Keywords
Last Name

Carlos Hirschberg, PhD

TitleProfessor
InstitutionBoston University Goldman School of Dental Medicine
DepartmentMolecular & Cell Biology
Address75 E. Newton St
Boston MA 02118
Phone(617) 414-1050
ORCID ORCID Icon0000-0003-2299-7721
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine
DepartmentGraduate Medical Sciences, Division of

 Research Expertise & Professional Interests
Expertise in the role of novel regulation of posttranslational modifications in development and disease.

Our laboratory is interested in studying the biogenesis, structure and function of lower and higher eukaryotes' cell surfaces and the extracellular matrix by using a combined biochemical, molecular biological and genetic approach. Our particular effort is focused on glycoproteins, glycolipids, and glycosaminoglycans. These play important roles in the regulation of cell growth, intercellular recognition, cell adhesion, and as receptors for hormones, toxins and growth factors.

A major research effort has centered around mechanisms of glycosylation, sulfation and phosphorylation of the above-named compounds. Specific questions which are being asked include the intracellular membrane topography of glycosylation, sulfation and phosphorylation reactions and how precursors are transported from their intracellular site of synthesis to the site(s) of glycosylation, sulfation and phosphorylation. We have characterized a number of transporters in the membrane of the rough endoplasmic reticulum and Golgi apparatus which transport precursors into the lumen of these organelles. These transporters are antiporters. We and others have described Chinese hamster ovary cells, yeast, protozoa, nematodes, insects and plants which are defective in transport of sugar nucleotides into the Golgi apparatus lumen. These mutants have a developmentally impaired phenotype and can cause a virulent wild type organism to become avirulent, demonstrating that the transporters are of physiologic relevance and may become drug targets. Recently the first diseases in such transporters were described: leukocyte adhesion deficiency II syndrome in humans and complex vertebral malformation in bovines. We have purified and cloned some of these transporters by using biochemical and molecular biological approaches, including genetic complementation. More recently, we are also studying the function of these transporters in C. elegans and are cloning and disrupting the genes of enzymes involved in the above posttranslational modifications, i.e., a Golgi GDPase from K. lactis, Candida albicans, and C. elegans. This approach should enable us to determine the functions of specific glycoproteins and glycosaminoglycans during development.

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Caffaro CE, Koshy AA, Liu L, Zeiner GM, Hirschberg CB, Boothroyd JC. A nucleotide sugar transporter involved in glycosylation of the Toxoplasma tissue cyst wall is required for efficient persistence of bradyzoites. PLoS Pathog. 2013; 9(5):e1003331.
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  2. Liu L, Xu YX, Caradonna KL, Kruzel EK, Burleigh BA, Bangs JD, Hirschberg CB. Inhibition of nucleotide sugar transport in Trypanosoma brucei alters surface glycosylation. J Biol Chem. 2013 Apr 12; 288(15):10599-615.
    View in: PubMed
  3. Liu L, Hirschberg CB. Developmental diseases caused by impaired nucleotide sugar transporters. Glycoconj J. 2013 Jan; 30(1):5-10.
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  4. Wickner WT, Stubbe J, Hirschberg CB, Garrett T, Dowhan W. Chris Raetz, scientist and enduring friend. Proc Natl Acad Sci U S A. 2011 Oct 18; 108(42):17255-6.
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  5. Xu YX, Liu L, Caffaro CE, Hirschberg CB. Inhibition of Golgi apparatus glycosylation causes endoplasmic reticulum stress and decreased protein synthesis. J Biol Chem. 2010 Aug 6; 285(32):24600-8.
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  6. Liu L, Xu YX, Hirschberg CB. The role of nucleotide sugar transporters in development of eukaryotes. Semin Cell Dev Biol. 2010 Aug; 21(6):600-8.
    View in: PubMed
  7. Caffaro CE, Luhn K, Bakker H, Vestweber D, Samuelson J, Berninsone P, Hirschberg CB. A single Caenorhabditis elegans Golgi apparatus-type transporter of UDP-glucose, UDP-galactose, UDP-N-acetylglucosamine, and UDP-N-acetylgalactosamine. Biochemistry. 2008 Apr 8; 47(14):4337-44.
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  8. Uccelletti D, Pascoli A, Farina F, Alberti A, Mancini P, Hirschberg CB, Palleschi C. APY-1, a novel Caenorhabditis elegans apyrase involved in unfolded protein response signalling and stress responses. Mol Biol Cell. 2008 Apr; 19(4):1337-45.
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  9. Caffaro CE, Hirschberg CB, Berninsone PM. Functional redundancy between two Caenorhabditis elegans nucleotide sugar transporters with a novel transport mechanism. J Biol Chem. 2007 Sep 21; 282(38):27970-5.
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  10. Caffaro CE, Hirschberg CB. Nucleotide sugar transporters of the Golgi apparatus: from basic science to diseases. Acc Chem Res. 2006 Nov; 39(11):805-12.
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  11. Caffaro CE, Hirschberg CB, Berninsone PM. Independent and simultaneous translocation of two substrates by a nucleotide sugar transporter. Proc Natl Acad Sci U S A. 2006 Oct 31; 103(44):16176-81.
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  12. Bredeston LM, Caffaro CE, Samuelson J, Hirschberg CB. Golgi and endoplasmic reticulum functions take place in different subcellular compartments of Entamoeba histolytica. J Biol Chem. 2005 Sep 16; 280(37):32168-76.
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  13. Cipollo JF, Awad AM, Costello CE, Hirschberg CB. N-Glycans of Caenorhabditis elegans are specific to developmental stages. J Biol Chem. 2005 Jul 15; 280(28):26063-72.
    View in: PubMed
  14. Cipollo JF, Awad AM, Costello CE, Hirschberg CB. srf-3, a mutant of Caenorhabditis elegans, resistant to bacterial infection and to biofilm binding, is deficient in glycoconjugates. J Biol Chem. 2004 Dec 17; 279(51):52893-903.
    View in: PubMed
  15. Höflich J, Berninsone P, Göbel C, Gravato-Nobre MJ, Libby BJ, Darby C, Politz SM, Hodgkin J, Hirschberg CB, Baumeister R. Loss of srf-3-encoded nucleotide sugar transporter activity in Caenorhabditis elegans alters surface antigenicity and prevents bacterial adherence. J Biol Chem. 2004 Jul 16; 279(29):30440-8.
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  16. Uccelletti D, O''Callaghan C, Berninsone P, Zemtseva I, Abeijon C, Hirschberg CB. ire-1-dependent transcriptional up-regulation of a lumenal uridine diphosphatase from Caenorhabditis elegans. J Biol Chem. 2004 Jun 25; 279(26):27390-8.
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  17. Cipollo JF, Awad A, Costello CE, Robbins PW, Hirschberg CB. Biosynthesis in vitro of Caenorhabditis elegans phosphorylcholine oligosaccharides. Proc Natl Acad Sci U S A. 2004 Mar 9; 101(10):3404-8.
    View in: PubMed
  18. Cipollo JF, Costello CE, Hirschberg CB. The fine structure of Caenorhabditis elegans N-glycans. J Biol Chem. 2002 Dec 20; 277(51):49143-57.
    View in: PubMed
  19. Etzioni A, Sturla L, Antonellis A, Green ED, Gershoni-Baruch R, Berninsone PM, Hirschberg CB, Tonetti M. Leukocyte adhesion deficiency (LAD) type II/carbohydrate deficient glycoprotein (CDG) IIc founder effect and genotype/phenotype correlation. Am J Med Genet. 2002 Jun 15; 110(2):131-5.
    View in: PubMed
  20. Herrero AB, Uccelletti D, Hirschberg CB, Dominguez A, Abeijon C. The Golgi GDPase of the fungal pathogen Candida albicans affects morphogenesis, glycosylation, and cell wall properties. Eukaryot Cell. 2002 Jun; 1(3):420-31.
    View in: PubMed
  21. Norambuena L, Marchant L, Berninsone P, Hirschberg CB, Silva H, Orellana A. Transport of UDP-galactose in plants. Identification and functional characterization of AtUTr1, an Arabidopsis thaliana UDP-galactos/UDP-glucose transporter. J Biol Chem. 2002 Sep 6; 277(36):32923-9.
    View in: PubMed
  22. Berninsone PM, Hirschberg CB. The nematode Caenorhabditis elegans as a model to study the roles of proteoglycans. Glycoconj J. 2002 May-Jun; 19(4-5):325-30.
    View in: PubMed
  23. Hirschberg CB. Golgi nucleotide sugar transport and leukocyte adhesion deficiency II. J Clin Invest. 2001 Jul; 108(1):3-6.
    View in: PubMed
  24. Lopez-Avalos MD, Uccelletti D, Abeijon C, Hirschberg CB. The UDPase activity of the Kluyveromyces lactis Golgi GDPase has a role in uridine nucleotide sugar transport into Golgi vesicles. Glycobiology. 2001 May; 11(5):413-22.
    View in: PubMed
  25. Sturla L, Puglielli L, Tonetti M, Berninsone P, Hirschberg CB, De Flora A, Etzioni A. Impairment of the Golgi GDP-L-fucose transport and unresponsiveness to fucose replacement therapy in LAD II patients. Pediatr Res. 2001 Apr; 49(4):537-42.
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  26. Berninsone P, Hwang HY, Zemtseva I, Horvitz HR, Hirschberg CB. SQV-7, a protein involved in Caenorhabditis elegans epithelial invagination and early embryogenesis, transports UDP-glucuronic acid, UDP-N- acetylgalactosamine, and UDP-galactose. Proc Natl Acad Sci U S A. 2001 Mar 27; 98(7):3738-43.
    View in: PubMed
  27. Berninsone PM, Hirschberg CB. Nucleotide sugar transporters of the Golgi apparatus. Curr Opin Struct Biol. 2000 Oct; 10(5):542-7.
    View in: PubMed
  28. Puglielli L, Hirschberg CB. Reconstitution, identification, and purification of the rat liver golgi membrane GDP-fucose transporter. J Biol Chem. 1999 Dec 10; 274(50):35596-600.
    View in: PubMed
  29. Puglielli L, Mandon EC, Hirschberg CB. Identification, purification, and characterization of the rat liver golgi membrane ATP transporter. J Biol Chem. 1999 Apr 30; 274(18):12665-9.
    View in: PubMed
  30. Guillen E, Abeijon C, Hirschberg CB. The genes for the Golgi apparatus N-acetylglucosaminyltransferase and the UDP-N-acetylglucosamine transporter are contiguous in Kluyveromyces lactis. J Biol Chem. 1999 Mar 5; 274(10):6641-6.
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  31. Puglielli L, Mandon EC, Rancour DM, Menon AK, Hirschberg CB. Identification and purification of the rat liver Golgi membrane UDP-N-acetylgalactosamine transporter. J Biol Chem. 1999 Feb 12; 274(7):4474-9.
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  32. Berninsone P, Hirschberg CB. Heparan sulfate/heparin N-deacetylase/N-sulfotransferase. The N-sulfotransferase activity domain is at the carboxyl half of the holoenzyme. J Biol Chem. 1998 Oct 2; 273(40):25556-9.
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  33. Toma L, Berninsone P, Hirschberg CB. The putative heparin-specific N-acetylglucosaminyl N-Deacetylase/N-sulfotransferase also occurs in non-heparin-producing cells. J Biol Chem. 1998 Aug 28; 273(35):22458-65.
    View in: PubMed
  34. Guillen E, Abeijon C, Hirschberg CB. Mammalian Golgi apparatus UDP-N-acetylglucosamine transporter: molecular cloning by phenotypic correction of a yeast mutant. Proc Natl Acad Sci U S A. 1998 Jul 7; 95(14):7888-92.
    View in: PubMed
  35. Berninsone P, Hirschberg CB. Nucleotide sugars, nucleotide sulfate, and ATP transporters of the endoplasmic reticulum and Golgi apparatus. Ann N Y Acad Sci. 1998 Apr 15; 842:91-9.
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  36. Hirschberg CB, Robbins PW, Abeijon C. Transporters of nucleotide sugars, ATP, and nucleotide sulfate in the endoplasmic reticulum and Golgi apparatus. Annu Rev Biochem. 1998; 67:49-69.
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  37. Abeijon C, Mandon EC, Hirschberg CB. Transporters of nucleotide sugars, nucleotide sulfate and ATP in the Golgi apparatus. Trends Biochem Sci. 1997 Jun; 22(6):203-7.
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  38. Berninsone P, Eckhardt M, Gerardy-Schahn R, Hirschberg CB. Functional expression of the murine Golgi CMP-sialic acid transporter in saccharomyces cerevisiae. J Biol Chem. 1997 May 9; 272(19):12616-9.
    View in: PubMed
  39. Hirschberg CB. Transporters of nucleotide sugars, nucleotide sulfate and ATP in the Golgi apparatus membrane: where next? Glycobiology. 1997 Mar; 7(2):169-71.
    View in: PubMed
  40. Abeijon C, Robbins PW, Hirschberg CB. Molecular cloning of the Golgi apparatus uridine diphosphate-N-acetylglucosamine transporter from Kluyveromyces lactis. Proc Natl Acad Sci U S A. 1996 Jun 11; 93(12):5963-8.
    View in: PubMed
  41. Abeijon C, Mandon EC, Robbins PW, Hirschberg CB. A mutant yeast deficient in Golgi transport of uridine diphosphate N-acetylglucosamine. J Biol Chem. 1996 Apr 12; 271(15):8851-4.
    View in: PubMed
  42. Toma L, Pinhal MA, Dietrich CP, Nader HB, Hirschberg CB. Transport of UDP-galactose into the Golgi lumen regulates the biosynthesis of proteoglycans. J Biol Chem. 1996 Feb 16; 271(7):3897-901.
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  43. Hirschberg CB. Transporters of nucleotides and nucleotide derivatives in the endoplasmic reticulum and Golgi apparatus. Soc Gen Physiol Ser. 1996; 51:105-20.
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  44. Berninsone P, Lin ZY, Kempner E, Hirschberg CB. Regulation of yeast Golgi glycosylation. Guanosine diphosphatase functions as a homodimer in the membrane. J Biol Chem. 1995 Jun 16; 270(24):14564-7.
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  45. Guillén E, Hirschberg CB. Transport of adenosine triphosphate into endoplasmic reticulum proteoliposomes. Biochemistry. 1995 Apr 25; 34(16):5472-6.
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  46. Mandon EC, Milla ME, Kempner E, Hirschberg CB. Purification of the Golgi adenosine 3'-phosphate 5'-phosphosulfate transporter, a homodimer within the membrane. Proc Natl Acad Sci U S A. 1994 Oct 25; 91(22):10707-11.
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  47. Mandon E, Kempner ES, Ishihara M, Hirschberg CB. A monomeric protein in the Golgi membrane catalyzes both N-deacetylation and N-sulfation of heparan sulfate. J Biol Chem. 1994 Apr 22; 269(16):11729-33.
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  48. Orellana A, Hirschberg CB, Wei Z, Swiedler SJ, Ishihara M. Molecular cloning and expression of a glycosaminoglycan N-acetylglucosaminyl N-deacetylase/N-sulfotransferase from a heparin-producing cell line. J Biol Chem. 1994 Jan 21; 269(3):2270-6.
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  49. Berninsone P, Miret JJ, Hirschberg CB. The Golgi guanosine diphosphatase is required for transport of GDP-mannose into the lumen of Saccharomyces cerevisiae Golgi vesicles. J Biol Chem. 1994 Jan 7; 269(1):207-11.
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  50. Ishihara M, Guo Y, Wei Z, Yang Z, Swiedler SJ, Orellana A, Hirschberg CB. Regulation of biosynthesis of the basic fibroblast growth factor binding domains of heparan sulfate by heparan sulfate-N-deacetylase/N-sulfotransferase expression. J Biol Chem. 1993 Sep 25; 268(27):20091-5.
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  51. Abeijon C, Yanagisawa K, Mandon EC, Häusler A, Moremen K, Hirschberg CB, Robbins PW. Guanosine diphosphatase is required for protein and sphingolipid glycosylation in the Golgi lumen of Saccharomyces cerevisiae. J Cell Biol. 1993 Jul; 122(2):307-23.
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  52. Wei Z, Swiedler SJ, Ishihara M, Orellana A, Hirschberg CB. A single protein catalyzes both N-deacetylation and N-sulfation during the biosynthesis of heparan sulfate. Proc Natl Acad Sci U S A. 1993 May 1; 90(9):3885-8.
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  53. Olofsson S, Sjöblom I, Hellstrand K, Shugar D, Clairmont C, Hirschberg C. 5-Propyl-2-deoxyuridine induced interference with glycosylation in herpes simplex virus infected cells. Nature of PdU-induced modifications of N-linked glycans. Arch Virol. 1993; 128(3-4):241-56.
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  54. Hashimoto Y, Orellana A, Gil G, Hirschberg CB. Molecular cloning and expression of rat liver N-heparan sulfate sulfotransferase. J Biol Chem. 1992 Aug 5; 267(22):15744-50.
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  55. Hashimoto Y, Hirschberg CB. [Purification of N-sulfotransferase]. Tanpakushitsu Kakusan Koso. 1992 Aug; 37(11 Suppl):1701-6.
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  56. Clairmont CA, De Maio A, Hirschberg CB. Translocation of ATP into the lumen of rough endoplasmic reticulum-derived vesicles and its binding to luminal proteins including BiP (GRP 78) and GRP 94. J Biol Chem. 1992 Feb 25; 267(6):3983-90.
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  57. Milla ME, Clairmont CA, Hirschberg CB. Reconstitution into proteoliposomes and partial purification of the Golgi apparatus membrane UDP-galactose, UDP-xylose, and UDP-glucuronic acid transport activities. J Biol Chem. 1992 Jan 5; 267(1):103-7.
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  58. Abeijon C, Hirschberg CB. Topography of glycosylation reactions in the endoplasmic reticulum. Trends Biochem Sci. 1992 Jan; 17(1):32-6.
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  59. Yanagisawa K, Resnick D, Abeijon C, Robbins PW, Hirschberg CB. A guanosine diphosphatase enriched in Golgi vesicles of Saccharomyces cerevisiae. Purification and characterization. J Biol Chem. 1990 Nov 5; 265(31):19351-5.
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  60. Abeijon C, Hirschberg CB. Topography of initiation of N-glycosylation reactions. J Biol Chem. 1990 Aug 25; 265(24):14691-5.
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  61. Perelman A, Abeijon C, Hirschberg CB, Inestrosa NC, Brandan E. Differential association and distribution of acetyl- and butyrylcholinesterases within rat liver subcellular organelles. J Biol Chem. 1990 Jan 5; 265(1):214-20.
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  62. Abeijon C, Orlean P, Robbins PW, Hirschberg CB. Topography of glycosylation in yeast: characterization of GDPmannose transport and lumenal guanosine diphosphatase activities in Golgi-like vesicles. Proc Natl Acad Sci U S A. 1989 Sep; 86(18):6935-9.
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  63. Brandan E, Hirschberg CB. Differential association of rat liver heparan sulfate proteoglycans in membranes of the Golgi apparatus and the plasma membrane. J Biol Chem. 1989 Jun 25; 264(18):10520-6.
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  64. Milla M, Capasso J, Hirschberg CB. Translocation of nucleotide sugars and nucleotide sulphate across membranes of the endoplasmic reticulum and Golgi apparatus. Biochem Soc Trans. 1989 Jun; 17(3):447-8.
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  65. Capasso JM, Keenan TW, Abeijon C, Hirschberg CB. Mechanism of phosphorylation in the lumen of the Golgi apparatus. Translocation of adenosine 5'-triphosphate into Golgi vesicles from rat liver and mammary gland. J Biol Chem. 1989 Mar 25; 264(9):5233-40.
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  66. Milla ME, Hirschberg CB. Reconstitution of Golgi vesicle CMP-sialic acid and adenosine 3'-phosphate 5'-phosphosulfate transport into proteoliposomes. Proc Natl Acad Sci U S A. 1989 Mar; 86(6):1786-90.
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  67. Capasso JM, Abeijon C, Hirschberg CB. An intrinsic membrane glycoprotein of the golgi apparatus with O-linked N-acetylglucosamine facing the cytosol. J Biol Chem. 1988 Dec 25; 263(36):19778-82.
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  68. Olofsson S, Milla M, Hirschberg C, De Clercq E, Datema R. Inhibition of terminal N- and O-glycosylation specific for herpesvirus-infected cells: mechanism of an inhibitor of sugar nucleotide transport across Golgi membranes. Virology. 1988 Oct; 166(2):440-50.
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  69. Brandan E, Hirschberg CB. Purification of rat liver N-heparan-sulfate sulfotransferase. J Biol Chem. 1988 Feb 15; 263(5):2417-22.
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  70. Abeijon C, Hirschberg CB. Intrinsic membrane glycoproteins with cytosol-oriented sugars in the endoplasmic reticulum. Proc Natl Acad Sci U S A. 1988 Feb; 85(4):1010-4.
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  71. Abeijon C, Hirschberg CB. Subcellular site of synthesis of the N-acetylgalactosamine (alpha 1-0) serine (or threonine) linkage in rat liver. J Biol Chem. 1987 Mar 25; 262(9):4153-9.
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  72. Hirschberg CB, Snider MD. Topography of glycosylation in the rough endoplasmic reticulum and Golgi apparatus. Annu Rev Biochem. 1987; 56:63-87.
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  73. Perez M, Hirschberg CB. Transport of sugar nucleotides into the lumen of vesicles derived from rat liver rough endoplasmic reticulum and Golgi apparatus. Methods Enzymol. 1987; 138:709-15.
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  74. Nuwayhid N, Glaser JH, Johnson JC, Conrad HE, Hauser SC, Hirschberg CB. Xylosylation and glucuronosylation reactions in rat liver Golgi apparatus and endoplasmic reticulum. J Biol Chem. 1986 Oct 5; 261(28):12936-41.
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  75. Perez M, Hirschberg CB. Transport of sugar nucleotides and adenosine 3'-phosphate 5'-phosphosulfate into vesicles derived from the Golgi apparatus. Biochim Biophys Acta. 1986 Sep 22; 864(2):213-22.
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  76. Abeijon C, Capasso JM, Tal D, Vann WF, Hirschberg CB. 3'-O-(4-benzoyl)benzoylcytidine 5'-triphosphate. A substrate and photoaffinity label for CMP-N-acetylneuraminic acid synthetase. J Biol Chem. 1986 Aug 25; 261(24):11374-7.
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  77. Abeijon C, Capasso JM, Hirschberg CB. High-performance ion-exchange chromatographic separation of cytidine monophosphate-N-acetylneuraminic acid and cytidine nucleotides. J Chromatogr. 1986 Jun 6; 360(1):293-7.
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  78. Perez M, Hirschberg CB. Topography of glycosylation reactions in the rough endoplasmic reticulum membrane. J Biol Chem. 1986 May 25; 261(15):6822-30.
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  79. Deutscher SL, Hirschberg CB. Mechanism of galactosylation in the Golgi apparatus. A Chinese hamster ovary cell mutant deficient in translocation of UDP-galactose across Golgi vesicle membranes. J Biol Chem. 1986 Jan 5; 261(1):96-100.
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  80. Capasso JM, Abeijon C, Hirschberg CB. Phosphoproteins and protein kinases of the Golgi apparatus membrane. J Biol Chem. 1985 Nov 25; 260(27):14879-84.
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  81. Perez M, Hirschberg CB. Translocation of UDP-N-acetylglucosamine into vesicles derived from rat liver rough endoplasmic reticulum and Golgi apparatus. J Biol Chem. 1985 Apr 25; 260(8):4671-8.
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  82. Deutscher SL, Nuwayhid N, Stanley P, Briles EI, Hirschberg CB. Translocation across Golgi vesicle membranes: a CHO glycosylation mutant deficient in CMP-sialic acid transport. Cell. 1984 Dec; 39(2 Pt 1):295-9.
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  83. Capasso JM, Hirschberg CB. Mechanisms of glycosylation and sulfation in the Golgi apparatus: evidence for nucleotide sugar/nucleoside monophosphate and nucleotide sulfate/nucleoside monophosphate antiports in the Golgi apparatus membrane. Proc Natl Acad Sci U S A. 1984 Nov; 81(22):7051-5.
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  84. Capasso JM, Hirschberg CB. Effect of nucleotides on translocation of sugar nucleotides and adenosine 3'-phosphate 5'-phosphosulfate into Golgi apparatus vesicles. Biochim Biophys Acta. 1984 Oct 17; 777(1):133-9.
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  85. Capasso JM, Hirschberg CB. Effect of atractylosides, palmitoyl coenzyme A, and anion transport inhibitors on translocation of nucleotide sugars and nucleotide sulfate into Golgi vesicles. J Biol Chem. 1984 Apr 10; 259(7):4263-6.
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  86. Schwarz JK, Capasso JM, Hirschberg CB. Translocation of adenosine 3'-phosphate 5'-phosphosulfate into rat liver Golgi vesicles. J Biol Chem. 1984 Mar 25; 259(6):3554-9.
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  87. Deutscher SL, Creek KE, Merion M, Hirschberg CB. Subfractionation of rat liver Golgi apparatus: separation of enzyme activities involved in the biosynthesis of the phosphomannosyl recognition marker in lysosomal enzymes. Proc Natl Acad Sci U S A. 1983 Jul; 80(13):3938-42.
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  88. Sommers LW, Hirschberg CB. Transport of sugar nucleotides into rat liver Golgi. A new Golgi marker activity. J Biol Chem. 1982 Sep 25; 257(18):10811-7.
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  89. Hirschberg CB, Perez M, Snider M, Hanneman WL, Esko J, Raetz CR. Autoradiographic detection and characterization of a Chinese hamster ovary cell mutant deficient in fucoproteins. J Cell Physiol. 1982 Jun; 111(3):255-63.
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  90. Baker RM, Hirschberg CB, O'Brien WA, Awerbuch TE, Watson D. Isolation of somatic cell glycoprotein mutants. Methods Enzymol. 1982; 83:444-58.
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  91. Hirschberg CB, Baker RM, Perez M, Spencer LA, Watson D. Selection of mutant Chinese hamster ovary cells altered glycoproteins by means of tritiated fucose suicide. Mol Cell Biol. 1981 Oct; 1(10):902-9.
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  92. Carey DJ, Hirschberg CB. Topography of sialoglycoproteins and sialyltransferases in mouse and rat liver Golgi. J Biol Chem. 1981 Jan 25; 256(2):989-93.
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  93. Carey DJ, Hirschberg CB. Kinetics of glycosylation and intracellular transport of sialoglycoproteins in mouse liver. J Biol Chem. 1980 May 10; 255(9):4348-54.
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  94. Carey DJ, Hirschberg CB. Metabolism of N-acetylneuraminic acid in mammals: isolation and characterization of CMP-N-acetylneuraminic acid. Biochemistry. 1979 May 15; 18(10):2086-92.
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  95. Hirschberg CB, Goodman SR, Green C. Sialic acid uptake by fibroblasts. Biochemistry. 1976 Aug 10; 15(16):3591-9.
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  96. Hirschberg CB, Wolf BA, Robbins PW. Synthesis of glycolipids and phospholipids in hamster cells: dependence on cell density and the cell cycle. J Cell Physiol. 1975 Feb; 85(1):31-9.
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  97. Robbins PW, Wickus GG, Branton PE, Gaffney BJ, Hirschberg CB, Fuchs P, Blumberg P. The chick fibroblast cell surface after transformation by Rous sarcoma virus. Cold Spring Harb Symp Quant Biol. 1975; 39 Pt 2:1173-80.
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  98. Hirschberg CB, Robbins PW. The glycolipids and phospholipids of Sindbis virus and their relation to the lipids of the host cell plasma membrane. Virology. 1974 Oct; 61(2):602-8.
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  99. Raetz CR, Hirschberg CB, Dowhan W, Wickner WT, Kennedy EP. A membrane-bound pyrophosphatase in Escherichia coli catalyzing the hydrolysis of cytidine diphosphate-diglyceride. J Biol Chem. 1972 Apr 10; 247(7):2245-7.
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  100. Carter HE, Hirschberg CB. Phytosphingosines and branched sphingosines in kidney. Biochemistry. 1968 Jun; 7(6):2296-300.
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