Keywords
Last Name

Philip C. Trackman, PhD

TitleProfessor
InstitutionBoston University Goldman School of Dental Medicine
DepartmentMolecular & Cell Biology
Address700 Albany St CABR
Boston MA 02118
Phone(617) 638-4076
ORCID ORCID Icon0000-0001-5064-614X
Other Positions
TitleDirector of Graduate Programs, Molecular & Cell Biology
InstitutionBoston University Goldman School of Dental Medicine
DepartmentMolecular & Cell Biology

TitleResearch Assistant Professor
InstitutionBoston University School of Medicine
DepartmentBiochemistry

TitleMentor for Graduate Medical Students
InstitutionBoston University School of Medicine
DepartmentGraduate Medical Sciences, Division of

 Awards and Honors

Start-EndDescription
1975American Chemical Society : Outstanding Senior Award
1977-1980Boston University School of Medicine: Predoctoral NIH Traineeship
1981-1983Brandeis University: American Cancer Society Postdoctoral Fellow
1997-2011Listed in Marquis Who’s Who in Science and Engineering
2013PloS One: Academic Editor
 Research Expertise & Professional Interests
Research in Dr. Trackman’s laboratory is focused on the regulation of extracellular matrix accumulation in mineralized and non-mineralized normal tissues, and in pathologies in which extracellular matrix accumulation is affected. Studies, which utilize cell culture, animal models, and human tissues, encompass a wide range of experimental approaches derived from the disciplines of biochemistry, enzymology, cell biology, and quantitative biology. Goals of these studies are to obtain a greater understanding of the molecular and cellular basis for gingival overgrowth and other fibrotic diseases, and to understand mechanisms of osteopenia that occurs as a complication of type I diabetes. Recent important findings show that oral fibroblasts are resistant to the effects of certain inflammatory factors, and that this resistance contributes to the elevated expression of connective tissue growth factor (CCN2/CTGF). This growth factor, in turn, contributes to gingival overgrowth and oral fibrosis. In addition, the biological process of epithelial to mesenchymal transition has been identified as a contributor to gingival overgrowth. These understandings provide new avenues for therapeutic approaches to prevent and treat gingival overgrowth.
The mechanism by which lysyl oxidase acts as a tumor suppressor is under investigation. Dr. Trackman’s laboratory has made the novel discovery that the tumor suppressor function of lysyl oxidase resides in the propeptide (LOX-PP) region of a proenzyme precursor. This propeptide is released from the proenzyme by extracellular proteolytic processing, and the released propeptide inhibits growth of tumor cells and tumor formation. A focus of the laboratory is to identify mechanisms by which the lysyl oxidase propeptide can suppress tumor formation or tumor growth and tumor metastasis. A major target of LOX-PP was found to be the fibroblast growth factor receptor-1 (FGFR1). Intracellular targets are now under investigation. A polymorphism in LOX-PP was found to have impaired ability to suppress tumors in mice, and is a risk factor for breast cancer in estrogen receptor-negative breast tumors in humans. rLOX-PP is effective as an inhibitor of tumor growth in xenograft models. Dr. Trackman’s laboratory works on this project in collaboration with the laboratories of Dr. Gail Sonenshein (Tufts University School of Medicine) and Dr. Kathrin Kirsch of Boston University School of Medicine, Department of Biochemistry. The potential use of LOX-PP as a pharmacologic agent has been submitted and is pending in the U.S. patent office; and preclinical studies continue.

 Self-Described Keywords
  • bone
  • cancer
  • CCN2
  • connective tissue growth factor
  • diabetic bone disease
  • fibrosis
  • gingival overgrowth
  • lysyl oxidase propeptide
  • lysyl oxidases
  • tumor suppressor
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Khosravi R, Sodek KL, Xu WP, Bais MV, Saxena D, Faibish M, Trackman PC. A novel function for lysyl oxidase in pluripotent mesenchymal cell proliferation and relevance to inflammation-associated osteopenia. PLoS One. 2014; 9(6):e100669.
    View in: PubMed
  2. Perbal B, Trackman P, Castellot J, Brigstock D, Takigawa M, Lau L, Leask A. Report on the 7(th) international workshop on the CCN family of genes : October 16-19, 2013-Nice, France. J Cell Commun Signal. 2014 Mar; 8(1):71-6.
    View in: PubMed
  3. Sato S, Zhao Y, Imai M, Simister PC, Feller SM, Trackman PC, Kirsch KH, Sonenshein GE. Inhibition of CIN85-mediated invasion by a novel SH3 domain binding motif in the lysyl oxidase propeptide. PLoS One. 2013; 8(10):e77288.
    View in: PubMed
  4. Khosravi R, Sodek KL, Faibish M, Trackman PC. Collagen advanced glycation inhibits its Discoidin Domain Receptor 2 (DDR2)-mediated induction of lysyl oxidase in osteoblasts. Bone. 2014 Jan; 58:33-41.
    View in: PubMed
  5. Bahammam M, Black SA, Sume SS, Assaggaf MA, Faibish M, Trackman PC. Requirement for active glycogen synthase kinase-3ß in TGF-ß1 upregulation of connective tissue growth factor (CCN2/CTGF) levels in human gingival fibroblasts. Am J Physiol Cell Physiol. 2013 Sep 15; 305(6):C581-90.
    View in: PubMed
  6. Beerlage C, Greb J, Kretschmer D, Assaggaf M, Trackman PC, Hansmann ML, Bonin M, Eble JA, Peschel A, Brüne B, Kempf VA. Hypoxia-inducible factor 1-regulated lysyl oxidase is involved in Staphylococcus aureus abscess formation. Infect Immun. 2013 Jul; 81(7):2562-73.
    View in: PubMed
  7. Eliades A, Papadantonakis N, Matsuura S, Mi R, Bais MV, Trackman P, Ravid K. Megakaryocyte polyploidy is inhibited by lysyl oxidase propeptide. Cell Cycle. 2013 Apr 15; 12(8):1242-50.
    View in: PubMed
  8. Yu Z, Sato S, Trackman PC, Kirsch KH, Sonenshein GE. Blimp1 activation by AP-1 in human lung cancer cells promotes a migratory phenotype and is inhibited by the lysyl oxidase propeptide. PLoS One. 2012; 7(3):e33287.
    View in: PubMed
  9. Bais MV, Nugent MA, Stephens DN, Sume SS, Kirsch KH, Sonenshein GE, Trackman PC. Recombinant lysyl oxidase propeptide protein inhibits growth and promotes apoptosis of pre-existing murine breast cancer xenografts. PLoS One. 2012; 7(2):e31188.
    View in: PubMed
  10. Sánchez-Morgan N, Kirsch KH, Trackman PC, Sonenshein GE. The lysyl oxidase propeptide interacts with the receptor-type protein tyrosine phosphatase kappa and inhibits ß-catenin transcriptional activity in lung cancer cells. Mol Cell Biol. 2011 Aug; 31(16):3286-97.
    View in: PubMed
  11. Eliades A, Papadantonakis N, Bhupatiraju A, Burridge KA, Johnston-Cox HA, Migliaccio AR, Crispino JD, Lucero HA, Trackman PC, Ravid K. Control of megakaryocyte expansion and bone marrow fibrosis by lysyl oxidase. J Biol Chem. 2011 Aug 5; 286(31):27630-8.
    View in: PubMed
  12. Sato S, Trackman PC, Mäki JM, Myllyharju J, Kirsch KH, Sonenshein GE. The Ras signaling inhibitor LOX-PP interacts with Hsp70 and c-Raf to reduce Erk activation and transformed phenotype of breast cancer cells. Mol Cell Biol. 2011 Jul; 31(13):2683-95.
    View in: PubMed
  13. Kantarci A, Nseir Z, Kim YS, Sume SS, Trackman PC. Loss of basement membrane integrity in human gingival overgrowth. J Dent Res. 2011 Jul; 90(7):887-93.
    View in: PubMed
  14. Chen H, Koupenova M, Yang D, Sume SS, Trackman PC, Ravid K. Regulation of MMP-9 expression by the A2b adenosine receptor and its dependency on TNF-a signaling. Exp Hematol. 2011 May; 39(5):525-30.
    View in: PubMed
  15. Min C, Zhao Y, Romagnoli M, Trackman PC, Sonenshein GE, Kirsch KH. Lysyl oxidase propeptide sensitizes pancreatic and breast cancer cells to doxorubicin-induced apoptosis. J Cell Biochem. 2010 Dec 1; 111(5):1160-8.
    View in: PubMed
  16. Grimsby JL, Lucero HA, Trackman PC, Ravid K, Kagan HM. Role of lysyl oxidase propeptide in secretion and enzyme activity. J Cell Biochem. 2010 Dec 1; 111(5):1231-43.
    View in: PubMed
  17. Iftikhar M, Hurtado P, Bais MV, Wigner N, Stephens DN, Gerstenfeld LC, Trackman PC. Lysyl oxidase-like-2 (LOXL2) is a major isoform in chondrocytes and is critically required for differentiation. J Biol Chem. 2011 Jan 14; 286(2):909-18.
    View in: PubMed
  18. Chronopoulos A, Tang A, Beglova E, Trackman PC, Roy S. High glucose increases lysyl oxidase expression and activity in retinal endothelial cells: mechanism for compromised extracellular matrix barrier function. Diabetes. 2010 Dec; 59(12):3159-66.
    View in: PubMed
  19. Sume SS, Kantarci A, Lee A, Hasturk H, Trackman PC. Epithelial to mesenchymal transition in gingival overgrowth. Am J Pathol. 2010 Jul; 177(1):208-18.
    View in: PubMed
  20. Vora SR, Guo Y, Stephens DN, Salih E, Vu ED, Kirsch KH, Sonenshein GE, Trackman PC. Characterization of recombinant lysyl oxidase propeptide. Biochemistry. 2010 Apr 6; 49(13):2962-72.
    View in: PubMed
  21. Vora SR, Palamakumbura AH, Mitsi M, Guo Y, Pischon N, Nugent MA, Trackman PC. Lysyl oxidase propeptide inhibits FGF-2-induced signaling and proliferation of osteoblasts. J Biol Chem. 2010 Mar 5; 285(10):7384-93.
    View in: PubMed
  22. Min C, Yu Z, Kirsch KH, Zhao Y, Vora SR, Trackman PC, Spicer DB, Rosenberg L, Palmer JR, Sonenshein GE. A loss-of-function polymorphism in the propeptide domain of the LOX gene and breast cancer. Cancer Res. 2009 Aug 15; 69(16):6685-93.
    View in: PubMed
  23. Palamakumbura AH, Vora SR, Nugent MA, Kirsch KH, Sonenshein GE, Trackman PC. Lysyl oxidase propeptide inhibits prostate cancer cell growth by mechanisms that target FGF-2-cell binding and signaling. Oncogene. 2009 Sep 24; 28(38):3390-400.
    View in: PubMed
  24. Pischon N, Mäki JM, Weisshaupt P, Heng N, Palamakumbura AH, N'Guessan P, Ding A, Radlanski R, Renz H, Bronckers TA, Myllyharju J, Kielbassa AM, Kleber BM, Bernimoulin JP, Trackman PC. Lysyl oxidase (lox) gene deficiency affects osteoblastic phenotype. Calcif Tissue Int. 2009 Aug; 85(2):119-26.
    View in: PubMed
  25. Zhao Y, Min C, Vora SR, Trackman PC, Sonenshein GE, Kirsch KH. The lysyl oxidase pro-peptide attenuates fibronectin-mediated activation of focal adhesion kinase and p130Cas in breast cancer cells. J Biol Chem. 2009 Jan 16; 284(3):1385-93.
    View in: PubMed
  26. Gonçalves LD, Oliveira G, Hurtado PA, Feitosa A, Takiya CM, Granjeiro JM, Trackman PC, Otazú I, Feres-Filho EJ. Expression of metalloproteinases and their tissue inhibitors in inflamed gingival biopsies. J Periodontal Res. 2008 Oct; 43(5):570-7.
    View in: PubMed
  27. Weishaupt P, Bernimoulin JP, Trackman P, Hägewald S. Stimulation of osteoblasts with Emdogain increases the expression of specific mineralization markers. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008 Aug; 106(2):304-8.
    View in: PubMed
  28. Black SA, Trackman PC. Transforming growth factor-beta1 (TGFbeta1) stimulates connective tissue growth factor (CCN2/CTGF) expression in human gingival fibroblasts through a RhoA-independent, Rac1/Cdc42-dependent mechanism: statins with forskolin block TGFbeta1-induced CCN2/CTGF expression. J Biol Chem. 2008 Apr 18; 283(16):10835-47.
    View in: PubMed
  29. Hurtado PA, Vora S, Sume SS, Yang D, St Hilaire C, Guo Y, Palamakumbura AH, Schreiber BM, Ravid K, Trackman PC. Lysyl oxidase propeptide inhibits smooth muscle cell signaling and proliferation. Biochem Biophys Res Commun. 2008 Feb 1; 366(1):156-61.
    View in: PubMed
  30. Kakar S, Einhorn TA, Vora S, Miara LJ, Hon G, Wigner NA, Toben D, Jacobsen KA, Al-Sebaei MO, Song M, Trackman PC, Morgan EF, Gerstenfeld LC, Barnes GL. Enhanced chondrogenesis and Wnt signaling in PTH-treated fractures. J Bone Miner Res. 2007 Dec; 22(12):1903-12.
    View in: PubMed
  31. Kantarci A, Augustin P, Firatli E, Sheff MC, Hasturk H, Graves DT, Trackman PC. Apoptosis in gingival overgrowth tissues. J Dent Res. 2007 Sep; 86(9):888-92.
    View in: PubMed
  32. Wu M, Min C, Wang X, Yu Z, Kirsch KH, Trackman PC, Sonenshein GE. Repression of BCL2 by the tumor suppressor activity of the lysyl oxidase propeptide inhibits transformed phenotype of lung and pancreatic cancer cells. Cancer Res. 2007 Jul 1; 67(13):6278-85.
    View in: PubMed
  33. Black SA, Palamakumbura AH, Stan M, Trackman PC. Tissue-specific mechanisms for CCN2/CTGF persistence in fibrotic gingiva: interactions between cAMP and MAPK signaling pathways, and prostaglandin E2-EP3 receptor mediated activation of the c-JUN N-terminal kinase. J Biol Chem. 2007 May 25; 282(21):15416-29.
    View in: PubMed
  34. Guo Y, Pischon N, Palamakumbura AH, Trackman PC. Intracellular distribution of the lysyl oxidase propeptide in osteoblastic cells. Am J Physiol Cell Physiol. 2007 Jun; 292(6):C2095-102.
    View in: PubMed
  35. Min C, Kirsch KH, Zhao Y, Jeay S, Palamakumbura AH, Trackman PC, Sonenshein GE. The tumor suppressor activity of the lysyl oxidase propeptide reverses the invasive phenotype of Her-2/neu-driven breast cancer. Cancer Res. 2007 Feb 1; 67(3):1105-12.
    View in: PubMed
  36. Ding Y, Kantarci A, Hasturk H, Trackman PC, Malabanan A, Van Dyke TE. Activation of RAGE induces elevated O2- generation by mononuclear phagocytes in diabetes. J Leukoc Biol. 2007 Feb; 81(2):520-7.
    View in: PubMed
  37. Alikhani M, Alikhani Z, Boyd C, MacLellan CM, Raptis M, Liu R, Pischon N, Trackman PC, Gerstenfeld L, Graves DT. Advanced glycation end products stimulate osteoblast apoptosis via the MAP kinase and cytosolic apoptotic pathways. Bone. 2007 Feb; 40(2):345-53.
    View in: PubMed
  38. Alikhani M, Maclellan CM, Raptis M, Vora S, Trackman PC, Graves DT. Advanced glycation end products induce apoptosis in fibroblasts through activation of ROS, MAP kinases, and the FOXO1 transcription factor. Am J Physiol Cell Physiol. 2007 Feb; 292(2):C850-6.
    View in: PubMed
  39. Santana RB, Trackman PC. Controlled release of fibroblast growth factor 2 stimulates bone healing in an animal model of diabetes mellitus. Int J Oral Maxillofac Implants. 2006 Sep-Oct; 21(5):711-8.
    View in: PubMed
  40. Kantarci A, Black SA, Xydas CE, Murawel P, Uchida Y, Yucekal-Tuncer B, Atilla G, Emingil G, Uzel MI, Lee A, Firatli E, Sheff M, Hasturk H, Van Dyke TE, Trackman PC. Epithelial and connective tissue cell CTGF/CCN2 expression in gingival fibrosis. J Pathol. 2006 Sep; 210(1):59-66.
    View in: PubMed
  41. Heng EC, Huang Y, Black SA, Trackman PC. CCN2, connective tissue growth factor, stimulates collagen deposition by gingival fibroblasts via module 3 and alpha6- and beta1 integrins. J Cell Biochem. 2006 May 15; 98(2):409-20.
    View in: PubMed
  42. Graves DT, Liu R, Alikhani M, Al-Mashat H, Trackman PC. Diabetes-enhanced inflammation and apoptosis--impact on periodontal pathology. J Dent Res. 2006 Jan; 85(1):15-21.
    View in: PubMed
  43. Trackman PC. Diverse biological functions of extracellular collagen processing enzymes. J Cell Biochem. 2005 Dec 1; 96(5):927-37.
    View in: PubMed
  44. Karima M, Kantarci A, Ohira T, Hasturk H, Jones VL, Nam BH, Malabanan A, Trackman PC, Badwey JA, Van Dyke TE. Enhanced superoxide release and elevated protein kinase C activity in neutrophils from diabetic patients: association with periodontitis. J Leukoc Biol. 2005 Oct; 78(4):862-70.
    View in: PubMed
  45. Pischon N, Babakhanlou-Chase H, Darbois L, Ho WB, Brenner MC, Kessler E, Palamakumbura AH, Trackman PC. A procollagen C-proteinase inhibitor diminishes collagen and lysyl oxidase processing but not collagen cross-linking in osteoblastic cultures. J Cell Physiol. 2005 Apr; 203(1):111-7.
    View in: PubMed
  46. Alikhani Z, Alikhani M, Boyd CM, Nagao K, Trackman PC, Graves DT. Advanced glycation end products enhance expression of pro-apoptotic genes and stimulate fibroblast apoptosis through cytoplasmic and mitochondrial pathways. J Biol Chem. 2005 Apr 1; 280(13):12087-95.
    View in: PubMed
  47. Palamakumbura AH, Jeay S, Guo Y, Pischon N, Sommer P, Sonenshein GE, Trackman PC. The propeptide domain of lysyl oxidase induces phenotypic reversion of ras-transformed cells. J Biol Chem. 2004 Sep 24; 279(39):40593-600.
    View in: PubMed
  48. Hong HH, Pischon N, Santana RB, Palamakumbura AH, Chase HB, Gantz D, Guo Y, Uzel MI, Ma D, Trackman PC. A role for lysyl oxidase regulation in the control of normal collagen deposition in differentiating osteoblast cultures. J Cell Physiol. 2004 Jul; 200(1):53-62.
    View in: PubMed
  49. Trackman PC, Kantarci A. Connective tissue metabolism and gingival overgrowth. Crit Rev Oral Biol Med. 2004; 15(3):165-75.
    View in: PubMed
  50. Pischon N, Darbois LM, Palamakumbura AH, Kessler E, Trackman PC. Regulation of collagen deposition and lysyl oxidase by tumor necrosis factor-alpha in osteoblasts. J Biol Chem. 2004 Jul 16; 279(29):30060-5.
    View in: PubMed
  51. Casavecchia P, Uzel MI, Kantarci A, Hasturk H, Dibart S, Hart TC, Trackman PC, Van Dyke TE. Hereditary gingival fibromatosis associated with generalized aggressive periodontitis: a case report. J Periodontol. 2004 May; 75(5):770-8.
    View in: PubMed
  52. Palamakumbura AH, Sommer P, Trackman PC. Autocrine growth factor regulation of lysyl oxidase expression in transformed fibroblasts. J Biol Chem. 2003 Aug 15; 278(33):30781-7.
    View in: PubMed
  53. Santana RB, Xu L, Chase HB, Amar S, Graves DT, Trackman PC. A role for advanced glycation end products in diminished bone healing in type 1 diabetes. Diabetes. 2003 Jun; 52(6):1502-10.
    View in: PubMed
  54. Harlow CR, Rae M, Davidson L, Trackman PC, Hillier SG. Lysyl oxidase gene expression and enzyme activity in the rat ovary: regulation by follicle-stimulating hormone, androgen, and transforming growth factor-beta superfamily members in vitro. Endocrinology. 2003 Jan; 144(1):154-62.
    View in: PubMed
  55. Hong HH, Trackman PC. Cytokine regulation of gingival fibroblast lysyl oxidase, collagen, and elastin. J Periodontol. 2002 Feb; 73(2):145-52.
    View in: PubMed
  56. Palamakumbura AH, Trackman PC. A fluorometric assay for detection of lysyl oxidase enzyme activity in biological samples. Anal Biochem. 2002 Jan 15; 300(2):245-51.
    View in: PubMed
  57. Uzel MI, Kantarci A, Hong HH, Uygur C, Sheff MC, Firatli E, Trackman PC. Connective tissue growth factor in drug-induced gingival overgrowth. J Periodontol. 2001 Jul; 72(7):921-31.
    View in: PubMed
  58. Uzel MI, Scott IC, Babakhanlou-Chase H, Palamakumbura AH, Pappano WN, Hong HH, Greenspan DS, Trackman PC. Multiple bone morphogenetic protein 1-related mammalian metalloproteinases process pro-lysyl oxidase at the correct physiological site and control lysyl oxidase activation in mouse embryo fibroblast cultures. J Biol Chem. 2001 Jun 22; 276(25):22537-43.
    View in: PubMed
  59. Uzel MI, Shih SD, Gross H, Kessler E, Gerstenfeld LC, Trackman PC. Molecular events that contribute to lysyl oxidase enzyme activity and insoluble collagen accumulation in osteosarcoma cell clones. J Bone Miner Res. 2000 Jun; 15(6):1189-97.
    View in: PubMed
  60. Hong HH, Uzel MI, Duan C, Sheff MC, Trackman PC. Regulation of lysyl oxidase, collagen, and connective tissue growth factor by TGF-beta1 and detection in human gingiva. Lab Invest. 1999 Dec; 79(12):1655-67.
    View in: PubMed
  61. Han XY, Wang W, Komulainen J, Koskinen SO, Kovanen V, Vihko V, Trackman PC, Takala TE. Increased mRNAs for procollagens and key regulating enzymes in rat skeletal muscle following downhill running. Pflugers Arch. 1999 May; 437(6):857-64.
    View in: PubMed
  62. Trackman PC, Graham RJ, Bittner HK, Carnes DL, Gilles JA, Graves DT. Inflammation-associated lysyl oxidase protein expression in vivo, and modulation by FGF-2 plus IGF-1. Histochem Cell Biol. 1998 Jul; 110(1):9-14.
    View in: PubMed
  63. Feres-Filho EJ, Menassa GB, Trackman PC. Regulation of lysyl oxidase by basic fibroblast growth factor in osteoblastic MC3T3-E1 cells. J Biol Chem. 1996 Mar 15; 271(11):6411-6.
    View in: PubMed
  64. Csiszar K, Entersz I, Trackman PC, Samid D, Boyd CD. Functional analysis of the promoter and first intron of the human lysyl oxidase gene. Mol Biol Rep. 1996; 23(2):97-108.
    View in: PubMed
  65. Feres-Filho EJ, Choi YJ, Han X, Takala TE, Trackman PC. Pre- and post-translational regulation of lysyl oxidase by transforming growth factor-beta 1 in osteoblastic MC3T3-E1 cells. J Biol Chem. 1995 Dec 22; 270(51):30797-803.
    View in: PubMed
  66. Trackman PC, Feres-Filho EJ, Choi YJ. The 3'-untranslated region of rat lysyl oxidase cDNA. Biochim Biophys Acta. 1995 Feb 21; 1260(3):355-60.
    View in: PubMed
  67. Sommer P, Gleyzal C, Raccurt M, Delbourg M, Serrar M, Joazeiro P, Peyrol S, Kagan H, Trackman PC, Grimaud JA. Transient expression of lysyl oxidase by liver myofibroblasts in murine schistosomiasis. Lab Invest. 1993 Oct; 69(4):460-70.
    View in: PubMed
  68. Shah MA, Trackman PC, Gallop PM, Kagan HM. Reaction of lysyl oxidase with trans-2-phenylcyclopropylamine. J Biol Chem. 1993 Jun 5; 268(16):11580-5.
    View in: PubMed
  69. Bedell-Hogan D, Trackman P, Abrams W, Rosenbloom J, Kagan H. Oxidation, cross-linking, and insolubilization of recombinant tropoelastin by purified lysyl oxidase. J Biol Chem. 1993 May 15; 268(14):10345-50.
    View in: PubMed
  70. Wu Y, Rich CB, Lincecum J, Trackman PC, Kagan HM, Foster JA. Characterization and developmental expression of chick aortic lysyl oxidase. J Biol Chem. 1992 Dec 5; 267(34):24199-206.
    View in: PubMed
  71. Mariani TJ, Trackman PC, Kagan HM, Eddy RL, Shows TB, Boyd CD, Deak SB. The complete derived amino acid sequence of human lysyl oxidase and assignment of the gene to chromosome 5 (extensive sequence homology with the murine ras recision gene). Matrix. 1992 Jun; 12(3):242-8.
    View in: PubMed
  72. Trackman PC, Bedell-Hogan D, Tang J, Kagan HM. Post-translational glycosylation and proteolytic processing of a lysyl oxidase precursor. J Biol Chem. 1992 Apr 25; 267(12):8666-71.
    View in: PubMed
  73. Kagan HM, Trackman PC. Properties and function of lysyl oxidase. Am J Respir Cell Mol Biol. 1991 Sep; 5(3):206-10.
    View in: PubMed
  74. Trackman PC, Pratt AM, Wolanski A, Tang SS, Offner GD, Troxler RF, Kagan HM. Cloning of rat aorta lysyl oxidase cDNA: complete codons and predicted amino acid sequence. Biochemistry. 1991 Aug 20; 30(33):8282.
    View in: PubMed
  75. Kenyon K, Contente S, Trackman PC, Tang J, Kagan HM, Friedman RM. Lysyl oxidase and rrg messenger RNA. Science. 1991 Aug 16; 253(5021):802.
    View in: PubMed
  76. Almassian B, Trackman PC, Iguchi H, Boak A, Calvaresi D, Kagan HM. Induction of lung lysyl oxidase activity and lysyl oxidase protein by exposure of rats to cadmium chloride: properties of the induced enzyme. Connect Tissue Res. 1991; 25(3-4):197-208.
    View in: PubMed
  77. Gacheru SN, Trackman PC, Shah MA, O'Gara CY, Spacciapoli P, Greenaway FT, Kagan HM. Structural and catalytic properties of copper in lysyl oxidase. J Biol Chem. 1990 Nov 5; 265(31):19022-7.
    View in: PubMed
  78. Trackman PC, Pratt AM, Wolanski A, Tang SS, Offner GD, Troxler RF, Kagan HM. Cloning of rat aorta lysyl oxidase cDNA: complete codons and predicted amino acid sequence. Biochemistry. 1990 May 22; 29(20):4863-70.
    View in: PubMed
  79. Gacheru SN, Trackman PC, Calaman SD, Greenaway FT, Kagan HM. Vicinal diamines as pyrroloquinoline quinone-directed irreversible inhibitors of lysyl oxidase. J Biol Chem. 1989 Aug 5; 264(22):12963-9.
    View in: PubMed
  80. Gacheru SN, Trackman PC, Kagan HM. Evidence for a functional role for histidine in lysyl oxidase catalysis. J Biol Chem. 1988 Nov 15; 263(32):16704-8.
    View in: PubMed
  81. Ghoda LY, Savarese TM, Dexter DL, Parks RE, Trackman PC, Abeles RH. Characterization of a defect in the pathway for converting 5'-deoxy-5'-methylthioadenosine to methionine in a subline of a cultured heterogeneous human colon carcinoma. J Biol Chem. 1984 Jun 10; 259(11):6715-9.
    View in: PubMed
  82. Trackman PC, Abeles RH. Methionine synthesis from 5'-S-Methylthioadenosine. Resolution of enzyme activities and identification of 1-phospho-5-S methylthioribulose. J Biol Chem. 1983 Jun 10; 258(11):6717-20.
    View in: PubMed
  83. Tang SS, Trackman PC, Kagan HM. Reaction of aortic lysyl oxidase with beta-aminopropionitrile. J Biol Chem. 1983 Apr 10; 258(7):4331-8.
    View in: PubMed
  84. Trackman PC, Abeles RH. The metabolism of 1-phospho-5-methylthioribose. Biochem Biophys Res Commun. 1981 Dec 31; 103(4):1238-44.
    View in: PubMed
  85. Trackman PC, Zoski CG, Kagan HM. Development of a peroxidase-coupled fluorometric assay for lysyl oxidase. Anal Biochem. 1981 May 15; 113(2):336-42.
    View in: PubMed
  86. Kagan HM, Tseng L, Trackman PC, Okamoto K, Rapaka RS, Urry DW. Repeat polypeptide models of elastin as substrates for lysyl oxidase. J Biol Chem. 1980 Apr 25; 255(8):3656-9.
    View in: PubMed
  87. Trackman PC, Kagan HM. Nonpeptidyl amine inhibitors are substrates of lysyl oxidase. J Biol Chem. 1979 Aug 25; 254(16):7831-6.
    View in: PubMed
  88. Jordan RE, Milbury P, Sullivan KA, Trackman PC, Kagan HM. Studies on lysyl oxidase of bovine ligamentum nuchae and bovine aorta. Adv Exp Med Biol. 1977; 79:531-42.
    View in: PubMed
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