Keywords
Last Name

John H. Connor, PhD

TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentMicrobiology
Address72 E. Concord St Housman (R)
Boston MA 02118
Phone(617) 638-0339
ORCID ORCID Icon0000-0002-8867-7256
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine
DepartmentGraduate Medical Sciences, Division of

TitleMember
InstitutionBoston University
DepartmentBioinformatics Graduate Program

 Research Expertise & Professional Interests
My laboratory studies the virus-host interaction. We take a variety of approaches from genetic to systems biology to biochemistry and molecular biology. We are studying how viruses take over the cellular protein synthesis apparatus, how cells effectively fight virus infection, and how the host responds to infection with viruses that cause hemorrhagic fever.

 Self-Described Keywords
  • antiviral drugs
  • hemorrhagic fever viruses
  • microarray analysis
  • molecular biology
  • orthopoxvirus
  • protein biochemistry
  • reverse genetics
  • rhabdovirus
  • signal transduction
  • virology
  • virus-host interaction
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Reddington AP, Trueb JT, Freedman DS, Tuysuzoglu A, Daaboul GG, Lopez CA, Karl WC, Connor JH, Fawcett H, Unlu MS. An interferometric reflectance imaging sensor for point of care viral diagnostics. IEEE Trans Biomed Eng. 2013 Dec; 60(12):3276-83.
    View in: PubMed
  2. Malhotra S, Yen JY, Honko AN, Garamszegi S, Caballero IS, Johnson JC, Mucker EM, Trefry JC, Hensley LE, Connor JH. Transcriptional profiling of the circulating immune response to lassa virus in an aerosol model of exposure. PLoS Negl Trop Dis. 2013; 7(4):e2171.
    View in: PubMed
  3. Filone CM, Hodges EN, Honeyman B, Bushkin GG, Boyd K, Platt A, Ni F, Strom K, Hensley L, Snyder JK, Connor JH. Identification of a broad-spectrum inhibitor of viral RNA synthesis: validation of a prototype virus-based approach. Chem Biol. 2013 Mar 21; 20(3):424-33.
    View in: PubMed
  4. Chan WM, Bartee EC, Moreb JS, Dower K, Connor JH, McFadden G. Myxoma and vaccinia viruses bind differentially to human leukocytes. J Virol. 2013 Apr; 87(8):4445-60.
    View in: PubMed
  5. Hodges EN, Connor JH. Translational control by negative-strand RNA viruses: methods for the study of a crucial virus/host interaction. Methods. 2013 Feb; 59(2):180-7.
    View in: PubMed
  6. Hodges EN, Heinrich BS, Connor JH. A vesiculovirus showing a steepened transcription gradient and dominant trans-repression of virus transcription. J Virol. 2012 Aug; 86(16):8884-9.
    View in: PubMed
  7. Johnston SC, Lin KL, Connor JH, Ruthel G, Goff A, Hensley LE. In vitro inhibition of monkeypox virus production and spread by Interferon-ß. Virol J. 2012; 9:5.
    View in: PubMed
  8. Yurt A, Daaboul GG, Connor JH, Goldberg BB, Ünlü MS. Single nanoparticle detectors for biological applications. Nanoscale. 2012 Feb 7; 4(3):715-26.
    View in: PubMed
  9. Dunn EF, Connor JH. HijAkt: The PI3K/Akt pathway in virus replication and pathogenesis. Prog Mol Biol Transl Sci. 2012; 106:223-50.
    View in: PubMed
  10. Scott C. Benson, Lily Lee, Wanguo Wei, Feng Ni, Julian David Janna Olmos, Kyle R. Strom, Aaron B. Beeler, Ken Chih-Chien Cheng, James Inglese, Smitha Kota, Virginia Takahashi, A. Donny Strosberg, John H. Connor, G. Guy Bushkin, John K. Snyder. Truncated Aspidosperma Alkaloid-Like Scaffolds: Unique Structures for the Discovery of New, Bioactive Compounds. Heterocycles 84 No. 1. 2012; 135–155.
  11. Dower K, Filone CM, Hodges EN, Bjornson ZB, Rubins KH, Brown LE, Schaus S, Hensley LE, Connor JH. Identification of a pyridopyrimidinone inhibitor of orthopoxviruses from a diversity-oriented synthesis library. J Virol. 2012 Mar; 86(5):2632-40.
    View in: PubMed
  12. Yen JY, Garamszegi S, Geisbert JB, Rubins KH, Geisbert TW, Honko A, Xia Y, Connor JH, Hensley LE. Therapeutics of Ebola hemorrhagic fever: whole-genome transcriptional analysis of successful disease mitigation. J Infect Dis. 2011 Nov; 204 Suppl 3:S1043-52.
    View in: PubMed
  13. Yanik AA, Cetin AE, Huang M, Artar A, Mousavi SH, Khanikaev A, Connor JH, Shvets G, Altug H. Seeing protein monolayers with naked eye through plasmonic Fano resonances. Proc Natl Acad Sci U S A. 2011 Jul 19; 108(29):11784-9.
    View in: PubMed
  14. Dower K, Rubins KH, Hensley LE, Connor JH. Development of Vaccinia reporter viruses for rapid, high content analysis of viral function at all stages of gene expression. Antiviral Res. 2011 Jul; 91(1):72-80.
    View in: PubMed
  15. Lopez CA, Daaboul GG, Ahn S, Reddington AP, Monroe MR, Zhang X, Irani RJ, Yu C, Genco CA, Cretich M, Chiari M, Goldberg BB, Connor JH, Ünlü MS. Biomolecular detection employing the Interferometric Reflectance Imaging Sensor (IRIS). J Vis Exp. 2011; (51).
    View in: PubMed
  16. Lopez CA, Daaboul GG, Vedula RS, Ozkumur E, Bergstein DA, Geisbert TW, Fawcett HE, Goldberg BB, Connor JH, Unlü MS. Label-free multiplexed virus detection using spectral reflectance imaging. Biosens Bioelectron. 2011 Apr 15; 26(8):3432-7.
    View in: PubMed
  17. Simpson-Holley M, Kedersha N, Dower K, Rubins KH, Anderson P, Hensley LE, Connor JH. Formation of antiviral cytoplasmic granules during orthopoxvirus infection. J Virol. 2011 Feb; 85(4):1581-93.
    View in: PubMed
  18. Yanik AA, Huang M, Kamohara O, Artar A, Geisbert TW, Connor JH, Altug H. An optofluidic nanoplasmonic biosensor for direct detection of live viruses from biological media. Nano Lett. 2010 Dec 8; 10(12):4962-9.
    View in: PubMed
  19. Dunn EF, Connor JH. Dominant inhibition of Akt/protein kinase B signaling by the matrix protein of a negative-strand RNA virus. J Virol. 2011 Jan; 85(1):422-31.
    View in: PubMed
  20. Smith DR, McCarthy S, Chrovian A, Olinger G, Stossel A, Geisbert TW, Hensley LE, Connor JH. Inhibition of heat-shock protein 90 reduces Ebola virus replication. Antiviral Res. 2010 Aug; 87(2):187-94.
    View in: PubMed
  21. Ozkumur E, Lopez CA, Yalcin A, Connor JH, Chiari M, Unlu MS. Spectral Reflectance Imaging for a Multiplexed, High-Throughput, Label-Free, and Dynamic Biosensing Platform Journal of Selected Topics in Quantum Electronics. 2010; PP(99):1-12.
  22. Dunn EF, Fearns R, Connor JH. Akt inhibitor Akt-IV blocks virus replication through an Akt-independent mechanism. J Virol. 2009 Nov; 83(22):11665-72.
    View in: PubMed
  23. Green NM, Laws A, Kiefer K, Busconi L, Kim YM, Brinkmann MM, Trail EH, Yasuda K, Christensen SR, Shlomchik MJ, Vogel S, Connor JH, Ploegh H, Eilat D, Rifkin IR, van Seventer JM, Marshak-Rothstein A. Murine B cell response to TLR7 ligands depends on an IFN-beta feedback loop. J Immunol. 2009 Aug 1; 183(3):1569-76.
    View in: PubMed
  24. Dancho B, McKenzie MO, Connor JH, Lyles DS. Vesicular stomatitis virus matrix protein mutations that affect association with host membranes and viral nucleocapsids. J Biol Chem. 2009 Feb 13; 284(7):4500-9.
    View in: PubMed
  25. Pettit Kneller EL, Connor JH, Lyles DS. hnRNPs Relocalize to the cytoplasm following infection with vesicular stomatitis virus. J Virol. 2009 Jan; 83(2):770-80.
    View in: PubMed
  26. Izquierdo-Useros N, Naranjo-Gómez M, Archer J, Hatch SC, Erkizia I, Blanco J, Borràs FE, Puertas MC, Connor JH, Fernández-Figueras MT, Moore L, Clotet B, Gummuluru S, Martinez-Picado J. Capture and transfer of HIV-1 particles by mature dendritic cells converges with the exosome-dissemination pathway. Blood. 2009 Mar 19; 113(12):2732-41.
    View in: PubMed
  27. Whitlow ZW, Connor JH, Lyles DS. New mRNAs are preferentially translated during vesicular stomatitis virus infection. J Virol. 2008 Mar; 82(5):2286-94.
    View in: PubMed
  28. Connor JH, McKenzie MO, Parks GD, Lyles DS. Antiviral activity and RNA polymerase degradation following Hsp90 inhibition in a range of negative strand viruses. Virology. 2007 May 25; 362(1):109-19.
    View in: PubMed
  29. Hantgan RR, Stahle MC, Connor JH, Connor RF, Mousa SA. AlphaIIbbeta3 priming and clustering by orally active and intravenous integrin antagonists. J Thromb Haemost. 2007 Mar; 5(3):542-50.
    View in: PubMed
  30. Whitlow ZW, Connor JH, Lyles DS. Preferential translation of vesicular stomatitis virus mRNAs is conferred by transcription from the viral genome. J Virol. 2006 Dec; 80(23):11733-42.
    View in: PubMed
  31. Hantgan RR, Stahle MC, Connor JH, Horita DA, Rocco M, McLane MA, Yakovlev S, Medved L. Integrin alphaIIbbeta3:ligand interactions are linked to binding-site remodeling. Protein Sci. 2006 Aug; 15(8):1893-906.
    View in: PubMed
  32. Connor JH, McKenzie MO, Lyles DS. Role of residues 121 to 124 of vesicular stomatitis virus matrix protein in virus assembly and virus-host interaction. J Virol. 2006 Apr; 80(8):3701-11.
    View in: PubMed
  33. Connor JH, Lyles DS. Inhibition of host and viral translation during vesicular stomatitis virus infection. eIF2 is responsible for the inhibition of viral but not host translation. J Biol Chem. 2005 Apr 8; 280(14):13512-9.
    View in: PubMed
  34. Hantgan RR, Stahle MC, Connor JH, Lyles DS, Horita DA, Rocco M, Nagaswami C, Weisel JW, McLane MA. The disintegrin echistatin stabilizes integrin alphaIIbbeta3's open conformation and promotes its oligomerization. J Mol Biol. 2004 Oct 1; 342(5):1625-36.
    View in: PubMed
  35. Connor JH, Naczki C, Koumenis C, Lyles DS. Replication and cytopathic effect of oncolytic vesicular stomatitis virus in hypoxic tumor cells in vitro and in vivo. J Virol. 2004 Sep; 78(17):8960-70.
    View in: PubMed
  36. Brush MH, Guardiola A, Connor JH, Yao TP, Shenolikar S. Deactylase inhibitors disrupt cellular complexes containing protein phosphatases and deacetylases. J Biol Chem. 2004 Feb 27; 279(9):7685-91.
    View in: PubMed
  37. Connor JH, Lyles DS. Vesicular stomatitis virus infection alters the eIF4F translation initiation complex and causes dephosphorylation of the eIF4E binding protein 4E-BP1. J Virol. 2002 Oct; 76(20):10177-87.
    View in: PubMed
  38. Terry-Lorenzo RT, Carmody LC, Voltz JW, Connor JH, Li S, Smith FD, Milgram SL, Colbran RJ, Shenolikar S. The neuronal actin-binding proteins, neurabin I and neurabin II, recruit specific isoforms of protein phosphatase-1 catalytic subunits. J Biol Chem. 2002 Aug 2; 277(31):27716-24.
    View in: PubMed
  39. Morishita W, Connor JH, Xia H, Quinlan EM, Shenolikar S, Malenka RC. Regulation of synaptic strength by protein phosphatase 1. Neuron. 2001 Dec 20; 32(6):1133-48.
    View in: PubMed
  40. Connor JH, Weiser DC, Li S, Hallenbeck JM, Shenolikar S. Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1. Mol Cell Biol. 2001 Oct; 21(20):6841-50.
    View in: PubMed
  41. Connor, J.H., Weiser, D.C., Li, S., Hallenbeck, J., and Shenolikar, S.; (2001) 21: 6841-6850. . Growth Arrest and DNA Damage-Induced Protein, GADD34, Assembles a Novel Signaling Complex Containing Protein Phosphatase-1 and Inhibitor-1. Mol. Cell. Biol. 2001; 21:6841-6850.
  42. Brown GP, Blitzer RD, Connor JH, Wong T, Shenolikar S, Iyengar R, Landau EM. Long-term potentiation induced by theta frequency stimulation is regulated by a protein phosphatase-1-operated gate. J Neurosci. 2000 Nov 1; 20(21):7880-7.
    View in: PubMed
  43. Shen K, Teruel MN, Connor JH, Shenolikar S, Meyer T. Molecular memory by reversible translocation of calcium/calmodulin-dependent protein kinase II. Nat Neurosci. 2000 Sep; 3(9):881-6.
    View in: PubMed
  44. Connor JH, Frederick D, Huang Hb, Yang J, Helps NR, Cohen PT, Nairn AC, DePaoli-Roach A, Tatchell K, Shenolikar S. Cellular mechanisms regulating protein phosphatase-1. A key functional interaction between inhibitor-2 and the type 1 protein phosphatase catalytic subunit. J Biol Chem. 2000 Jun 23; 275(25):18670-5.
    View in: PubMed
  45. Terry-Lorenzo RT, Inoue M, Connor JH, Haystead TA, Armbruster BN, Gupta RP, Oliver CJ, Shenolikar S. Neurofilament-L is a protein phosphatase-1-binding protein associated with neuronal plasma membrane and post-synaptic density. J Biol Chem. 2000 Jan 28; 275(4):2439-46.
    View in: PubMed
  46. Connor JH, Kleeman T, Barik S, Honkanen RE, Shenolikar S. Importance of the beta12-beta13 loop in protein phosphatase-1 catalytic subunit for inhibition by toxins and mammalian protein inhibitors. J Biol Chem. 1999 Aug 6; 274(32):22366-72.
    View in: PubMed
  47. Beullens M, Van Eynde A, Vulsteke V, Connor J, Shenolikar S, Stalmans W, Bollen M. Molecular determinants of nuclear protein phosphatase-1 regulation by NIPP-1. J Biol Chem. 1999 May 14; 274(20):14053-61.
    View in: PubMed
  48. Connor JH, Quan HN, Ramaswamy NT, Zhang L, Barik S, Zheng J, Cannon JF, Lee EY, Shenolikar S. Inhibitor-1 interaction domain that mediates the inhibition of protein phosphatase-1. J Biol Chem. 1998 Oct 16; 273(42):27716-24.
    View in: PubMed
  49. Blitzer RD, Connor JH, Brown GP, Wong T, Shenolikar S, Iyengar R, Landau EM. Gating of CaMKII by cAMP-regulated protein phosphatase activity during LTP. Science. 1998 Jun 19; 280(5371):1940-2.
    View in: PubMed
  50. Connor JH, Quan H, Oliver C, Shenolikar S. Inhibitor-1, a regulator of protein phosphatase 1 function. Methods Mol Biol. 1998; 93:41-58.
    View in: PubMed
  51. Endo S, Connor JH, Forney B, Zhang L, Ingebritsen TS, Lee EY, Shenolikar S. Conversion of protein phosphatase 1 catalytic subunit to a Mn(2+)-dependent enzyme impairs its regulation by inhibitor 1. Biochemistry. 1997 Jun 10; 36(23):6986-92.
    View in: PubMed
  52. Endo, S., Xiaozhen, Z., Connor, J., Wang, B., Shenolikar, S. . Multiple Structural Elements Define the Specificity of Recombinant Human Inhibitor-1 as a Protein Phosphatase Inhibitor. Biochemistry. 1996; 35:5220-5228.
John's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts
_
BU Co-Authors
_
Similar BU People
_
Same Department