitleZoltan Kohn Professor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionMolecular Medicine (Obesity)
Address650 Albany St Evans Biomed Research Ctr
Boston MA 02118
Phone(617) 638-7091
ORCID ORCID Icon0000-0002-5467-1630
Other Positions
TitleVice Chair of Research
InstitutionBoston University School of Medicine
DepartmentMedicine

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentBiochemistry

TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Graduate Medical Sciences

InstitutionBoston Medical Center

 Research Expertise & Professional Interests
Expertise includes: Metabolic regulation; pancreatic ß-cell metabolism and signal transduction; adipocyte metabolism and metabolic signal transduction; mitochondrial metabolism; cellular imaging of cations; reactive oxygen species; membrane potential and lipids; branched chain amino acid metabolism; inborn errors of mitochondrial metabolism; and acyl CoA regulation.

 Self-Described Keywords
  • metabolism
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Corkey BE. Diabetes: have we got it all wrong? Insulin hypersecretion and food additives: cause of obesity and diabetes? Diabetes Care. 2012 Dec; 35(12):2432-7.
    View in: PubMed
  2. Corkey BE, Shirihai O. Metabolic master regulators: sharing information among multiple systems. Trends Endocrinol Metab. 2012 Dec; 23(12):594-601.
    View in: PubMed
  3. Saadeh M, Ferrante TC, Kane A, Shirihai O, Corkey BE, Deeney JT. Reactive oxygen species stimulate insulin secretion in rat pancreatic islets: studies using mono-oleoyl-glycerol. PLoS One. 2012; 7(1):e30200.
    View in: PubMed
  4. Corkey BE. Banting lecture 2011: hyperinsulinemia: cause or consequence? Diabetes. 2012 Jan; 61(1):4-13.
    View in: PubMed
  5. Haller JF, Krawczyk SA, Gostilovitch L, Corkey BE, Zoeller RA. Glucose-6-phosphate isomerase deficiency results in mTOR activation, failed translocation of lipin 1a to the nucleus and hypersensitivity to glucose: Implications for the inherited glycolytic disease. Biochim Biophys Acta. 2011 Nov; 1812(11):1393-402.
    View in: PubMed
  6. Zhong J, Krawczyk SA, Chaerkady R, Huang H, Goel R, Bader JS, Wong GW, Corkey BE, Pandey A. Temporal profiling of the secretome during adipogenesis in humans. J Proteome Res. 2010 Oct 1; 9(10):5228-38.
    View in: PubMed
  7. Wang T, Si Y, Shirihai OS, Si H, Schultz V, Corkey RF, Hu L, Deeney JT, Guo W, Corkey BE. Respiration in adipocytes is inhibited by reactive oxygen species. Obesity (Silver Spring). 2010 Aug; 18(8):1493-502.
    View in: PubMed
  8. Getty-Kaushik L, Richard AM, Deeney JT, Krawczyk S, Shirihai O, Corkey BE. The CB1 antagonist rimonabant decreases insulin hypersecretion in rat pancreatic islets. Obesity (Silver Spring). 2009 Oct; 17(10):1856-60.
    View in: PubMed
  9. Molina AJ, Wikstrom JD, Stiles L, Las G, Mohamed H, Elorza A, Walzer G, Twig G, Katz S, Corkey BE, Shirihai OS. Mitochondrial networking protects beta-cells from nutrient-induced apoptosis. Diabetes. 2009 Oct; 58(10):2303-15.
    View in: PubMed
  10. Pi J, Zhang Q, Fu J, Woods CG, Hou Y, Corkey BE, Collins S, Andersen ME. ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function. Toxicol Appl Pharmacol. 2010 Apr 1; 244(1):77-83.
    View in: PubMed
  11. Pi J, Bai Y, Daniel KW, Liu D, Lyght O, Edelstein D, Brownlee M, Corkey BE, Collins S. Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic beta-cell function. Endocrinology. 2009 Jul; 150(7):3040-8.
    View in: PubMed
  12. Field AE, Javaras KM, Aneja P, Kitos N, Camargo CA, Taylor CB, Laird NM. Family, peer, and media predictors of becoming eating disordered. Arch Pediatr Adolesc Med. 2008 Jun; 162(6):574-9.
    View in: PubMed
  13. Karagiannides I, Torres D, Tseng YH, Bowe C, Carvalho E, Espinoza D, Pothoulakis C, Kokkotou E. Substance P as a novel anti-obesity target. Gastroenterology. 2008 Mar; 134(3):747-55.
    View in: PubMed
  14. Zabolotny JM, Kim YB, Welsh LA, Kershaw EE, Neel BG, Kahn BB. Protein-tyrosine phosphatase 1B expression is induced by inflammation in vivo. J Biol Chem. 2008 May 23; 283(21):14230-41.
    View in: PubMed
  15. Wee CC, Davis RB, Hamel MB. Comparing the SF-12 and SF-36 health status questionnaires in patients with and without obesity. Health Qual Life Outcomes. 2008; 6:11.
    View in: PubMed
  16. Danial NN, Walensky LD, Zhang CY, Choi CS, Fisher JK, Molina AJ, Datta SR, Pitter KL, Bird GH, Wikstrom JD, Deeney JT, Robertson K, Morash J, Kulkarni A, Neschen S, Kim S, Greenberg ME, Corkey BE, Shirihai OS, Shulman GI, Lowell BB, Korsmeyer SJ. Dual role of proapoptotic BAD in insulin secretion and beta cell survival. Nat Med. 2008 Feb; 14(2):144-53.
    View in: PubMed
  17. Twig G, Elorza A, Molina AJ, Mohamed H, Wikstrom JD, Walzer G, Stiles L, Haigh SE, Katz S, Las G, Alroy J, Wu M, Py BF, Yuan J, Deeney JT, Corkey BE, Shirihai OS. Fission and selective fusion govern mitochondrial segregation and elimination by autophagy. EMBO J. 2008 Jan 23; 27(2):433-46.
    View in: PubMed
  18. Adebamowo CA, Spiegelman D, Berkey CS, Danby FW, Rockett HH, Colditz GA, Willett WC, Holmes MD. Milk consumption and acne in teenaged boys. J Am Acad Dermatol. 2008 May; 58(5):787-93.
    View in: PubMed
  19. Must A, Bandini LG, Tybor DJ, Janssen I, Ross R, Dietz WH. Behavioral risk factors in relation to visceral adipose tissue deposition in adolescent females. Int J Pediatr Obes. 2008; 3 Suppl 1:28-36.
    View in: PubMed
  20. Corkey, B. E. (2008) Metabolic Regulation of Insulin Secretion, Monograph entitled “Pancreatic Beta Cell in Health and Disease,” Springer Japan KK (53-75) . Metabolic Regulation of Insulin Secretion. Monograph entitled Pancreatic Beta Cell in Health and Disease. Springer. Japan KK. 2008; 53-75.
  21. Gray SH, Austin SB, Huang B, Frazier AL, Field AE, Kahn JA. Predicting sexual initiation in a prospective cohort study of adolescents. Arch Pediatr Adolesc Med. 2008 Jan; 162(1):55-9.
    View in: PubMed
  22. Tsai CJ, Leitzmann MF, Willett WC, Giovannucci EL. Long-term effect of magnesium consumption on the risk of symptomatic gallstone disease among men. Am J Gastroenterol. 2008 Feb; 103(2):375-82.
    View in: PubMed
  23. Trus M, Corkey RF, Nesher R, Richard AM, Deeney JT, Corkey BE, Atlas D. The L-type voltage-gated Ca2+ channel is the Ca2+ sensor protein of stimulus-secretion coupling in pancreatic beta cells. Biochemistry. 2007 Dec 18; 46(50):14461-7.
    View in: PubMed
  24. Song DH, Getty-Kaushik L, Tseng E, Simon J, Corkey BE, Wolfe MM. Glucose-dependent insulinotropic polypeptide enhances adipocyte development and glucose uptake in part through Akt activation. Gastroenterology. 2007 Dec; 133(6):1796-805.
    View in: PubMed
  25. Wikstrom JD, Katzman SM, Mohamed H, Twig G, Graf SA, Heart E, Molina AJ, Corkey BE, de Vargas LM, Danial NN, Collins S, Shirihai OS. beta-Cell mitochondria exhibit membrane potential heterogeneity that can be altered by stimulatory or toxic fuel levels. Diabetes. 2007 Oct; 56(10):2569-78.
    View in: PubMed
  26. Deeney JT, Bränström R, Corkey BE, Larsson O, Berggren PO. 3H-serotonin as a marker of oscillatory insulin secretion in clonal beta-cells (INS-1). FEBS Lett. 2007 Aug 21; 581(21):4080-4.
    View in: PubMed
  27. Guo W, Bigornia S, Leizerman I, Xie W, McDonnell M, Clemente K, Pirtskhalava T, Kirkland JL, Gokce N, Corkey BE, Sullivan LM, Apovian CM. New scanning electron microscopic method for determination of adipocyte size in humans and mice. Obesity (Silver Spring). 2007 Jul; 15(7):1657-65.
    View in: PubMed
  28. Han JR, Deng B, Sun J, Chen CG, Corkey BE, Kirkland JL, Ma J, Guo W. Effects of dietary medium-chain triglyceride on weight loss and insulin sensitivity in a group of moderately overweight free-living type 2 diabetic Chinese subjects. Metabolism. 2007 Jul; 56(7):985-91.
    View in: PubMed
  29. Bränström R, Leibiger IB, Leibiger B, Klement G, Nilsson J, Arhem P, Aspinwall CA, Corkey BE, Larsson O, Berggren PO. Single residue (K332A) substitution in Kir6.2 abolishes the stimulatory effect of long-chain acyl-CoA esters: indications for a long-chain acyl-CoA ester binding motif. Diabetologia. 2007 Aug; 50(8):1670-7.
    View in: PubMed
  30. Heart E, Yaney GC, Corkey RF, Schultz V, Luc E, Liu L, Deeney JT, Shirihai O, Tornheim K, Smith PJ, Corkey BE. Ca2+, NAD(P)H and membrane potential changes in pancreatic beta-cells by methyl succinate: comparison with glucose. Biochem J. 2007 Apr 1; 403(1):197-205.
    View in: PubMed
  31. Pi J, Bai Y, Zhang Q, Wong V, Floering LM, Daniel K, Reece JM, Deeney JT, Andersen ME, Corkey BE, Collins S. Reactive oxygen species as a signal in glucose-stimulated insulin secretion. Diabetes. 2007 Jul; 56(7):1783-91.
    View in: PubMed
  32. Corkey, B. E. and Prentki, M. Malonyl CoA and Long Chain Acyl-CoA Signaling in Health, Obesity and Diabetes. Diabetes. 2007.
  33. Guo W, Pirtskhalava T, Tchkonia T, Xie W, Thomou T, Han J, Wang T, Wong S, Cartwright A, Hegardt FG, Corkey BE, Kirkland JL. Aging results in paradoxical susceptibility of fat cell progenitors to lipotoxicity. Am J Physiol Endocrinol Metab. 2007 Apr; 292(4):E1041-51.
    View in: PubMed
  34. Getty-Kaushik L, Song DH, Boylan MO, Corkey BE, Wolfe MM. Glucose-dependent insulinotropic polypeptide modulates adipocyte lipolysis and reesterification. Obesity (Silver Spring). 2006 Jul; 14(7):1124-31.
    View in: PubMed
  35. Xie W, Hamilton JA, Kirkland JL, Corkey BE, Guo W. Oleate-induced formation of fat cells with impaired insulin sensitivity. Lipids. 2006 Mar; 41(3):267-71.
    View in: PubMed
  36. Kirkland, J.L., Corkey, B.E., Tchkonia, T. Current views of the fat cell as an endocrine cell: lipotoxicity. Overweight and the Metabolic Syndrome, George A. Bray and Donna H. Ryan, Eds., Endocrine Updates. Springer. 2006; pp 105-123.
  37. Getty-Kaushik L, Richard AM, Corkey BE. Glucose-dependent insulin modulation of oscillatory lipolysis in perifused rat adipocytes. Obes Res. 2005 Dec; 13(12):2058-65.
    View in: PubMed
  38. Heart E, Corkey RF, Wikstrom JD, Shirihai OS, Corkey BE. Glucose-dependent increase in mitochondrial membrane potential, but not cytoplasmic calcium, correlates with insulin secretion in single islet cells. Am J Physiol Endocrinol Metab. 2006 Jan; 290(1):E143-E148.
    View in: PubMed
  39. Zang Y, Wang T, Xie W, Wang-Fischer YL, Getty L, Han J, Corkey BE, Guo W. Regulation of acetyl CoA carboxylase and carnitine palmitoyl transferase-1 in rat adipocytes. Obes Res. 2005 Sep; 13(9):1530-9.
    View in: PubMed
  40. Hu L, Deeney JT, Nolan CJ, Peyot ML, Ao A, Richard AM, Luc E, Faergeman NJ, Knudsen J, Guo W, Sorhede-Winzell M, Prentki M, Corkey BE. Regulation of lipolytic activity by long-chain acyl-coenzyme A in islets and adipocytes. Am J Physiol Endocrinol Metab. 2005 Dec; 289(6):E1085-92.
    View in: PubMed
  41. Getty-Kaushik L, Richard AM, Corkey BE. Free fatty acid regulation of glucose-dependent intrinsic oscillatory lipolysis in perifused isolated rat adipocytes. Diabetes. 2005 Mar; 54(3):629-37.
    View in: PubMed
  42. Wang YL, Guo W, Zang Y, Yaney GC, Vallega G, Getty-Kaushik L, Pilch P, Kandror K, Corkey BE. Acyl coenzyme a synthetase regulation: putative role in long-chain acyl coenzyme a partitioning. Obes Res. 2004 Nov; 12(11):1781-8.
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  43. Katzman SM, Messerli MA, Barry DT, Grossman A, Harel T, Wikstrom JD, Corkey BE, Smith PJ, Shirihai OS. Mitochondrial metabolism reveals a functional architecture in intact islets of Langerhans from normal and diabetic Psammomys obesus. Am J Physiol Endocrinol Metab. 2004 Dec; 287(6):E1090-9.
    View in: PubMed
  44. Peyot ML, Nolan CJ, Soni K, Joly E, Lussier R, Corkey BE, Wang SP, Mitchell GA, Prentki M. Hormone-sensitive lipase has a role in lipid signaling for insulin secretion but is nonessential for the incretin action of glucagon-like peptide 1. Diabetes. 2004 Jul; 53(7):1733-42.
    View in: PubMed
  45. Perdomo G, Commerford SR, Richard AM, Adams SH, Corkey BE, O'Doherty RM, Brown NF. Increased beta-oxidation in muscle cells enhances insulin-stimulated glucose metabolism and protects against fatty acid-induced insulin resistance despite intramyocellular lipid accumulation. J Biol Chem. 2004 Jun 25; 279(26):27177-86.
    View in: PubMed
  46. Lei T, Xie W, Han J, Corkey BE, Hamilton JA, Guo W. Medium-chain Fatty acids attenuate agonist-stimulated lipolysis, mimicking the effects of starvation. Obes Res. 2004 Apr; 12(4):599-611.
    View in: PubMed
  47. Bränström R, Aspinwall CA, Välimäki S, Ostensson CG, Tibell A, Eckhard M, Brandhorst H, Corkey BE, Berggren PO, Larsson O. Long-chain CoA esters activate human pancreatic beta-cell KATP channels: potential role in Type 2 diabetes. Diabetologia. 2004 Feb; 47(2):277-83.
    View in: PubMed
  48. Kamp F, Kizilbash N, Corkey BE, Berggren PO, Hamilton JA. Sulfonylureas rapidly cross phospholipid bilayer membranes by a free-diffusion mechanism. Diabetes. 2003 Oct; 52(10):2526-31.
    View in: PubMed
  49. Yaney GC, Corkey BE. Fatty acid metabolism and insulin secretion in pancreatic beta cells. Diabetologia. 2003 Oct; 46(10):1297-312.
    View in: PubMed
  50. Guo W, Lei T, Wang T, Corkey BE, Han J. Octanoate inhibits triglyceride synthesis in 3T3-L1 and human adipocytes. J Nutr. 2003 Aug; 133(8):2512-8.
    View in: PubMed
  51. Wang T, Zang Y, Ling W, Corkey BE, Guo W. Metabolic partitioning of endogenous fatty acid in adipocytes. Obes Res. 2003 Jul; 11(7):880-7.
    View in: PubMed
  52. Han J, Hamilton JA, Kirkland JL, Corkey BE, Guo W. Medium-chain oil reduces fat mass and down-regulates expression of adipogenic genes in rats. Obes Res. 2003 Jun; 11(6):734-44.
    View in: PubMed
  53. Cunningham BA, Richard AM, Dillon JS, Daley JT, Civelek VN, Deeney JT, Yaney GC, Corkey BE, Tornheim K. Glucagon-like peptide 1 and fatty acids amplify pulsatile insulin secretion from perifused rat islets. Biochem J. 2003 Jan 1; 369(Pt 1):173-8.
    View in: PubMed
  54. Kamp F, Guo W, Souto R, Pilch PF, Corkey BE, Hamilton JA. Rapid flip-flop of oleic acid across the plasma membrane of adipocytes. J Biol Chem. 2003 Mar 7; 278(10):7988-95.
    View in: PubMed
  55. Yaney GC, Fairbanks JM, Deeney JT, Korchak HM, Tornheim K, Corkey BE. Potentiation of insulin secretion by phorbol esters is mediated by PKC-alpha and nPKC isoforms. Am J Physiol Endocrinol Metab. 2002 Nov; 283(5):E880-8.
    View in: PubMed
  56. Alarcon C, Wicksteed B, Prentki M, Corkey BE, Rhodes CJ. Succinate is a preferential metabolic stimulus-coupling signal for glucose-induced proinsulin biosynthesis translation. Diabetes. 2002 Aug; 51(8):2496-504.
    View in: PubMed
  57. Han J, Farmer SR, Kirkland JL, Corkey BE, Yoon R, Pirtskhalava T, Ido Y, Guo W. Octanoate attenuates adipogenesis in 3T3-L1 preadipocytes. J Nutr. 2002 May; 132(5):904-10.
    View in: PubMed
  58. Korchak HM, Corkey BE, Yaney GC, Kilpatrick LE. Negative regulation of ligand-initiated Ca(2+) uptake by PKC-beta II in differentiated HL60 cells. Am J Physiol Cell Physiol. 2001 Aug; 281(2):C514-23.
    View in: PubMed
  59. Deeney JT, Köhler M, Kubik K, Brown G, Schultz V, Tornheim K, Corkey BE, Berggren PO. Glucose-induced metabolic oscillations parallel those of Ca(2+) and insulin release in clonal insulin-secreting cells. A multiwell approach to oscillatory cell behavior. J Biol Chem. 2001 Oct 5; 276(40):36946-50.
    View in: PubMed
  60. Faradji RN, Havari E, Chen Q, Gray J, Tornheim K, Corkey BE, Mulligan RC, Lipes MA. Glucose-induced toxicity in insulin-producing pituitary cells that coexpress GLUT2 and glucokinase. Implications for metabolic engineering. J Biol Chem. 2001 Sep 28; 276(39):36695-702.
    View in: PubMed
  61. Caserta F, Tchkonia T, Civelek VN, Prentki M, Brown NF, McGarry JD, Forse RA, Corkey BE, Hamilton JA, Kirkland JL. Fat depot origin affects fatty acid handling in cultured rat and human preadipocytes. Am J Physiol Endocrinol Metab. 2001 Feb; 280(2):E238-47.
    View in: PubMed
  62. Yaney GC, Civelek VN, Richard AM, Dillon JS, Deeney JT, Hamilton JA, Korchak HM, Tornheim K, Corkey BE, Boyd AE. Glucagon-like peptide 1 stimulates lipolysis in clonal pancreatic beta-cells (HIT). Diabetes. 2001 Jan; 50(1):56-62.
    View in: PubMed
  63. Prentki, M., Roduit, R., Lameloise, N., Corkey, B. E. and Assimacopoulos-Jeannet, F. . Glucotoxicity, lipotoxicity and pancreatic ß-cell failure: A role for malonyl CoA, PPARa and altered lipid partitioning?. Can. J. Diabetes Care. 2001; 25:36-46.
  64. Dillon JS, Yaney GC, Zhou Y, Voilley N, Bowen S, Chipkin S, Bliss CR, Schultz V, Schuit FC, Prentki M, Waxman DJ, Corkey BE. Dehydroepiandrosterone sulfate and beta-cell function: enhanced glucose-induced insulin secretion and altered gene expression in rodent pancreatic beta-cells. Diabetes. 2000 Dec; 49(12):2012-20.
    View in: PubMed
  65. Porterfield DM, Corkey RF, Sanger RH, Tornheim K, Smith PJ, Corkey BE. Oxygen consumption oscillates in single clonal pancreatic beta-cells (HIT). Diabetes. 2000 Sep; 49(9):1511-6.
    View in: PubMed
  66. Deeney JT, Prentki M, Corkey BE. Metabolic control of beta-cell function. Semin Cell Dev Biol. 2000 Aug; 11(4):267-75.
    View in: PubMed
  67. Guo W, Choi JK, Kirkland JL, Corkey BE, Hamilton JA. Esterification of free fatty acids in adipocytes: a comparison between octanoate and oleate. Biochem J. 2000 Jul 15; 349(Pt 2):463-71.
    View in: PubMed
  68. Yaney GC, Korchak HM, Corkey BE. Long-chain acyl CoA regulation of protein kinase C and fatty acid potentiation of glucose-stimulated insulin secretion in clonal beta-cells. Endocrinology. 2000 Jun; 141(6):1989-98.
    View in: PubMed
  69. Deeney JT, Gromada J, Høy M, Olsen HL, Rhodes CJ, Prentki M, Berggren PO, Corkey BE. Acute stimulation with long chain acyl-CoA enhances exocytosis in insulin-secreting cells (HIT T-15 and NMRI beta-cells). J Biol Chem. 2000 Mar 31; 275(13):9363-8.
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  70. Brown H, Meister B, Deeney J, Corkey BE, Yang SN, Larsson O, Rhodes CJ, Seino S, Berggren PO, Fried G. Synaptotagmin III isoform is compartmentalized in pancreatic beta-cells and has a functional role in exocytosis. Diabetes. 2000 Mar; 49(3):383-91.
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  71. Corkey BE, Deeney JT, Yaney GC, Tornheim K, Prentki M. The role of long-chain fatty acyl-CoA esters in beta-cell signal transduction. J Nutr. 2000 Feb; 130(2S Suppl):299S-304S.
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  72. Corkey, B. E., Deeney, J. T., Yaney, G. C., Tornheim, K. and Prentki, M. . The Role of Long Chain Fatty Acyl CoA Esters in ß-Cell Signal Transduction. J. Nutr. 2000; 130:299S-304S.
  73. Segall L, Lameloise N, Assimacopoulos-Jeannet F, Roche E, Corkey P, Thumelin S, Corkey BE, Prentki M. Lipid rather than glucose metabolism is implicated in altered insulin secretion caused by oleate in INS-1 cells. Am J Physiol. 1999 Sep; 277(3 Pt 1):E521-8.
    View in: PubMed
  74. Guo W, Choi JK, Kirkland JL, Corkey BE, Hamilton JA. Incorporation of [1-13C]oleate into cellular triglycerides in differentiating 3T3L1 cells. Lipids. 1999 Aug; 34(8):825-31.
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  75. Prentki, M., Segall, L., Roche, E., Thumelin, S., Brun, T., McGarry, J. D., Corkey, B. E. et Assimacopoulos-Jeannet, F. Gluco-lipotoxicité et expression génique dans la cellule ß-pancréatique. Diabète et Metabolism. 1999; 17-27.
  76. Bränström R, Leibiger IB, Leibiger B, Corkey BE, Berggren PO, Larsson O. Long chain coenzyme A esters activate the pore-forming subunit (Kir6. 2) of the ATP-regulated potassium channel. J Biol Chem. 1998 Nov 20; 273(47):31395-400.
    View in: PubMed
  77. Gribble FM, Proks P, Corkey BE, Ashcroft FM. Mechanism of cloned ATP-sensitive potassium channel activation by oleoyl-CoA. J Biol Chem. 1998 Oct 9; 273(41):26383-7.
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  78. Brown H, Larsson O, Bränström R, Yang SN, Leibiger B, Leibiger I, Fried G, Moede T, Deeney JT, Brown GR, Jacobsson G, Rhodes CJ, Braun JE, Scheller RH, Corkey BE, Berggren PO, Meister B. Cysteine string protein (CSP) is an insulin secretory granule-associated protein regulating beta-cell exocytosis. EMBO J. 1998 Sep 1; 17(17):5048-58.
    View in: PubMed
  79. Roche E, Farfari S, Witters LA, Assimacopoulos-Jeannet F, Thumelin S, Brun T, Corkey BE, Saha AK, Prentki M. Long-term exposure of beta-INS cells to high glucose concentrations increases anaplerosis, lipogenesis, and lipogenic gene expression. Diabetes. 1998 Jul; 47(7):1086-94.
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  80. Skelly RH, Bollheimer LC, Wicksteed BL, Corkey BE, Rhodes CJ. A distinct difference in the metabolic stimulus-response coupling pathways for regulating proinsulin biosynthesis and insulin secretion that lies at the level of a requirement for fatty acyl moieties. Biochem J. 1998 Apr 15; 331 ( Pt 2):553-61.
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  81. Prentki M, Segall L, Roche E, Thumelin S, Brun T, McGarry JD, Corkey BE, Assimacopoulos-Jeannet F. [Gluco-lipotoxicity and gene expression in the pancreatic beta cell]. Journ Annu Diabetol Hotel Dieu. 1998; 17-27.
    View in: PubMed
  82. Brown NF, Hill JK, Esser V, Kirkland JL, Corkey BE, Foster DW, McGarry JD. Mouse white adipocytes and 3T3-L1 cells display an anomalous pattern of carnitine palmitoyltransferase (CPT) I isoform expression during differentiation. Inter-tissue and inter-species expression of CPT I and CPT II enzymes. Biochem J. 1997 Oct 1; 327 ( Pt 1):225-31.
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  83. Bränström R, Corkey BE, Berggren PO, Larsson O. Evidence for a unique long chain acyl-CoA ester binding site on the ATP-regulated potassium channel in mouse pancreatic beta cells. J Biol Chem. 1997 Jul 11; 272(28):17390-4.
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  84. Grujic D, Susulic VS, Harper ME, Himms-Hagen J, Cunningham BA, Corkey BE, Lowell BB. Beta3-adrenergic receptors on white and brown adipocytes mediate beta3-selective agonist-induced effects on energy expenditure, insulin secretion, and food intake. A study using transgenic and gene knockout mice. J Biol Chem. 1997 Jul 11; 272(28):17686-93.
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  85. Prentki M, Tornheim K, Corkey BE. Signal transduction mechanisms in nutrient-induced insulin secretion. Diabetologia. 1997 Jul; 40 Suppl 2:S32-41.
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  86. Hosokawa H, Corkey BE, Leahy JL. Beta-cell hypersensitivity to glucose following 24-h exposure of rat islets to fatty acids. Diabetologia. 1997 Apr; 40(4):392-7.
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  87. Brun T, Assimacopoulos-Jeannet F, Corkey BE, Prentki M. Long-chain fatty acids inhibit acetyl-CoA carboxylase gene expression in the pancreatic beta-cell line INS-1. Diabetes. 1997 Mar; 46(3):393-400.
    View in: PubMed
  88. Lieu YK, Hsu BY, Price WA, Corkey BE, Stanley CA. Carnitine effects on coenzyme A profiles in rat liver with hypoglycin inhibition of multiple dehydrogenases. Am J Physiol. 1997 Mar; 272(3 Pt 1):E359-66.
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  89. Prentki, M., Tornheim, K. and Corkey, B. E. Signal transduction mechanisms in nutrient-induced secretion. Diabetologia. 1997; 40:S32-S41.
  90. Civelek VN, Deeney JT, Fusonie GE, Corkey BE, Tornheim K. Oscillations in oxygen consumption by permeabilized clonal pancreatic beta-cells (HIT) incubated in an oscillatory glycolyzing muscle extract: roles of free Ca2+, substrates, and the ATP/ADP ratio. Diabetes. 1997 Jan; 46(1):51-6.
    View in: PubMed
  91. Cunningham BA, Deeney JT, Bliss CR, Corkey BE, Tornheim K. Glucose-induced oscillatory insulin secretion in perifused rat pancreatic islets and clonal beta-cells (HIT). Am J Physiol. 1996 Oct; 271(4 Pt 1):E702-10.
    View in: PubMed
  92. Civelek VN, Hamilton JA, Tornheim K, Kelly KL, Corkey BE. Intracellular pH in adipocytes: effects of free fatty acid diffusion across the plasma membrane, lipolytic agonists, and insulin. Proc Natl Acad Sci U S A. 1996 Sep 17; 93(19):10139-44.
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  93. Civelek VN, Deeney JT, Shalosky NJ, Tornheim K, Hansford RG, Prentki M, Corkey BE. Regulation of pancreatic beta-cell mitochondrial metabolism: influence of Ca2+, substrate and ADP. Biochem J. 1996 Sep 1; 318 ( Pt 2):615-21.
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  94. Deeney JT, Cunningham BA, Chheda S, Bokvist K, Juntti-Berggren L, Lam K, Korchak HM, Corkey BE, Berggren PO. Reversible Ca2+-dependent translocation of protein kinase C and glucose-induced insulin release. J Biol Chem. 1996 Jul 26; 271(30):18154-60.
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  95. Larsson O, Deeney JT, Bränström R, Berggren PO, Corkey BE. Activation of the ATP-sensitive K+ channel by long chain acyl-CoA. A role in modulation of pancreatic beta-cell glucose sensitivity. J Biol Chem. 1996 May 3; 271(18):10623-6.
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  96. Civelek VN, Deeney JT, Kubik K, Schultz V, Tornheim K, Corkey BE. Temporal sequence of metabolic and ionic events in glucose-stimulated clonal pancreatic beta-cells (HIT). Biochem J. 1996 May 1; 315 ( Pt 3):1015-9.
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  97. Kurowski TG, Saha AK, Cunningham BA, Holbert RI, Colca JR, Corkey BE, Ruderman NB. Malonyl coenzyme A and adiposity in the Dahl salt-sensitive rat: effects of pioglitazone. Metabolism. 1996 Apr; 45(4):519-25.
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  98. Prentki M, Corkey BE. Are the beta-cell signaling molecules malonyl-CoA and cystolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM? Diabetes. 1996 Mar; 45(3):273-83.
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  99. Nilsson T, Schultz V, Berggren PO, Corkey BE, Tornheim K. Temporal patterns of changes in ATP/ADP ratio, glucose 6-phosphate and cytoplasmic free Ca2+ in glucose-stimulated pancreatic beta-cells. Biochem J. 1996 Feb 15; 314 ( Pt 1):91-4.
    View in: PubMed
  100. Brun T, Roche E, Assimacopoulos-Jeannet F, Corkey BE, Kim KH, Prentki M. Evidence for an anaplerotic/malonyl-CoA pathway in pancreatic beta-cell nutrient signaling. Diabetes. 1996 Feb; 45(2):190-8.
    View in: PubMed
  101. Prentki, M. and Corkey, B. E. Are the ß-Cell Signaling Molecules, Malonyl and Cytosolic Long Chain Acyl-CoA, Implicated in Multiple Tissue Defects of Obesity and NIDDM?. Diabetes. 1996; 45:273-283.
  102. Yaney GC, Schultz V, Cunningham BA, Dunaway GA, Corkey BE, Tornheim K. Phosphofructokinase isozymes in pancreatic islets and clonal beta-cells (INS-1). Diabetes. 1995 Nov; 44(11):1285-9.
    View in: PubMed
  103. Korchak HM, Kane LH, Rossi MW, Corkey BE. Long chain acyl coenzyme A and signaling in neutrophils. An inhibitor of acyl coenzyme A synthetase, triacsin C, inhibits superoxide anion generation and degranulation by human neutrophils. J Biol Chem. 1994 Dec 2; 269(48):30281-7.
    View in: PubMed
  104. Olszewski S, Deeney JT, Schuppin GT, Williams KP, Corkey BE, Rhodes CJ. Rab3A effector domain peptides induce insulin exocytosis via a specific interaction with a cytosolic protein doublet. J Biol Chem. 1994 Nov 11; 269(45):27987-91.
    View in: PubMed
  105. Hamilton JA, Civelek VN, Kamp F, Tornheim K, Corkey BE. Changes in internal pH caused by movement of fatty acids into and out of clonal pancreatic beta-cells (HIT). J Biol Chem. 1994 Aug 19; 269(33):20852-6.
    View in: PubMed
  106. Juntti-Berggren L, Civelek VN, Berggren PO, Schultz V, Corkey BE, Tornheim K. Glucose-stimulated increase in cytoplasmic pH precedes increase in free Ca2+ in pancreatic beta-cells. A possible role for pyruvate. J Biol Chem. 1994 May 20; 269(20):14391-5.
    View in: PubMed
  107. Nachiappan V, Curtiss D, Corkey BE, Kilpatrick L. Cytokines inhibit fatty acid oxidation in isolated rat hepatocytes: synergy among TNF, IL-6, and IL-1. Shock. 1994 Feb; 1(2):123-9.
    View in: PubMed
  108. Corkey, B. E., Deeney, J. T., Varnum, B. A., Civelek, V., Tornheim, K. and Prentki, M. Metabolic basis for glucose-induced insulin secretion in pancreatic ß-cells. Frontiers of Pancreatic ß-Cell Research (ed, P. R. Flatt). 1994; pp 91-96.
  109. Juntti-Berggren, L., Tornheim, K., Corkey, B. E. and Berggren, P.-O. Regulation of intracellular pH in the pancreatic ß-cell. Frontiers of Pancreatic ß-Cell Research (ed, P. R. Flatt). 1994; pp 145-151.
  110. Deeney JT, Tornheim K, Korchak HM, Prentki M, Corkey BE. Acyl-CoA esters modulate intracellular Ca2+ handling by permeabilized clonal pancreatic beta-cells. J Biol Chem. 1992 Oct 5; 267(28):19840-5.
    View in: PubMed
  111. Hopkins WF, Fatherazi S, Peter-Riesch B, Corkey BE, Cook DL. Two sites for adenine-nucleotide regulation of ATP-sensitive potassium channels in mouse pancreatic beta-cells and HIT cells. J Membr Biol. 1992 Sep; 129(3):287-95.
    View in: PubMed
  112. Prentki M, Vischer S, Glennon MC, Regazzi R, Deeney JT, Corkey BE. Malonyl-CoA and long chain acyl-CoA esters as metabolic coupling factors in nutrient-induced insulin secretion. J Biol Chem. 1992 Mar 25; 267(9):5802-10.
    View in: PubMed
  113. Gilbert RJ, Valente G, Deeney JT, Corkey BE. ATP-dependent control of steady-state cytosolic calcium in cultured gastric smooth muscle. Am J Physiol. 1991 Oct; 261(4 Pt 1):G634-40.
    View in: PubMed
  114. Majumdar S, Rossi MW, Fujiki T, Phillips WA, Disa S, Queen CF, Johnston RB, Rosen OM, Corkey BE, Korchak HM. Protein kinase C isotypes and signaling in neutrophils. Differential substrate specificities of a translocatable calcium- and phospholipid-dependent beta-protein kinase C and a phospholipid-dependent protein kinase which is inhibited by long chain fatty acyl coenzyme A. J Biol Chem. 1991 May 15; 266(14):9285-94.
    View in: PubMed
  115. Longo EA, Tornheim K, Deeney JT, Varnum BA, Tillotson D, Prentki M, Corkey BE. Oscillations in cytosolic free Ca2+, oxygen consumption, and insulin secretion in glucose-stimulated rat pancreatic islets. J Biol Chem. 1991 May 15; 266(14):9314-9.
    View in: PubMed
  116. Corkey BE, Geschwind JF, Deeney JT, Hale DE, Douglas SD, Kilpatrick L. Ca2+ responses to interleukin 1 and tumor necrosis factor in cultured human skin fibroblasts. Possible implications for Reye syndrome. J Clin Invest. 1991 Mar; 87(3):778-86.
    View in: PubMed
  117. 13.  Prentki, M., Visher, S., Brun, T., Glennon, M. C. and Corkey, B. E. Metabolic coupling factors in ß-cell insulin secretion. Diabetes 1991 (eds. H. Rifkin, J. A. Colwell, S. I. Taylor). Elsevier. Amsterdam. 1991; pp 156-160.
  118. McCormack JG, Longo EA, Corkey BE. Glucose-induced activation of pyruvate dehydrogenase in isolated rat pancreatic islets. Biochem J. 1990 Apr 15; 267(2):527-30.
    View in: PubMed
  119. Corkey BE, Deeney JT. Acyl CoA regulation of metabolism and signal transduction. Prog Clin Biol Res. 1990; 321:217-32.
    View in: PubMed
  120. Corkey BE, Glennon MC, Chen KS, Deeney JT, Matschinsky FM, Prentki M. A role for malonyl-CoA in glucose-stimulated insulin secretion from clonal pancreatic beta-cells. J Biol Chem. 1989 Dec 25; 264(36):21608-12.
    View in: PubMed
  121. Kelly KL, Deeney JT, Corkey BE. Cytosolic free calcium in adipocytes. Distinct mechanisms of regulation and effects on insulin action. J Biol Chem. 1989 Aug 5; 264(22):12754-7.
    View in: PubMed
  122. Geschwind JF, Hiriart M, Glennon MC, Najafi H, Corkey BE, Matschinsky FM, Prentki M. Selective activation of Ca2+ influx by extracellular ATP in a pancreatic beta-cell line (HIT). Biochim Biophys Acta. 1989 Jun 15; 1012(1):107-15.
    View in: PubMed
  123. Corkey, B. E., Tornheim, K., Deeney, J.T., Glennon, M.C., Matschinsky, F.M., Ruderman, N.B. and Prentki, M. Metabolic regulation of Ca2+ handling in permeabilized insulinoma cells. Cell Calcium Metabolism '87 (ed. G. Fiskum). Plenum. New York. 1989; pp 369-377.
  124. Corkey, B. E., Tornheim, K., Deeney, J.T., Glennon, M.C., Matschinsky, F.M., Ruderman, N.B. and Prentki, M. . Integrated mitochondrial and microsomal regulation of free Ca2+ in permeabilized insulinoma cells. Integration of Mitochondrial Function (ed. J. J. Lemasters, C.R. Hockenbrock, R.G. Thurman and H.V. Westerhoff). Plenum. New York. 1989; pp 543-550.
  125. Matschinsky, F. M., Corkey, B. E., Prentki, M., Meglasson, M. D., Erecinska, M., Shimazu, T., Ghosh, A. and Parker, J. Metabolic connectivity and signaling in pancreatic ß-cells. Diabetes 1988 (eds. R. G. Larkins, P. Z. Zimmet, and D. J. Chisholm). Excerpta Medica. Amsterdam. 1989; pp 17-26.
  126. Corkey BE, Hale DE, Glennon MC, Kelley RI, Coates PM, Kilpatrick L, Stanley CA. Relationship between unusual hepatic acyl coenzyme A profiles and the pathogenesis of Reye syndrome. J Clin Invest. 1988 Sep; 82(3):782-8.
    View in: PubMed
  127. Corkey BE, Deeney JT, Glennon MC, Matschinsky FM, Prentki M. Regulation of steady-state free Ca2+ levels by the ATP/ADP ratio and orthophosphate in permeabilized RINm5F insulinoma cells. J Biol Chem. 1988 Mar 25; 263(9):4247-53.
    View in: PubMed
  128. Corkey BE, Tornheim K, Deeney JT, Glennon MC, Parker JC, Matschinsky FM, Ruderman NB, Prentki M. Linked oscillations of free Ca2+ and the ATP/ADP ratio in permeabilized RINm5F insulinoma cells supplemented with a glycolyzing cell-free muscle extract. J Biol Chem. 1988 Mar 25; 263(9):4254-8.
    View in: PubMed
  129. Corkey, B. E. Analysis of acyl CoA esters in biological samples. Methods Enzymol. 1988; 166:55-70.
  130. Williamson, J.R., Corkey, B. E., Martin-Requero, A., Walajtys-Rode, E. and Coll, K.E. (. Metabolic repercussions of branched chain ketoacid metabolism in liver. Problems and Potential of Branched Chain Amino Acids in Physiology and Medicine (R. Odessey, ed.). Elsevier. North Holland, Amsterdam. 1986; pp. 135-172.
  131. Matschinsky, F.M., Meglasson, M., Ghosh, A., Appel, M., Bedoya, F., Prentki, M., Corkey, B. E., Shimizu, T., Berner, D., Najafi, H. and Manning, C. Biochemical design features of the pancreatic islet cell glucose-sensory system. Adv. Exp. Biol. Med. 1986; 211:459-469.
  132. Williamson, J.R., Corkey, B. E., Martin-Requero, A., Walajtys-Rode, E. and Coll, K.E. a-Ketoisovalerate metabolism in liver and interactions with other metabolic pathways. Proceedings of International Symposium on Branched Chain Aminoacids and Ketoacids in Health and Disease. (P. Schauder, ed.). Karger, Basel. 1984; pp. 41-80.
  133. Corkey, B. E., Martin-Requero, A., Brandt, M. and Williamson, J.R. Regulation of a-ketoisocaproate and a-ketoisovalerate metabolism and their interactions with the citric acid cycle in isolated hep­atocytes. Metabolism and Clinical Implications of Branched Chain Amino and Ketoacids (Walser,M. and Williamson, J.R., Eds.). Elsevier. North Holland, New York. 1981; pp. 119-127.
  134. Williamson, J.R., Martin-Requero, A., Corkey, B. E., Brandt, M. and Rothman, R. Interactions between a-ketoisovalerate, propionate, and fatty acids on gluconeogenesis and ureogenesis in isolated hepatocytes. Metabolism and Clinical Implications of Branched Chain Amino and Ketoacids (Walser, M. and Williamson,J.R., Eds.). Elsevier. North Holland, New York. 1981; pp. 105-117.
  135. Williamson, J.R. and Corkey, B. E. Assay of citric acid cycle intermediates and related compounds: Update with tissue metabolite levels and intracellular distribution. Methods Enzymol. 1979; 55:200-222.
  136. Williamson, J.R. and Corkey, B. E. Assays of intermediates of the citric acid cycle and related compounds by fluorometric enzyme methods. Methods Enzymol. 1969; 13:434-513.
  137. Williamson JR, Herczeg BE, Coles HS, Cheung WY. Glycolytic control mechanisms. V. Kinetics of high energy phosphate intermediate changes during electrical discharge and recovery in the main organ of Electrophorus electricus. J Biol Chem. 1967 Nov 10; 242(21):5119-24.
    View in: PubMed
  138. Williamson JR, Cheung WY, Coles HS, Herczeg BE. Glycolytic control mechanisms. IV. Kinetics of glycolytic intermediate changes during electrical discharge and recovery in the main organ of Electrophorus electricus. J Biol Chem. 1967 Nov 10; 242(21):5112-8.
    View in: PubMed
  139. Williamson JR, Olson MS, Herczeg BE, Coles HS. Control of citrate formation in rat liver mitochondria. Biochem Biophys Res Commun. 1967 Jun 9; 27(5):595-600.
    View in: PubMed
  140. Williamson JR, Herczeg B, Coles H, Danish R. Studies on the ketogenic effect of glucagon in intact rat liver. Biochem Biophys Res Commun. 1966 Aug 12; 24(3):437-42.
    View in: PubMed
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