Keywords
Last Name

Salomon Amar, DMD, PhD

TitleProfessor
InstitutionBoston University Goldman School of Dental Medicine
DepartmentMolecular & Cell Biology
Address650 Albany St Evans Biomed Ctr
Boston MA 02118
Phone(617) 638-4445
ORCID ORCID Icon0000-0002-0017-5930
Other Positions
TitleDirector of Center for Anti-Inflammatory Therapeutics
InstitutionBoston University Goldman School of Dental Medicine
DepartmentPeriodontology & Oral Biology

TitleProfessor
InstitutionBoston University Goldman School of Dental Medicine
DepartmentPeriodontics

TitleResearch Associate Professor
InstitutionBoston University School of Medicine
DepartmentBiochemistry

TitleMentor for Graduate Medical Students
InstitutionBoston University School of Medicine
DepartmentGraduate Medical Sciences, Division of

TitleMember
InstitutionBoston University
DepartmentBioinformatics Graduate Program

 Research Expertise & Professional Interests
Expertise in cytokines and periodontal diseases. In inflammatory processes (Periodontal Disease), the overexpression of cytokines (IL-1; TNF) is extremely detrimental for the host. Our approach to reduce deleterious effects associated with the overexpression of these cytokines consisted in identifying molecular factors controlling cytokine gene expression in inflammatory processes and particularly in gingivitis and in periodontitis. Recently, we have cloned a novel transcription factor capable of repressing significantly TNF gene expression.

Expertise in wound healing and periodontal regeneration. My group has been interested in the identification and characterization of cells and extracellular matrix macromolecules involved in periodontal wound healing. Particularly, our effort has focused on the identification of critical factors involved in driving periodontal wounds into the regeneration of periodontal structures after periodontal diseases.

 NIH RePORTER Grants
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Yuan H, Zelka S, Burkatovskaya M, Gupte R, Leeman SE, Amar S. Pivotal role of NOD2 in inflammatory processes affecting atherosclerosis and periodontal bone loss. Proc Natl Acad Sci U S A. 2013 Dec 24; 110(52):E5059-68.
    View in: PubMed
  2. Mazumdar V, Amar S, Segrè D. Metabolic proximity in the order of colonization of a microbial community. PLoS One. 2013; 8(10):e77617.
    View in: PubMed
  3. Amar S, Leeman S. Periodontal innate immune mechanisms relevant to obesity. Mol Oral Microbiol. 2013 Oct; 28(5):331-41.
    View in: PubMed
  4. Richard G, Trivedi N, Belta C, Amar S. Partial restoration of macrophage alteration from diet-induced obesity in response to Porphyromonas gingivalis infection. PLoS One. 2013; 8(7):e70320.
    View in: PubMed
  5. Bertolo C, Roa S, Sagardoy A, Mena-Varas M, Robles EF, Martinez-Ferrandis JI, Sagaert X, Tousseyn T, Orta A, Lossos IS, Amar S, Natkunam Y, Briones J, Melnick A, Malumbres R, Martinez-Climent JA. LITAF, a BCL6 target gene, regulates autophagy in mature B-cell lymphomas. Br J Haematol. 2013 Sep; 162(5):621-30.
    View in: PubMed
  6. Tang X, Yang Y, Yuan H, You J, Burkatovskaya M, Amar S. Novel transcriptional regulation of VEGF in inflammatory processes. J Cell Mol Med. 2013 Mar; 17(3):386-97.
    View in: PubMed
  7. Treves-Manusevitz S, Hoz L, Rachima H, Montoya G, Tzur E, Vardimon A, Narayanan AS, Amar S, Arzate H, Pitaru S. Stem cells of the lamina propria of human oral mucosa and gingiva develop into mineralized tissues in vivo. J Clin Periodontol. 2013 Jan; 40(1):73-81.
    View in: PubMed
  8. Liu B, Faller LL, Klitgord N, Mazumdar V, Ghodsi M, Sommer DD, Gibbons TR, Treangen TJ, Chang YC, Li S, Stine OC, Hasturk H, Kasif S, Segrè D, Pop M, Amar S. Deep sequencing of the oral microbiome reveals signatures of periodontal disease. PLoS One. 2012; 7(6):e37919.
    View in: PubMed
  9. Brown BN, Ratner BD, Goodman SB, Amar S, Badylak SF. Macrophage polarization: an opportunity for improved outcomes in biomaterials and regenerative medicine. Biomaterials. 2012 May; 33(15):3792-802.
    View in: PubMed
  10. Richard G, Belta C, Julius AA, Amar S. Controlling the outcome of the Toll-like receptor signaling pathways. PLoS One. 2012; 7(2):e31341.
    View in: PubMed
  11. Merrill JC, You J, Constable C, Leeman SE, Amar S. Whole-body deletion of LPS-induced TNF-a factor (LITAF) markedly improves experimental endotoxic shock and inflammatory arthritis. Proc Natl Acad Sci U S A. 2011 Dec 27; 108(52):21247-52.
    View in: PubMed
  12. Bushell KN, Leeman SE, Gillespie E, Gower AC, Reed KL, Stucchi AF, Becker JM, Amar S. LITAF mediation of increased TNF-a secretion from inflamed colonic lamina propria macrophages. PLoS One. 2011; 6(9):e25849.
    View in: PubMed
  13. Tang X, Yang Y, Amar S. Novel regulation of CCL2 gene expression by murine LITAF and STAT6B. PLoS One. 2011; 6(9):e25083.
    View in: PubMed
  14. Yuan H, Gupte R, Zelkha S, Amar S. Receptor activator of nuclear factor kappa B ligand antagonists inhibit tissue inflammation and bone loss in experimental periodontitis. J Clin Periodontol. 2011 Nov; 38(11):1029-36.
    View in: PubMed
  15. Tang X, O'Reilly A, Asano M, Merrill JC, Yokoyama KK, Amar S. p53 peptide prevents LITAF-induced TNF-alpha-mediated mouse lung lesions and endotoxic shock. Curr Mol Med. 2011 Aug; 11(6):439-52.
    View in: PubMed
  16. Zhou Q, Leeman SE, Amar S. Signaling mechanisms in the restoration of impaired immune function due to diet-induced obesity. Proc Natl Acad Sci U S A. 2011 Feb 15; 108(7):2867-72.
    View in: PubMed
  17. Zhou J, Yang Z, Tsuji T, Gong J, Xie J, Chen C, Li W, Amar S, Luo Z. LITAF and TNFSF15, two downstream targets of AMPK, exert inhibitory effects on tumor growth. Oncogene. 2011 Apr 21; 30(16):1892-900.
    View in: PubMed
  18. Yu WH, Hu H, Zhou Q, Xia Y, Amar S. Bioinformatics analysis of macrophages exposed to Porphyromonas gingivalis: implications in acute vs. chronic infections. PLoS One. 2010; 5(12):e15613.
    View in: PubMed
  19. Zelkha SA, Freilich RW, Amar S. Periodontal innate immune mechanisms relevant to atherosclerosis and obesity. Periodontol 2000. 2010 Oct; 54(1):207-21.
    View in: PubMed
  20. Zawawi KH, Kantarci A, Schulze-Späte U, Fujita T, Batista EL, Amar S, Van Dyke TE. Moesin-induced signaling in response to lipopolysaccharide in macrophages. J Periodontal Res. 2010 Oct; 45(5):589-601.
    View in: PubMed
  21. Srinivasan S, Leeman SE, Amar S. Beneficial dysregulation of the time course of inflammatory mediators in lipopolysaccharide-induced tumor necrosis factor alpha factor-deficient mice. Clin Vaccine Immunol. 2010 May; 17(5):699-704.
    View in: PubMed
  22. Wilson AA, Murphy GJ, Hamakawa H, Kwok LW, Srinivasan S, Hovav AH, Mulligan RC, Amar S, Suki B, Kotton DN. Amelioration of emphysema in mice through lentiviral transduction of long-lived pulmonary alveolar macrophages. J Clin Invest. 2010 Jan; 120(1):379-89.
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  23. Tang X, Woodward T, Amar S. A PTP4A3 peptide PIMAP39 modulates TNF-alpha levels and endotoxic shock. J Innate Immun. 2010; 2(1):43-55.
    View in: PubMed
  24. Iwata T, Kantarci A, Yagi M, Jackson T, Hasturk H, Kurihara H, Van Dyke TE. Ceruloplasmin induces polymorphonuclear leukocyte priming in localized aggressive periodontitis. J Periodontol. 2009 Aug; 80(8):1300-6.
    View in: PubMed
  25. Lenders CM, Feldman HA, Von Scheven E, Merewood A, Sweeney C, Wilson DM, Lee PD, Abrams SH, Gitelman SE, Wertz MS, Klish WJ, Taylor GA, Chen TC, Holick MF. Relation of body fat indexes to vitamin D status and deficiency among obese adolescents. Am J Clin Nutr. 2009 Sep; 90(3):459-67.
    View in: PubMed
  26. Green RC, Roberts JS, Cupples LA, Relkin NR, Whitehouse PJ, Brown T, Eckert SL, Butson M, Sadovnick AD, Quaid KA, Chen C, Cook-Deegan R, Farrer LA. Disclosure of APOE genotype for risk of Alzheimer's disease. N Engl J Med. 2009 Jul 16; 361(3):245-54.
    View in: PubMed
  27. Zhou Q, Leeman SE, Amar S. Signaling mechanisms involved in altered function of macrophages from diet-induced obese mice affect immune responses. Proc Natl Acad Sci U S A. 2009 Jun 30; 106(26):10740-5.
    View in: PubMed
  28. Pollastri MP, Whitty A, Merrill JC, Tang X, Ashton TD, Amar S. Identification and characterization of kava-derived compounds mediating TNF-alpha suppression. Chem Biol Drug Des. 2009 Aug; 74(2):121-8.
    View in: PubMed
  29. Saitz R, Palfai TP, Cheng DM, Horton NJ, Dukes K, Kraemer KL, Roberts MS, Guerriero RT, Samet JH. Some medical inpatients with unhealthy alcohol use may benefit from brief intervention. J Stud Alcohol Drugs. 2009 May; 70(3):426-35.
    View in: PubMed
  30. Lafyatis R, Kissin E, York M, Farina G, Viger K, Fritzler MJ, Merkel PA, Simms RW. B cell depletion with rituximab in patients with diffuse cutaneous systemic sclerosis. Arthritis Rheum. 2009 Feb; 60(2):578-83.
    View in: PubMed
  31. Cheng DM, Libman H, Bridden C, Saitz R, Samet JH. Alcohol consumption and lipodystrophy in HIV-infected adults with alcohol problems. Alcohol. 2009 Feb; 43(1):65-71.
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  32. Amar S, Wu SC, Madan M. Is Porphyromonas gingivalis cell invasion required for atherogenesis? Pharmacotherapeutic implications. J Immunol. 2009 Feb 1; 182(3):1584-92.
    View in: PubMed
  33. Chung WB, Hamburg NM, Holbrook M, Shenouda SM, Dohadwala MM, Terry DF, Gokce N, Vita JA. The brachial artery remodels to maintain local shear stress despite the presence of cardiovascular risk factors. Arterioscler Thromb Vasc Biol. 2009 Apr; 29(4):606-12.
    View in: PubMed
  34. Gavett BE, Poon SJ, Ozonoff A, Jefferson AL, Nair AK, Green RC, Stern RA. Diagnostic utility of the NAB List Learning test in Alzheimer's disease and amnestic mild cognitive impairment. J Int Neuropsychol Soc. 2009 Jan; 15(1):121-9.
    View in: PubMed
  35. Chung WW, Chen CA, Cupples LA, Roberts JS, Hiraki SC, Nair AK, Green RC, Stern RA. A new scale measuring psychologic impact of genetic susceptibility testing for Alzheimer disease. Alzheimer Dis Assoc Disord. 2009 Jan-Mar; 23(1):50-6.
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  36. Rose-Jacobs R, Waber D, Beeghly M, Cabral H, Appugleise D, Heeren T, Marani J, Frank DA. Intrauterine cocaine exposure and executive functioning in middle childhood. Neurotoxicol Teratol. 2009 May-Jun; 31(3):159-68.
    View in: PubMed
  37. Grossman RB, Schneps MH, Tager-Flusberg H. Slipped lips: onset asynchrony detection of auditory-visual language in autism. J Child Psychol Psychiatry. 2009 Apr; 50(4):491-7.
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  38. Mazumdar V, Snitkin ES, Amar S, Segrè D. Metabolic network model of a human oral pathogen. J Bacteriol. 2009 Jan; 191(1):74-90.
    View in: PubMed
  39. Madan M, Amar S. Toll-like receptor-2 mediates diet and/or pathogen associated atherosclerosis: proteomic findings. PLoS One. 2008; 3(9):e3204.
    View in: PubMed
  40. Amar S, Zhou Q, Shaik-Dasthagirisaheb Y, Leeman S. Diet-induced obesity in mice causes changes in immune responses and bone loss manifested by bacterial challenge. Proc Natl Acad Sci U S A. 2007 Dec 18; 104(51):20466-71.
    View in: PubMed
  41. Lowry MH, McAllister BP, Jean JC, Brown LA, Hughey RP, Cruikshank WW, Amar S, Lucey EC, Braun K, Johnson P, Wight TN, Joyce-Brady M. Lung lining fluid glutathione attenuates IL-13-induced asthma. Am J Respir Cell Mol Biol. 2008 May; 38(5):509-16.
    View in: PubMed
  42. Zhou Q, Amar S. Identification of signaling pathways in macrophage exposed to Porphyromonas gingivalis or to its purified cell wall components. J Immunol. 2007 Dec 1; 179(11):7777-90.
    View in: PubMed
  43. Li CH, Amar S. Inhibition of SFRP1 reduces severity of periodontitis. J Dent Res. 2007 Sep; 86(9):873-7.
    View in: PubMed
  44. Li CH, Amar S. Morphometric, histomorphometric, and microcomputed tomographic analysis of periodontal inflammatory lesions in a murine model. J Periodontol. 2007 Jun; 78(6):1120-8.
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  45. Saba JA, McComb ME, Potts DL, Costello CE, Amar S. Proteomic mapping of stimulus-specific signaling pathways involved in THP-1 cells exposed to Porphyromonas gingivalis or its purified components. J Proteome Res. 2007 Jun; 6(6):2211-21.
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  46. Madan M, Bishayi B, Hoge M, Amar S. Atheroprotective role of interleukin-6 in diet- and/or pathogen-associated atherosclerosis using an ApoE heterozygote murine model. Atherosclerosis. 2008 Apr; 197(2):504-14.
    View in: PubMed
  47. Tang X, Molina M, Amar S. p53 short peptide (p53pep164) regulates lipopolysaccharide-induced tumor necrosis factor-alpha factor/cytokine expression. Cancer Res. 2007 Feb 1; 67(3):1308-16.
    View in: PubMed
  48. Hoge M, Amar S. Role of interleukin-1 in bacterial atherogenesis. Timely Top Med Cardiovasc Dis. 2007; 11:E5.
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  49. Hoge M, Amar S. Role of interleukin-1 in bacterial atherogenesis. Drugs Today (Barc). 2006 Oct; 42(10):683-8.
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  50. Tang X, Metzger D, Leeman S, Amar S. LPS-induced TNF-alpha factor (LITAF)-deficient mice express reduced LPS-induced cytokine: Evidence for LITAF-dependent LPS signaling pathways. Proc Natl Acad Sci U S A. 2006 Sep 12; 103(37):13777-82.
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  51. Kim J, Amar S. Periodontal disease and systemic conditions: a bidirectional relationship. Odontology. 2006 Sep; 94(1):10-21.
    View in: PubMed
  52. Shiomi N, Myokai F, Naruishi K, Oyaizu K, Senoo K, Yamaguchi T, Amar S, Takashiba S. Cloning and characterization of lipopolysaccharide-induced tumor necrosis factor alpha factor promoter. FEMS Immunol Med Microbiol. 2006 Aug; 47(3):360-8.
    View in: PubMed
  53. Stucchi A, Reed K, O'Brien M, Cerda S, Andrews C, Gower A, Bushell K, Amar S, Leeman S, Becker J. A new transcription factor that regulates TNF-alpha gene expression, LITAF, is increased in intestinal tissues from patients with CD and UC. Inflamm Bowel Dis. 2006 Jul; 12(7):581-7.
    View in: PubMed
  54. Leone CW, Bokhadhoor H, Kuo D, Desta T, Yang J, Siqueira MF, Amar S, Graves DT. Immunization enhances inflammation and tissue destruction in response to Porphyromonas gingivalis. Infect Immun. 2006 Apr; 74(4):2286-92.
    View in: PubMed
  55. Li CH, Amar S. Role of secreted frizzled-related protein 1 (SFRP1) in wound healing. J Dent Res. 2006 Apr; 85(4):374-8.
    View in: PubMed
  56. Madan M, Bishayi B, Hoge M, Messas E, Amar S. Doxycycline affects diet- and bacteria-associated atherosclerosis in an ApoE heterozygote murine model: cytokine profiling implications. Atherosclerosis. 2007 Jan; 190(1):62-72.
    View in: PubMed
  57. Zhou Q, Amar S. Identification of proteins differentially expressed in human monocytes exposed to Porphyromonas gingivalis and its purified components by high-throughput immunoblotting. Infect Immun. 2006 Feb; 74(2):1204-14.
    View in: PubMed
  58. Petrungaro PS, Amar S. Localized ridge augmentation with allogenic block grafts prior to implant placement: case reports and histologic evaluations. Implant Dent. 2005 Jun; 14(2):139-48.
    View in: PubMed
  59. Tang X, Marciano DL, Leeman SE, Amar S. LPS induces the interaction of a transcription factor, LPS-induced TNF-alpha factor, and STAT6(B) with effects on multiple cytokines. Proc Natl Acad Sci U S A. 2005 Apr 5; 102(14):5132-7.
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  60. Zhou Q, Desta T, Fenton M, Graves DT, Amar S. Cytokine profiling of macrophages exposed to Porphyromonas gingivalis, its lipopolysaccharide, or its FimA protein. Infect Immun. 2005 Feb; 73(2):935-43.
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  61. Graves DT, Naguib G, Lu H, Desta T, Amar S. Porphyromonas gingivalis fimbriae are pro-inflammatory but do not play a prominent role in the innate immune response to P. gingivalis. J Endotoxin Res. 2005; 11(1):13-8.
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  62. Chi H, Messas E, Levine RA, Graves DT, Amar S. Interleukin-1 receptor signaling mediates atherosclerosis associated with bacterial exposure and/or a high-fat diet in a murine apolipoprotein E heterozygote model: pharmacotherapeutic implications. Circulation. 2004 Sep 21; 110(12):1678-85.
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  63. Zhang X, Kohli M, Zhou Q, Graves DT, Amar S. Short- and long-term effects of IL-1 and TNF antagonists on periodontal wound healing. J Immunol. 2004 Sep 1; 173(5):3514-23.
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  64. Lu H, Raptis M, Black E, Stan M, Amar S, Graves DT. Influence of diabetes on the exacerbation of an inflammatory response in cardiovascular tissue. Endocrinology. 2004 Nov; 145(11):4934-9.
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  65. Iontcheva I, Amar S, Zawawi KH, Kantarci A, Van Dyke TE. Role for moesin in lipopolysaccharide-stimulated signal transduction. Infect Immun. 2004 Apr; 72(4):2312-20.
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  66. Bolcato-Bellemin AL, Mattei MG, Fenton M, Amar S. Molecular cloning and characterization of mouse LITAF cDNA: role in the regulation of tumor necrosis factor-alpha (TNF-alpha) gene expression. J Endotoxin Res. 2004; 10(1):15-23.
    View in: PubMed
  67. Amar S, Han X. The impact of periodontal infection on systemic diseases. Med Sci Monit. 2003 Dec; 9(12):RA291-9.
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  68. Han X, Amar S. Secreted frizzled-related protein 1 (SFRP1) protects fibroblasts from ceramide-induced apoptosis. J Biol Chem. 2004 Jan 23; 279(4):2832-40.
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  69. Han X, Amar S. Role of insulin-like growth factor-1 signaling in dental fibroblast apoptosis. J Periodontol. 2003 Aug; 74(8):1176-82.
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  70. Han X, Amar S. IGF-1 signaling enhances cell survival in periodontal ligament fibroblasts vs. gingival fibroblasts. J Dent Res. 2003 Jun; 82(6):454-9.
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  71. Santana RB, Xu L, Chase HB, Amar S, Graves DT, Trackman PC. A role for advanced glycation end products in diminished bone healing in type 1 diabetes. Diabetes. 2003 Jun; 52(6):1502-10.
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  72. Amar S, Gokce N, Morgan S, Loukideli M, Van Dyke TE, Vita JA. Periodontal disease is associated with brachial artery endothelial dysfunction and systemic inflammation. Arterioscler Thromb Vasc Biol. 2003 Jul 1; 23(7):1245-9.
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  73. Tang X, Fenton MJ, Amar S. Identification and functional characterization of a novel binding site on TNF-alpha promoter. Proc Natl Acad Sci U S A. 2003 Apr 1; 100(7):4096-101.
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  74. Delima AJ, Karatzas S, Amar S, Graves DT. Inflammation and tissue loss caused by periodontal pathogens is reduced by interleukin-1 antagonists. J Infect Dis. 2002 Aug 15; 186(4):511-6.
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  75. Li L, Khansari A, Shapira L, Graves DT, Amar S. Contribution of interleukin-11 and prostaglandin(s) in lipopolysaccharide-induced bone resorption in vivo. Infect Immun. 2002 Jul; 70(7):3915-22.
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  76. Han X, Amar S. Identification of genes differentially expressed in cultured human periodontal ligament fibroblasts vs. human gingival fibroblasts by DNA microarray analysis. J Dent Res. 2002 Jun; 81(6):399-405.
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  77. Li L, Messas E, Batista EL, Levine RA, Amar S. Porphyromonas gingivalis infection accelerates the progression of atherosclerosis in a heterozygous apolipoprotein E-deficient murine model. Circulation. 2002 Feb 19; 105(7):861-7.
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  78. Han X, Bolcato AL, Amar S. Identification of genes differentially expressed in cultured human osteoblasts versus human fibroblasts by DNA microarray analysis. Connect Tissue Res. 2002; 43(1):63-75.
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  79. Amar S. and Han X. Regulation of tumour necrosis factor-a gene expression. Applied Genomics and Proteomics. 2002; (1):31-45.
  80. Graves DT, Nooh N, Gillen T, Davey M, Patel S, Cottrell D, Amar S. IL-1 plays a critical role in oral, but not dermal, wound healing. J Immunol. 2001 Nov 1; 167(9):5316-20.
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  81. Delima AJ, Oates T, Assuma R, Schwartz Z, Cochran D, Amar S, Graves DT. Soluble antagonists to interleukin-1 (IL-1) and tumor necrosis factor (TNF) inhibits loss of tissue attachment in experimental periodontitis. J Clin Periodontol. 2001 Mar; 28(3):233-40.
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  82. Amar S, Oyaisu K, Li L, Van Dyke T. Moesin: a potential LPS receptor on human monocytes. J Endotoxin Res. 2001; 7(4):281-6.
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  83. Takashiba S, Van Dyke TE, Amar S, Murayama Y, Soskolne AW, Shapira L. Differentiation of monocytes to macrophages primes cells for lipopolysaccharide stimulation via accumulation of cytoplasmic nuclear factor kappaB. Infect Immun. 1999 Nov; 67(11):5573-8.
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  84. Karatzas S, Zavras A, Greenspan D, Amar S. Histologic observations of periodontal wound healing after treatment with PerioGlas in nonhuman primates. Int J Periodontics Restorative Dent. 1999 Oct; 19(5):489-99.
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  85. Soolari AS, Champagne C, Punzi JS, Amar S, Van Dyke TE. Serum modulation of neutrophil response to Porphyromonas gingivalis LPS in periodontal disease. J Int Acad Periodontol. 1999 Oct; 1(4):101-9.
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  86. Chiang CY, Kyritsis G, Graves DT, Amar S. Interleukin-1 and tumor necrosis factor activities partially account for calvarial bone resorption induced by local injection of lipopolysaccharide. Infect Immun. 1999 Aug; 67(8):4231-6.
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  87. Tohme ZN, Amar S, Van Dyke TE. Moesin functions as a lipopolysaccharide receptor on human monocytes. Infect Immun. 1999 Jul; 67(7):3215-20.
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  88. Myokai F, Takashiba S, Lebo R, Amar S. A novel lipopolysaccharide-induced transcription factor regulating tumor necrosis factor alpha gene expression: molecular cloning, sequencing, characterization, and chromosomal assignment. Proc Natl Acad Sci U S A. 1999 Apr 13; 96(8):4518-23.
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  89. Graves DT, Delima AJ, Assuma R, Amar S, Oates T, Cochran D. Interleukin-1 and tumor necrosis factor antagonists inhibit the progression of inflammatory cell infiltration toward alveolar bone in experimental periodontitis. J Periodontol. 1998 Dec; 69(12):1419-25.
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  90. Genco CA, Van Dyke T, Amar S. Animal models for Porphyromonas gingivalis-mediated periodontal disease. Trends Microbiol. 1998 Nov; 6(11):444-9.
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  91. Shapira L, Champagne C, Van Dyke TE, Amar S. Strain-dependent activation of monocytes and inflammatory macrophages by lipopolysaccharide of Porphyromonas gingivalis. Infect Immun. 1998 Jun; 66(6):2736-42.
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  92. Assuma R, Oates T, Cochran D, Amar S, Graves DT. IL-1 and TNF antagonists inhibit the inflammatory response and bone loss in experimental periodontitis. J Immunol. 1998 Jan 1; 160(1):403-9.
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  93. Landi L, Amar S, Polins AS, Van Dyke TE. Host mechanisms in the pathogenesis of periodontal disease. Curr Opin Periodontol. 1997; 4:3-10.
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  94. Amar S, Chung KM, Nam SH, Karatzas S, Myokai F, Van Dyke TE. Markers of bone and cementum formation accumulate in tissues regenerated in periodontal defects treated with expanded polytetrafluoroethylene membranes. J Periodontal Res. 1997 Jan; 32(1 Pt 2):148-58.
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  95. Takashiba S, Van Dyke TE, Amar S. Inhibition of nuclear factor kappa B subunit p65 mRNA accumulation in lipopolysaccharide-stimulated human monocytic cells treated with sodium salicylate. Oral Microbiol Immunol. 1996 Dec; 11(6):420-4.
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  96. Amar S. Implications of cellular and molecular biology advances in periodontal regeneration. Anat Rec. 1996 Jun; 245(2):361-73.
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  97. Landi L., Pretel R., Ross K. And Amar S. J. Parodont. Impl. Oral. Factors Responsible For Failures Associated With Guided Tissue Regeneration Procedures. 1996; (15):129-151.
  98. Amar S, Petrungaro P, Amar A, Van Dyke TE. Immunolocalization of bone matrix macromolecules in human tissues regenerated from periodontal defects treated with expanded polytetrafluoroethylene membranes. Arch Oral Biol. 1995 Jul; 40(7):653-61.
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  99. Shapira L, Champagne C, Gordon B, Amar S, Van Dyke TE. Lipopolysaccharide priming of superoxide release by human neutrophils: role of membrane CD14 and serum LPS binding protein. Inflammation. 1995 Jun; 19(3):289-95.
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  100. Takashiba S, Van Dyke TE, Shapira L, Amar S. Lipopolysaccharide-inducible and salicylate-sensitive nuclear factor(s) on human tumor necrosis factor alpha promoter. Infect Immun. 1995 Apr; 63(4):1529-34.
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  101. Chung KM, Amar S. Molecular and cellular biology research in periodontal regeneration and its clinical implication. Ann Acad Med Singapore. 1995 Jan; 24(1):58-67.
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  102. Amar S, Van Dyke TE, Eugster HP, Schultze N, Koebel P, Bluethmann H. Tumor necrosis factor (TNF)-induced cutaneous necrosis is mediated by TNF receptor 1. J Inflamm. 1995-1996; 47(4):180-9.
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  103. Amar S, Chung KM. Influence of hormonal variation on the periodontium in women. Periodontol 2000. 1994 Oct; 6:79-87.
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  104. Shapira L, Takashiba S, Amar S, Van Dyke TE. Porphyromonas gingivalis lipopolysaccharide stimulation of human monocytes: dependence on serum and CD14 receptor. Oral Microbiol Immunol. 1994 Apr; 9(2):112-7.
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  105. Amar S, Chung KM. Clinical implications of cellular biologic advances in periodontal regeneration. Curr Opin Periodontol. 1994; 128-40.
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  106. Massarat T, Amar S, Veis A, Osetek E. Immunolocalization of phenotypic cartilage macromolecules within fibroblastic cellular nodules induced by chondrogenic inducing agents in vitro. Northwest Dent Res. 1994; 5(1):25-9.
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  107. Takashiba S, Shapira L, Amar S, Van Dyke TE. Cloning and characterization of human TNF alpha promoter region. Gene. 1993 Sep 15; 131(2):307-8.
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  108. Yamada J, Amar S, Petrungaro P. Psoriasis-associated periodontitis: a case report. J Periodontol. 1992 Oct; 63(10):854-7.
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  109. Amar S, Fabre M, Ruch JV. Effects of ascorbate-deficiency on collagen secretion and resorption in cultured mouse incisor germs. Connect Tissue Res. 1992; 28(1-2):125-42.
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  110. Amar S, Sires B, Sabsay B, Clohisy J, Veis A. The isolation and partial characterization of a rat incisor dentin matrix polypeptide with in vitro chondrogenic activity. J Biol Chem. 1991 May 5; 266(13):8609-18.
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  111. Amar S, Sires B, Veis A. A rat incisor dentin matrix protein can induce neonatal rat muscle fibroblasts, in culture, to express phenotypic products of chondroblastic cells. J Biol Buccale. 1991 Mar; 19(1):55-60.
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  112. Veis A, Sires B, Clohisy J, Sabsay B, Amar S. Rat incisor dentine contains a factor which alters the phenotypic expression and stimulates chondrogenesis in fibroblast-like cells in vitro. Biomaterials. 1990 Jul; 11:35-7.
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  114. Amar S, Luo W, Snead ML, Ruch JV. Amelogenin gene expression in mouse incisor heterotopic recombinations. Differentiation. 1989 Jul; 41(1):56-61.
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  116. Tziafas D, Amar S, Staubli A, Meyer JM, Ruch JV. Effects of glycosaminoglycans on in vitro mouse dental cells. Arch Oral Biol. 1988; 33(10):735-40.
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  117. Tenenbaum H, Amar S, Klewansky P. [A case of orificial plasmacytosis with periodontal localization]. Ann Dermatol Venereol. 1988; 115(4):479-82.
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  118. Amar S and Ruch J.V. Mouse incisor lingual inner dental epithelium does not contain potential ameloblasts. Med. Sci. Res. 1987; (15):949-950.
  119. Amar S., Karcher-Djuricic V., Meyer J.M., and Ruch J.V. Root-analog and crown-analog mouse incisor dentin promotes ameloblast differentiation: An evidence of absence of heterotypic cell contacts. Proc. Finn. Dent. Soc. 1987; (83):225-236.
  120. Amar S, Karcher-Djuricic V, Meyer JM, Ruch JV. The lingual (root analogue) and the labial (crown analogue) mouse incisor dentin promotes ameloblast differentiation. Arch Anat Microsc Morphol Exp. 1986-1987; 75(4):229-39.
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