Keywords
Last Name

Clifford M. Knapp, PhD

TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentPsychiatry
Address720 Harrison Ave
Boston MA 02118
Phone(617) 414-1990
ORCID ORCID Icon0000-0003-4482-7678
Other Positions
InstitutionBoston Medical Center

 Research Expertise & Professional Interests
I have expertise in running behavioral pharmacology studies, particularly in conducting brain stimulation experiments. I also have a background in the design and analysis of clinical studies that evaluate medications for their use in the treatment of addictive disorders.

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Ciraulo DA, Barlow DH, Gulliver SB, Farchione T, Morissette SB, Kamholz BW, Eisenmenger K, Brown B, Devine E, Brown TA, Knapp CM. The effects of venlafaxine and cognitive behavioral therapy alone and combined in the treatment of co-morbid alcohol use-anxiety disorders. Behav Res Ther. 2013 Nov; 51(11):729-35.
    View in: PubMed
  2. Zirker W, Dorokhine I, Knapp CM, Patel N, Musuku M. Haloperidol overdosing in the treatment of agitated hospitalized older people with delirium: a retrospective chart review from a community teaching hospital. Drugs Aging. 2013 Aug; 30(8):639-44.
    View in: PubMed
  3. Devine EG, Waters ME, Putnam M, Surprise C, O'Malley K, Richambault C, Fishman RL, Knapp CM, Patterson EH, Sarid-Segal O, Streeter C, Colanari L, Ciraulo DA. Concealment and fabrication by experienced research subjects. Clin Trials. 2013; 10(6):935-48.
    View in: PubMed
  4. Dobracki AE, Zirker WS, Knapp CM. Underrecognition of weight loss in community-dwelling elderly adults. J Am Geriatr Soc. 2012 Nov; 60(11):2173-5.
    View in: PubMed
  5. Iemolo A, Valenza M, Tozier L, Knapp CM, Kornetsky C, Steardo L, Sabino V, Cottone P. Withdrawal from chronic, intermittent access to a highly palatable food induces depressive-like behavior in compulsive eating rats. Behav Pharmacol. 2012 Sep; 23(5-6):593-602.
    View in: PubMed
  6. Afshar M, Knapp CM, Sarid-Segal O, Devine E, Colaneri LS, Tozier L, Waters ME, Putnam MA, Ciraulo DA. The efficacy of mirtazapine in the treatment of cocaine dependence with comorbid depression. Am J Drug Alcohol Abuse. 2012 Mar; 38(2):181-6.
    View in: PubMed
  7. Knapp CM, Sarid-Segal O, Richardson MA, Colaneri LS, Afshar M, Devine E, Streeter CC, Piechniczek-Buczek J, Ciraulo DA. Open label trial of the tolerability and efficacy of zonisamide in the treatment of alcohol dependence. Am J Drug Alcohol Abuse. 2010 Mar; 36(2):102-5.
    View in: PubMed
  8. Kornetsky C, Knapp CM, Tozier L, Pak A. Medial forebrain stimulation enhances intracranial nociception and attenuates morphine analgesia suggesting the existence of an endogenous opioid antagonist. Pharmacol Biochem Behav. 2010 May; 95(3):273-7.
    View in: PubMed
  9. Knapp CM, Tozier L, Pak A, Ciraulo DA, Kornetsky C. Deep brain stimulation of the nucleus accumbens reduces ethanol consumption in rats. Pharmacol Biochem Behav. 2009 May; 92(3):474-9.
    View in: PubMed
  10. Sarid-Segal O, Knapp CM, Burch W, Richardson MA, Bahtia S, DeQuattro K, Afshar M, Richambault C, Sickels L, Devine E, Ciraulo DA. The anticonvulsant zonisamide reduces ethanol self-administration by risky drinkers. Am J Drug Alcohol Abuse. 2009; 35(5):316-9.
    View in: PubMed
  11. Vassoler FM, Schmidt HD, Gerard ME, Famous KR, Ciraulo DA, Kornetsky C, Knapp CM, Pierce RC. Deep brain stimulation of the nucleus accumbens shell attenuates cocaine priming-induced reinstatement of drug seeking in rats. J Neurosci. 2008 Aug 27; 28(35):8735-9.
    View in: PubMed
  12. Sarid-Segal O, Piechniczek-Buczek J, Knapp C, Afshar M, Devine E, Sickles L, Uwodukunda E, Richambault C, Koplow J, Ciraulo D. The effects of levetiracetam on alcohol consumption in alcohol-dependent subjects: an open label study. Am J Drug Alcohol Abuse. 2008; 34(4):441-7.
    View in: PubMed
  13. Knapp CM, Mercado M, Markley TL, Crosby S, Ciraulo DA, Kornetsky C. Zonisamide decreases ethanol intake in rats and mice. Pharmacol Biochem Behav. 2007 May; 87(1):65-72.
    View in: PubMed
  14. Crosby SJ, Knapp CM, Kornetsky C. Nociceptive threshold and analgesic response to morphine in aged and young adult rats as determined by thermal radiation and intracerebral electrical stimulation. Pharmacol Biochem Behav. 2006 May; 84(1):148-57.
    View in: PubMed
  15. Ciraulo DA, Hitzemann RJ, Somoza E, Knapp CM, Rotrosen J, Sarid-Segal O, Ciraulo AM, Greenblatt DJ, Chiang CN. Pharmacokinetics and pharmacodynamics of multiple sublingual buprenorphine tablets in dose-escalation trials. J Clin Pharmacol. 2006 Feb; 46(2):179-92.
    View in: PubMed
  16. Streeter CC, Hennen J, Ke Y, Jensen JE, Sarid-Segal O, Nassar LE, Knapp C, Meyer AA, Kwak T, Renshaw PF, Ciraulo DA. Prefrontal GABA levels in cocaine-dependent subjects increase with pramipexole and venlafaxine treatment. Psychopharmacology (Berl). 2005 Nov; 182(4):516-26.
    View in: PubMed
  17. Ciraulo DA, Knapp C, Rotrosen J, Sarid-Segal O, Ciraulo AM, LoCastro J, Greenblatt DJ, Leiderman D. Nefazodone treatment of cocaine dependence with comorbid depressive symptoms. Addiction. 2005 Mar; 100 Suppl 1:23-31.
    View in: PubMed
  18. Ciraulo DA, Sarid-Segal O, Knapp CM, Ciraulo AM, LoCastro J, Bloch DA, Montgomery MA, Leiderman DB, Elkashef A. Efficacy screening trials of paroxetine, pentoxifylline, riluzole, pramipexole and venlafaxine in cocaine dependence. Addiction. 2005 Mar; 100 Suppl 1:12-22.
    View in: PubMed
  19. Jha SH, Knapp CM, Kornetsky C. Effects of morphine on brain-stimulation reward thresholds in young and aged rats. Pharmacol Biochem Behav. 2004 Nov; 79(3):483-90.
    View in: PubMed
  20. Knapp CM, Jha SH, Kornetsky C. Increased sensitization to morphine-induced oral stereotypy in aged rats. Pharmacol Biochem Behav. 2004 Nov; 79(3):491-7.
    View in: PubMed
  21. Monnelly EP, Ciraulo DA, Knapp C, LoCastro J, Sepulveda I. Quetiapine for treatment of alcohol dependence. J Clin Psychopharmacol. 2004 Oct; 24(5):532-5.
    View in: PubMed
  22. Gill BM, Knapp CM, Kornetsky C. The effects of cocaine on the rate independent brain stimulation reward threshold in the mouse. Pharmacol Biochem Behav. 2004 Sep; 79(1):165-70.
    View in: PubMed
  23. Ke Y, Streeter CC, Nassar LE, Sarid-Segal O, Hennen J, Yurgelun-Todd DA, Awad LA, Rendall MJ, Gruber SA, Nason A, Mudrick MJ, Blank SR, Meyer AA, Knapp C, Ciraulo DA, Renshaw PF. Frontal lobe GABA levels in cocaine dependence: a two-dimensional, J-resolved magnetic resonance spectroscopy study. Psychiatry Res. 2004 Apr 30; 130(3):283-93.
    View in: PubMed
  24. Monnelly EP, Ciraulo DA, Knapp C, Keane T. Low-dose risperidone as adjunctive therapy for irritable aggression in posttraumatic stress disorder. J Clin Psychopharmacol. 2003 Apr; 23(2):193-6.
    View in: PubMed
  25. Knapp CM, Printseva B, Cottam N, Kornetsky C. Effects of cue exposure on brain glucose utilization 8 days after repeated cocaine administration. Brain Res. 2002 Sep 20; 950(1-2):119-26.
    View in: PubMed
  26. Knapp CM, Lee K, Foye M, Ciraulo DA, Kornetsky C. Additive effects of intra-accumbens infusion of the cAMP-specific phosphodiesterase inhibitor, rolipram and cocaine on brain stimulation reward. Life Sci. 2001 Aug 24; 69(14):1673-82.
    View in: PubMed
  27. Ciraulo DA, Knapp CM, LoCastro J, Greenblatt DJ, Shader RI. A benzodiazepine mood effect scale: reliability and validity determined for alcohol-dependent subjects and adults with a parental history of alcoholism. Am J Drug Alcohol Abuse. 2001 May; 27(2):339-47.
    View in: PubMed
  28. Knapp CM, Foye MM, Cottam N, Ciraulo DA, Kornetsky C. Adenosine agonists CGS 21680 and NECA inhibit the initiation of cocaine self-administration. Pharmacol Biochem Behav. 2001 Apr; 68(4):797-803.
    View in: PubMed
  29. Sarid-Segal O, Knapp CM, Ciraulo AM, Greenblatt DJ, Shader RI, Ciraulo DA. Decreased EEG sensitivity to alprazolam in subjects with a parental history of alcoholism. J Clin Pharmacol. 2000 Jan; 40(1):84-90.
    View in: PubMed
  30. Knapp CM, Foye MM, Ciraulo DA, Kornetsky C. The type IV phosphodiesterase inhibitors, Ro 20-1724 and rolipram, block the initiation of cocaine self-administration. Pharmacol Biochem Behav. 1999 Jan; 62(1):151-8.
    View in: PubMed
  31. Streeter CC, Ciraulo DA, Harris GJ, Kaufman MJ, Lewis RF, Knapp CM, Ciraulo AM, Maas LC, Ungeheuer M, Szulewski S, Renshaw PF. Functional magnetic resonance imaging of alprazolam-induced changes in humans with familial alcoholism. Psychiatry Res. 1998 May 20; 82(2):69-82.
    View in: PubMed
  32. Ciraulo DA, Barnhill JG, Ciraulo AM, Sarid-Segal O, Knapp C, Greenblatt DJ, Shader RI. Alterations in pharmacodynamics of anxiolytics in abstinent alcoholic men: subjective responses, abuse liability, and electroencephalographic effects of alprazolam, diazepam, and buspirone. J Clin Pharmacol. 1997 Jan; 37(1):64-73.
    View in: PubMed
  33. Knapp CM, Kornetsky C. Low-dose apomorphine attenuates morphine-induced enhancement of brain stimulation reward. Pharmacol Biochem Behav. 1996 Sep; 55(1):87-91.
    View in: PubMed
  34. Knapp CM, Kornetsky C. Bromocriptine, a D2 receptor agonist, lowers the threshold for rewarding brain stimulation. Pharmacol Biochem Behav. 1994 Dec; 49(4):901-4.
    View in: PubMed
  35. Knapp CM, Kornetsky C. The effects of amfonelic acid alone and in combination with naloxone on brain-stimulation reward. Pharmacol Biochem Behav. 1989 Apr; 32(4):977-82.
    View in: PubMed
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