Keywords
Last Name

John C Samuelson, MD, PhD

TitleProfessor
InstitutionBoston University Goldman School of Dental Medicine
DepartmentMolecular & Cell Biology
Address75 E. Newton St Evans Building
Boston MA 02118
Phone(617) 414-1054
ORCID ORCID Icon0000-0001-9533-3040
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine
DepartmentGraduate Medical Sciences, Division of

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentMicrobiology

TitleMember
InstitutionBoston University
DepartmentBioinformatics Graduate Program

 Research Expertise & Professional Interests
Entamoeba histolytica, Giardia lamblia, and Trichomonas are simple eukaryotes, which cause dysentery, diarrhea, and vaginitis, respectively. Our laboratory uses molecular biological methods to study the biochemistry, cell biology, pathogenesis, and evolution of these important human pathogens.

One project attempts to determine the composition of the walls of Entamoeba cysts, which are the infectious and diagnostic form. Chitin in cyst wall is made by stage-specific chitin synthases and is modified by endogenous chitin deacetylases and chitinases. Chitin fibrils in the wall are held together unique lectins , which have multiple chitin-binding domains. Post-translation modifications of the cyst wall lectins include addition of unusual O-phosphodiester-linked sugars and cleavages between chitin-binding domains. Identification of these cyst wall-associated lectins may lead to better diagnostic reagents for distinguishing pathogenic from non-pathogenic amebae.

A second project, which is performed in collaboration with my colleague Phillips Robbins, attempts to understand Asn-linked glycosylation in Entamoeba, Giardia, and other protists . In particular, we use bioinformatics to predict lipid-linked N-glycan precursors, as well as N-glycan associated proteins involved in quality control in the ER lumen. We test our predictions using biochemical methods, which include determinations of carbohydrate structures and purification of glycoproteins by lectin columns. These studies suggest 1) the present diversity of N-glycans derives in part from secondary loss of genes encoding enzyme involved in N-glycan precursor synthesis, 2) protists with short N-glycans lack N-glycan-dependent quality control, and 3) there is Darwinian selection for sites of N-glycans in secreted proteins of diverse eukaryotes and viruses. Unique parasite sugars may be novel vaccine candidates or targets for anti-microbial lectins.

A third project is concerned with how Entamoeba, Giardia, and Trichomonas adapt to the anaerobic environment in the intestinal lumen. We have identified an atrophic mitochondrion-derived organelle, which lacks enzymes of oxidative phosphorylation in Entamoeba. We have also identified numerous bacterium-like fermentation enzymes in these protists, which appear to have been obtained by lateral gene transfer (LGT). Although LGT is frequent between bacteria, it is unusual between bacteria and eukaryotes. Two of the bacterial genes acquired by LGT appear to be important for activating and inactivating metronidazole, the best drug against these organisms.



 NIH RePORTER Grants
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Samuelson J, Bushkin GG, Chatterjee A, Robbins PW. Strategies to discover the structural components of cyst and oocyst walls. Eukaryot Cell. 2013 Dec; 12(12):1578-87.
    View in: PubMed
  2. Bushkin GG, Motari E, Carpentieri A, Dubey JP, Costello CE, Robbins PW, Samuelson J. Evidence for a structural role for acid-fast lipids in oocyst walls of Cryptosporidium, Toxoplasma, and Eimeria. MBio. 2013; 4(5):e00387-13.
    View in: PubMed
  3. Bushkin GG, Motari E, Magnelli P, Gubbels MJ, Dubey JP, Miska KB, Bullitt E, Costello CE, Robbins PW, Samuelson J. ß-1,3-glucan, which can be targeted by drugs, forms a trabecular scaffold in the oocyst walls of Toxoplasma and Eimeria. MBio. 2012; 3(5).
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  4. Samuelson J, Robbins P. A simple fibril and lectin model for cyst walls of Entamoeba and perhaps Giardia. Trends Parasitol. 2011 Jan; 27(1):17-22.
    View in: PubMed
  5. Szmola R, Bence M, Carpentieri A, Szabó A, Costello CE, Samuelson J, Sahin-Tóth M. Chymotrypsin C is a co-activator of human pancreatic procarboxypeptidases A1 and A2. J Biol Chem. 2011 Jan 21; 286(3):1819-27.
    View in: PubMed
  6. Carpentieri A, Ratner DM, Ghosh SK, Banerjee S, Bushkin GG, Cui J, Lubrano M, Steffen M, Costello CE, O'Keefe B, Robbins PW, Samuelson J. The antiretroviral lectin cyanovirin-N targets well-known and novel targets on the surface of Entamoeba histolytica trophozoites. Eukaryot Cell. 2010 Nov; 9(11):1661-8.
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  7. Chatterjee A, Carpentieri A, Ratner DM, Bullitt E, Costello CE, Robbins PW, Samuelson J. Giardia cyst wall protein 1 is a lectin that binds to curled fibrils of the GalNAc homopolymer. PLoS Pathog. 2010; 6(8):e1001059.
    View in: PubMed
  8. Cui J, Das S, Smith TF, Samuelson J. Trichomonas transmembrane cyclases result from massive gene duplication and concomitant development of pseudogenes. PLoS Negl Trop Dis. 2010; 4(8):e782.
    View in: PubMed
  9. Ghosh SK, Van Dellen KL, Chatterjee A, Dey T, Haque R, Robbins PW, Samuelson J. The Jacob2 lectin of the Entamoeba histolytica cyst wall binds chitin and is polymorphic. PLoS Negl Trop Dis. 2010; 4(7):e750.
    View in: PubMed
  10. Mitra S, Cui J, Robbins PW, Samuelson J. A deeply divergent phosphoglucomutase (PGM) of Giardia lamblia has both PGM and phosphomannomutase activities. Glycobiology. 2010 Oct; 20(10):1233-40.
    View in: PubMed
  11. Grabinska KA, Cui J, Chatterjee A, Guan Z, Raetz CR, Robbins PW, Samuelson J. Molecular characterization of the cis-prenyltransferase of Giardia lamblia. Glycobiology. 2010 Jul; 20(7):824-32.
    View in: PubMed
  12. Chatterjee A, Banerjee S, Steffen M, O'Connor RM, Ward HD, Robbins PW, Samuelson J. Evidence for mucin-like glycoproteins that tether sporozoites of Cryptosporidium parvum to the inner surface of the oocyst wall. Eukaryot Cell. 2010 Jan; 9(1):84-96.
    View in: PubMed
  13. Bushkin GG, Ratner DM, Cui J, Banerjee S, Duraisingh MT, Jennings CV, Dvorin JD, Gubbels MJ, Robertson SD, Steffen M, O'Keefe BR, Robbins PW, Samuelson J. Suggestive evidence for Darwinian Selection against asparagine-linked glycans of Plasmodium falciparum and Toxoplasma gondii. Eukaryot Cell. 2010 Feb; 9(2):228-41.
    View in: PubMed
  14. Cui J, Smith T, Robbins PW, Samuelson J. Darwinian selection for sites of Asn-linked glycosylation in phylogenetically disparate eukaryotes and viruses. Proc Natl Acad Sci U S A. 2009 Aug 11; 106(32):13421-6.
    View in: PubMed
  15. Chatterjee A, Ghosh SK, Jang K, Bullitt E, Moore L, Robbins PW, Samuelson J. Evidence for a "wattle and daub" model of the cyst wall of entamoeba. PLoS Pathog. 2009 Jul; 5(7):e1000498.
    View in: PubMed
  16. Pal D, Banerjee S, Cui J, Schwartz A, Ghosh SK, Samuelson J. Giardia, Entamoeba, and Trichomonas enzymes activate metronidazole (nitroreductases) and inactivate metronidazole (nitroimidazole reductases). Antimicrob Agents Chemother. 2009 Feb; 53(2):458-64.
    View in: PubMed
  17. Banerjee S, Robbins PW, Samuelson J. Molecular characterization of nucleocytosolic O-GlcNAc transferases of Giardia lamblia and Cryptosporidium parvum. Glycobiology. 2009 Apr; 19(4):331-6.
    View in: PubMed
  18. Ratner DM, Cui J, Steffen M, Moore LL, Robbins PW, Samuelson J. Changes in the N-glycome, glycoproteins with Asn-linked glycans, of Giardia lamblia with differentiation from trophozoites to cysts. Eukaryot Cell. 2008 Nov; 7(11):1930-40.
    View in: PubMed
  19. Grabinska KA, Ghosh SK, Guan Z, Cui J, Raetz CR, Robbins PW, Samuelson J. Dolichyl-phosphate-glucose is used to make O-glycans on glycoproteins of Trichomonas vaginalis. Eukaryot Cell. 2008 Aug; 7(8):1344-51.
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  20. Magnelli P, Cipollo JF, Ratner DM, Cui J, Kelleher D, Gilmore R, Costello CE, Robbins PW, Samuelson J. Unique Asn-linked oligosaccharides of the human pathogen Entamoeba histolytica. J Biol Chem. 2008 Jun 27; 283(26):18355-64.
    View in: PubMed
  21. Caffaro CE, Luhn K, Bakker H, Vestweber D, Samuelson J, Berninsone P, Hirschberg CB. A single Caenorhabditis elegans Golgi apparatus-type transporter of UDP-glucose, UDP-galactose, UDP-N-acetylglucosamine, and UDP-N-acetylgalactosamine. Biochemistry. 2008 Apr 8; 47(14):4337-44.
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  22. Banerjee S, Cui J, Robbins PW, Samuelson J. Use of Giardia, which appears to have a single nucleotide-sugar transporter for UDP-GlcNAc, to identify the UDP-Glc transporter of Entamoeba. Mol Biochem Parasitol. 2008 May; 159(1):44-53.
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  23. Morrison HG, McArthur AG, Gillin FD, Aley SB, Adam RD, Olsen GJ, Best AA, Cande WZ, Chen F, Cipriano MJ, Davids BJ, Dawson SC, Elmendorf HG, Hehl AB, Holder ME, Huse SM, Kim UU, Lasek-Nesselquist E, Manning G, Nigam A, Nixon JE, Palm D, Passamaneck NE, Prabhu A, Reich CI, Reiner DS, Samuelson J, Svard SG, Sogin ML. Genomic minimalism in the early diverging intestinal parasite Giardia lamblia. Science. 2007 Sep 28; 317(5846):1921-6.
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  24. Banerjee S, Vishwanath P, Cui J, Kelleher DJ, Gilmore R, Robbins PW, Samuelson J. The evolution of N-glycan-dependent endoplasmic reticulum quality control factors for glycoprotein folding and degradation. Proc Natl Acad Sci U S A. 2007 Jul 10; 104(28):11676-81.
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  25. Catic A, Sun ZY, Ratner DM, Misaghi S, Spooner E, Samuelson J, Wagner G, Ploegh HL. Sequence and structure evolved separately in a ribosomal ubiquitin variant. EMBO J. 2007 Jul 25; 26(14):3474-83.
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  26. Kelleher DJ, Banerjee S, Cura AJ, Samuelson J, Gilmore R. Dolichol-linked oligosaccharide selection by the oligosaccharyltransferase in protist and fungal organisms. J Cell Biol. 2007 Apr 9; 177(1):29-37.
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  27. Clark CG, Alsmark UC, Tazreiter M, Saito-Nakano Y, Ali V, Marion S, Weber C, Mukherjee C, Bruchhaus I, Tannich E, Leippe M, Sicheritz-Ponten T, Foster PG, Samuelson J, Noël CJ, Hirt RP, Embley TM, Gilchrist CA, Mann BJ, Singh U, Ackers JP, Bhattacharya S, Bhattacharya A, Lohia A, Guillén N, Duchêne M, Nozaki T, Hall N. Structure and content of the Entamoeba histolytica genome. Adv Parasitol. 2007; 65:51-190.
    View in: PubMed
  28. Cui J, Smith TF, Samuelson J. Gene expansion in Trichomonas vaginalis: a case study on transmembrane cyclases. Genome Inform. 2007; 18:35-43.
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  29. Van Dellen KL, Chatterjee A, Ratner DM, Magnelli PE, Cipollo JF, Steffen M, Robbins PW, Samuelson J. Unique posttranslational modifications of chitin-binding lectins of Entamoeba invadens cyst walls. Eukaryot Cell. 2006 May; 5(5):836-48.
    View in: PubMed
  30. Das S, Van Dellen K, Bulik D, Magnelli P, Cui J, Head J, Robbins PW, Samuelson J. The cyst wall of Entamoeba invadens contains chitosan (deacetylated chitin). Mol Biochem Parasitol. 2006 Jul; 148(1):86-92.
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  31. Van Dellen KL, Bulik DA, Specht CA, Robbins PW, Samuelson JC. Heterologous expression of an Entamoeba histolytica chitin synthase in Saccharomyces cerevisiae. Eukaryot Cell. 2006 Jan; 5(1):203-6.
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  32. Anderson IJ, Watkins RF, Samuelson J, Spencer DF, Majoros WH, Gray MW, Loftus BJ. Gene discovery in the Acanthamoeba castellanii genome. Protist. 2005 Aug; 156(2):203-14.
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  33. Bredeston LM, Caffaro CE, Samuelson J, Hirschberg CB. Golgi and endoplasmic reticulum functions take place in different subcellular compartments of Entamoeba histolytica. J Biol Chem. 2005 Sep 16; 280(37):32168-76.
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  34. Robbins PW, Samuelson J. Asparagine linked glycosylation in Giardia. Glycobiology. 2005 Jun; 15(6):15G-16G.
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  35. Loftus B, Anderson I, Davies R, Alsmark UC, Samuelson J, Amedeo P, Roncaglia P, Berriman M, Hirt RP, Mann BJ, Nozaki T, Suh B, Pop M, Duchene M, Ackers J, Tannich E, Leippe M, Hofer M, Bruchhaus I, Willhoeft U, Bhattacharya A, Chillingworth T, Churcher C, Hance Z, Harris B, Harris D, Jagels K, Moule S, Mungall K, Ormond D, Squares R, Whitehead S, Quail MA, Rabbinowitsch E, Norbertczak H, Price C, Wang Z, Guillén N, Gilchrist C, Stroup SE, Bhattacharya S, Lohia A, Foster PG, Sicheritz-Ponten T, Weber C, Singh U, Mukherjee C, El-Sayed NM, Petri WA, Clark CG, Embley TM, Barrell B, Fraser CM, Hall N. The genome of the protist parasite Entamoeba histolytica. Nature. 2005 Feb 24; 433(7028):865-8.
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  36. Samuelson J, Banerjee S, Magnelli P, Cui J, Kelleher DJ, Gilmore R, Robbins PW. The diversity of dolichol-linked precursors to Asn-linked glycans likely results from secondary loss of sets of glycosyltransferases. Proc Natl Acad Sci U S A. 2005 Feb 1; 102(5):1548-53.
    View in: PubMed
  37. Wang Z, Samuelson J, Clark CG, Eichinger D, Paul J, Van Dellen K, Hall N, Anderson I, Loftus B. Gene discovery in the Entamoeba invadens genome. Mol Biochem Parasitol. 2003 Jun; 129(1):23-31.
    View in: PubMed
  38. Nixon JE, Field J, McArthur AG, Sogin ML, Yarlett N, Loftus BJ, Samuelson J. Iron-dependent hydrogenases of Entamoeba histolytica and Giardia lamblia: activity of the recombinant entamoebic enzyme and evidence for lateral gene transfer. Biol Bull. 2003 Feb; 204(1):1-9.
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  39. Van Dellen K, Field J, Wang Z, Loftus B, Samuelson J. LINEs and SINE-like elements of the protist Entamoeba histolytica. Gene. 2002 Sep 4; 297(1-2):229-39.
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  40. Van Dellen K, Ghosh SK, Robbins PW, Loftus B, Samuelson J. Entamoeba histolytica lectins contain unique 6-Cys or 8-Cys chitin-binding domains. Infect Immun. 2002 Jun; 70(6):3259-63.
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  41. Nixon JE, Wang A, Field J, Morrison HG, McArthur AG, Sogin ML, Loftus BJ, Samuelson J. Evidence for lateral transfer of genes encoding ferredoxins, nitroreductases, NADH oxidase, and alcohol dehydrogenase 3 from anaerobic prokaryotes to Giardia lamblia and Entamoeba histolytica. Eukaryot Cell. 2002 Apr; 1(2):181-90.
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  42. Nixon JE, Wang A, Morrison HG, McArthur AG, Sogin ML, Loftus BJ, Samuelson J. A spliceosomal intron in Giardia lamblia. Proc Natl Acad Sci U S A. 2002 Mar 19; 99(6):3701-5.
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  43. Ghosh S, Frisardi M, Rogers R, Samuelson J. How Giardia swim and divide. Infect Immun. 2001 Dec; 69(12):7866-72.
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  44. Field J, Rosenthal B, Samuelson J. Early lateral transfer of genes encoding malic enzyme, acetyl-CoA synthetase and alcohol dehydrogenases from anaerobic prokaryotes to Entamoeba histolytica. Mol Microbiol. 2000 Nov; 38(3):446-55.
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  45. Ghosh S, Frisardi M, Ramirez-Avila L, Descoteaux S, Sturm-Ramirez K, Newton-Sanchez OA, Santos-Preciado JI, Ganguly C, Lohia A, Reed S, Samuelson J. Molecular epidemiology of Entamoeba spp.: evidence of a bottleneck (Demographic sweep) and transcontinental spread of diploid parasites. J Clin Microbiol. 2000 Oct; 38(10):3815-21.
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  46. Field J, Van Dellen K, Ghosh SK, Samuelson J. Responses of Entamoeba invadens to heat shock and encystation are related. J Eukaryot Microbiol. 2000 Sep-Oct; 47(5):511-4.
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  47. Ghosh S, Field J, Rogers R, Hickman M, Samuelson J. The Entamoeba histolytica mitochondrion-derived organelle (crypton) contains double-stranded DNA and appears to be bound by a double membrane. Infect Immun. 2000 Jul; 68(7):4319-22.
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  48. Frisardi M, Ghosh SK, Field J, Van Dellen K, Rogers R, Robbins P, Samuelson J. The most abundant glycoprotein of amebic cyst walls (Jacob) is a lectin with five Cys-rich, chitin-binding domains. Infect Immun. 2000 Jul; 68(7):4217-24.
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  49. Ghosh SK, Rosenthal B, Rogers R, Samuelson J. Vacuolar localization of an Entamoeba histolytica homologue of the plasma membrane ATPase (PMCA). Mol Biochem Parasitol. 2000 Apr 30; 108(1):125-30.
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  50. Field J, Wilson MP, Mai Z, Majerus PW, Samuelson J. An Entamoeba histolytica inositol 1,3,4-trisphosphate 5/6-kinase has a novel 3-kinase activity. Mol Biochem Parasitol. 2000 Apr 30; 108(1):119-23.
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  51. Samuelson J. Why metronidazole is active against both bacteria and parasites. Antimicrob Agents Chemother. 1999 Jul; 43(7):1533-41.
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  52. Ghosh SK, Field J, Frisardi M, Rosenthal B, Mai Z, Rogers R, Samuelson J. Chitinase secretion by encysting Entamoeba invadens and transfected Entamoeba histolytica trophozoites: localization of secretory vesicles, endoplasmic reticulum, and Golgi apparatus. Infect Immun. 1999 Jun; 67(6):3073-81.
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  53. Mai Z, Ghosh S, Frisardi M, Rosenthal B, Rogers R, Samuelson J. Hsp60 is targeted to a cryptic mitochondrion-derived organelle ("crypton") in the microaerophilic protozoan parasite Entamoeba histolytica. Mol Cell Biol. 1999 Mar; 19(3):2198-205.
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  54. Paintlia AS, Descoteaux S, Spencer B, Chakraborti A, Ganguly NK, Mahajan RC, Samuelson J. Giardia lamblia groups A and B among young adults in India. Clin Infect Dis. 1998 Jan; 26(1):190-1.
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  55. Mai Z, Samuelson J. A new gene family (ariel) encodes asparagine-rich Entamoeba histolytica antigens, which resemble the amebic vaccine candidate serine-rich E. histolytica protein. Infect Immun. 1998 Jan; 66(1):353-5.
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  56. Ray SS, Gangopadhyay SS, Pande G, Samuelson J, Lohia A. Primary structure of Entamoeba histolytica gamma-tubulin and localisation of amoebic microtubule organising centres. Mol Biochem Parasitol. 1997 Dec 1; 90(1):331-6.
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  57. Ghosh SK, Samuelson J. Involvement of p21racA, phosphoinositide 3-kinase, and vacuolar ATPase in phagocytosis of bacteria and erythrocytes by Entamoeba histolytica: suggestive evidence for coincidental evolution of amebic invasiveness. Infect Immun. 1997 Oct; 65(10):4243-9.
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  58. Rosenthal B, Mai Z, Caplivski D, Ghosh S, de la Vega H, Graf T, Samuelson J. Evidence for the bacterial origin of genes encoding fermentation enzymes of the amitochondriate protozoan parasite Entamoeba histolytica. J Bacteriol. 1997 Jun; 179(11):3736-45.
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  59. de la Vega H, Specht CA, Semino CE, Robbins PW, Eichinger D, Caplivski D, Ghosh S, Samuelson J. Cloning and expression of chitinases of Entamoebae. Mol Biochem Parasitol. 1997 Apr; 85(2):139-47.
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  60. de la Vega H, Specht CA, Chau A, Semino CE, Robbins PW, Eichinger D, Caplivski D, Ghosh S, Samuelson J. Cyst-specific exochitinases of Entamoebae contain unique hydrophilic repeats at their amino termini. Arch Med Res. 1997; 28 Spec No:143-6.
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  61. Newton-Sánchez OA, Sturm-Ramirez K, Romero-Zamora JL, Santos-Preciado JI, Samuelson J. High rate of occult infection with Entamoeba histolytica among non-dysenteric Mexican children. Arch Med Res. 1997; 28 Spec No:311-3.
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  62. Rosenthal B, Mai Z, Caplivski D, Ghosh S, Meckler J, Samuelson J. A revised endosymbiont hypothesis to explain the bacterial origin of amebic glycolytic and fermentation enzymes. Arch Med Res. 1997; 28 Spec No:71-2.
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  63. Samuelson J, Caplivski D, Sturm-Ramirez K, Kretzinger K, Descoteaux S, Hernández G, Vargas G, Mammo R, Newton O, Santos J, de la Vega H, Robbins P, Ganguly C, Lohia A. A proposal for a molecular biologic system for classifying isolates of Entamoeba histolytica and Entamoeba dispar. Arch Med Res. 1997; 28 Spec No:274-5.
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  64. Ghosh SK, Lohia A, Kumar A, Samuelson J. Overexpression of P-glycoprotein gene 1 by transfected Entamoeba histolytica confers emetine-resistance. Mol Biochem Parasitol. 1996 Nov 25; 82(2):257-60.
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  65. Lohia A, Samuelson J. Heterogeneity of Entamoeba histolytica rac genes encoding p21rac homologues. Gene. 1996 Sep 16; 173(2):205-8.
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  66. Loda M, Fiorentino M, Meckler J, Khettry U, Lewis D, Washburn K, Jenkins R, Mendoza AE, Samuelson J. Hepatitis C virus reinfection in orthotopic liver transplant patients with or without concomitant hepatitis B infection. Diagn Mol Pathol. 1996 Jun; 5(2):81-7.
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  67. Gómez MD, Pérez DG, Ayala P, Samuelson J, Orozco E. Physiology and molecular biology of multidrug resistance in Entamoeba histolytica. Arch Med Res. 1996; 27(3):421-5.
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  68. Shen PS, Sanford JC, Samuelson J. Entamoeba histolytica: isoprenylation of p21ras and p21rap in vitro. Exp Parasitol. 1996 Jan; 82(1):65-8.
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  69. Descoteaux S, Ayala P, Samuelson J, Orozco E. Increase in mRNA of multiple Eh pgp genes encoding P-glycoprotein homologues in emetine-resistant Entamoeba histolytica parasites. Gene. 1995 Oct 16; 164(1):179-84.
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  70. Vines RR, Purdy JE, Ragland BD, Samuelson J, Mann BJ, Petri WA. Stable episomal transfection of Entamoeba histolytica. Mol Biochem Parasitol. 1995 May; 71(2):265-7.
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  71. Yu Y, Samuelson J. Primary structure of an Entamoeba histolytica nicotinamide nucleotide transhydrogenase. Mol Biochem Parasitol. 1994 Dec; 68(2):323-8.
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  72. Descoteaux S, Yu Y, Samuelson J. Cloning of Entamoeba genes encoding proteolipids of putative vacuolar proton-translocating ATPases. Infect Immun. 1994 Aug; 62(8):3572-5.
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  73. Yi Y, Samuelson J. Primary structure of the Entamoeba histolytica gene (Ehvma1) encoding the catalytic peptide of a putative vacuolar membrane proton-transporting ATPase (V-ATPase). Mol Biochem Parasitol. 1994 Jul; 66(1):165-9.
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  74. Lohia A, Samuelson J. Molecular cloning of an Entamoeba histolytica gene encoding a putative mos family serine/threonine-kinase. Biochim Biophys Acta. 1994 May 26; 1222(1):122-4.
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  75. Shen PS, Lohia A, Samuelson J. Molecular cloning of ras and rap genes from Entamoeba histolytica. Mol Biochem Parasitol. 1994 Mar; 64(1):111-20.
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  76. Zhang WW, Shen PS, Descoteaux S, Samuelson J. Cloning and expression of the gene for an NADP(+)-dependent aldehyde dehydrogenase of Entamoeba histolytica. Mol Biochem Parasitol. 1994 Jan; 63(1):157-61.
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  77. Zhang WW, Samuelson J. Molecular cloning of the gene for a novel ABC superfamily transporter of Entamoeba histolytica. Mol Biochem Parasitol. 1993 Nov; 62(1):131-4.
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  78. Que X, Samuelson J, Reed S. Molecular cloning of a rac family protein kinase and identification of a serine/threonine protein kinase gene family of Entamoeba histolytica. Mol Biochem Parasitol. 1993 Aug; 60(2):161-70.
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  79. Zhang WW, Samuelson J. The cDNA sequence of an abundant Entamoeba histolytica 20-kilodalton protein containing four repetitive domains. Mol Biochem Parasitol. 1993 Aug; 60(2):323-6.
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  80. Lohia A, Samuelson J. Cloning of the Eh cdc2 gene from Entamoeba histolytica encoding a protein kinase p34cdc2 homologue. Gene. 1993 May 30; 127(2):203-7.
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  81. Lohia A, Samuelson J. Molecular cloning of a rho family gene of Entamoeba histolytica. Mol Biochem Parasitol. 1993 Mar; 58(1):177-80.
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  82. Acuna-Soto R, Samuelson J, De Girolami P, Zarate L, Millan-Velasco F, Schoolnick G, Wirth D. Application of the polymerase chain reaction to the epidemiology of pathogenic and nonpathogenic Entamoeba histolytica. Am J Trop Med Hyg. 1993 Jan; 48(1):58-70.
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  83. Samuelson JC, Burke A, Courval JM. Susceptibility of an emetine-resistant mutant of Entamoeba histolytica to multiple drugs and to channel blockers. Antimicrob Agents Chemother. 1992 Nov; 36(11):2392-7.
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  84. Kumar A, Shen PS, Descoteaux S, Pohl J, Bailey G, Samuelson J. Cloning and expression of an NADP(+)-dependent alcohol dehydrogenase gene of Entamoeba histolytica. Proc Natl Acad Sci U S A. 1992 Nov 1; 89(21):10188-92.
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  85. Descoteaux S, Ayala P, Orozco E, Samuelson J. Primary sequences of two P-glycoprotein genes of Entamoeba histolytica. Mol Biochem Parasitol. 1992 Sep; 54(2):201-11.
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  86. Romero JL, Descoteaux S, Reed S, Orozco E, Santos J, Samuelson J. Use of polymerase chain reaction and nonradioactive DNA probes to diagnose Entamoeba histolytica in clinical samples. Arch Med Res. 1992; 23(2):277-9.
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  87. Samuelson J, Zhang WW, Kumar A, Descoteaux S, Shen PS, Bailey G. Primary structures of alcohol and aldehyde dehydrogenase genes of Entamoeba histolytica. Arch Med Res. 1992; 23(2):31-3.
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  88. Descoteaux S, Shen PS, Ayala P, Orozco E, Samuelson J. P-glycoprotein genes of Entamoeba histolytica. Arch Med Res. 1992; 23(2):23-5.
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  89. Samuelson J, Lerner E, Tesh R, Titus R. A mouse model of Leishmania braziliensis braziliensis infection produced by coinjection with sand fly saliva. J Exp Med. 1991 Jan 1; 173(1):49-54.
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  90. Ayala P, Samuelson J, Wirth D, Orozco E. Entamoeba histolytica: physiology of multidrug resistance. Exp Parasitol. 1990 Aug; 71(2):169-75.
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  91. Samuelson J, Ayala P, Orozco E, Wirth D. Emetine-resistant mutants of Entamoeba histolytica overexpress mRNAs for multidrug resistance. Mol Biochem Parasitol. 1990 Jan 15; 38(2):281-90.
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  92. Ayala P, Samuelson J, Wirth D, Orozco E. [Multidrug resistance in Entamoeba histolytica]. Arch Invest Med (Mex). 1990; 21 Suppl 1:103-7.
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  93. Samuelson J, Ayala P, Orozco E, Whirth D. Emetine resistant mutants of Entamoeba histolytica overexpress mRNAs for multidrug resistance. Arch Invest Med (Mex). 1990; 21 Suppl 1:183-9.
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  94. Samuelson J, Acuna-Soto R, Reed S, Biagi F, Wirth D. DNA hybridization probe for clinical diagnosis of Entamoeba histolytica. J Clin Microbiol. 1989 Apr; 27(4):671-6.
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  95. Samuelson JC, Caulfield JP. Cercarial glycocalyx of Schistosoma mansoni activates human complement. Infect Immun. 1986 Jan; 51(1):181-6.
    View in: PubMed
  96. Samuelson JC, Caulfield JP. The cercarial glycocalyx of Schistosoma mansoni. J Cell Biol. 1985 May; 100(5):1423-34.
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  97. Samuelson JC, Caulfield JP. Role of pleated septate junctions in the epithelium of miracidia of Schistosoma mansoni during transformation to sporocysts in vitro. Tissue Cell. 1985; 17(5):667-82.
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  98. Samuelson JC, Quinn JJ, Caulfield JP. Video microscopy of swimming and secreting cercariae of Schistosoma mansoni. J Parasitol. 1984 Dec; 70(6):996-9.
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  99. Samuelson JC, Quinn JJ, Caulfield JP. Hatching, chemokinesis, and transformation of miracidia of Schistosoma mansoni. J Parasitol. 1984 Jun; 70(3):321-31.
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  100. Caulfield JP, Korman G, Samuelson JC. Human neutrophils endocytose multivalent ligands from the surface of schistosomula of Schistosoma mansoni before membrane fusion. J Cell Biol. 1982 Aug; 94(2):370-8.
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  101. Samuelson JC, Caulfield JP. Loss of covalently labeled glycoproteins and glycolipids from the surface of newly transformed schistosomula of Schistosoma mansoni. J Cell Biol. 1982 Aug; 94(2):363-9.
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  102. Samuelson JC, Caulfield JP, David JR. Schistosomula of Schistosoma mansoni clear concanavalin A from their surface by sloughing. J Cell Biol. 1982 Aug; 94(2):355-62.
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  103. Dessein A, Samuelson JC, Butterworth AE, Hogan M, Sherry BA, Vadas MA, David JR. Immune evasion by Schistosoma mansoni: loss of susceptibility to antibody or complement-dependent eosinophil attack by schistosomula cultured in medium free of macromolecules. Parasitology. 1981 Jun; 82(Pt 3):357-74.
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  104. Samuelson JC, Caulfield JP, David JR. Schistosoma mansoni: post-transformational surface changes in schistosomula grown in vitro and in mice. Exp Parasitol. 1980 Dec; 50(3):369-83.
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  105. Samuelson JC, Sher A, Caulfield JP. Newly transformed schistosomula spontaneously lose surface antigens and C3 acceptor sites during culture. J Immunol. 1980 Apr; 124(4):2055-7.
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  106. Zimmermann A, Sutter A, Samuelson J, Shooter EM. A serological assay for the detection of cell surface receptors of nerve growth factor. J Supramol Struct. 1978; 9(3):351-61.
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