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Last Name

John R. Murphy, PhD

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionInfectious Disease
Address650 Albany St Evans Biomed Research Ctr
Boston MA 02118
Phone(617) 638-6014
ORCID ORCID Icon0000-0002-8526-5256
Other Positions
TitleCo-Director of National Emerging Infectious Disease Lab
InstitutionBoston University School of Medicine
DepartmentNational Emerging Infectious Disease Lab

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentMicrobiology

TitleMentor for Graduate Medical Students
InstitutionBoston University School of Medicine, Graduate Medical Sciences

InstitutionBoston Medical Center

 NIH RePORTER Grants

Yr Title Project-Sub Proj Pubs
2014 National Emerging Infectious Diseases Laboratories Operations 1UC7AI095321-01
2014 Administration 1UC7AI095321-01-6076
2014 Facility Maintenance 1UC7AI095321-01-6077
2014 Biosecurity 1UC7AI095321-01-6078
2014 Environmental Health &Biosafety Regulations and Requirements 1UC7AI095321-01-6079
2014 Regulatory Compliance 1UC7AI095321-01-6080
2014 Integrated Support Services-Animal 1UC7AI095321-01-6081
2013 Community Relations Core 3UC7AI070088-05S3-6807 1
2013 Administration Core 3UC7AI070088-05S3-6811 1
2012 COPI interactions mediate toxin entry: a common shared mechanism of translocation 5U54AI057159-09-5568 296
Showing the 10 most recent of 77 results. Show All Results

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Tamayo AG, Slater L, Taylor-Parker J, Bharti A, Harrison R, Hung DT, Murphy JR. GRP78(BiP) facilitates the cytosolic delivery of anthrax lethal factor (LF) in vivo and functions as an unfoldase in vitro. Mol Microbiol. 2011 Sep; 81(5):1390-401.
    View in: PubMed
  2. Wan ES, Hokanson JE, Murphy JR, Regan EA, Make BJ, Lynch DA, Crapo JD, Silverman EK. Clinical and radiographic predictors of GOLD-unclassified smokers in the COPDGene study. Am J Respir Crit Care Med. 2011 Jul 1; 184(1):57-63.
    View in: PubMed
  3. Murphy JR. Mechanism of diphtheria toxin catalytic domain delivery to the eukaryotic cell cytosol and the cellular factors that directly participate in the process. Toxins (Basel). 2011 Mar; 3(3):294-308.
    View in: PubMed
  4. Lasalle-Williams M, Nuss R, Le T, Cole L, Hassell K, Murphy JR, Ambruso DR. Extended red blood cell antigen matching for transfusions in sickle cell disease: a review of a 14-year experience from a single center (CME). Transfusion. 2011 Aug; 51(8):1732-9.
    View in: PubMed
  5. Phasomkusolsil S, Lerdthusnee K, Khuntirat B, Kongtak W, Pantuwatana K, Murphy JR. Effect of temperature on laboratory reared Anopheles dirus Peyton and Harrison and Anopheles sawadwongporni Rattanarithikul and Green. Southeast Asian J Trop Med Public Health. 2011 Jan; 42(1):63-70.
    View in: PubMed
  6. Trujillo C, Taylor-Parker J, Harrison R, Murphy JR. Essential lysine residues within transmembrane helix 1 of diphtheria toxin facilitate COPI binding and catalytic domain entry. Mol Microbiol. 2010 May; 76(4):1010-9.
    View in: PubMed
  7. Wright DG, Zhang Y, Murphy JR. Effective delivery of antisense peptide nucleic acid oligomers into cells by anthrax protective antigen. Biochem Biophys Res Commun. 2008 Nov 7; 376(1):200-5.
    View in: PubMed
  8. Chiavolini D, Weir S, Murphy JR, Wetzler LM. Neisseria meningitidis PorB, a Toll-like receptor 2 ligand, improves the capacity of Francisella tularensis lipopolysaccharide to protect mice against experimental tularemia. Clin Vaccine Immunol. 2008 Sep; 15(9):1322-9.
    View in: PubMed
  9. Tamayo AG, Bharti A, Trujillo C, Harrison R, Murphy JR. COPI coatomer complex proteins facilitate the translocation of anthrax lethal factor across vesicular membranes in vitro. Proc Natl Acad Sci U S A. 2008 Apr 1; 105(13):5254-9.
    View in: PubMed
  10. Chiavolini D, Alroy J, King CA, Jorth P, Weir S, Madico G, Murphy JR, Wetzler LM. Identification of immunologic and pathologic parameters of death versus survival in respiratory tularemia. Infect Immun. 2008 Feb; 76(2):486-96.
    View in: PubMed
  11. Ratts R, Trujillo C, Bharti A, vanderSpek J, Harrison R, Murphy JR. A conserved motif in transmembrane helix 1 of diphtheria toxin mediates catalytic domain delivery to the cytosol. Proc Natl Acad Sci U S A. 2005 Oct 25; 102(43):15635-40.
    View in: PubMed
  12. Manabe YC, Hatem CL, Kesavan AK, Durack J, Murphy JR. Both Corynebacterium diphtheriae DtxR(E175K) and Mycobacterium tuberculosis IdeR(D177K) are dominant positive repressors of IdeR-regulated genes in M. tuberculosis. Infect Immun. 2005 Sep; 73(9):5988-94.
    View in: PubMed
  13. Rangachari V, Marin V, Bienkiewicz EA, Semavina M, Guerrero L, Love JF, Murphy JR, Logan TM. Sequence of ligand binding and structure change in the diphtheria toxin repressor upon activation by divalent transition metals. Biochemistry. 2005 Apr 19; 44(15):5672-82.
    View in: PubMed
  14. Wylie GP, Rangachari V, Bienkiewicz EA, Marin V, Bhattacharya N, Love JF, Murphy JR, Logan TM. Prolylpeptide binding by the prokaryotic SH3-like domain of the diphtheria toxin repressor: a regulatory switch. Biochemistry. 2005 Jan 11; 44(1):40-51.
    View in: PubMed
  15. Love JF, vanderSpek JC, Marin V, Guerrero L, Logan TM, Murphy JR. Genetic and biophysical studies of diphtheria toxin repressor (DtxR) and the hyperactive mutant DtxR(E175K) support a multistep model of activation. Proc Natl Acad Sci U S A. 2004 Feb 24; 101(8):2506-11.
    View in: PubMed
  16. Ando M, Manabe YC, Converse PJ, Miyazaki E, Harrison R, Murphy JR, Bishai WR. Characterization of the role of the divalent metal ion-dependent transcriptional repressor MntR in the virulence of Staphylococcus aureus. Infect Immun. 2003 May; 71(5):2584-90.
    View in: PubMed
  17. Love JF, VanderSpek JC, Murphy JR. The src homology 3-like domain of the diphtheria toxin repressor (DtxR) modulates repressor activation through interaction with the ancillary metal ion-binding site. J Bacteriol. 2003 Apr; 185(7):2251-8.
    View in: PubMed
  18. Ratts R, Zeng H, Berg EA, Blue C, McComb ME, Costello CE, vanderSpek JC, Murphy JR. The cytosolic entry of diphtheria toxin catalytic domain requires a host cell cytosolic translocation factor complex. J Cell Biol. 2003 Mar 31; 160(7):1139-50.
    View in: PubMed
  19. Spiering MM, Ringe D, Murphy JR, Marletta MA. Metal stoichiometry and functional studies of the diphtheria toxin repressor. Proc Natl Acad Sci U S A. 2003 Apr 1; 100(7):3808-13.
    View in: PubMed
  20. Love JF, Murphy JR. Design and development of a novel genetic probe for the analysis of repressor-operator interactions. J Microbiol Methods. 2002 Sep; 51(1):63-72.
    View in: PubMed
  21. Sebastian S, Agarwal S, Murphy JR, Genco CA. The gonococcal fur regulon: identification of additional genes involved in major catabolic, recombination, and secretory pathways. J Bacteriol. 2002 Jul; 184(14):3965-74.
    View in: PubMed
  22. vanderSpek JC, Sutherland JA, Gill BM, Gorgun G, Foss FM, Murphy JR. Structure function analysis of interleukin 7: requirement for an aromatic ring at position 143 of helix D. Cytokine. 2002 Mar 7; 17(5):227-33.
    View in: PubMed
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