Keywords
Last Name

Jeffrey L. Browning, PhD

TitleResearch Professor
InstitutionBoston University School of Medicine
DepartmentMicrobiology
Address72 E. Concord St Instructional (L)
Boston MA 02118
Phone(617) 638-0334
ORCID ORCID Icon0000-0001-9168-5233
Other Positions
TitleResearch Professor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionRheumatology (Arthritis)

 Research Expertise & Professional Interests
My interests focus on understanding how the immune system interacts with stromal elements to form the specialized structures that orchestrate immunological encounters in lymphoid organs. On a different plane, the barriers to effective quantitation of disease are formidable in some autoimmune diseases especially those with considerable unmet need such as lupus and scleroderma. I am interested in bringing new views onto the human immune system to improve clinical studies.

Mesenchymal cell differentiation pathways are intimately interwoven with pathological processes e.g. compromised vascular integrity, aberrant tissue remodeling and fibrosis and tumor-stromal interactions. In lymphoid organs, the lymphotoxin pathway, a TNF family member, is one mechanism by which both innate and adaptive lymphoid cells communicate with their stromal microenvironments. The maintenance of a differentiated follicular dendritic cell network to scaffold the B cell follicle is a well-studied example of this communication. More recently, it is becoming clearer that another network, the fibroblastoid reticular cell network, is a differentiated form of mural cells, e.g. pericytes or vascular smooth muscle cells. The precise role of the lymphotoxin pathway in controlling this structure is an area of investigation. As lymph nodes can undergo massive expansion in response to danger following by involution, they form an intriguing model of physiological tissue remodeling. One-approach we are taking addresses whether the control of these cells in lymphoid tissue provides lessons that are applicable to non-lymphoid disease settings such as scleroderma skin and lung.

The ability to assess drug function in complex immunological diseases can be seriously limited by the quality of the metrics used to quantitate disease. One focus is on a potential new blood test for salivary gland function in Sjogren’s disease. Additionally, there is interest in understanding the origin of the blood RNA interferon signature commonly observed in autoimmune diseases and how this signature may provide insight into the ongoing pathology in lupus, Sjogren’s and scleroderma. The overarching goal is to understand how readily measureable blood parameters such as chemokine levels or various RNA signatures can report on the activity in lymph nodes and the spleen and hence inform on whether the immune system is flaring or smoldering.

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Gardet A, Chou WC, Reynolds TL, Velez DB, Fu K, Czerkowicz JM, Bajko J, Ranger AM, Allaire N, Kerns HM, Ryan S, Legault HM, Dunstan RW, Lafyatis R, Lukashev M, Viney JL, Browning JL, Rabah D. Pristane-Accelerated Autoimmune Disease in (SWR X NZB) F1 Mice Leads to Prominent Tubulointerstitial Inflammation and Human Lupus Nephritis-Like Fibrosis. PLoS One. 2016; 11(10):e0164423. PMID: 27760209.
    View in: PubMed
  2. Chia JJ, Zhu T, Chyou S, Dasoveanu DC, Carballo C, Tian S, Magro CM, Rodeo S, Spiera RF, Ruddle NH, McGraw TE, Browning JL, Lafyatis R, Gordon JK, Lu TT. Dendritic cells maintain dermal adipose-derived stromal cells in skin fibrosis. J Clin Invest. 2016 Nov 1; 126(11):4331-4345. PMID: 27721238.
    View in: PubMed
  3. Nazari B, Rice LM, Stifano G, Barron AM, Wang YM, Korndorf T, Lee J, Bhawan J, Lafyatis R, Browning JL. Altered Dermal Fibroblasts in Systemic Sclerosis Display Podoplanin and CD90. Am J Pathol. 2016 Oct; 186(10):2650-64. PMID: 27565038.
    View in: PubMed
  4. Seleznik G, Seeger H, Bauer J, Fu K, Czerkowicz J, Papandile A, Poreci U, Rabah D, Ranger A, Cohen CD, Lindenmeyer M, Chen J, Edenhofer I, Anders HJ, Lech M, Wüthrich RP, Ruddle NH, Moeller MJ, Kozakowski N, Regele H, Browning JL, Heikenwalder M, Segerer S. The lymphotoxin ß receptor is a potential therapeutic target in renal inflammation. Kidney Int. 2016 Jan; 89(1):113-26. PMID: 26398497.
    View in: PubMed
  5. Rice LM, Ziemek J, Stratton EA, McLaughlin SR, Padilla CM, Mathes AL, Christmann RB, Stifano G, Browning JL, Whitfield ML, Spiera RF, Gordon JK, Simms RW, Zhang Y, Lafyatis R. A longitudinal biomarker for the extent of skin disease in patients with diffuse cutaneous systemic sclerosis. Arthritis Rheumatol. 2015 Nov; 67(11):3004-15. PMID: 26240058.
    View in: PubMed
  6. Finkin S, Yuan D, Stein I, Taniguchi K, Weber A, Unger K, Browning JL, Goossens N, Nakagawa S, Gunasekaran G, Schwartz ME, Kobayashi M, Kumada H, Berger M, Pappo O, Rajewsky K, Hoshida Y, Karin M, Heikenwalder M, Ben-Neriah Y, Pikarsky E. Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma. Nat Immunol. 2015 Dec; 16(12):1235-44. PMID: 26502405.
    View in: PubMed
  7. Bienkowska J, Allaire N, Thai A, Goyal J, Plavina T, Nirula A, Weaver M, Newman C, Petri M, Beckman E, Browning JL. Lymphotoxin-LIGHT pathway regulates the interferon signature in rheumatoid arthritis. PLoS One. 2014; 9(11):e112545. PMID: 25405351.
    View in: PubMed
  8. Thiago TT, Merle E, Fricot A, Monteiro R, Moura IC, Seleznik G, Seeger H, Papandile A, Fu K, Poreci U, Czerkowicz J, Rabah D, Ranger A, Cohen CD, Lindenmeyer M, Chen J, Edenhofer I, Anders HJ, Lech M, Wüthrich RP, Ruddle NH, Moeller MJ, Regele H, Kozakowski N, Bauer J, Heikenwälder M, Browning JL, Segerer S, Kirsch AH, Artinger K, Rho E, Wolf AM, Cornez I, Eller P, Wolf D, Rosenkranz AR, Eller K, Rho E, Artinger K, Kirsch AH, Schaubettl C, Aringer I, Rosenkranz AR, Eller P, Eller K, Grande JP, Hartono SP, Kashyap S, Knudsen B. Pathology inflammation. Nephrol Dial Transplant. 2014 May; 29 Suppl 3:iii25-iii26. PMID: 24849966.
    View in: PubMed
  9. Gommerman JL, Browning JL, Ware CF. The Lymphotoxin Network: orchestrating a type I interferon response to optimize adaptive immunity. Cytokine Growth Factor Rev. 2014 Apr; 25(2):139-45. PMID: 24698108.
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  10. Crowe PD, Vanarsdale TL, Walter BN, Ware CF, Hession C, Ehrenfels B, Browning JL, Din WS, Goodwin RG, Smith CA. Pillars article: A lymphotoxin-B-specific receptor. Science. 1994. 264: 707-710. J Immunol. 2014 Mar 1; 192(5):2015-8. PMID: 24563505.
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  11. Lucifora J, Xia Y, Reisinger F, Zhang K, Stadler D, Cheng X, Sprinzl MF, Koppensteiner H, Makowska Z, Volz T, Remouchamps C, Chou WM, Thasler WE, Hüser N, Durantel D, Liang TJ, Münk C, Heim MH, Browning JL, Dejardin E, Dandri M, Schindler M, Heikenwalder M, Protzer U. Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA. Science. 2014 Mar 14; 343(6176):1221-8. PMID: 24557838.
    View in: PubMed
  12. Lu TT, Browning JL. Role of the Lymphotoxin/LIGHT System in the Development and Maintenance of Reticular Networks and Vasculature in Lymphoid Tissues. Front Immunol. 2014; 5:47. PMID: 24575096.
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  13. Edwards KR, Goyal J, Plavina T, Czerkowicz J, Goelz S, Ranger A, Cadavid D, Browning JL. Feasibility of the use of combinatorial chemokine arrays to study blood and CSF in multiple sclerosis. PLoS One. 2013; 8(11):e81007. PMID: 24278364.
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  14. Hu X, Zimmerman MA, Bardhan K, Yang D, Waller JL, Liles GB, Lee JR, Pollock R, Lev D, Ware CF, Garber E, Bailly V, Browning JL, Liu K. Lymphotoxin ß receptor mediates caspase-dependent tumor cell apoptosis in vitro and tumor suppression in vivo despite induction of NF-?B activation. Carcinogenesis. 2013 May; 34(5):1105-14. PMID: 23349015.
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  15. Seleznik GM, Reding T, Romrig F, Saito Y, Mildner A, Segerer S, Sun LK, Regenass S, Lech M, Anders HJ, McHugh D, Kumagi T, Hiasa Y, Lackner C, Haybaeck J, Angst E, Perren A, Balmer ML, Slack E, MacPherson A, Manz MG, Weber A, Browning JL, Arkan MC, Rülicke T, Aguzzi A, Prinz M, Graf R, Heikenwalder M. Lymphotoxin ß receptor signaling promotes development of autoimmune pancreatitis. Gastroenterology. 2012 Nov; 143(5):1361-74. PMID: 22863765.
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  16. Krautler NJ, Kana V, Kranich J, Tian Y, Perera D, Lemm D, Schwarz P, Armulik A, Browning JL, Tallquist M, Buch T, Oliveira-Martins JB, Zhu C, Hermann M, Wagner U, Brink R, Heikenwalder M, Aguzzi A. Follicular dendritic cells emerge from ubiquitous perivascular precursors. Cell. 2012 Jul 6; 150(1):194-206. PMID: 22770220.
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  17. León B, Ballesteros-Tato A, Browning JL, Dunn R, Randall TD, Lund FE. Regulation of T(H)2 development by CXCR5+ dendritic cells and lymphotoxin-expressing B cells. Nat Immunol. 2012 Jul; 13(7):681-90. PMID: 22634865.
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  18. Browning JL. Lymphotoxin and the amazing technicolor circus of intestinal homeostasis. Mucosal Immunol. 2012 May; 5(3):228-31. PMID: 22318496.
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  19. Srinivasan M, Flynn R, Price A, Ranger A, Browning JL, Taylor PA, Ritz J, Antin JH, Murphy WJ, Luznik L, Shlomchik MJ, Panoskaltsis-Mortari A, Blazar BR. Donor B-cell alloantibody deposition and germinal center formation are required for the development of murine chronic GVHD and bronchiolitis obliterans. Blood. 2012 Feb 9; 119(6):1570-80. PMID: 22072556.
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  20. Fava RA, Kennedy SM, Wood SG, Bolstad AI, Bienkowska J, Papandile A, Kelly JA, Mavragani CP, Gatumu M, Skarstein K, Browning JL. Lymphotoxin-beta receptor blockade reduces CXCL13 in lacrimal glands and improves corneal integrity in the NOD model of Sjögren's syndrome. Arthritis Res Ther. 2011; 13(6):R182. PMID: 22044682.
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  21. McCarthy DD, Kujawa J, Wilson C, Papandile A, Poreci U, Porfilio EA, Ward L, Lawson MA, Macpherson AJ, McCoy KD, Pei Y, Novak L, Lee JY, Julian BA, Novak J, Ranger A, Gommerman JL, Browning JL. Mice overexpressing BAFF develop a commensal flora-dependent, IgA-associated nephropathy. J Clin Invest. 2011 Oct; 121(10):3991-4002. PMID: 21881212.
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  22. Ware CF, Browning JL. Workshop summary: control of lymphocyte function and repertoire by the TNF superfamily. Adv Exp Med Biol. 2011; 691:351-2. PMID: 21153338.
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  23. Fava RA, Browning JL, Gatumu M, Skarstein K, Bolstad AI. LTBR-pathway in Sjogren's syndrome: CXCL13 levels and B-cell-enriched ectopic lymphoid aggregates in NOD mouse lacrimal glands are dependent on LTBR. Adv Exp Med Biol. 2011; 691:383-90. PMID: 21153342.
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  24. Widmayer MA, Browning JL, Gopinath SP, Robertson CS, Baskin DS. Increased intracranial pressure is associated with elevated cerebrospinal fluid ADH levels in closed-head injury. Neurol Res. 2010 Dec; 32(10):1021-6. PMID: 20810023.
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  25. Bista P, Zeng W, Ryan S, Bailly V, Browning JL, Lukashev ME. TRAF3 controls activation of the canonical and alternative NFkappaB by the lymphotoxin beta receptor. J Biol Chem. 2010 Apr 23; 285(17):12971-8. PMID: 20185819.
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  26. Haybaeck J, Zeller N, Wolf MJ, Weber A, Wagner U, Kurrer MO, Bremer J, Iezzi G, Graf R, Clavien PA, Thimme R, Blum H, Nedospasov SA, Zatloukal K, Ramzan M, Ciesek S, Pietschmann T, Marche PN, Karin M, Kopf M, Browning JL, Aguzzi A, Heikenwalder M. A lymphotoxin-driven pathway to hepatocellular carcinoma. Cancer Cell. 2009 Oct 6; 16(4):295-308. PMID: 19800575.
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  27. Michaelson JS, Demarest SJ, Miller B, Amatucci A, Snyder WB, Wu X, Huang F, Phan S, Gao S, Doern A, Farrington GK, Lugovskoy A, Joseph I, Bailly V, Wang X, Garber E, Browning J, Glaser SM. Anti-tumor activity of stability-engineered IgG-like bispecific antibodies targeting TRAIL-R2 and LTbetaR. MAbs. 2009 Mar-Apr; 1(2):128-41. PMID: 20061822.
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  28. Gatumu MK, Skarstein K, Papandile A, Browning JL, Fava RA, Bolstad AI. Blockade of lymphotoxin-beta receptor signaling reduces aspects of Sjögren's syndrome in salivary glands of non-obese diabetic mice. Arthritis Res Ther. 2009; 11(1):R24. PMID: 19222863.
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  29. Browning JL. Inhibition of the lymphotoxin pathway as a therapy for autoimmune disease. Immunol Rev. 2008 Jun; 223:202-20. PMID: 18613838.
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  30. Lukashev M, LePage D, Wilson C, Bailly V, Garber E, Lukashin A, Ngam-ek A, Zeng W, Allaire N, Perrin S, Xu X, Szeliga K, Wortham K, Kelly R, Bottiglio C, Ding J, Griffith L, Heaney G, Silverio E, Yang W, Jarpe M, Fawell S, Reff M, Carmillo A, Miatkowski K, Amatucci J, Crowell T, Prentice H, Meier W, Violette SM, Mackay F, Yang D, Hoffman R, Browning JL. Targeting the lymphotoxin-beta receptor with agonist antibodies as a potential cancer therapy. Cancer Res. 2006 Oct 1; 66(19):9617-24. PMID: 17018619.
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  31. Browning JL. B cells move to centre stage: novel opportunities for autoimmune disease treatment. Nat Rev Drug Discov. 2006 Jul; 5(7):564-76. PMID: 16816838.
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  32. Browning JL, Allaire N, Ngam-Ek A, Notidis E, Hunt J, Perrin S, Fava RA. Lymphotoxin-beta receptor signaling is required for the homeostatic control of HEV differentiation and function. Immunity. 2005 Nov; 23(5):539-50. PMID: 16286021.
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  33. Browning JL, Patel T, Brandt PC, Young KA, Holcomb LA, Hicks PB. Clozapine and the mitogen-activated protein kinase signal transduction pathway: implications for antipsychotic actions. Biol Psychiatry. 2005 Mar 15; 57(6):617-23. PMID: 15780848.
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  34. Shao Z, Browning JL, Lee X, Scott ML, Shulga-Morskaya S, Allaire N, Thill G, Levesque M, Sah D, McCoy JM, Murray B, Jung V, Pepinsky RB, Mi S. TAJ/TROY, an orphan TNF receptor family member, binds Nogo-66 receptor 1 and regulates axonal regeneration. Neuron. 2005 Feb 3; 45(3):353-9. PMID: 15694322.
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  35. Gommerman JL, Giza K, Perper S, Sizing I, Ngam-Ek A, Nickerson-Nutter C, Browning JL. A role for surface lymphotoxin in experimental autoimmune encephalomyelitis independent of LIGHT. J Clin Invest. 2003 Sep; 112(5):755-67. PMID: 12952924.
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  36. Gommerman JL, Browning JL. Lymphotoxin/light, lymphoid microenvironments and autoimmune disease. Nat Rev Immunol. 2003 Aug; 3(8):642-55. PMID: 12974479.
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  37. Fava RA, Notidis E, Hunt J, Szanya V, Ratcliffe N, Ngam-Ek A, De Fougerolles AR, Sprague A, Browning JL. A role for the lymphotoxin/LIGHT axis in the pathogenesis of murine collagen-induced arthritis. J Immunol. 2003 Jul 1; 171(1):115-26. PMID: 12816989.
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  38. Wilson CA, Browning JL. Death of HT29 adenocarcinoma cells induced by TNF family receptor activation is caspase-independent and displays features of both apoptosis and necrosis. Cell Death Differ. 2002 Dec; 9(12):1321-33. PMID: 12478469.
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  39. Gommerman JL, Mackay F, Donskoy E, Meier W, Martin P, Browning JL. Manipulation of lymphoid microenvironments in nonhuman primates by an inhibitor of the lymphotoxin pathway. J Clin Invest. 2002 Nov; 110(9):1359-69. PMID: 12417575.
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  40. Mackay F, Browning JL. BAFF: a fundamental survival factor for B cells. Nat Rev Immunol. 2002 Jul; 2(7):465-75. PMID: 12094221.
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  41. Browning JL, French LE. Visualization of lymphotoxin-beta and lymphotoxin-beta receptor expression in mouse embryos. J Immunol. 2002 May 15; 168(10):5079-87. PMID: 11994460.
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  42. Mackay F, Schneider P, Rennert P, Browning J. BAFF AND APRIL: a tutorial on B cell survival. Annu Rev Immunol. 2003; 21:231-64. PMID: 12427767.
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  43. Dohi T, Rennert PD, Fujihashi K, Kiyono H, Shirai Y, Kawamura YI, Browning JL, McGhee JR. Elimination of colonic patches with lymphotoxin beta receptor-Ig prevents Th2 cell-type colitis. J Immunol. 2001 Sep 1; 167(5):2781-90. PMID: 11509623.
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  44. Thompson JS, Bixler SA, Qian F, Vora K, Scott ML, Cachero TG, Hession C, Schneider P, Sizing ID, Mullen C, Strauch K, Zafari M, Benjamin CD, Tschopp J, Browning JL, Ambrose C. BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF. Science. 2001 Sep 14; 293(5537):2108-11. PMID: 11509692.
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  45. Rennert PD, Hochman PS, Flavell RA, Chaplin DD, Jayaraman S, Browning JL, Fu YX. Essential role of lymph nodes in contact hypersensitivity revealed in lymphotoxin-alpha-deficient mice. J Exp Med. 2001 Jun 4; 193(11):1227-38. PMID: 11390430.
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  46. Debard N, Sierro F, Browning J, Kraehenbuhl JP. Effect of mature lymphocytes and lymphotoxin on the development of the follicle-associated epithelium and M cells in mouse Peyer's patches. Gastroenterology. 2001 Apr; 120(5):1173-82. PMID: 11266381.
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  47. Simmons WJ, Simms M, Chiarle R, Mackay F, Tsiagbe VK, Browning J, Inghirami G, Thorbecke GJ. Induction of germinal centers by MMTV encoded superantigen on B cells. Dev Immunol. 2001; 8(3-4):201-11. PMID: 11785670.
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  48. Rennert P, Schneider P, Cachero TG, Thompson J, Trabach L, Hertig S, Holler N, Qian F, Mullen C, Strauch K, Browning JL, Ambrose C, Tschopp J. A soluble form of B cell maturation antigen, a receptor for the tumor necrosis factor family member APRIL, inhibits tumor cell growth. J Exp Med. 2000 Dec 4; 192(11):1677-84. PMID: 11104810.
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  49. Batten M, Groom J, Cachero TG, Qian F, Schneider P, Tschopp J, Browning JL, Mackay F. BAFF mediates survival of peripheral immature B lymphocytes. J Exp Med. 2000 Nov 20; 192(10):1453-66. PMID: 11085747.
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  50. Husson H, Lugli SM, Ghia P, Cardoso A, Roth A, Brohmi K, Carideo EG, Choi YS, Browning J, Freedman AS. Functional effects of TNF and lymphotoxin alpha1beta2 on FDC-like cells. Cell Immunol. 2000 Aug 1; 203(2):134-43. PMID: 11006011.
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  51. Ansel KM, Ngo VN, Hyman PL, Luther SA, Förster R, Sedgwick JD, Browning JL, Lipp M, Cyster JG. A chemokine-driven positive feedback loop organizes lymphoid follicles. Nature. 2000 Jul 20; 406(6793):309-14. PMID: 10917533.
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  52. Thompson JS, Schneider P, Kalled SL, Wang L, Lefevre EA, Cachero TG, MacKay F, Bixler SA, Zafari M, Liu ZY, Woodcock SA, Qian F, Batten M, Madry C, Richard Y, Benjamin CD, Browning JL, Tsapis A, Tschopp J, Ambrose C. BAFF binds to the tumor necrosis factor receptor-like molecule B cell maturation antigen and is important for maintaining the peripheral B cell population. J Exp Med. 2000 Jul 3; 192(1):129-35. PMID: 10880534.
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  53. Mackay F, Woodcock SA, Lawton P, Ambrose C, Baetscher M, Schneider P, Tschopp J, Browning JL. Mice transgenic for BAFF develop lymphocytic disorders along with autoimmune manifestations. J Exp Med. 1999 Dec 6; 190(11):1697-710. PMID: 10587360.
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  54. Lucas R, Tacchini-Cottier F, Guler R, Vesin D, Jemelin S, Olleros ML, Marchal G, Browning JL, Vassalli P, Garcia I. A role for lymphotoxin beta receptor in host defense against Mycobacterium bovis BCG infection. Eur J Immunol. 1999 Dec; 29(12):4002-10. PMID: 10602010.
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  55. Puglielli MT, Browning JL, Brewer AW, Schreiber RD, Shieh WJ, Altman JD, Oldstone MB, Zaki SR, Ahmed R. Reversal of virus-induced systemic shock and respiratory failure by blockade of the lymphotoxin pathway. Nat Med. 1999 Dec; 5(12):1370-4. PMID: 10581078.
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  56. Wu Q, Wang Y, Wang J, Hedgeman EO, Browning JL, Fu YX. The requirement of membrane lymphotoxin for the presence of dendritic cells in lymphoid tissues. J Exp Med. 1999 Sep 6; 190(5):629-38. PMID: 10477548.
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  57. Schneider P, MacKay F, Steiner V, Hofmann K, Bodmer JL, Holler N, Ambrose C, Lawton P, Bixler S, Acha-Orbea H, Valmori D, Romero P, Werner-Favre C, Zubler RH, Browning JL, Tschopp J. BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth. J Exp Med. 1999 Jun 7; 189(11):1747-56. PMID: 10359578.
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  58. Marshall WL, Brinkman BM, Ambrose CM, Pesavento PA, Uglialoro AM, Teng E, Finberg RW, Browning JL, Goldfeld AE. Signaling through the lymphotoxin-beta receptor stimulates HIV-1 replication alone and in cooperation with soluble or membrane-bound TNF-alpha. J Immunol. 1999 May 15; 162(10):6016-23. PMID: 10229841.
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  59. Ngo VN, Korner H, Gunn MD, Schmidt KN, Riminton DS, Cooper MD, Browning JL, Sedgwick JD, Cyster JG. Lymphotoxin alpha/beta and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen. J Exp Med. 1999 Jan 18; 189(2):403-12. PMID: 9892622.
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  60. Mackay F, Browning JL, Lawton P, Shah SA, Comiskey M, Bhan AK, Mizoguchi E, Terhorst C, Simpson SJ. Both the lymphotoxin and tumor necrosis factor pathways are involved in experimental murine models of colitis. Gastroenterology. 1998 Dec; 115(6):1464-75. PMID: 9834274.
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  61. Mackay F, Browning JL. Turning off follicular dendritic cells. Nature. 1998 Sep 3; 395(6697):26-7. PMID: 9738494.
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  62. Rennert PD, James D, Mackay F, Browning JL, Hochman PS. Lymph node genesis is induced by signaling through the lymphotoxin beta receptor. Immunity. 1998 Jul; 9(1):71-9. PMID: 9697837.
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  63. Ettinger R, Mebius R, Browning JL, Michie SA, van Tuijl S, Kraal G, van Ewijk W, McDevitt HO. Effects of tumor necrosis factor and lymphotoxin on peripheral lymphoid tissue development. Int Immunol. 1998 Jun; 10(6):727-41. PMID: 9678753.
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  64. Murphy M, Walter BN, Pike-Nobile L, Fanger NA, Guyre PM, Browning JL, Ware CF, Epstein LB. Expression of the lymphotoxin beta receptor on follicular stromal cells in human lymphoid tissues. Cell Death Differ. 1998 Jun; 5(6):497-505. PMID: 10200501.
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  65. Gonzalez M, Mackay F, Browning JL, Kosco-Vilbois MH, Noelle RJ. The sequential role of lymphotoxin and B cells in the development of splenic follicles. J Exp Med. 1998 Apr 6; 187(7):997-1007. PMID: 9529316.
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  66. Chicheportiche Y, Bourdon PR, Xu H, Hsu YM, Scott H, Hession C, Garcia I, Browning JL. TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis. J Biol Chem. 1997 Dec 19; 272(51):32401-10. PMID: 9405449.
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  67. Rennert PD, Browning JL, Hochman PS. Selective disruption of lymphotoxin ligands reveals a novel set of mucosal lymph nodes and unique effects on lymph node cellular organization. Int Immunol. 1997 Nov; 9(11):1627-39. PMID: 9418124.
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  68. Browning JL, Sizing ID, Lawton P, Bourdon PR, Rennert PD, Majeau GR, Ambrose CM, Hession C, Miatkowski K, Griffiths DA, Ngam-ek A, Meier W, Benjamin CD, Hochman PS. Characterization of lymphotoxin-alpha beta complexes on the surface of mouse lymphocytes. J Immunol. 1997 Oct 1; 159(7):3288-98. PMID: 9317127.
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  69. Mackay F, Bourdon PR, Griffiths DA, Lawton P, Zafari M, Sizing ID, Miatkowski K, Ngam-ek A, Benjamin CD, Hession C, Ambrose CM, Meier W, Browning JL. Cytotoxic activities of recombinant soluble murine lymphotoxin-alpha and lymphotoxin-alpha beta complexes. J Immunol. 1997 Oct 1; 159(7):3299-310. PMID: 9317128.
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  70. Cannella B, Sizing ID, Benjamin CD, Browning JL, Raine CS. Antibodies to lymphotoxin alpha (LT alpha) and LT beta recognize different glial cell types in the central nervous system. J Neuroimmunol. 1997 Sep; 78(1-2):172-9. PMID: 9307242.
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  71. Mackay F, Majeau GR, Lawton P, Hochman PS, Browning JL. Lymphotoxin but not tumor necrosis factor functions to maintain splenic architecture and humoral responsiveness in adult mice. Eur J Immunol. 1997 Aug; 27(8):2033-42. PMID: 9295042.
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  72. Browning JL, Heizer ML, Widmayer MA, Baskin DS. Effects of halothane, alpha-chloralose, and pCO2 on injury volume and CSF beta-endorphin levels in focal cerebral ischemia. Mol Chem Neuropathol. 1997 May; 31(1):29-42. PMID: 9271003.
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  73. Koni PA, Sacca R, Lawton P, Browning JL, Ruddle NH, Flavell RA. Distinct roles in lymphoid organogenesis for lymphotoxins alpha and beta revealed in lymphotoxin beta-deficient mice. Immunity. 1997 Apr; 6(4):491-500. PMID: 9133428.
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  74. Bodmer JL, Burns K, Schneider P, Hofmann K, Steiner V, Thome M, Bornand T, Hahne M, Schröter M, Becker K, Wilson A, French LE, Browning JL, MacDonald HR, Tschopp J. TRAMP, a novel apoptosis-mediating receptor with sequence homology to tumor necrosis factor receptor 1 and Fas(Apo-1/CD95). Immunity. 1997 Jan; 6(1):79-88. PMID: 9052839.
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  75. Ettinger R, Browning JL, Michie SA, van Ewijk W, McDevitt HO. Disrupted splenic architecture, but normal lymph node development in mice expressing a soluble lymphotoxin-beta receptor-IgG1 fusion protein. Proc Natl Acad Sci U S A. 1996 Nov 12; 93(23):13102-7. PMID: 8917551.
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  76. Rennert PD, Browning JL, Mebius R, Mackay F, Hochman PS. Surface lymphotoxin alpha/beta complex is required for the development of peripheral lymphoid organs. J Exp Med. 1996 Nov 1; 184(5):1999-2006. PMID: 8920886.
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  77. Mackay F, Majeau GR, Hochman PS, Browning JL. Lymphotoxin beta receptor triggering induces activation of the nuclear factor kappaB transcription factor in some cell types. J Biol Chem. 1996 Oct 4; 271(40):24934-8. PMID: 8798772.
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  78. Browning JL, Widmayer MA, Hoffmann KK, Dudley AW, Baskin DS. Time-dependent variability of infarct size and hemispheric volume in experimental focal cerebral ischemia in the rabbit. J Neurotrauma. 1996 Oct; 13(10):583-8. PMID: 8915910.
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  79. Browning JL, Miatkowski K, Griffiths DA, Bourdon PR, Hession C, Ambrose CM, Meier W. Preparation and characterization of soluble recombinant heterotrimeric complexes of human lymphotoxins alpha and beta. J Biol Chem. 1996 Apr 12; 271(15):8618-26. PMID: 8621492.
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  80. Browning JL, Miatkowski K, Sizing I, Griffiths D, Zafari M, Benjamin CD, Meier W, Mackay F. Signaling through the lymphotoxin beta receptor induces the death of some adenocarcinoma tumor lines. J Exp Med. 1996 Mar 1; 183(3):867-78. PMID: 8642291.
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  81. Force WR, Walter BN, Hession C, Tizard R, Kozak CA, Browning JL, Ware CF. Mouse lymphotoxin-beta receptor. Molecular genetics, ligand binding, and expression. J Immunol. 1995 Dec 1; 155(11):5280-8. PMID: 7594541.
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  82. Browning JL, Dougas I, Ngam-ek A, Bourdon PR, Ehrenfels BN, Miatkowski K, Zafari M, Yampaglia AM, Lawton P, Meier W, et al. Characterization of surface lymphotoxin forms. Use of specific monoclonal antibodies and soluble receptors. J Immunol. 1995 Jan 1; 154(1):33-46. PMID: 7995952.
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  83. Lawton P, Nelson J, Tizard R, Browning JL. Characterization of the mouse lymphotoxin-beta gene. J Immunol. 1995 Jan 1; 154(1):239-46. PMID: 7995944.
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  84. Ware CF, VanArsdale TL, Crowe PD, Browning JL. The ligands and receptors of the lymphotoxin system. Curr Top Microbiol Immunol. 1995; 198:175-218. PMID: 7774281.
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  85. Hochman PS, Majeau GR, Mackay F, Browning JL. Proinflammatory responses are efficiently induced by homotrimeric but not heterotrimeric lymphotoxin ligands. J Inflamm. 1995-1996; 46(4):220-34. PMID: 8878796.
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  86. Cirino G, Cicala C, Sorrentino L, Maiello FM, Browning JL. Recombinant secreted nonpancreatic phospholipase A2 induces a synovitis-like inflammation in the rat air pouch. J Rheumatol. 1994 May; 21(5):824-9. PMID: 8064721.
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  87. Crowe PD, VanArsdale TL, Walter BN, Ware CF, Hession C, Ehrenfels B, Browning JL, Din WS, Goodwin RG, Smith CA. A lymphotoxin-beta-specific receptor. Science. 1994 Apr 29; 264(5159):707-10. PMID: 8171323.
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  88. Cirino G, Cicala C, Sorrentino R, Sorrentino L, Browning JL, Page CP. Human recombinant phospholipase A2 inhibits platelet aggregation in vitro and in vivo in rat and guinea pig. Eur J Pharmacol. 1994 Feb 3; 252(2):147-54. PMID: 8157055.
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  89. Santos AA, Browning JL, Scheltinga MR, Lynch EA, Brown EF, Lawton P, Chambers E, Dougas I, Benjamin CD, Dinarello CA, et al. Are events after endotoxemia related to circulating phospholipase A2? Ann Surg. 1994 Feb; 219(2):183-92. PMID: 8129489.
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  90. Pruzanski W, Vadas P, Browning J. Secretory non-pancreatic group II phospholipase A2: role in physiologic and inflammatory processes. J Lipid Mediat. 1993 Nov; 8(3):161-7. PMID: 8268462.
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  91. Vadas P, Browning J, Edelson J, Pruzanski W. Extracellular phospholipase A2 expression and inflammation: the relationship with associated disease states. J Lipid Mediat. 1993 Aug; 8(1):1-30. PMID: 8257775.
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  92. Cirino G, Cicala C, Sorrentino L, Browning JL. Human recombinant non pancreatic secreted platelet phospholipase A2 has anticoagulant activity in vitro on human plasma. Thromb Res. 1993 May 15; 70(4):337-42. PMID: 8332963.
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  93. Browning JL, Ngam-ek A, Lawton P, DeMarinis J, Tizard R, Chow EP, Hession C, O'Brine-Greco B, Foley SF, Ware CF. Lymphotoxin beta, a novel member of the TNF family that forms a heteromeric complex with lymphotoxin on the cell surface. Cell. 1993 Mar 26; 72(6):847-56. PMID: 7916655.
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  94. Santos AA, Scheltinga MR, Lynch E, Brown EF, Lawton P, Chambers E, Browning J, Dinarello CA, Wolff SM, Wilmore DW. Elaboration of interleukin 1-receptor antagonist is not attenuated by glucocorticoids after endotoxemia. Arch Surg. 1993 Feb; 128(2):138-43; discussion 143-4. PMID: 8431115.
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  95. Bayburt T, Yu BZ, Lin HK, Browning J, Jain MK, Gelb MH. Human nonpancreatic secreted phospholipase A2: interfacial parameters, substrate specificities, and competitive inhibitors. Biochemistry. 1993 Jan 19; 32(2):573-82. PMID: 8422368.
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  96. Ware CF, Crowe PD, Grayson MH, Androlewicz MJ, Browning JL. Expression of surface lymphotoxin and tumor necrosis factor on activated T, B, and natural killer cells. J Immunol. 1992 Dec 15; 149(12):3881-8. PMID: 1281193.
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  97. Pruzanski W, Wilmore DW, Suffredini A, Martich GD, Hoffman AG, Browning JL, Stefanski E, Sternby B, Vadas P. Hyperphospholipasemia A2 in human volunteers challenged with intravenous endotoxin. Inflammation. 1992 Oct; 16(5):561-70. PMID: 1428127.
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  98. Browning JL, Heizer ML, Baskin DS. Variations in corticomotor and somatosensory evoked potentials: effects of temperature, halothane anesthesia, and arterial partial pressure of CO2. Anesth Analg. 1992 May; 74(5):643-8. PMID: 1567029.
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  99. Androlewicz MJ, Browning JL, Ware CF. Lymphotoxin is expressed as a heteromeric complex with a distinct 33-kDa glycoprotein on the surface of an activated human T cell hybridoma. J Biol Chem. 1992 Feb 5; 267(4):2542-7. PMID: 1733951.
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  100. Scott DL, White SP, Browning JL, Rosa JJ, Gelb MH, Sigler PB. Structures of free and inhibited human secretory phospholipase A2 from inflammatory exudate. Science. 1991 Nov 15; 254(5034):1007-10. PMID: 1948070.
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  101. Browning JL, Androlewicz MJ, Ware CF. Lymphotoxin and an associated 33-kDa glycoprotein are expressed on the surface of an activated human T cell hybridoma. J Immunol. 1991 Aug 15; 147(4):1230-7. PMID: 1714477.
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  102. Bomalaski JS, Lawton P, Browning JL. Human extracellular recombinant phospholipase A2 induces an inflammatory response in rabbit joints. J Immunol. 1991 Jun 1; 146(11):3904-10. PMID: 2033260.
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  103. Pepinsky RB, Sinclair LK, Dougas I, Liang CM, Lawton P, Browning JL. Monoclonal antibodies to lipocortin-1 as probes for biological function. FEBS Lett. 1990 Feb 26; 261(2):247-52. PMID: 1690147.
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  104. Browning JL, Ward MP, Wallner BP, Pepinsky RB. Studies on the structural properties of lipocortin-1 and the regulation of its synthesis by steroids. Prog Clin Biol Res. 1990; 349:27-45. PMID: 2144640.
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  105. Violette SM, King I, Browning JL, Pepinsky RB, Wallner BP, Sartorelli AC. Role of lipocortin I in the glucocorticoid induction of the terminal differentiation of a human squamous carcinoma. J Cell Physiol. 1990 Jan; 142(1):70-7. PMID: 2137129.
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  106. Goulding NJ, Podgorski MR, Hall ND, Flower RJ, Browning JL, Pepinsky RB, Maddison PJ. Autoantibodies to recombinant lipocortin-1 in rheumatoid arthritis and systemic lupus erythematosus. Ann Rheum Dis. 1989 Oct; 48(10):843-50. PMID: 2554826.
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  107. Browning J, Ribolini A. Studies on the differing effects of tumor necrosis factor and lymphotoxin on the growth of several human tumor lines. J Immunol. 1989 Sep 15; 143(6):1859-67. PMID: 2550545.
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  108. Cirino G, Peers SH, Flower RJ, Browning JL, Pepinsky RB. Human recombinant lipocortin 1 has acute local anti-inflammatory properties in the rat paw edema test. Proc Natl Acad Sci U S A. 1989 May; 86(9):3428-32. PMID: 2470103.
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  109. Pepinsky RB, Tizard R, Mattaliano RJ, Sinclair LK, Miller GT, Browning JL, Chow EP, Burne C, Huang KS, Pratt D, et al. Five distinct calcium and phospholipid binding proteins share homology with lipocortin I. J Biol Chem. 1988 Aug 5; 263(22):10799-811. PMID: 2968983.
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  110. Cirino G, Flower RJ, Browning JL, Sinclair LK, Pepinsky RB. Recombinant human lipocortin 1 inhibits thromboxane release from guinea-pig isolated perfused lung. Nature. 1987 Jul 16-22; 328(6127):270-2. PMID: 2955229.
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  111. Browning JL, Ribolini A. Interferon blocks interleukin 1-induced prostaglandin release from human peripheral monocytes. J Immunol. 1987 May 1; 138(9):2857-63. PMID: 3106491.
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  112. Browning J. Interferons and rheumatoid arthritis: insight into interferon biology? Immunol Today. 1987; 8(12):372-4. PMID: 25291271.
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  113. Browning JL, Mattaliano RJ, Chow EP, Liang SM, Allet B, Rosa J, Smart JE. Disulfide scrambling of interleukin-2: HPLC resolution of the three possible isomers. Anal Biochem. 1986 May 15; 155(1):123-8. PMID: 3487260.
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  114. Pepinsky RB, Sinclair LK, Browning JL, Mattaliano RJ, Smart JE, Chow EP, Falbel T, Ribolini A, Garwin JL, Wallner BP. Purification and partial sequence analysis of a 37-kDa protein that inhibits phospholipase A2 activity from rat peritoneal exudates. J Biol Chem. 1986 Mar 25; 261(9):4239-46. PMID: 3081518.
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