Keywords
Last Name

Julia Xu, PhD

TitleResearch Instructor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionEndocrinology, Diabetes & Nutrition
Address650 Albany St
Boston MA 02118
Phone(617) 638-7080
ORCID ORCID Icon0000-0002-2564-8052
Other Positions
InstitutionBoston Medical Center

 Research Expertise & Professional Interests
Dr. Xu received her Ph.D. in Pathology and Laboratory Medicine from Brown University, Providence. She completed postdoctoral work at Boston University Medical Center and is currently an Instructor in Medicine at Boston University Medical Center.

Obesity and its associated complications are a threat to our public health, and the rising incidence of diabetes is linked to the obesity epidemic. Dr. Xu’s research efforts are centered on understanding the relationship between obesity-induced metabolic disorders and adipose tissue biology. Dr. Xu is particularly interested in identifying factors that can distinguish insulin sensitive from insulin resistance in obese individuals, since the former population despite being obese, is less likely to develop cardiovascular disease (CVD) and presumably other obesity-associated comorbidities such as type 2 diabetes, non-alcoholic fatty liver disease (NAFLD), and certain cancers. In addition, Dr. Xu is exploring signal transduction mechanism(s) that can explain how inflammation develops in rodent adipose tissue in the setting of obesity.

 Self-Described Keywords
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Xu XJ, Pories WJ, Dohm LG, Ruderman NB. What distinguishes adipose tissue of severely obese humans who are insulin sensitive and resistant? Curr Opin Lipidol. 2013 Feb; 24(1):49-56.
    View in: PubMed
  2. Xu XJ, Gauthier MS, Hess DT, Apovian CM, Cacicedo JM, Gokce N, Farb M, Valentine RJ, Ruderman NB. Insulin sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue. J Lipid Res. 2012 Apr; 53(4):792-801.
    View in: PubMed
  3. Saha AK, Xu XJ, Balon TW, Brandon A, Kraegen EW, Ruderman NB. Insulin resistance due to nutrient excess: is it a consequence of AMPK downregulation? Cell Cycle. 2011 Oct 15; 10(20):3447-51.
    View in: PubMed
  4. Liesa M, Luptak I, Qin F, Hyde BB, Sahin E, Siwik DA, Zhu Z, Pimentel DR, Xu XJ, Ruderman NB, Huffman KD, Doctrow SR, Richey L, Colucci WS, Shirihai OS. Mitochondrial transporter ATP binding cassette mitochondrial erythroid is a novel gene required for cardiac recovery after ischemia/reperfusion. Circulation. 2011 Aug 16; 124(7):806-13.
    View in: PubMed
  5. Brandon AE, Hoy AJ, Wright LE, Turner N, Hegarty BD, Iseli TJ, Julia Xu X, Cooney GJ, Saha AK, Ruderman NB, Kraegen EW. The evolution of insulin resistance in muscle of the glucose infused rat. Arch Biochem Biophys. 2011 May 15; 509(2):133-41.
    View in: PubMed
  6. Gauthier MS, O''Brien EL, Bigornia S, Mott M, Cacicedo JM, Xu XJ, Gokce N, Apovian C, Ruderman N. Decreased AMP-activated protein kinase activity is associated with increased inflammation in visceral adipose tissue and with whole-body insulin resistance in morbidly obese humans. Biochem Biophys Res Commun. 2011 Jan 7; 404(1):382-7.
    View in: PubMed
  7. Saha AK, Xu XJ, Lawson E, Deoliveira R, Brandon AE, Kraegen EW, Ruderman NB. Downregulation of AMPK accompanies leucine- and glucose-induced increases in protein synthesis and insulin resistance in rat skeletal muscle. Diabetes. 2010 Oct; 59(10):2426-34.
    View in: PubMed
  8. Ruderman NB, Xu XJ, Nelson L, Cacicedo JM, Saha AK, Lan F, Ido Y. AMPK and SIRT1: a long-standing partnership? Am J Physiol Endocrinol Metab. 2010 Apr; 298(4):E751-60.
    View in: PubMed
  9. Xu XJ, Reichner JS, Mastrofrancesco B, Henry WL, Albina JE. Prostaglandin E2 suppresses lipopolysaccharide-stimulated IFN-beta production. J Immunol. 2008 Feb 15; 180(4):2125-31.
    View in: PubMed
  10. Lahousse SA, Carter JJ, Xu XJ, Wands JR, de la Monte SM. Differential growth factor regulation of aspartyl-(asparaginyl)-beta-hydroxylase family genes in SH-Sy5y human neuroblastoma cells. BMC Cell Biol. 2006; 7:41.
    View in: PubMed
  11. Soscia SJ, Tong M, Xu XJ, Cohen AC, Chu J, Wands JR, de la Monte SM. Chronic gestational exposure to ethanol causes insulin and IGF resistance and impairs acetylcholine homeostasis in the brain. Cell Mol Life Sci. 2006 Sep; 63(17):2039-56.
    View in: PubMed
  12. de la Monte SM, Xu XJ, Wands JR. Ethanol inhibits insulin expression and actions in the developing brain. Cell Mol Life Sci. 2005 May; 62(10):1131-45.
    View in: PubMed
  13. Steen E, Terry BM, Rivera EJ, Cannon JL, Neely TR, Tavares R, Xu XJ, Wands JR, de la Monte SM. Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease--is this type 3 diabetes? J Alzheimers Dis. 2005 Feb; 7(1):63-80.
    View in: PubMed
  14. Xu J, McRae MA, Harron S, Rob B, Huber RE. A study of the relationships of interactions between Asp-201, Na+ or K+, and galactosyl C6 hydroxyl and their effects on binding and reactivity of beta-galactosidase. Biochem Cell Biol. 2004 Apr; 82(2):275-84.
    View in: PubMed
  15. Yeon JE, Califano S, Xu J, Wands JR, De La Monte SM. Potential role of PTEN phosphatase in ethanol-impaired survival signaling in the liver. Hepatology. 2003 Sep; 38(3):703-14.
    View in: PubMed
  16. Chen GJ, Xu J, Lahousse SA, Caggiano NL, de la Monte SM. Transient hypoxia causes Alzheimer-type molecular and biochemical abnormalities in cortical neurons: potential strategies for neuroprotection. J Alzheimers Dis. 2003 Jun; 5(3):209-28.
    View in: PubMed
  17. Xu J, Yeon JE, Chang H, Tison G, Chen GJ, Wands J, de la Monte S. Ethanol impairs insulin-stimulated neuronal survival in the developing brain: role of PTEN phosphatase. J Biol Chem. 2003 Jul 18; 278(29):26929-37.
    View in: PubMed
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