Keywords
Last Name

Rahul Ray, PhD

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionEndocrinology, Diabetes & Nutrition
Address85 E. Newton St Fuller Bldg
Boston MA 02118
Phone(617) 638-8199
ORCID ORCID Icon0000-0002-2078-2201
Other Positions
TitleMentor for Graduate Medical Students
InstitutionBoston University School of Medicine, Graduate Medical Sciences

TitleResearch Professor
InstitutionBoston University School of Medicine
DepartmentPhysiology & Biophysics

InstitutionBoston Medical Center

 Research Expertise & Professional Interests
Expertise includes: Nanomedicine; Cancer drug therapeutics; Targeted drug delivery.

 Self-Described Keywords
  • Grant writing
  • Translational research
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Datta-Mitra A, Mitra A, Ray R, Raychaudhuri SP, Kundu-Raychaudhuri S. 1,25-dihydroxyvitamin D3-3-bromoacetate, a novel vitamin D analog induces immunosuppression through PI3K/Akt/mTOR signaling cascade. Int Immunopharmacol. 2013 Nov; 17(3):744-51.
    View in: PubMed
  2. Datta Mitra A, Raychaudhuri SP, Abria CJ, Mitra A, Wright R, Ray R, Kundu-Raychaudhuri S. 1a,25-Dihydroxyvitamin-D3-3-bromoacetate regulates AKT/mTOR signaling cascades: a therapeutic agent for psoriasis. J Invest Dermatol. 2013 Jun; 133(6):1556-64.
    View in: PubMed
  3. Ray R, Banks M, Abuzahra H, Eddy VJ, Persons KS, Lucia MS, Lambert JR, Holick MF. Effect of dietary vitamin D and calcium on the growth of androgen-insensitive human prostate tumor in a murine model. Anticancer Res. 2012 Mar; 32(3):727-31.
    View in: PubMed
  4. Sadler S, Persons KS, Jones GB, Ray R. Internalization of a C17a-alkynylestradiol-porphyrin conjugate into estrogen receptor positive MCF-7 breast cancer cells. Bioorg Med Chem Lett. 2011 Aug 1; 21(15):4638-41.
    View in: PubMed
  5. Ray R, Lambert JR. 1a,25-Dihydroxyvitamin D3-3ß-bromoacetate, a potential cancer therapeutic agent: synthesis and molecular mechanism of action. Bioorg Med Chem Lett. 2011 Apr 15; 21(8):2537-40.
    View in: PubMed
  6. Lambert JR, Eddy VJ, Young CD, Persons KS, Sarkar S, Kelly JA, Genova E, Lucia MS, Faller DV, Ray R. A vitamin D receptor-alkylating derivative of 1a,25-dihydroxyvitamin D3 inhibits growth of human kidney cancer cells and suppresses tumor growth. Cancer Prev Res (Phila). 2010 Dec; 3(12):1596-607.
    View in: PubMed
  7. Persons KS, Eddy VJ, Chadid S, Deoliveira R, Saha AK, Ray R. Anti-growth effect of 1,25-dihydroxyvitamin D3-3-bromoacetate alone or in combination with 5-amino-imidazole-4-carboxamide-1-beta-4-ribofuranoside in pancreatic cancer cells. Anticancer Res. 2010 Jun; 30(6):1875-80.
    View in: PubMed
  8. Kaya T, Swamy N, Persons KS, Ray S, Mohr SC, Ray R. Covalent labeling of nuclear vitamin D receptor with affinity labeling reagents containing a cross-linking probe at three different positions of the parent ligand: structural and biochemical implications. Bioorg Chem. 2009 Apr; 37(2):57-63.
    View in: PubMed
  9. Swamy N, Ray R. Fatty acid-binding site environments of serum vitamin D-binding protein and albumin are different. Bioorg Chem. 2008 Jun; 36(3):165-8.
    View in: PubMed
  10. Ray A, Swamy N, Ray R. Cross-talk among structural domains of human DBP upon binding 25-hydroxyvitamin D. Biochem Biophys Res Commun. 2008 Jan 25; 365(4):746-50.
    View in: PubMed
  11. Lambert JR, Young CD, Persons KS, Ray R. Mechanistic and pharmacodynamic studies of a 25-hydroxyvitamin D3 derivative in prostate cancer cells. Biochem Biophys Res Commun. 2007 Sep 14; 361(1):189-95.
    View in: PubMed
  12. Fernandez Gacio A, Fernandez-Marcos C, Swamy N, Dunn D, Ray R. Photodynamic cell-kill analysis of breast tumor cells with a tamoxifen-pyropheophorbide conjugate. J Cell Biochem. 2006 Oct 15; 99(3):665-70.
    View in: PubMed
  13. Swamy N, Purohit A, Fernandez-Gacio A, Jones GB, Ray R. Nuclear estrogen receptor targeted photodynamic therapy: selective uptake and killing of MCF-7 breast cancer cells by a C17alpha-alkynylestradiol-porphyrin conjugate. J Cell Biochem. 2006 Oct 15; 99(3):966-77.
    View in: PubMed
  14. Swamy N, Chen TC, Peleg S, Dhawan P, Christakos S, Stewart LV, Weigel NL, Mehta RG, Holick MF, Ray R. Inhibition of proliferation and induction of apoptosis by 25-hydroxyvitamin D3-3beta-(2)-Bromoacetate, a nontoxic and vitamin D receptor-alkylating analog of 25-hydroxyvitamin D3 in prostate cancer cells. Clin Cancer Res. 2004 Dec 1; 10(23):8018-27.
    View in: PubMed
  15. Swamy N, Persons KS, Chen TC, Ray R. 1alpha,25-Dihydroxyvitamin D3-3beta-(2)-bromoacetate, an affinity labeling derivative of 1alpha,25-dihydroxyvitamin D3 displays strong antiproliferative and cytotoxic behavior in prostate cancer cells. J Cell Biochem. 2003 Aug 1; 89(5):909-16.
    View in: PubMed
  16. Fernández-Gacio A, Fernández-Marcos C, Swamy N, Ray R. Affinity labeling of the nuclear vitamin D receptor with nonsteroidal alkylating agents. Bioorg Med Chem Lett. 2003 Jan 20; 13(2):213-6.
    View in: PubMed
  17. Hussain EA, Mehta RR, Ray R, Das Gupta TK, Mehta RG. Efficacy and mechanism of action of 1alpha-hydroxy-24-ethyl-cholecalciferol (1alpha[OH]D5) in breast cancer prevention and therapy. Recent Results Cancer Res. 2003; 164:393-411.
    View in: PubMed
  18. Kisker O, Onizuka S, Becker CM, Fannon M, Flynn E, D'Amato R, Zetter B, Folkman J, Ray R, Swamy N, Pirie-Shepherd S. Vitamin D binding protein-macrophage activating factor (DBP-maf) inhibits angiogenesis and tumor growth in mice. Neoplasia. 2003 Jan-Feb; 5(1):32-40.
    View in: PubMed
  19. Swamy N, James DA, Mohr SC, Hanson RN, Ray R. An estradiol-porphyrin conjugate selectively localizes into estrogen receptor-positive breast cancer cells. Bioorg Med Chem. 2002 Oct; 10(10):3237-43.
    View in: PubMed
  20. Head JF, Swamy N, Ray R. Crystal structure of the complex between actin and human vitamin D-binding protein at 2.5 A resolution. Biochemistry. 2002 Jul 23; 41(29):9015-20.
    View in: PubMed
  21. Swamy N, Head JF, Weitz D, Ray R. Biochemical and preliminary crystallographic characterization of the vitamin D sterol- and actin-binding by human vitamin D-binding protein. Arch Biochem Biophys. 2002 Jun 1; 402(1):14-23.
    View in: PubMed
  22. Addo JK, Swamy N, Ray R. The C(19) position of 25-hydroxyvitamin D(3) faces outward in the vitamin D sterol-binding pocket of vitamin D-binding protein. Bioorg Med Chem Lett. 2002 Feb 11; 12(3):279-81.
    View in: PubMed
  23. Swamy N, Ghosh S, Schneider GB, Ray R. Baculovirus-expressed vitamin D-binding protein-macrophage activating factor (DBP-maf) activates osteoclasts and binding of 25-hydroxyvitamin D(3) does not influence this activity. J Cell Biochem. 2001; 81(3):535-46.
    View in: PubMed
  24. Swamy N, Xu W, Paz N, Hsieh JC, Haussler MR, Maalouf GJ, Mohr SC, Ray R. Molecular modeling, affinity labeling, and site-directed mutagenesis define the key points of interaction between the ligand-binding domain of the vitamin D nuclear receptor and 1 alpha,25-dihydroxyvitamin D3. Biochemistry. 2000 Oct 10; 39(40):12162-71.
    View in: PubMed
  25. Swamy N, Addo JK, Ray R. Development of an affinity-driven cross-linker: isolation of a vitamin D receptor associated factor. Bioorg Med Chem Lett. 2000 Feb 21; 10(4):361-4.
    View in: PubMed
  26. Swamy N, Addo J, Vskokovic MR, Ray R. Probing the vitamin D sterol-binding pocket of human vitamin D-binding protein with bromoacetate affinity labeling reagents containing the affinity probe at C-3, C-6, C-11, and C-19 positions of parent vitamin D sterols. Arch Biochem Biophys. 2000 Jan 15; 373(2):471-8.
    View in: PubMed
  27. Chen ML, Ray S, Swamy N, Holick MF, Ray R. Mechanistic studies to evaluate the enhanced antiproliferation of human keratinocytes by 1alpha,25-dihydroxyvitamin D(3)-3-bromoacetate, a covalent modifier of vitamin D receptor, compared to 1alpha,25-dihydroxyvitamin D(3). Arch Biochem Biophys. 1999 Oct 1; 370(1):34-44.
    View in: PubMed
  28. James DA, Swamy N, Paz N, Hanson RN, Ray R. Synthesis and estrogen receptor binding affinity of a porphyrin-estradiol conjugate for targeted photodynamic therapy of cancer. Bioorg Med Chem Lett. 1999 Aug 16; 9(16):2379-84.
    View in: PubMed
  29. Addo JK, Swamy N, Ray R. C-6 functionalized analogs of 25-hydroxyvitamin D3 and 1alpha,25-dihydroxyvitamin D3: synthesis and binding analysis with vitamin D-binding protein and vitamin D receptor. Steroids. 1999 Apr; 64(4):273-82.
    View in: PubMed
  30. Swamy N, Mohr SC, Xu W, Ray R. Vitamin D receptor interacts with DnaK/heat shock protein 70: identification of DnaK interaction site on vitamin D receptor. Arch Biochem Biophys. 1999 Mar 15; 363(2):219-26.
    View in: PubMed
  31. Addo JK, Ray R. Synthesis and binding-analysis of 5E-[19-(2-bromoacetoxy)methyl]25-hydroxyvitamin D3 and 5E-25-hydroxyvitamin D3-19-methyl[(4-azido-2-nitro)phenyl]glycinate: novel C19-modified affinity and photoaffinity analogs of 25-hydroxyvitamin D3. Steroids. 1998 Apr; 63(4):218-23.
    View in: PubMed
  32. Swamy N, Kounine M, Ray R. Identification of the subdomain in the nuclear receptor for the hormonal form of vitamin D3, 1 alpha,25-dihydroxyvitamin D3, vitamin D receptor, that is covalently modified by an affinity labeling reagent. Arch Biochem Biophys. 1997 Dec 1; 348(1):91-5.
    View in: PubMed
  33. Swamy N, Dutta A, Ray R. Roles of the structure and orientation of ligands and ligand mimics inside the ligand-binding pocket of the vitamin D-binding protein. Biochemistry. 1997 Jun 17; 36(24):7432-6.
    View in: PubMed
  34. Swamy N, Ghosh S, Ray R. Bacterial expression of human vitamin D-binding protein (Gc2) in functional form. Protein Expr Purif. 1997 Jun; 10(1):115-22.
    View in: PubMed
  35. Ray R, Holick MF. Synthesis of [3 alpha-3H]vitamin D3 and 1 alpha,25-dihydroxy[1 beta-3H]vitamin D3. Methods Enzymol. 1997; 282:157-64.
    View in: PubMed
  36. Swamy N, Ray R. Affinity labeling of rat serum vitamin D binding protein. Arch Biochem Biophys. 1996 Sep 1; 333(1):139-44.
    View in: PubMed
  37. Ray R. Molecular recognition in vitamin D-binding protein. Proc Soc Exp Biol Med. 1996 Sep; 212(4):305-12.
    View in: PubMed
  38. Ray R, Swamy N, MacDonald PN, Ray S, Haussler MR, Holick MF. Affinity labeling of the 1 alpha,25-dihydroxyvitamin D3 receptor. J Biol Chem. 1996 Jan 26; 271(4):2012-7.
    View in: PubMed
  39. Ray S, Ray R, Holick MF. Metabolism of 3H-1 alpha,25-dihydroxyvitamin D3 in cultured human keratinocytes. J Cell Biochem. 1995 Sep; 59(1):117-22.
    View in: PubMed
  40. Roy A, Ray R. Aminopropylation of vitamin D hormone (1 alpha,25-dihydroxyvitamin D3), its biological precursors, and other steroidal alcohols: an anchoring moiety for affinity studies of sterols. Steroids. 1995 Aug; 60(8):530-3.
    View in: PubMed
  41. Swamy N, Ray R. 25-Hydroxy[26,27-methyl-3H]vitamin D3-3 beta-(1,2-epoxypropyl)ether: an affinity labeling reagent for human vitamin D-binding protein. Arch Biochem Biophys. 1995 Jun 1; 319(2):504-7.
    View in: PubMed
  42. Swamy N, Roy A, Chang R, Brisson M, Ray R. Affinity purification of human plasma vitamin D-binding protein. Protein Expr Purif. 1995 Apr; 6(2):185-8.
    View in: PubMed
  43. Swamy N, Brisson M, Ray R. Trp-145 is essential for the binding of 25-hydroxyvitamin D3 to human serum vitamin D-binding protein. J Biol Chem. 1995 Feb 10; 270(6):2636-9.
    View in: PubMed
  44. Ray R, Ray S, Rose S, Holick MF. Photoaffinity labeling of chick intestinal 1 alpha,25-dihydroxyvitamin D3 receptor. Steroids. 1993 Oct; 58(10):462-5.
    View in: PubMed
  45. Ray R, Vicchio D, Yergey A, Holick MF. Synthesis of 25-hydroxy-[6,19,19'-2H3]vitamin D3 and 1 alpha,25-dihydroxy-[6,19,19'-2H3]vitamin D3. Steroids. 1992 Mar; 57(3):142-6.
    View in: PubMed
  46. Ray R, Bouillon R, Van Baelen H, Holick MF. Photoaffinity labeling of human serum vitamin D binding protein and chemical cleavages of the labeled protein: identification of an 11.5-kDa peptide containing the putative 25-hydroxyvitamin D3 binding site. Biochemistry. 1991 Jul 30; 30(30):7638-42.
    View in: PubMed
  47. Ray R, Bouillon R, Van Baelen H, Holick MF. Synthesis of 25-hydroxyvitamin D3 3 beta-3'-[N-(4-azido-2-nitrophenyl)amino]propyl ether, a second-generation photoaffinity analogue of 25-hydroxyvitamin D3: photoaffinity labeling of rat serum vitamin D binding protein. Biochemistry. 1991 May 14; 30(19):4809-13.
    View in: PubMed
  48. Ray R, Holick MF. The synthesis of a radiolabeled photoaffinity analog of 1,25-dihydroxyvitamin D3. Steroids. 1988 May-Jun; 51(5-6):623-30.
    View in: PubMed
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