Keywords
Last Name

Neil B. Ruderman, MD, PhD

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionEndocrinology, Diabetes & Nutrition
Address650 Albany St
Boston MA 02118
Phone(617) 638-7079
ORCID ORCID Icon0000-0002-6589-6587
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Graduate Medical Sciences

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentPhysiology & Biophysics

TitleActive Staff Privileges
InstitutionBoston Medical Center
DepartmentMedicine
DivisionEndocrinology, Diabetes & Nutrition

 Research Expertise & Professional Interests
Expertise in carrying out metabolic research, writing grants and manuscripts. I also have experience in mentoring young investigators and working as a member of various national and international scientific groups. Finally, I have organized many multi-investigator research groups and scientific meetings.

 Self-Described Keywords
  • AMP activated protein kinase
  • Atherosclerosis
  • Diabetes
  • Exercise
  • Metabolic Syndrome
  • Metabolism
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Coughlan KA, Valentine RJ, Ruderman NB, Saha AK. AMPK activation: a therapeutic target for type 2 diabetes? Diabetes Metab Syndr Obes. 2014; 7:241-53.
    View in: PubMed
  2. Krasner NM, Ido Y, Ruderman NB, Cacicedo JM. Glucagon-Like Peptide-1 (GLP-1) Analog Liraglutide Inhibits Endothelial Cell Inflammation through a Calcium and AMPK Dependent Mechanism. PLoS One. 2014; 9(5):e97554.
    View in: PubMed
  3. Ruderman NB, Carling D, Prentki M, Cacicedo JM. AMPK, insulin resistance, and the metabolic syndrome. J Clin Invest. 2013 Jul 1; 123(7):2764-72.
    View in: PubMed
  4. Nolan CJ, Ruderman NB, Prentki M. Intensive insulin for type 2 diabetes: the risk of causing harm. Lancet Diabetes Endocrinol. 2013 Sep; 1(1):9-10.
    View in: PubMed
  5. Laurent G, German NJ, Saha AK, de Boer VC, Davies M, Koves TR, Dephoure N, Fischer F, Boanca G, Vaitheesvaran B, Lovitch SB, Sharpe AH, Kurland IJ, Steegborn C, Gygi SP, Muoio DM, Ruderman NB, Haigis MC. SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase. Mol Cell. 2013 Jun 6; 50(5):686-98.
    View in: PubMed
  6. Xu XJ, Pories WJ, Dohm LG, Ruderman NB. What distinguishes adipose tissue of severely obese humans who are insulin sensitive and resistant? Curr Opin Lipidol. 2013 Feb; 24(1):49-56.
    View in: PubMed
  7. Lamontagne J, Jalbert-Arsenault E, Pepin E, Peyot ML, Ruderman NB, Nolan CJ, Joly E, Madiraju SR, Poitout V, Prentki M. Pioglitazone acutely reduces energy metabolism and insulin secretion in rats. Diabetes. 2013 Jun; 62(6):2122-9.
    View in: PubMed
  8. Tabit CE, Shenouda SM, Holbrook M, Fetterman JL, Kiani S, Frame AA, Kluge MA, Held A, Dohadwala MM, Gokce N, Farb MG, Rosenzweig J, Ruderman N, Vita JA, Hamburg NM. Protein kinase C-ß contributes to impaired endothelial insulin signaling in humans with diabetes mellitus. Circulation. 2013 Jan 1; 127(1):86-95.
    View in: PubMed
  9. Ix JH, Biggs ML, Mukamal KJ, Kizer JR, Zieman SJ, Siscovick DS, Mozzaffarian D, Jensen MK, Nelson L, Ruderman N, Djousse L. Association of fetuin-a with incident diabetes mellitus in community-living older adults: the cardiovascular health study. Circulation. 2012 May 15; 125(19):2316-22.
    View in: PubMed
  10. Ido Y, Duranton A, Lan F, Cacicedo JM, Chen TC, Breton L, Ruderman NB. Acute activation of AMP-activated protein kinase prevents H2O2-induced premature senescence in primary human keratinocytes. PLoS One. 2012; 7(4):e35092.
    View in: PubMed
  11. Nelson LE, Valentine RJ, Cacicedo JM, Gauthier MS, Ido Y, Ruderman NB. A novel inverse relationship between metformin-triggered AMPK-SIRT1 signaling and p53 protein abundance in high glucose-exposed HepG2 cells. Am J Physiol Cell Physiol. 2012 Jul 1; 303(1):C4-C13.
    View in: PubMed
  12. Xu XJ, Gauthier MS, Hess DT, Apovian CM, Cacicedo JM, Gokce N, Farb M, Valentine RJ, Ruderman NB. Insulin sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue. J Lipid Res. 2012 Apr; 53(4):792-801.
    View in: PubMed
  13. Xu X.J., Gauthier M.S., Hess D.T., Apovian C., Cacicedo J.M., Gokce N., Farb M.G., Valentine R.J., Ruderman N.B. Insulin sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue. J Lipid Res. 2012; In press.
  14. Saha AK, Xu XJ, Balon TW, Brandon A, Kraegen EW, Ruderman NB. Insulin resistance due to nutrient excess: is it a consequence of AMPK downregulation? Cell Cycle. 2011 Oct 15; 10(20):3447-51.
    View in: PubMed
  15. Chuang JH, Kao YJ, Ruderman NB, Tung LC, Lin Y. Optimal concentrations of N-decanoyl-N-methylglucamine and sodium dodecyl sulfate allow the extraction and analysis of membrane proteins. Anal Biochem. 2011 Nov 15; 418(2):298-300.
    View in: PubMed
  16. Liesa M, Luptak I, Qin F, Hyde BB, Sahin E, Siwik DA, Zhu Z, Pimentel DR, Xu XJ, Ruderman NB, Huffman KD, Doctrow SR, Richey L, Colucci WS, Shirihai OS. Mitochondrial transporter ATP binding cassette mitochondrial erythroid is a novel gene required for cardiac recovery after ischemia/reperfusion. Circulation. 2011 Aug 16; 124(7):806-13.
    View in: PubMed
  17. Cacicedo JM, Gauthier MS, Lebrasseur NK, Jasuja R, Ruderman NB, Ido Y. Acute exercise activates AMPK and eNOS in the mouse aorta. Am J Physiol Heart Circ Physiol. 2011 Oct; 301(4):H1255-65.
    View in: PubMed
  18. Cacicedo JM, Benjachareonwong S, Chou E, Yagihashi N, Ruderman NB, Ido Y. Activation of AMP-activated protein kinase prevents lipotoxicity in retinal pericytes. Invest Ophthalmol Vis Sci. 2011 May; 52(6):3630-9.
    View in: PubMed
  19. Brandon AE, Hoy AJ, Wright LE, Turner N, Hegarty BD, Iseli TJ, Julia Xu X, Cooney GJ, Saha AK, Ruderman NB, Kraegen EW. The evolution of insulin resistance in muscle of the glucose infused rat. Arch Biochem Biophys. 2011 May 15; 509(2):133-41.
    View in: PubMed
  20. Tornheim, K. and Ruderman, N.B. Intermediary metabolism of carbohydrate, protein and fat. In Ahima, R.S. ed. Metabolic Basis of Obesity. Springer, 2011:25-51. Cited: N/A . Intermediary metabolism of carbohydrate, protein and fat. Ahima, R.S. ed. Metabolic Basis of Obesity. Springer. 2011; 25-51.
  21. Gauthier MS, O''Brien EL, Bigornia S, Mott M, Cacicedo JM, Xu XJ, Gokce N, Apovian C, Ruderman N. Decreased AMP-activated protein kinase activity is associated with increased inflammation in visceral adipose tissue and with whole-body insulin resistance in morbidly obese humans. Biochem Biophys Res Commun. 2011 Jan 7; 404(1):382-7.
    View in: PubMed
  22. Gauthier MS, Ruderman NB. Adipose tissue inflammation and insulin resistance: all obese humans are not created equal. Biochem J. 2010 Sep 1; 430(2):e1-4.
    View in: PubMed
  23. Saha AK, Xu XJ, Lawson E, Deoliveira R, Brandon AE, Kraegen EW, Ruderman NB. Downregulation of AMPK accompanies leucine- and glucose-induced increases in protein synthesis and insulin resistance in rat skeletal muscle. Diabetes. 2010 Oct; 59(10):2426-34.
    View in: PubMed
  24. Liu Q, Gauthier MS, Sun L, Ruderman N, Lodish H. Activation of AMP-activated protein kinase signaling pathway by adiponectin and insulin in mouse adipocytes: requirement of acyl-CoA synthetases FATP1 and Acsl1 and association with an elevation in AMP/ATP ratio. FASEB J. 2010 Nov; 24(11):4229-39.
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  25. Hirschey MD, Shimazu T, Goetzman E, Jing E, Schwer B, Lombard DB, Grueter CA, Harris C, Biddinger S, Ilkayeva OR, Stevens RD, Li Y, Saha AK, Ruderman NB, Bain JR, Newgard CB, Farese RV, Alt FW, Kahn CR, Verdin E. SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature. 2010 Mar 4; 464(7285):121-5.
    View in: PubMed
  26. Ruderman NB, Xu XJ, Nelson L, Cacicedo JM, Saha AK, Lan F, Ido Y. AMPK and SIRT1: a long-standing partnership? Am J Physiol Endocrinol Metab. 2010 Apr; 298(4):E751-60.
    View in: PubMed
  27. Xu X.J., Nelson L., Ruderman, N.B. Do AMPK and SIRT1 talk to each other?. Cell Science Reviews. 2010; 7(1).
  28. Ruderman NB, Shulman, G.I. The metabolic syndrome. De Groot L.J., Jamieson, J.L., Endocrinology. Elsevier, Saunders. Philadelphia. 2010; 822-839.
  29. Ritov VB, Menshikova EV, Azuma K, Wood R, Toledo FG, Goodpaster BH, Ruderman NB, Kelley DE. Deficiency of electron transport chain in human skeletal muscle mitochondria in type 2 diabetes mellitus and obesity. Am J Physiol Endocrinol Metab. 2010 Jan; 298(1):E49-58.
    View in: PubMed
  30. Joly E, Roduit R, Peyot ML, Habinowski SA, Ruderman NB, Witters LA, Prentki M. Glucose represses PPARa gene expression via AMP-activated protein kinase but not via p38 mitogen-activated protein kinase in the pancreatic ß-cell. J Diabetes. 2009 Dec; 1(4):263-72.
    View in: PubMed
  31. Bendayan M, Londono I, Kemp BE, Hardie GD, Ruderman N, Prentki M. Association of AMP-activated protein kinase subunits with glycogen particles as revealed in situ by immunoelectron microscopy. J Histochem Cytochem. 2009 Oct; 57(10):963-71.
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  32. Kelly M, Gauthier MS, Saha AK, Ruderman NB. Activation of AMP-activated protein kinase by interleukin-6 in rat skeletal muscle: association with changes in cAMP, energy state, and endogenous fuel mobilization. Diabetes. 2009 Sep; 58(9):1953-60.
    View in: PubMed
  33. Wang XL, Suzuki R, Lee K, Tran T, Gunton JE, Saha AK, Patti ME, Goldfine A, Ruderman NB, Gonzalez FJ, Kahn CR. Ablation of ARNT/HIF1beta in liver alters gluconeogenesis, lipogenic gene expression, and serum ketones. Cell Metab. 2009 May; 9(5):428-39.
    View in: PubMed
  34. Lamontagne J, Pepin E, Peyot ML, Joly E, Ruderman NB, Poitout V, Madiraju SR, Nolan CJ, Prentki M. Pioglitazone acutely reduces insulin secretion and causes metabolic deceleration of the pancreatic beta-cell at submaximal glucose concentrations. Endocrinology. 2009 Aug; 150(8):3465-74.
    View in: PubMed
  35. Peyot ML, Guay C, Latour MG, Lamontagne J, Lussier R, Pineda M, Ruderman NB, Haemmerle G, Zechner R, Joly E, Madiraju SR, Poitout V, Prentki M. Adipose triglyceride lipase is implicated in fuel- and non-fuel-stimulated insulin secretion. J Biol Chem. 2009 Jun 19; 284(25):16848-59.
    View in: PubMed
  36. Richter EA, Ruderman NB. AMPK and the biochemistry of exercise: implications for human health and disease. Biochem J. 2009 Mar 1; 418(2):261-75.
    View in: PubMed
  37. Suchankova G, Nelson LE, Gerhart-Hines Z, Kelly M, Gauthier MS, Saha AK, Ido Y, Puigserver P, Ruderman NB. Concurrent regulation of AMP-activated protein kinase and SIRT1 in mammalian cells. Biochem Biophys Res Commun. 2009 Jan 23; 378(4):836-41.
    View in: PubMed
  38. Lan F, Cacicedo JM, Ruderman N, Ido Y. SIRT1 modulation of the acetylation status, cytosolic localization, and activity of LKB1. Possible role in AMP-activated protein kinase activation. J Biol Chem. 2008 Oct 10; 283(41):27628-35.
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  39. Gauthier MS, Miyoshi H, Souza SC, Cacicedo JM, Saha AK, Greenberg AS, Ruderman NB. AMP-activated protein kinase is activated as a consequence of lipolysis in the adipocyte: potential mechanism and physiological relevance. J Biol Chem. 2008 Jun 13; 283(24):16514-24.
    View in: PubMed
  40. Hamburg NM, McMackin CJ, Huang AL, Shenouda SM, Widlansky ME, Schulz E, Gokce N, Ruderman NB, Keaney JF, Vita JA. Physical inactivity rapidly induces insulin resistance and microvascular dysfunction in healthy volunteers. Arterioscler Thromb Vasc Biol. 2007 Dec; 27(12):2650-6.
    View in: PubMed
  41. Ruderman NB, Chisholm D., Pi-Sunyer X., Schneider S. The metabolically-obese, normal-weight individual: Revisited. Perspectives in Diabetes, ed. by R.P. Robertson. American Diabetes Association. Alexandria, VA. 2007.
  42. Ruderman NB, Keller C, Richard AM, Saha AK, Luo Z, Xiang X, Giralt M, Ritov VB, Menshikova EV, Kelley DE, Hidalgo J, Pedersen BK, Kelly M. Interleukin-6 regulation of AMP-activated protein kinase. Potential role in the systemic response to exercise and prevention of the metabolic syndrome. Diabetes. 2006 Dec; 55 Suppl 2:S48-54.
    View in: PubMed
  43. Saha AK, Persons K, Safer JD, Luo Z, Holick MF, Ruderman NB. AMPK regulation of the growth of cultured human keratinocytes. Biochem Biophys Res Commun. 2006 Oct 20; 349(2):519-24.
    View in: PubMed
  44. LeBrasseur NK, Kelly M, Tsao TS, Farmer SR, Saha AK, Ruderman NB, Tomas E. Thiazolidinediones can rapidly activate AMP-activated protein kinase in mammalian tissues. Am J Physiol Endocrinol Metab. 2006 Jul; 291(1):E175-81.
    View in: PubMed
  45. Ruderman NB, Saha AK. Metabolic syndrome: adenosine monophosphate-activated protein kinase and malonyl coenzyme A. Obesity (Silver Spring). 2006 Feb; 14 Suppl 1:25S-33S.
    View in: PubMed
  46. Kuhl JE, Ruderman NB, Musi N, Goodyear LJ, Patti ME, Crunkhorn S, Dronamraju D, Thorell A, Nygren J, Ljungkvist O, Degerblad M, Stahle A, Brismar TB, Andersen KL, Saha AK, Efendic S, Bavenholm PN. Exercise training decreases the concentration of malonyl-CoA and increases the expression and activity of malonyl-CoA decarboxylase in human muscle. Am J Physiol Endocrinol Metab. 2006 Jun; 290(6):E1296-303.
    View in: PubMed
  47. Kelly, M., Ruderman, N.B., Tomas, E. AMP-activated protein kinase and its regulation by adiponectin and interleukin-6. Swedish Journal of Food and Nutrition. 2006; 50:85-91.
  48. Nawrocki AR, Rajala MW, Tomas E, Pajvani UB, Saha AK, Trumbauer ME, Pang Z, Chen AS, Ruderman NB, Chen H, Rossetti L, Scherer PE. Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists. J Biol Chem. 2006 Feb 3; 281(5):2654-60.
    View in: PubMed
  49. LeBrasseur NK, Ruderman NB. Why might thiazolidinediones increase exercise capacity in patients with type 2 diabetes? Diabetes Care. 2005 Dec; 28(12):2975-7.
    View in: PubMed
  50. Boden G, She P, Mozzoli M, Cheung P, Gumireddy K, Reddy P, Xiang X, Luo Z, Ruderman N. Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-kappaB pathway in rat liver. Diabetes. 2005 Dec; 54(12):3458-65.
    View in: PubMed
  51. Joly E, Bendayan M, Roduit R, Saha AK, Ruderman NB, Prentki M. Malonyl-CoA decarboxylase is present in the cytosolic, mitochondrial and peroxisomal compartments of rat hepatocytes. FEBS Lett. 2005 Dec 5; 579(29):6581-6.
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  52. Kraegen EW, Saha AK, Preston E, Wilks D, Hoy AJ, Cooney GJ, Ruderman NB. Increased malonyl-CoA and diacylglycerol content and reduced AMPK activity accompany insulin resistance induced by glucose infusion in muscle and liver of rats. Am J Physiol Endocrinol Metab. 2006 Mar; 290(3):E471-9.
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  53. Miller TA, LeBrasseur NK, Cote GM, Trucillo MP, Pimentel DR, Ido Y, Ruderman NB, Sawyer DB. Oleate prevents palmitate-induced cytotoxic stress in cardiac myocytes. Biochem Biophys Res Commun. 2005 Oct 14; 336(1):309-15.
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  54. Ruderman N. Cardiorespiratory fitness attenuates mortality associated with the metabolic syndrome. Clin J Sport Med. 2005 Jul; 15(4):282-3.
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  55. Assifi MM, Suchankova G, Constant S, Prentki M, Saha AK, Ruderman NB. AMP-activated protein kinase and coordination of hepatic fatty acid metabolism of starved/carbohydrate-refed rats. Am J Physiol Endocrinol Metab. 2005 Nov; 289(5):E794-800.
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  56. Cacicedo JM, Benjachareowong S, Chou E, Ruderman NB, Ido Y. Palmitate-induced apoptosis in cultured bovine retinal pericytes: roles of NAD(P)H oxidase, oxidant stress, and ceramide. Diabetes. 2005 Jun; 54(6):1838-45.
    View in: PubMed
  57. Luo Z, Saha AK, Xiang X, Ruderman NB. AMPK, the metabolic syndrome and cancer. Trends Pharmacol Sci. 2005 Feb; 26(2):69-76.
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  58. Suchankova G, Tekle M, Saha AK, Ruderman NB, Clarke SD, Gettys TW. Dietary polyunsaturated fatty acids enhance hepatic AMP-activated protein kinase activity in rats. Biochem Biophys Res Commun. 2005 Jan 28; 326(4):851-8.
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  59. Ruderman NB, Myers, M., Chipkin, S.R., Tornheim, K. Hormone-fuel interrelationships: Fed state, starvation, and diabetes mellitus. Joslin’s Diabetes Mellitus. 2005; Chapter 6: 127-144.
  60. Panzer, C., Ido, Y., Ruderman, N.B. Diabetes mellitus as an atherogenic factor. In Molecular mechanisms of atherosclerosis. J. Loscalzo, ed. United Kingdom, Taylor & Francis, 2005, pp 175-193. Cited: N/A. Diabetes mellitus as an atherogenic factor. Molecular mechanisms of atherosclerosis. J. Loscalzo, ed. Taylor & Francis. United Kingdom. 2005; pp 175-193.
  61. Ye, J., Ruderman, N.B., Kraegen, E.W. AMP-activated protein kinase and malonyl CoA: targets for treating insulin resistance?. Drug Discovery Today, Therapeutic Strategies. 2005; 2:157-163.
  62. Ruderman NB, Shulman, G.I. The metabolic syndrome. De Groot L.J., Jamieson, J.L., Endocrinology. Elsevier, Saunders. Philadelphia. 2005; pp 1149-1166.
  63. Yu X, McCorkle S, Wang M, Lee Y, Li J, Saha AK, Unger RH, Ruderman NB. Leptinomimetic effects of the AMP kinase activator AICAR in leptin-resistant rats: prevention of diabetes and ectopic lipid deposition. Diabetologia. 2004 Nov; 47(11):2012-21.
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  64. Cacicedo JM, Yagihashi N, Keaney JF, Ruderman NB, Ido Y. AMPK inhibits fatty acid-induced increases in NF-kappaB transactivation in cultured human umbilical vein endothelial cells. Biochem Biophys Res Commun. 2004 Nov 26; 324(4):1204-9.
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  65. Roepstorff C, Halberg N, Hillig T, Saha AK, Ruderman NB, Wojtaszewski JF, Richter EA, Kiens B. Malonyl-CoA and carnitine in regulation of fat oxidation in human skeletal muscle during exercise. Am J Physiol Endocrinol Metab. 2005 Jan; 288(1):E133-42.
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  66. Zang M, Zuccollo A, Hou X, Nagata D, Walsh K, Herscovitz H, Brecher P, Ruderman NB, Cohen RA. AMP-activated protein kinase is required for the lipid-lowering effect of metformin in insulin-resistant human HepG2 cells. J Biol Chem. 2004 Nov 12; 279(46):47898-905.
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  67. Xiang X, Saha AK, Wen R, Ruderman NB, Luo Z. AMP-activated protein kinase activators can inhibit the growth of prostate cancer cells by multiple mechanisms. Biochem Biophys Res Commun. 2004 Aug 13; 321(1):161-7.
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  68. Kelly M, Keller C, Avilucea PR, Keller P, Luo Z, Xiang X, Giralt M, Hidalgo J, Saha AK, Pedersen BK, Ruderman NB. AMPK activity is diminished in tissues of IL-6 knockout mice: the effect of exercise. Biochem Biophys Res Commun. 2004 Jul 23; 320(2):449-54.
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  69. Tomas E, Kelly M, Xiang X, Tsao TS, Keller C, Keller P, Luo Z, Lodish H, Saha AK, Unger R, Ruderman NB. Metabolic and hormonal interactions between muscle and adipose tissue. Proc Nutr Soc. 2004 May; 63(2):381-5.
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  70. Ruderman N, Prentki M. AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome. Nat Rev Drug Discov. 2004 Apr; 3(4):340-51.
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  71. Roduit R, Nolan C, Alarcon C, Moore P, Barbeau A, Delghingaro-Augusto V, Przybykowski E, Morin J, Massé F, Massie B, Ruderman N, Rhodes C, Poitout V, Prentki M. A role for the malonyl-CoA/long-chain acyl-CoA pathway of lipid signaling in the regulation of insulin secretion in response to both fuel and nonfuel stimuli. Diabetes. 2004 Apr; 53(4):1007-19.
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  72. Saha AK, Avilucea PR, Ye JM, Assifi MM, Kraegen EW, Ruderman NB. Pioglitazone treatment activates AMP-activated protein kinase in rat liver and adipose tissue in vivo. Biochem Biophys Res Commun. 2004 Feb 6; 314(2):580-5.
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  73. Saha AK, Ruderman NB. Malonyl-CoA and AMP-activated protein kinase: an expanding partnership. Mol Cell Biochem. 2003 Nov; 253(1-2):65-70.
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  74. Tsao TS, Tomas E, Murrey HE, Hug C, Lee DH, Ruderman NB, Heuser JE, Lodish HF. Role of disulfide bonds in Acrp30/adiponectin structure and signaling specificity. Different oligomers activate different signal transduction pathways. J Biol Chem. 2003 Dec 12; 278(50):50810-7.
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  75. Ruderman NB, Saha AK, Kraegen EW. Minireview: malonyl CoA, AMP-activated protein kinase, and adiposity. Endocrinology. 2003 Dec; 144(12):5166-71.
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  76. Ruderman NB, Park H, Kaushik VK, Dean D, Constant S, Prentki M, Saha AK. AMPK as a metabolic switch in rat muscle, liver and adipose tissue after exercise. Acta Physiol Scand. 2003 Aug; 178(4):435-42.
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  77. Itani SI, Saha AK, Kurowski TG, Coffin HR, Tornheim K, Ruderman NB. Glucose autoregulates its uptake in skeletal muscle: involvement of AMP-activated protein kinase. Diabetes. 2003 Jul; 52(7):1635-40.
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  78. Ruderman NB, Cacicedo JM, Itani S, Yagihashi N, Saha AK, Ye JM, Chen K, Zou M, Carling D, Boden G, Cohen RA, Keaney J, Kraegen EW, Ido Y. Malonyl-CoA and AMP-activated protein kinase (AMPK): possible links between insulin resistance in muscle and early endothelial cell damage in diabetes. Biochem Soc Trans. 2003 Feb; 31(Pt 1):202-6.
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  79. Båvenholm PN, Kuhl J, Pigon J, Saha AK, Ruderman NB, Efendic S. Insulin resistance in type 2 diabetes: association with truncal obesity, impaired fitness, and atypical malonyl coenzyme A regulation. J Clin Endocrinol Metab. 2003 Jan; 88(1):82-7.
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  80. Zinman B, Ruderman N, Campaigne BN, Devlin JT, Schneider SH. Physical activity/exercise and diabetes mellitus. Diabetes Care. 2003 Jan; 26 Suppl 1:S73-7.
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  81. Michael, M.D., Ruderman, N.B. Insulin, insulin-like growth factors, and their receptors. The Liver: Biology and Pathobiology. (Arias, I., Boyer, J., Chisari, F., Fausto, N., Schachter, D., Shafritz, D., eds.). Lippincott, Williams and Wilkins. 2003; 511-523.
  82. Riddell, M.C., Ruderman, N.B., Tsiani, E., Vranic, M. The endocrine system: metabolic effects of the pancreatic, adrenal, thyroidal, and growth hormones. Exercise Physiology: People and Ideas. Am. Physiological Society. Oxford University Press. 2003; 361-422.
  83. Panzer, C., Brieke, A. & Ruderman, N.B. Prevention of type 2 diabetes and its macrovascular complications: whom, when, and how should we treat?. Current Opinion in Endocrinology & Diabetes. 2003; 10:229-236.
  84. Tomas E, Tsao TS, Saha AK, Murrey HE, Zhang Cc Cc, Itani SI, Lodish HF, Ruderman NB. Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxylase inhibition and AMP-activated protein kinase activation. Proc Natl Acad Sci U S A. 2002 Dec 10; 99(25):16309-13.
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  85. Iglesias MA, Ye JM, Frangioudakis G, Saha AK, Tomas E, Ruderman NB, Cooney GJ, Kraegen EW. AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed rats. Diabetes. 2002 Oct; 51(10):2886-94.
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  86. Lin Y, Brady MJ, Wolanske K, Holbert R, Ruderman NB, Yaney GC. Alterations of nPKC distribution, but normal Akt/PKB activation in denervated rat soleus muscle. Am J Physiol Endocrinol Metab. 2002 Aug; 283(2):E318-25.
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  87. Tomás E, Zorzano A, Ruderman NB. Exercise and insulin signaling: a historical perspective. J Appl Physiol (1985). 2002 Aug; 93(2):765-72.
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  88. Itani SI, Ruderman NB, Schmieder F, Boden G. Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha. Diabetes. 2002 Jul; 51(7):2005-11.
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  89. Park H, Kaushik VK, Constant S, Prentki M, Przybytkowski E, Ruderman NB, Saha AK. Coordinate regulation of malonyl-CoA decarboxylase, sn-glycerol-3-phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues in response to exercise. J Biol Chem. 2002 Sep 6; 277(36):32571-7.
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  90. Tomás E, Lin YS, Dagher Z, Saha A, Luo Z, Ido Y, Ruderman NB. Hyperglycemia and insulin resistance: possible mechanisms. Ann N Y Acad Sci. 2002 Jun; 967:43-51.
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  91. Eckel RH, Wassef M, Chait A, Sobel B, Barrett E, King G, Lopes-Virella M, Reusch J, Ruderman N, Steiner G, Vlassara H. Prevention Conference VI: Diabetes and Cardiovascular Disease: Writing Group II: pathogenesis of atherosclerosis in diabetes. Circulation. 2002 May 7; 105(18):e138-43.
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  92. Shafrir E, Ziv E, Saha AK, Ruderman NB. Regulation of muscle malonyl-CoA levels in the nutritionally insulin-resistant desert gerbil, Psammomys obesus. Diabetes Metab Res Rev. 2002 May-Jun; 18(3):217-23.
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  93. Xiang X, Yuan M, Song Y, Ruderman N, Wen R, Luo Z. 14-3-3 facilitates insulin-stimulated intracellular trafficking of insulin receptor substrate 1. Mol Endocrinol. 2002 Mar; 16(3):552-62.
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  94. Gupta S, Chough E, Daley J, Oates P, Tornheim K, Ruderman NB, Keaney JF. Hyperglycemia increases endothelial superoxide that impairs smooth muscle cell Na+-K+-ATPase activity. Am J Physiol Cell Physiol. 2002 Mar; 282(3):C560-6.
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  95. Ido Y, Carling D, Ruderman N. Hyperglycemia-induced apoptosis in human umbilical vein endothelial cells: inhibition by the AMP-activated protein kinase activation. Diabetes. 2002 Jan; 51(1):159-67.
    View in: PubMed
  96. Tomas, E., Zorzano, A., Ruderman, N.B. Exercise effects on muscle insulin signaling and action. Exercise and insulin signaling: A historical perspective. J Appl Physiol. 2002; 93:765-72.
  97. Ruderman NB. A target population for diabetes prevention: The metabolically obese, normal-weight individual. N. Ruderman, J.T. Devlin, S.H. Schneider, A. Kriska eds. Handbook of Exercise in Diabetes. American Diabetes Association. Alexandria, VA. 2002; 235-249.
  98. Devlin, J.T., Ruderman, N.B. Diabetes and exercise: The risk-benefit profile revisited. N. Ruderman, J.T. Devlin, S.H. Schneider, A. Kriska eds. Handbook of Exercise in Diabetes. American Diabetes Association. Alexandria, VA. 2002; 17-20.
  99. Sternthal, E. and Ruderman, N. Insulin: Promise and problems at 80 years. Current Opinion in Endocrinology & Diabetes. 2002; 9:283-284.
  100. Dean, D.J., Ruderman, N.B. Role of AMP kinase and malonyl CoA in exercise-stimulated skeletal muscle metabolism and insulin action. Zierath, J.R., Wallberg-Henriksson, H., eds. Muscle Metabolism. Taylor and Francis. New York, NY. 2002; 211-225.
  101. Riddell, M.C., Ruderman, N.B., Berger, M., Vranic, M. Exercise physiology and diabetes: from antiquity to the age of the exercise sciences. N. Ruderman, J.T. Devlin, S.H. Schneider, A. Kriska eds. Handbook of Exercise in Diabetes. American Diabetes Association. Alexandria, VA. 2002; 3-15.
  102. Kaushik VK, Young ME, Dean DJ, Kurowski TG, Saha AK, Ruderman NB. Regulation of fatty acid oxidation and glucose metabolism in rat soleus muscle: effects of AICAR. Am J Physiol Endocrinol Metab. 2001 Aug; 281(2):E335-40.
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  103. Patel N, Khayat ZA, Ruderman NB, Klip A. Dissociation of 5' AMP-activated protein kinase activation and glucose uptake stimulation by mitochondrial uncoupling and hyperosmolar stress: differential sensitivities to intracellular Ca2+ and protein kinase C inhibition. Biochem Biophys Res Commun. 2001 Jul 27; 285(4):1066-70.
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  104. Lin Y, Itani SI, Kurowski TG, Dean DJ, Luo Z, Yaney GC, Ruderman NB. Inhibition of insulin signaling and glycogen synthesis by phorbol dibutyrate in rat skeletal muscle. Am J Physiol Endocrinol Metab. 2001 Jul; 281(1):E8-E15.
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  105. Dagher Z, Ruderman N, Tornheim K, Ido Y. Acute regulation of fatty acid oxidation and amp-activated protein kinase in human umbilical vein endothelial cells. Circ Res. 2001 Jun 22; 88(12):1276-82.
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  106. Ruderman N, Flier JS. Cell biology. Chewing the fat--ACC and energy balance. Science. 2001 Mar 30; 291(5513):2558-9.
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  107. Ruderman NB, Tornheim, K., Goodman, M.N. Fuel homeostasis and intermediary metabolism of carbohydrate, fat, and protein. Becker, K.L., et al. ed . Principles and Practice of Endocrinology and Metabolism. Lippincott Williams and Wilkins. Philadelphia, PA. 2001; 1257-1271.
  108. Saha AK, Schwarsin AJ, Roduit R, Masse F, Kaushik V, Tornheim K, Prentki M, Ruderman NB. Activation of malonyl-CoA decarboxylase in rat skeletal muscle by contraction and the AMP-activated protein kinase activator 5-aminoimidazole-4-carboxamide-1-beta -D-ribofuranoside. J Biol Chem. 2000 Aug 11; 275(32):24279-83.
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  109. Chien D, Dean D, Saha AK, Flatt JP, Ruderman NB. Malonyl-CoA content and fatty acid oxidation in rat muscle and liver in vivo. Am J Physiol Endocrinol Metab. 2000 Aug; 279(2):E259-65.
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  110. Dean D, Daugaard JR, Young ME, Saha A, Vavvas D, Asp S, Kiens B, Kim KH, Witters L, Richter EA, Ruderman N. Exercise diminishes the activity of acetyl-CoA carboxylase in human muscle. Diabetes. 2000 Aug; 49(8):1295-300.
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  111. Båvenholm PN, Pigon J, Saha AK, Ruderman NB, Efendic S. Fatty acid oxidation and the regulation of malonyl-CoA in human muscle. Diabetes. 2000 Jul; 49(7):1078-83.
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  112. Zinman, B, Ruderman, N., Campaigne, B.N., Devlin, J.T., Schneider, S.H. . Diabetes mellitus and exercise. Diabetes Care. 2000; 23(Suppl. 1):S50-S54.
  113. Laybutt DR, Schmitz-Peiffer C, Saha AK, Ruderman NB, Biden TJ, Kraegen EW. Muscle lipid accumulation and protein kinase C activation in the insulin-resistant chronically glucose-infused rat. Am J Physiol. 1999 Dec; 277(6 Pt 1):E1070-6.
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  114. Dagher Z, Ruderman N, Tornheim K, Ido Y. The effect of AMP-activated protein kinase and its activator AICAR on the metabolism of human umbilical vein endothelial cells. Biochem Biophys Res Commun. 1999 Nov; 265(1):112-5.
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  115. McDonnell ME, Ruderman NB. Cutting the Gordian knot. Addition of metformin to insulin therapy in a patient with uncontrolled diabetes and schizophrenia. Diabetes Care. 1999 Nov; 22(11):1912-3.
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  116. Saha AK, Laybutt DR, Dean D, Vavvas D, Sebokova E, Ellis B, Klimes I, Kraegen EW, Shafrir E, Ruderman NB. Cytosolic citrate and malonyl-CoA regulation in rat muscle in vivo. Am J Physiol. 1999 Jun; 276(6 Pt 1):E1030-7.
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  117. Goalstone ML, Wall K, Leitner JW, Kurowski T, Ruderman N, Pan SJ, Ivy JL, Moller DE, Draznin B. Increased amounts of farnesylated p21Ras in tissues of hyperinsulinaemic animals. Diabetologia. 1999 Mar; 42(3):310-6.
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  118. Kurowski TG, Lin Y, Luo Z, Tsichlis PN, Buse MG, Heydrick SJ, Ruderman NB. Hyperglycemia inhibits insulin activation of Akt/protein kinase B but not phosphatidylinositol 3-kinase in rat skeletal muscle. Diabetes. 1999 Mar; 48(3):658-63.
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  119. Ruderman NB, Saha AK, Vavvas D, Witters LA. Malonyl-CoA, fuel sensing, and insulin resistance. Am J Physiol. 1999 Jan; 276(1 Pt 1):E1-E18.
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  120. Ruderman NB, Saha, A.K., Vavvas, D., Kurowski, T., Laybutt, D.R., Kraegen, E.W. The malonyl CoA fuel sensing mechanism in muscle of insulin-resistant rodents. Lessons from Animal Diabetes IIV (E. Shafrir, ed.). Birkhauser. 1999.
  121. Ruderman NB. Diabetes and exercise: An overview. West Indian Medical Journal. 1999.
  122. Zinman, B., Ruderman, N.B., Campaigne, B.N., Devlin, J.T., Schneider, S.H. Diabetes mellitus and exercise. Diabetes Care. 1999; 22(Suppl. 1): S49-S53.
  123. Ruderman N, Chisholm D, Pi-Sunyer X, Schneider S. The metabolically obese, normal-weight individual revisited. Diabetes. 1998 May; 47(5):699-713.
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  124. Ruderman NB, Dean D. Malonyl CoA, long chain fatty acyl CoA and insulin resistance in skeletal muscle. J Basic Clin Physiol Pharmacol. 1998; 9(2-4):295-308.
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  125. Ruderman NB, Saha AK, Vavvas D, Kurowski T, Laybutt DR, Schmitz-Peiffer C, Biden T, Kraegen EW. Malonyl CoA as a metabolic switch and a regulator of insulin sensitivity. Adv Exp Med Biol. 1998; 441:263-70.
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  126. Oakes ND, Bell KS, Furler SM, Camilleri S, Saha AK, Ruderman NB, Chisholm DJ, Kraegen EW. Diet-induced muscle insulin resistance in rats is ameliorated by acute dietary lipid withdrawal or a single bout of exercise: parallel relationship between insulin stimulation of glucose uptake and suppression of long-chain fatty acyl-CoA. Diabetes. 1997 Dec; 46(12):2022-8.
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  127. Ruderman NB, Saha AK, Vavvas D, Heydrick SJ, Kurowski TG. Lipid abnormalities in muscle of insulin-resistant rodents. The malonyl CoA hypothesis. Ann N Y Acad Sci. 1997 Sep 20; 827:221-30.
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  128. Vavvas D, Apazidis A, Saha AK, Gamble J, Patel A, Kemp BE, Witters LA, Ruderman NB. Contraction-induced changes in acetyl-CoA carboxylase and 5'-AMP-activated kinase in skeletal muscle. J Biol Chem. 1997 May 16; 272(20):13255-61.
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  129. Saha AK, Vavvas D, Kurowski TG, Apazidis A, Witters LA, Shafrir E, Ruderman NB. Malonyl-CoA regulation in skeletal muscle: its link to cell citrate and the glucose-fatty acid cycle. Am J Physiol. 1997 Apr; 272(4 Pt 1):E641-8.
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  130. Schneider, S. and Ruderman, N.B. Use of exercise in the treatment of Type 2 Diabetes Mellitus. Clinical Diabetes. 1997; 15:176-179.
  131. Kurowski TG, Saha AK, Cunningham BA, Holbert RI, Colca JR, Corkey BE, Ruderman NB. Malonyl coenzyme A and adiposity in the Dahl salt-sensitive rat: effects of pioglitazone. Metabolism. 1996 Apr; 45(4):519-25.
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  132. Gupta S, Phipps K, Ruderman NB. Differential stimulation of Na+ pump activity by insulin and nitric oxide in rabbit aorta. Am J Physiol. 1996 Apr; 270(4 Pt 2):H1287-93.
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  133. Khan F, Cohen RA, Ruderman NB, Chipkin SR, Coffman JD. Vasodilator responses in the forearm skin of patients with insulin-dependent diabetes mellitus. Vasc Med. 1996; 1(3):187-93.
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  134. Saha AK, Kurowski TG, Ruderman NB. A malonyl-CoA fuel-sensing mechanism in muscle: effects of insulin, glucose, and denervation. Am J Physiol. 1995 Aug; 269(2 Pt 1):E283-9.
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  135. Ruderman NB, Tornheim, K., and Goodman, M.N. Fuel homeostasis and intermediary metabolism of carbohydrate, fat and protein. Principles and Practice of Endocrinology and Metabolism. K. Becker, C.R. Kahn, et al., eds. Lippincott. Philadelphia. 1995; pp 1174-1187.
  136. Devlin, J. and Ruderman, N.B. Handbook of diabetes and exercise: The risk-benefit profile. Health Professionals Guide to Diabetes and Exercise (NB Ruderman, J Devlin Eds.). Am. Diabetes Association. 1995; pp 3-4.
  137. Ruderman NB, and Devlin, J. Exercise in diabetics with complications. Diabetes (S. Baba, T. Kaneko, eds.). Elsevier. Amsterdam. 1995; pp 782-786.
  138. Ruderman NB. Exercise in special patient groups. Pre-diabetics and the insulin resistance syndrome. Health Professionals Guide to Diabetes and Exercise (N Ruderman and J. Devlin eds.). American Diabetes Association. Alexandria VA. 1995; pp 243-248.
  139. Lam K, Carpenter CL, Ruderman NB, Friel JC, Kelly KL. The phosphatidylinositol 3-kinase serine kinase phosphorylates IRS-1. Stimulation by insulin and inhibition by Wortmannin. J Biol Chem. 1994 Aug 12; 269(32):20648-52.
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  140. Saha AK, Kurowski TG, Colca JR, Ruderman NB. Lipid abnormalities in tissues of the KKAy mouse: effects of pioglitazone on malonyl-CoA and diacylglycerol. Am J Physiol. 1994 Jul; 267(1 Pt 1):E95-101.
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  141. Gupta S, McArthur C, Grady C, Ruderman NB. Stimulation of vascular Na(+)-K(+)-ATPase activity by nitric oxide: a cGMP-independent effect. Am J Physiol. 1994 May; 266(5 Pt 2):H2146-51.
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  142. Chen KS, Heydrick SJ, Brown ML, Friel JC, Ruderman NB. Insulin increases a biochemically distinct pool of diacylglycerol in the rat soleus muscle. Am J Physiol. 1994 Mar; 266(3 Pt 1):E479-85.
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  143. Gupta S, McArthur C, Grady C, Ruderman NB. Role of endothelium-derived nitric oxide in stimulation of Na(+)-K(+)-ATPase activity by endothelin in rabbit aorta. Am J Physiol. 1994 Feb; 266(2 Pt 2):H577-82.
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  144. Chipkin, S.R., Kelly, K.K. and Ruderman, N.B. Hormone-fuel interrelationships in the fed state, starvation and diabetes. Joslin’s Diabetes C.R. Kahn , G.C. Weir,eds. Lea and Febiger. Philadelphia. 1994; pp 97-115.
  145. Ruderman NB, Moses, A.C., and Moller, D.E. Insulin, insulin-like growth factors and their receptors. The Liver: Biology and Pathophysiology (I. Arias et al. eds.). Raven Press. New York. 1994; pp 969-996.
  146. Sussman I, Schultz V, Gupta S, Grady C, Ruderman NB, Tornheim K. Differential effect of metabolic fuels on the energy state and Na(+)-K(+)-ATPase in isolated cerebral microvessels. Am J Physiol. 1993 Nov; 265(5 Pt 1):E777-82.
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  147. Chen KS, Friel JC, Ruderman NB. Regulation of phosphatidylinositol 3-kinase by insulin in rat skeletal muscle. Am J Physiol. 1993 Nov; 265(5 Pt 1):E736-42.
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  148. Tesfamariam B, Gupta S, Oates PJ, Ruderman NB, Cohen RA. Reduced Na(+)-K+ pump activity in diabetic rabbit carotid artery: reversal by aldose reductase inhibition. Am J Physiol. 1993 Oct; 265(4 Pt 2):H1189-94.
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  149. Ruderman N, Horton E, Kemmer F, Berger M. The lost symposium. Diabetes and exercise 1990. Diabetes Care. 1993 Jun; 16(6):959-60.
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  150. Kelly KL, Ruderman NB. Insulin-stimulated phosphatidylinositol 3-kinase. Association with a 185-kDa tyrosine-phosphorylated protein (IRS-1) and localization in a low density membrane vesicle. J Biol Chem. 1993 Feb 25; 268(6):4391-8.
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  151. Young, J., and Ruderman, N.B. Exercise and metabolic disorders. Principles of Exercise Biochemistry (J. Poortmans, ed.). Med Sport Sci. Basel, Karger. 1993; 28:269-298.
  152. Young, J.C., Treadway, J.D. and Ruderman, N.B. . Effect of acarbose on glucose uptake in skeletal muscle. Drugs in Development. 1993; 1:75-84.
  153. Schneider SH, Khachadurian AK, Amorosa LF, Clemow L, Ruderman NB. Ten-year experience with an exercise-based outpatient life-style modification program in the treatment of diabetes mellitus. Diabetes Care. 1992 Nov; 15(11):1800-10.
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  154. Ruderman NB, Schneider SH. Diabetes, exercise, and atherosclerosis. Diabetes Care. 1992 Nov; 15(11):1787-93.
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  155. Coderre L, Monfar MM, Chen KS, Heydrick SJ, Kurowski TG, Ruderman NB, Pilch PF. Alteration in the expression of GLUT-1 and GLUT-4 protein and messenger RNA levels in denervated rat muscles. Endocrinology. 1992 Oct; 131(4):1821-5.
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  156. Gupta S, Sussman I, McArthur CS, Tornheim K, Cohen RA, Ruderman NB. Endothelium-dependent inhibition of Na(+)-K+ ATPase activity in rabbit aorta by hyperglycemia. Possible role of endothelium-derived nitric oxide. J Clin Invest. 1992 Sep; 90(3):727-32.
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  157. Ruderman NB, Williamson JR, Brownlee M. Glucose and diabetic vascular disease. FASEB J. 1992 Aug; 6(11):2905-14.
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  158. Balon TW, Treadway JL, Hughes JB, Young JC, Ruderman NB. Effect of prior exercise and insulin on potential thermogenic systems in rat skeletal muscle. J Appl Physiol (1985). 1992 Jun; 72(6):2203-9.
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  159. Kelly KL, Ruderman NB, Chen KS. Phosphatidylinositol-3-kinase in isolated rat adipocytes. Activation by insulin and subcellular distribution. J Biol Chem. 1992 Feb 15; 267(5):3423-8.
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  160. Ruderman NB, Brownlee, M., and Williamson, J.R.,eds. Ruderman NB, Brownlee, M., and Williamson, J.R.,eds. Hyperglycemia, diabetes and vascular disease. American Physiological Society, Clinical Physiology Series. Oxford Press. New York. 1992; pp 1-300.
  161. Ruderman NB, Chen, K., Heydrick, S., and Kurowski, T. Diacylglycerol-protein kinase C signaling in normal and denervated rat skeletal muscle. Diabetes Mellitus and Exercise. J. Devlin and E. Horton, eds. Smith Gordon. 1992; pp. 81-87.
  162. Ruderman NB, Gupta, S., and Sussman, I. Hyperglycemia, diabetes, and vascular disease: an overview. Hyperglycemia, Diabetes and Vascular Disease. Ruderman NB, Brownlee, M. and Williamson, J.R. eds. Oxford Press. New York. 1992; pp 3-20.
  163. Heydrick SJ, Ruderman NB, Kurowski TG, Adams HB, Chen KS. Enhanced stimulation of diacylglycerol and lipid synthesis by insulin in denervated muscle. Altered protein kinase C activity and possible link to insulin resistance. Diabetes. 1991 Dec; 40(12):1707-11.
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  164. Kimmerle R, Griffing G, McCall A, Ruderman NB, Stoltz E, Melby JC. Could intranasal insulin be useful in the treatment of non-insulin-dependent diabetes mellitus? Diabetes Res Clin Pract. 1991 Aug; 13(1-2):69-75.
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  165. Gupta S, Ruderman NB, Cragoe EJ, Sussman I. Endothelin stimulates Na(+)-K(+)-ATPase activity by a protein kinase C-dependent pathway in rabbit aorta. Am J Physiol. 1991 Jul; 261(1 Pt 2):H38-45.
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  166. Kapeller R, Chen KS, Yoakim M, Schaffhausen BS, Backer J, White MF, Cantley LC, Ruderman NB. Mutations in the juxtamembrane region of the insulin receptor impair activation of phosphatidylinositol 3-kinase by insulin. Mol Endocrinol. 1991 Jun; 5(6):769-77.
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  167. Young JC, Kurowski TG, Maurice AM, Nesher R, Ruderman NB. Polymyxin B inhibits contraction-stimulated glucose uptake in rat skeletal muscle. J Appl Physiol (1985). 1991 Apr; 70(4):1650-4.
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  168. Chen KS, Heydrick S, Kurowski T, Ruderman NB. Diacylglycerol-protein kinase C signalling in skeletal muscle: a possible link to insulin resistance. Trans Assoc Am Physicians. 1991; 104:206-12.
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  169. Ruderman NB and Schneider, S.H. Reducing cardiovascular risk factors in type 2 diabetes: In Diabetes, H. Rifkin, J.A. Colwell and S.I. Taylor, eds. New York: Elsevier, pp 1110-1113, 1991. Cited: N/A . Reducing cardiovascular risk factors in type 2 diabetes. Diabetes, H. Rifkin, J.A. Colwell and S.I. Taylor, eds. Elsevier. New York. 1991; pp 1110-1113.
  170. Schneider, S.H. and Ruderman, N.B. Exercise and NIDDM. Technical Review. Diabetes Care. 13. 1991; 785-789.
  171. Ruderman N, Apelian AZ, Schneider SH. Exercise in therapy and prevention of type II diabetes. Implications for blacks. Diabetes Care. 1990 Nov; 13(11):1163-8.
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  172. Gaposchkin CG, Tornheim K, Sussman I, Ruderman NB, McCall AL. Glucose is required to maintain ATP/ADP ratio of isolated bovine cerebral microvessels. Am J Physiol. 1990 Mar; 258(3 Pt 1):E543-7.
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  173. Ruderman NB, Kapeller R, White MF, Cantley LC. Activation of phosphatidylinositol 3-kinase by insulin. Proc Natl Acad Sci U S A. 1990 Feb; 87(4):1411-5.
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  174. Balon TW, Zorzano A, Treadway JL, Goodman MN, Ruderman NB. Effect of insulin on protein synthesis and degradation in skeletal muscle after exercise. Am J Physiol. 1990 Jan; 258(1 Pt 1):E92-7.
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  175. Treadway JL, James DE, Burcel E, Ruderman NB. Effect of exercise on insulin receptor binding and kinase activity in skeletal muscle. Am J Physiol. 1989 Jan; 256(1 Pt 1):E138-44.
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  176. Ruderman NB, Tornheim, K., and Goodman, M.N. Fuel homeostasis and intermediary metabolism of carbohydrate, fat and protein. Principles and Practice of Endocrinology and Metabolism. K. Becker, C.R. Kahn, et al., eds. Lippincott. Philadelphia. 1989; pp 1054-1064.
  177. Corkey, B.E., Tornheim, K., Deeney, J.T., Glennon, M.C., Parker, J.C., Matschinsky, F.M., Ruderman, N.B., and Prenki, M. Metabolic regulation of Ca2+ handling in permeabilized cells. Cell Calcium Metabolism '87 (G. Fiskum, ed.). Plenum Press. New York. 1989; pp 369-377.
  178. Ruderman NB and Schneider, S.H. Diabetes, exercise and atherosclerosis. Pfizer Publication. 1989.
  179. Sussman I, Carson MP, Schultz V, Wu XP, McCall AL, Ruderman NB, Tornheim K. Chronic exposure to high glucose decreases myo-inositol in cultured cerebral microvascular pericytes but not in endothelium. Diabetologia. 1988 Oct; 31(10):771-5.
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  180. Schneider SH, Kim HC, Khachadurian AK, Ruderman NB. Impaired fibrinolytic response to exercise in type II diabetes: effects of exercise and physical training. Metabolism. 1988 Oct; 37(10):924-9.
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  181. Zorzano A, James DE, Ruderman NB, Pilch PF. Insulin-like growth factor I binding and receptor kinase in red and white muscle. FEBS Lett. 1988 Jul 18; 234(2):257-62.
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  182. McCall AL, Valente J, Cordero R, Ruderman NB, Tornheim K. Metabolic characterization of isolated cerebral microvessels: ATP and ADP concentrations. Microvasc Res. 1988 May; 35(3):325-33.
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  183. Corkey BE, Tornheim K, Deeney JT, Glennon MC, Parker JC, Matschinsky FM, Ruderman NB, Prentki M. Linked oscillations of free Ca2+ and the ATP/ADP ratio in permeabilized RINm5F insulinoma cells supplemented with a glycolyzing cell-free muscle extract. J Biol Chem. 1988 Mar 25; 263(9):4254-8.
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  184. Sussman I, Carson MP, McCall AL, Schultz V, Ruderman NB, Tornheim K. Energy state of bovine cerebral microvessels: comparison of isolation methods. Microvasc Res. 1988 Mar; 35(2):167-78.
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  185. McCall AL, Sussman I, Tornheim K, Cordero R, Ruderman NB. Effects of hypoglycemia and diabetes on fuel metabolism by rat brain microvessels. Am J Physiol. 1988 Mar; 254(3 Pt 1):E272-8.
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  186. Young, J., and Ruderman, N.B. . Exercise and metabolic disorders. Principles of Exercise Biochemistry (J. Poortmans, ed.). Med Sport Sci. Basel, Karger. 1988; 27:pp. 230-254.
  187. Vitug A, Schneider SH, Ruderman NB. Exercise and type I diabetes mellitus. Exerc Sport Sci Rev. 1988; 16:285-304.
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  188. Corkey, B.E., Tornheim, K., Deeney, J.T., Glennon, M.C., Matschinsky, F.M., Ruderman, N.B., and Prenki, M. Integrated mitochondrial and microsomal regulation of free Ca2+ in permeabilized insulinoma cells. integration of mitochondrial function (J.J. Lemasters, C.R. Hackenbrock, R.G. Thurman and H.B. Westerhoff, eds.). Plenum Press. New York. 1988; pp 543-550.
  189. Schneider SH, Khachadurian AK, Amorosa LF, Gavras H, Fineberg SE, Ruderman NB. Abnormal glucoregulation during exercise in type II (non-insulin-dependent) diabetes. Metabolism. 1987 Dec; 36(12):1161-6.
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  190. Zorzano A, Balon TW, Jakubowski JA, Goodman MN, Deykin D, Ruderman NB. Effects of insulin and prior exercise on prostaglandin release from perfused rat muscle. Evidence that prostaglandins do not mediate changes in glucose uptake. Biochem J. 1986 Dec 1; 240(2):437-43.
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  191. Lowell BB, Ruderman NB, Goodman MN. Regulation of myofibrillar protein degradation in rat skeletal muscle during brief and prolonged starvation. Metabolism. 1986 Dec; 35(12):1121-7.
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  192. Zorzano A, Balon TW, Goodman MN, Ruderman NB. Glycogen depletion and increased insulin sensitivity and responsiveness in muscle after exercise. Am J Physiol. 1986 Dec; 251(6 Pt 1):E664-9.
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  193. James DE, Zorzano A, Böni-Schnetzler M, Nemenoff RA, Powers A, Pilch PF, Ruderman NB. Intrinsic differences of insulin receptor kinase activity in red and white muscle. J Biol Chem. 1986 Nov 15; 261(32):14939-44.
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  194. Young JC, Treadway JL, Balon TW, Gavras HP, Ruderman NB. Prior exercise potentiates the thermic effect of a carbohydrate load. Metabolism. 1986 Nov; 35(11):1048-53.
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  195. McCall AL, Fixman LB, Fleming N, Tornheim K, Chick W, Ruderman NB. Chronic hypoglycemia increases brain glucose transport. Am J Physiol. 1986 Oct; 251(4 Pt 1):E442-7.
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  196. Balon TW, Zorzano A, Goodman MN, Ruderman NB. Insulin-enhanced thermogenesis in skeletal muscle after exercise: regulatory factors. Am J Physiol. 1986 Sep; 251(3 Pt 1):E294-8.
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  197. Zorzano A, Balon TW, Goodman MN, Ruderman NB. Additive effects of prior exercise and insulin on glucose and AIB uptake by rat muscle. Am J Physiol. 1986 Jul; 251(1 Pt 1):E21-6.
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  198. Ruderman NB, Schneider S. Exercise and the insulin-dependent diabetic. Hosp Pract (Off Ed). 1986 May 30; 21(5A):41-51.
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  199. Lowell BB, Ruderman NB, Goodman MN. Evidence that lysosomes are not involved in the degradation of myofibrillar proteins in rat skeletal muscle. Biochem J. 1986 Feb 15; 234(1):237-40.
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  200. Zorzano A, Balon TW, Goodman MN, Ruderman NB. Insulin and exercise stimulate muscle alpha-aminoisobutyric acid transport by a Na+-K+-ATPase independent pathway. Biochem Biophys Res Commun. 1986 Feb 13; 134(3):1342-9.
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  201. Vitug, A., Schneider, S.H., and Ruderman, N.B. . Lifestyle studies indicate moderate exercise can decrease the threat of atherosclerosis. Diabetes Countdown. 1986; VII(3):21-23.
  202. Ruderman NB and Schneider, S.H. Exercise in type 2 diabetes. In, Diabetes 1985, (M. Serranos-Rios and P.J. Lefebvre, eds.), Elsevier Science Publishers, 1986, pp 949-953. Cited: N/A . Exercise in type 2 diabetes. Diabetes 1985, (M. Serranos-Rios and P.J. Lefebvre, eds.). Elsevier Science Publishers. 1986; pp 949-953.
  203. Ruderman NB, Balon T, Zorzano A, Goodman MN, Young J. Acute and chronic metabolism changes following exercise: mechanisms and physiological relevance. Curr Concepts Nutr. 1986; 15:1-8.
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  204. Ruderman NB, McCall, A., and Schneider, S. Exercise and endocrine disorders. Scand. J. Sports Sci. 1986; 8:43-50.
  205. Schneider, S.H., Young, J.C., Ruderman, N.B. Exercise studies in the diabetic. Methods in Diabetes Research, V2, Clinical Methods. J. Larner, S. Pohl and W. Clarke, eds. Wiley. New York. 1986; pp. 407-423.
  206. Schneider SH, Vitug A, Ruderman N. Atherosclerosis and physical activity. Diabetes Metab Rev. 1986; 1(4):513-53.
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  207. Ruderman NB, Balon T, Zorzano A, Goodman M. The postexercise state: altered effects of insulin on skeletal muscle and their physiologic relevance. Diabetes Metab Rev. 1986; 1(4):425-44.
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  208. Ruderman NB and Schneider, S. Exercise in type 2 diabetes. Biochemistry of Exercise. (B. Saltin, H. Galbo, and E.A. Richter, eds.). Human Kinetics Publishers. Champaign. 1986; pp 255-265.
  209. Schneider SH, Ruderman NB. Exercise and physical training in the treatment of diabetes mellitus. Compr Ther. 1986 Jan; 12(1):49-56.
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  210. Zorzano A, Balon TW, Brady LJ, Rivera P, Garetto LP, Young JC, Goodman MN, Ruderman NB. Effects of starvation and exercise on concentrations of citrate, hexose phosphates and glycogen in skeletal muscle and heart. Evidence for selective operation of the glucose-fatty acid cycle. Biochem J. 1985 Dec 1; 232(2):585-91.
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  211. Ruderman NB, Berger M. Muscle glucose oxidation. Am J Physiol. 1985 Oct; 249(4 Pt 1):E433-4.
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  212. Zorzano A, Balon TW, Garetto LP, Goodman MN, Ruderman NB. Muscle alpha-aminoisobutyric acid transport after exercise: enhanced stimulation by insulin. Am J Physiol. 1985 May; 248(5 Pt 1):E546-52.
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  213. Salzman R, Manson JE, Griffing GT, Kimmerle R, Ruderman N, McCall A, Stoltz EI, Mullin C, Small D, Armstrong J, et al. Intranasal aerosolized insulin. Mixed-meal studies and long-term use in type I diabetes. N Engl J Med. 1985 Apr 25; 312(17):1078-84.
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  214. Balon TW, Zorzano A, Goodman MN, Ruderman NB. Insulin increases thermogenesis in rat skeletal muscle following exercise. Am J Physiol. 1985 Jan; 248(1 Pt 1):E148-51.
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  215. McCall AL, Gould JB, Ruderman NB. Diabetes-induced alterations of glucose metabolism in rat cerebral microvessels. Am J Physiol. 1984 Oct; 247(4 Pt 1):E462-7.
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  216. Waldorf AR, Ruderman N, Diamond RD. Specific susceptibility to mucormycosis in murine diabetes and bronchoalveolar macrophage defense against Rhizopus. J Clin Invest. 1984 Jul; 74(1):150-60.
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  217. Richter EA, Garetto LP, Goodman MN, Ruderman NB. Enhanced muscle glucose metabolism after exercise: modulation by local factors. Am J Physiol. 1984 Jun; 246(6 Pt 1):E476-82.
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  218. Garetto LP, Richter EA, Goodman MN, Ruderman NB. Enhanced muscle glucose metabolism after exercise in the rat: the two phases. Am J Physiol. 1984 Jun; 246(6 Pt 1):E471-5.
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  219. Schneider SH, Amorosa LF, Khachadurian AK, Ruderman NB. Studies on the mechanism of improved glucose control during regular exercise in type 2 (non-insulin-dependent) diabetes. Diabetologia. 1984 May; 26(5):355-60.
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  220. Goodman MN, Lowell B, Belur E, Ruderman NB. Sites of protein conservation and loss during starvation: influence of adiposity. Am J Physiol. 1984 May; 246(5 Pt 1):E383-90.
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  221. Ruderman NB, Haudenschild C. Diabetes as an atherogenic factor. Prog Cardiovasc Dis. 1984 Mar-Apr; 26(5):373-412.
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  222. Ruderman, N. B., Garetto, L.P., Richter, E.A., and Goodman, M.N. Enhanced muscle glucose metabolism following exercise: role of insulin. Lessons from Animal Diabetes, (E. Shafrir, ed.). J. Libbey. London. 1984; pp184-189.
  223. Ruderman NB, Young, J.C., and Schneider, S.S. Exercise as a therapeutic tool in the type I diabetic. Practical Cardiology. 1984; 10:143-153.
  224. Ruderman NB, McCall, A.L. and Hannon, C. Role of diet in the therapy and etiology human diabetes. Animal Models in Nutrition Research, Report of the Fifth Ross Conference on Medical Research. 1984; p28-32.
  225. Goodman MN, Dluz SM, McElaney MA, Belur E, Ruderman NB. Glucose uptake and insulin sensitivity in rat muscle: changes during 3-96 weeks of age. Am J Physiol. 1983 Jan; 244(1):E93-100.
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  226. Ruderman NB, and McCall, A.L. Disorders of carbohydrate metabolism. Wilkin's Textbook of Medicine (N.G. Levinsky, ed.). Little, Brown and Co. Boston. 1983; pp. 778-797.
  227. Richter, E.A., Ruderman, N.B. and Galbo, H. Alpha and Beta adrenergic effects on muscle metabolism in contracting perfused rat muscle. International Series of Sports Sciences, V13, Biochemistry of Exercise, (H.Knuttgen, ed.). U.S. Human Kinetics Publishers. Champaign, IL. 1983; pp. 766-772.
  228. Garetto, L.P., Richter, E.A., Goodman, M.G., and Ruderman, N.B. Enhanced insulin sensitivity of skeletal muscle following exercise. Biochemistry of Exercise, H. Knuttgen, ed. Human Kinetics Publishers. Champaign, IL. 1983; pp. 681-687.
  229. Richter EA, Ruderman NB, Galbo H. Alpha and beta adrenergic effects on metabolism in contracting, perfused muscle. Acta Physiol Scand. 1982 Nov; 116(3):215-22.
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  230. Conover C, Rozovski SJ, Ruderman NB. Partial characterization of an insulin-dependent serum factor that regulates ornithine decarboxylase in skeletal muscle. Diabetes. 1982 Jun; 31(6 Pt 1):500-5.
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  231. Richter EA, Garetto LP, Goodman MN, Ruderman NB. Muscle glucose metabolism following exercise in the rat: increased sensitivity to insulin. J Clin Invest. 1982 Apr; 69(4):785-93.
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  232. Ruderman NB, Berchtold P, Schneider S. Obesity-associated disorders in normal-weight individuals: some speculations. Int J Obes. 1982; 6 Suppl 1:151-7.
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  233. Richter EA, Ruderman NB, Gavras H, Belur ER, Galbo H. Muscle glycogenolysis during exercise: dual control by epinephrine and contractions. Am J Physiol. 1982 Jan; 242(1):E25-32.
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  234. Ruderman NB and Schneider, S.J. Exercise and diet in the therapy of diabetes. Diet and Exercise, Synergism in Health Maintenance. (P.L. White and T. Mondeika, eds.). Am. Med. Assoc. Chicago. 1982; pp. 143-152.
  235. Ruderman NB, Schneider S, Kramsch D. Physical training and cardiovascular disease in the diabetic. Curr Probl Clin Biochem. 1982; 11:166-70.
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  236. Goodman MN, Ruderman NB. Influence of muscle use on amino acid metabolism. Exerc Sport Sci Rev. 1982; 10:1-26.
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  237. Goodman MN, Lowell B, Ruderman NB. Protein conservation during starvation: possible role of lipid fuels. Prog Clin Biol Res. 1982; 102 Pt C:317-31.
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  238. Schneider, S.H. and Ruderman, N.B. Exercise and the diabetic. Diabetes Mellitus and Obesity (S. Bleicher and B. Brodoff, eds.). Williams and Wilkins. Baltimore. 1982.
  239. Goodman MN, McElaney MA, Ruderman NB. Adaptation to prolonged starvation in the rat: curtailment of skeletal muscle proteolysis. Am J Physiol. 1981 Oct; 241(4):E321-7.
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  240. Conover CA, Rozovski SJ, Ruderman NB. Regulation of ornithine decarboxylase in skeletal muscle: evidence for the involvement of an insulin-dependent serum factor. Diabetes. 1981 Aug; 30(8):678-84.
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  241. Ruderman NB, Schneider SH, Berchtold P. The "metabolically-obese," normal-weight individual. Am J Clin Nutr. 1981 Aug; 34(8):1617-21.
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  242. Schneider SH, Komanicky PM, Goodman MN, Ruderman NB. Dichloroacetate: effects on exercise endurance in untrained rats. Metabolism. 1981 Jun; 30(6):590-5.
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  243. Brady LJ, Goodman MN, Kalish FN, Ruderman NB. Insulin binding and sensitivity in rat skeletal muscle: effect of starvation. Am J Physiol. 1981 Feb; 240(2):E184-90.
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  244. Richter EA, Ruderman NB, Schneider SH. Diabetes and exercise. Am J Med. 1981 Jan; 70(1):201-9.
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  245. Conover CA, Rozovski SJ, Belur ER, Aoki TT, Ruderman NB. Ornithine decarboxylase activity in insulin-deficient states. Biochem J. 1980 Nov 15; 192(2):725-32.
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  246. Goodman MN, Larsen PR, Kaplan MM, Aoki TT, Young VR, Ruderman NB. Starvation in the rat. II. Effect of age and obesity on protein sparing and fuel metabolism. Am J Physiol. 1980 Oct; 239(4):E277-E286.
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  247. Goodman MN, Ruderman NB. Starvation in the rat. I. Effect of age and obesity on organ weights, RNA, DNA, and protein. Am J Physiol. 1980 Oct; 239(4):E269-E276.
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  248. Ruderman NB, Kemmer FW, Goodman MN, Berger M. Oxygen consumption in perfused skeletal muscle. Effect of perfusion with aged, fresh and aged-rejuvenated erythrocytes on oxygen consumption, tissue metabolites and inhibition of glucose utilization by acetoacetate. Biochem J. 1980 Jul 15; 190(1):57-64.
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  249. Ruderman NB, Brady, L., Kalish, P. and Goodman, M.N. Alterations of muscle metabolism in the diabetic rat. Diabetes, 1979, ed. by W.E. Waldhausl. Exerpta Medica, Int. Cong. Series 500, Amsterdam. Oxford-Princeton. 1980; pp. 329-332.
  250. Ruderman NB, Goodman MN. Brain metabolism in diabetes. Horm Metab Res Suppl. 1980; 9:1-8.
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  251. Ruderman NB. Glucose metabolism. Control of glucose production: Hepatic glycogenolysis and gluconeogenesis. Textbook of Diabetes (ed. by R. Assan, E. Marliss and J. Girard). 1980.
  252. Rozovski SJ, Conover CA, Ruderman NB. Effect of diabetes on the induction of ornithine decarboxylase by refeeding. Life Sci. 1979 Aug 6; 25(6):553-9.
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  253. Goodman MN, Ruderman NB. Insulin sensitivity of rat skeletal muscle: effects of starvation and aging. Am J Physiol. 1979 May; 236(5):E519-23.
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  254. Michael B, Camejo M, Jacobs J, Parker J, St Cry M, Ruderman NB. H.D.L. in diabetes. Lancet. 1979 Jan 20; 1(8108):155.
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  255. Ruderman NB, Goodman MN, Conover CA, Berger M. Substrate utilization in perfused skeletal muscle. Diabetes. 1979 Jan; 28 Suppl 1:13-7.
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  256. Plovnick H, Ruderman NB, Aoki T, Chideckel EW, Poffenbarger PL. Non-beta-cell tumor hypoglycemia associated with increased nonsuppressible insulin-like protein (NSILP). Am J Med. 1979 Jan; 66(1):154-9.
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  257. Ruderman NB, Ganda OP, Johansen K. The effect of physical training on glucose tolerance and plasma lipids in maturity-onset diabetes. Diabetes. 1979 Jan; 28 Suppl 1:89-92.
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  258. Goodman MN, Ruderman NB, Aoki TT. Glucose and amino acid metabolism in perfused skeletal muscle. Effect of dichloroacetate. Diabetes. 1978 Nov; 27(11):1065-74.
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  259. Ruderman, N. B., Berger, M., Hagg, S., Goodman, M. and Maizels, E. Muskelstoffwechsel, korperliche Leistungsfahigkeit und Diabetes mellitus: Theorie und Praxis. F.K. Schattauer Verlag. Stuttgart, New York. 1978; pp. 81-87.
  260. Ruderman NB, Berger, M. and Hagg, S. Stimulation of muscle glucose uptake during exercise: Requirement for insulin. Aktuelle Probleme der Diabetesfurschurg, Proceedings of the First Symposium of the Diabetes Forshungsinstitut, ed by F.A. Gries and H. Reinauer. University Dusseldorf. 1978; pp. 64-77.
  261. Ruderman NB, Maizels, E., Rabban, M. and Goodman, M.N. Interaction between ketone body and carbohydrate metabolism in peripheral tissue. FEBS Symposium, Regulatory Mechanisms of Carbohydrate Metabolism, ed. by V. Esmann. Pergamon Press. New York. 1978; 42(A1):pp. 171- 182.
  262. Ruderman NB, Schmahl FW, Goodman MN. Regulation of alanine formation and release in rat muscle in vivo: effect of starvation and diabetes. Am J Physiol. 1977 Aug; 233(2):E109-14.
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  263. Maizels EZ, Ruderman NB, Goodman MN, Lau D. Effect of acetoacetate on glucose metabolism in the soleus and extensor digitorum longus muscles of the rat. Biochem J. 1977 Mar 15; 162(3):557-68.
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  264. Ruderman NB, Goodman MN, Berger M, Hagg S. Effect of starvation on muscle glucose metabolism: studies with the isolated perfused rat hindquarter. Fed Proc. 1977 Feb; 36(2):171-6.
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  265. Berger, M., Kemmer, F.W., Goodman, M.N., Zimmerman-Telschow, H. and Ruderman, N.B. Ketone body metabolism in isolated perfused muscle. In, Biochemical and Clinical Aspects of Ketone Body Metabolism, ed. by Soling and Seufert, Academic Press, New York, 1977, pp. 193-203. Ketone body metabolism in isolated perfused muscle. Biochemical and Clinical Aspects of Ketone Body Metabolism, ed. by Soling and Seufert. Academic Press. New York. 1977; pp. 193-203.
  266. Berger, M., Gries, F.A. and Ruderman, N.B. Effect of muscle work on glucose metabolism in vitro. Muscle Metabolism During Exercise in Diabetes Mellitus: Theory and Practice, ed. by K. Jahnke, H. Mehnert and H.E. Reis. Schattauer Varlag. Stuttgart, NY. 1977; pp. 99-108.
  267. Berger M, Hagg SA, Goodman MN, Ruderman NB. Glucose metabolism in perfused skeletal muscle. Effects of starvation, diabetes, fatty acids, acetoacetate, insulin and exercise on glucose uptake and disposition. Biochem J. 1976 Aug 15; 158(2):191-202.
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  268. MacDonald M, Neufeldt N, Park BN, Berger M, Ruderman N. Alanine metabolism and gluconeogenesis in the rat. Am J Physiol. 1976 Aug; 231(2):619-26.
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  269. Ganda OP, Ruderman NB. Muscle nitrogen metabolism in chronic hepatic insufficiency. Metabolism. 1976 Apr; 25(4):427-35.
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  270. Hagg, S.A., Taylor, S.I. and Ruderman, N.B. Glucose metabolism in perfused skeletal muscle: Pyruvate dehydrogenase activity in starvation, diabetes and exercise. Biochem. J. 1976; 158:203-210.
  271. Aoki TT, Toews CJ, Rossini AA, Ruderman NB, Cahill GF. Glucogenic substrate levels in fasting man. Adv Enzyme Regul. 1975; 13:329-36.
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  272. Ruderman NB, Aoki, T.T. and Cahill, G.F., Jr. Gluconeogenesis and its disorders in man. Gluconeogenesis, ed. by M. Mehlman and R. Hanson. Academic Press. New York. 1975; pp.515-532.
  273. Berger M, Hagg S, Ruderman NB. Glucose metabolism in perfused skeletal muscle. Interaction of insulin and exercise on glucose uptake. Biochem J. 1975 Jan; 146(1):231-8.
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  274. Ruderman NB. Muscle amino acid metabolism and gluconeogenesis. Annu Rev Med. 1975; 26:245-58.
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  275. Shafrir E, Ruderman NB. Enzymes of carbohydrate and fat metabolism in anti-insulin serum diabetes; inactivation by free fatty acids and the protective effect of cellular protein. Diabetologia. 1974 Dec; 10(6):731-42.
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  276. Goodman MN, Berger M, Ruderman NB. Glucose metabolism in rat skeletal muscle at rest. Effect of starvation, diabetes, ketone bodies and free fatty acids. Diabetes. 1974 Nov; 23(11):881-8.
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  277. Ruderman NB, Berger M. The formation of glutamine and alanine in skeletal muscle. J Biol Chem. 1974 Sep 10; 249(17):5500-6.
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  278. Ordonez LA, Arbrus M, Boyson S, Goodman MN, Ruderman NB, Wurtman RJ. Skeletal muscle: reservoir for exogenous L-dopa. J Pharmacol Exp Ther. 1974 Jul; 190(1):187-91.
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  279. Ruderman NB, Ross PS, Berger M, Goodman MN. Regulation of glucose and ketone-body metabolism in brain of anaesthetized rats. Biochem J. 1974 Jan; 138(1):1-10.
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  280. Ruderman NB, Goodman MN. Inhibition of muscle acetoacetate utilization during diabetic ketoacidosis. Am J Physiol. 1974 Jan; 226(1):136-43.
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  281. Ruderman NB, MacDonald, M., Neufeldt, N., Park, B.and Berger, M. On the regulation of blood alanine. Benzon Foundation Symposium, ed. by F. Lundquist and N. Tygstrup. Munksgaard. Copenhagen. 1974; 8:pp. 209-223.
  282. Walser M, Lund P, Ruderman NB, Coulter AW. Synthesis of essential amino acids from their alpha-keto analogues by perfused rat liver and muscle. J Clin Invest. 1973 Nov; 52(11):2865-77.
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  283. Ruderman NB, Goodman MN. Regulation of ketone body metabolism in skeletal muscle. Am J Physiol. 1973 Jun; 224(6):1391-7.
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  284. Cahill GF, Aoki TT, Ruderman NB. Ketosis. Trans Am Clin Climatol Assoc. 1973; 84:184-202.
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  285. Ruderman NB, Lund P. Amino acid metabolism in skeletal muscle. Regulation of glutamine and alanine release in the perfused rat hindquarter. Isr J Med Sci. 1972 Mar; 8(3):295-302.
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  286. Ruderman NB, Houghton CR, Hems R. Evaluation of the isolated perfused rat hindquarter for the study of muscle metabolism. Biochem J. 1971 Sep; 124(3):639-51.
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  287. Salmon MA, Esiri MM, Ruderman NB. Myopathic disorder associated with mitochondrial abnormalities, hyperglycaemia, and hyperketonaemia. Lancet. 1971 Aug 7; 2(7719):290-2.
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  288. Ruderman NB, Jones AL, Krauss RM, Shafrir E. A biochemical and morphologic study of very low density lipoproteins in carbohydrate-induced hypertriglyceridemia. J Clin Invest. 1971 Jun; 50(6):1355-68.
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  289. Ruderman NB. Regulation of carbohydrate, lipid and amino acid metabolism with special reference to muscle. D. Phil. Thesis. Oxford, England. 1971.
  290. Houghton CR, Ruderman NB. Acetoacetate as a fuel for perfused rat skeletal muscle. Biochem J. 1971 Jan; 121(1):15P-16P.
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  291. Ruderman NB, Toews CJ, Lowy C, Vreeland I, Shafrir E. Inhibition of hepatic gluconeogenesis and fatty acid oxidation by pent-4-enoic acid. Am J Physiol. 1970 Jul; 219(1):51-7.
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  292. Ruderman NB, Toews CJ, Lowy C, Shafrir E. Inhibition of hepatic gluconeogenesis by 4-pentenoic acid. Hoppe Seylers Z Physiol Chem. 1970 Mar; 351(3):290-1.
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  293. Toews CJ, Lowy C, Ruderman NB. The regulation of gluconeogenesis. The effect of pent-4-enoic acid on gluconeogenesis and on the gluconeogenic metabolite concentrations of isolated perfused rat liver. J Biol Chem. 1970 Feb 25; 245(4):818-24.
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  294. Ruderman NB, Toews CJ, Shafrir E. Role of free fatty acids in glucose homeostasis. Arch Intern Med. 1969 Mar; 123(3):299-313.
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  295. Jones, A.L., Ruderman, N.B. and Evans, J. An electron microscopic study of lipoprotein synthesis by rat liver following anti-insulin serum, nicotinic acid and puromycin administration. Gastroenterology. 1969; 56:402.
  296. Ruderman N, Shafrir E, Bressler R. Relation of fatty acid oxidation tgluconeogenesis: effect of pentenoic acid. Life Sci. 1968 Oct 15; 7(20):1083-9.
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  297. Ruderman NB, Lauris V. Effect of acute insulin deprivation on rat liver glucokinase. Diabetes. 1968 Oct; 17(10):611-6.
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  298. Ruderman NB, Richards KC, Valles de Bourges V. Regulation of production and release of lipoprotein by the perfused rat liver. J Lipid Res. 1968 Sep; 9(5):613-9.
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  299. Ruderman NB, Herrera MG. Glucose regulation of hepatic gluconeogenesis. Am J Physiol. 1968 Jun; 214(6):1346-51.
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  300. Richards KC, Ruderman NB, Herrera MG. Effect of oleate concentration on its metabolism by the perfused rat liver. Biochim Biophys Acta. 1968 May 1; 152(3):632-5.
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  301. Jones AL, Ruderman NB, Herrera MG. Electron microscopic and biochemical study of lipoprotein synthesis in the isolated perfused rat liver. J Lipid Res. 1967 Sep; 8(5):429-46.
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  302. Ruderman NB, Lauris V, Herrera MG. Insulin preservation of glucokinase activity in isolated perfused rat liver. Am J Physiol. 1967 May; 212(5):1169-73.
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  303. Ruderman NB, Herrera, M.G. and Lauris, V. Insulin preservation of glucokinase activity in isolated perfused rat liver. Am. J. Physiol. 1967; 212:1169-1172.
  304. Jones AL, Ruderman NB, Herrera MG. An electron microscopic study of lipoprotein production and release by the isolated perfused rat liver. Proc Soc Exp Biol Med. 1966 Oct; 123(1):4-9.
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  305. Herrera MG, Kamm D, Ruderman N. Non-hormonal factors in the control of gluconeogenesis. Adv Enzyme Regul. 1966; 4:225-35.
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  306. Ruderman NB and Hall, T.C. The palliative use of glucocorticoids in the treatment of metastatic brain tumors. Cancer. 1965; 18:298-306.
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