Keywords
Last Name

William W. Cruikshank, PhD

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionPulmonary, Allergy, Sleep & Critical Care Medicine
Address72 E. Concord St Housman (R)
Boston MA 02118
Phone(617) 638-5295
ORCID ORCID Icon0000-0003-2161-4397
Other Positions
TitleAssistant Dean
InstitutionBoston University School of Medicine
DepartmentMinority Affairs

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentPathology & Laboratory Medicine

TitleMentor for Graduate Medical Students
InstitutionBoston University School of Medicine, Graduate Medical Sciences

 Research Expertise & Professional Interests
Expertise includes: T lymphocyte activation and recruitment at sites of inflammation; Regulation of T cell proliferation in association with T cell cancers.

 Self-Described Keywords
  • Cell activation
  • chemokines
  • Chemotaxis
  • T lymphocytes
  • T regulatory cells
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Richmond J, Tuzova M, Cruikshank W, Center D. Regulation of cellular processes by interleukin-16 in homeostasis and cancer. J Cell Physiol. 2014 Feb; 229(2):139-47.
    View in: PubMed
  2. Chen F, Marquez H, Kim YK, Qian J, Shao F, Fine A, Cruikshank WW, Quadro L, Cardoso WV. Prenatal retinoid deficiency leads to airway hyperresponsiveness in adult mice. J Clin Invest. 2014 Feb 3; 124(2):801-11.
    View in: PubMed
  3. Aven L, Paez-Cortez J, Achey R, Krishnan R, Ram-Mohan S, Cruikshank WW, Fine A, Ai X. An NT4/TrkB-dependent increase in innervation links early-life allergen exposure to persistent airway hyperreactivity. FASEB J. 2014 Feb; 28(2):897-907.
    View in: PubMed
  4. Richmond JM, Lee J, Green DS, Kornfeld H, Cruikshank WW. Mannose-capped lipoarabinomannan from Mycobacterium tuberculosis preferentially inhibits sphingosine-1-phosphate-induced migration of Th1 cells. J Immunol. 2012 Dec 15; 189(12):5886-95.
    View in: PubMed
  5. Gern JE, Pappas T, Visness CM, Jaffee KF, Lemanske RF, Togias A, Bloomberg GR, Cruikshank WW, Lamm C, Tuzova M, Wood RA, Lee WM. Comparison of the etiology of viral respiratory illnesses in inner-city and suburban infants. J Infect Dis. 2012 Nov; 206(9):1342-9.
    View in: PubMed
  6. Richmond JM, Duffy ER, Lee J, Kaboli K, Kim YS, Remick DG, Kornfeld H, Cruikshank WW. Mannose-capped Lipoarabinomannan from Mycobacterium tuberculosis induces soluble tumor necrosis factor receptor production through tumor necrosis factor alpha-converting enzyme activation. Infect Immun. 2012 Nov; 80(11):3858-68.
    View in: PubMed
  7. Natarajan S, Kim J, Bouchard J, Cruikshank W, Remick DG. Pulmonary endotoxin tolerance protects against cockroach allergen-induced asthma-like inflammation in a mouse model. Int Arch Allergy Immunol. 2012; 158(2):120-30.
    View in: PubMed
  8. Curiel-Lewandrowski C, Yamasaki H, Si CP, Jin X, Zhang Y, Richmond J, Tuzova M, Wilson K, Sullivan B, Jones D, Ryzhenko N, Little F, Kupper TS, Center DM, Cruikshank WW. Loss of nuclear pro-IL-16 facilitates cell cycle progression in human cutaneous T cell lymphoma. J Clin Invest. 2011 Dec; 121(12):4838-49.
    View in: PubMed
  9. Granada M, Wilk JB, Tuzova M, Strachan DP, Weidinger S, Albrecht E, Gieger C, Heinrich J, Himes BE, Hunninghake GM, Celedón JC, Weiss ST, Cruikshank WW, Farrer LA, Center DM, O'Connor GT. A genome-wide association study of plasma total IgE concentrations in the Framingham Heart Study. J Allergy Clin Immunol. 2012 Mar; 129(3):840-845.e21.
    View in: PubMed
  10. McLoughlin RM, Calatroni A, Visness CM, Wallace PK, Cruikshank WW, Tuzova M, Ly NP, Ruiz-Perez B, Kattan M, Bloomberg GR, Lederman H, Gern JE, Gold DR. Longitudinal relationship of early life immunomodulatory T cell phenotype and function to development of allergic sensitization in an urban cohort. Clin Exp Allergy. 2012 Mar; 42(3):392-404.
    View in: PubMed
  11. Kim J, Natarajan S, Vaickus LJ, Bouchard JC, Beal D, Cruikshank WW, Remick DG. Diesel exhaust particulates exacerbate asthma-like inflammation by increasing CXC chemokines. Am J Pathol. 2011 Dec; 179(6):2730-9.
    View in: PubMed
  12. Richmond J, Finkel M, Studwell A, Little F, Cruikshank W. Introduction of pro-interleukin-16 inhibits T-lymphoblastic leukemia growth in mice. J Cancer Res Clin Oncol. 2011 Oct; 137(10):1581-5.
    View in: PubMed
  13. Kim J, Natarajan S, Bae H, Jung SK, Cruikshank W, Remick DG. Herbal medicine treatment reduces inflammation in a murine model of cockroach allergen-induced asthma. Ann Allergy Asthma Immunol. 2011 Aug; 107(2):154-62.
    View in: PubMed
  14. Natarajan S, Kim J, Bouchard J, Cruikshank W, Remick DG. Reducing LPS content in cockroach allergens increases pulmonary cytokine production without increasing inflammation: a randomized laboratory study. BMC Pulm Med. 2011; 11:12.
    View in: PubMed
  15. Croq F, Vizioli J, Tuzova M, Tahtouh M, Sautiere PE, Van Camp C, Salzet M, Cruikshank WW, Pestel J, Lefebvre C. A homologous form of human interleukin 16 is implicated in microglia recruitment following nervous system injury in leech Hirudo medicinalis. Glia. 2010 Nov 1; 58(14):1649-62.
    View in: PubMed
  16. Richmond J, Tuzova M, Parks A, Adams N, Martin E, Tawa M, Morrison L, Chaney K, Kupper TS, Curiel-Lewandrowski C, Cruikshank W. Interleukin-16 as a marker of Sézary syndrome onset and stage. J Clin Immunol. 2011 Feb; 31(1):39-50.
    View in: PubMed
  17. Meagher C, Beilke J, Arreaza G, Mi QS, Chen W, Salojin K, Horst N, Cruikshank WW, Delovitch TL. Neutralization of interleukin-16 protects nonobese diabetic mice from autoimmune type 1 diabetes by a CCL4-dependent mechanism. Diabetes. 2010 Nov; 59(11):2862-71.
    View in: PubMed
  18. Warstat K, Hoberg M, Rudert M, Tsui S, Pap T, Angres B, Essl M, Smith TJ, Cruikshank WW, Klein G, Gay S, Aicher WK. Transforming growth factor beta1 and laminin-111 cooperate in the induction of interleukin-16 expression in synovial fibroblasts from patients with rheumatoid arthritis. Ann Rheum Dis. 2010 Jan; 69(1):270-5.
    View in: PubMed
  19. Gold DR, Bloomberg GR, Cruikshank WW, Visness CM, Schwarz J, Kattan M, O'Connor GT, Wood RA, Burger MS, Wright RJ, Witter F, Lee-Parritz A, Sperling R, Sadovsky Y, Togias A, Gern JE. Parental characteristics, somatic fetal growth, and season of birth influence innate and adaptive cord blood cytokine responses. J Allergy Clin Immunol. 2009 Nov; 124(5):1078-87.
    View in: PubMed
  20. Garcia-Saura MF, Fernandez BO, McAllister BP, Whitlock DR, Cruikshank WW, Feelisch M. Dermal nitrite application enhances global nitric oxide availability: new therapeutic potential for immunomodulation? J Invest Dermatol. 2010 Feb; 130(2):608-11.
    View in: PubMed
  21. Ly NP, Ruiz-Perez B, McLoughlin RM, Visness CM, Wallace PK, Cruikshank WW, Tzianabos AO, O'Connor GT, Gold DR, Gern JE. Characterization of regulatory T cells in urban newborns. Clin Mol Allergy. 2009; 7:8.
    View in: PubMed
  22. Radstake TR, van Bon L, Broen J, Wenink M, Santegoets K, Deng Y, Hussaini A, Simms R, Cruikshank WW, Lafyatis R. Increased frequency and compromised function of T regulatory cells in systemic sclerosis (SSc) is related to a diminished CD69 and TGFbeta expression. PLoS One. 2009; 4(6):e5981.
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  23. Green DS, Center DM, Cruikshank WW. Human immunodeficiency virus type 1 gp120 reprogramming of CD4+ T-cell migration provides a mechanism for lymphadenopathy. J Virol. 2009 Jun; 83(11):5765-72.
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  24. Matsumoto Y, Fujita T, Hirai I, Sahara H, Torigoe T, Ezoe K, Saito T, Cruikshank WW, Yotsuyanagi T, Sato N. Immunosuppressive effect on T cell activation by interleukin-16- and interleukin-10-cDNA-double-transfected human squamous cell line. Burns. 2009 May; 35(3):383-9.
    View in: PubMed
  25. Tzianabos AO, Holsti MA, Zheng XX, Stucchi AF, Kuchroo VK, Strom TB, Glimcher LH, Cruikshank WW. Functional Th1 cells are required for surgical adhesion formation in a murine model. J Immunol. 2008 May 15; 180(10):6970-6.
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  26. Cruikshank W, Little F. lnterleukin-16: the ins and outs of regulating T-cell activation. Crit Rev Immunol. 2008; 28(6):467-83.
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  27. Zhang Y, Tuzova M, Xiao ZX, Cruikshank WW, Center DM. Pro-IL-16 recruits histone deacetylase 3 to the Skp2 core promoter through interaction with transcription factor GABP. J Immunol. 2008 Jan 1; 180(1):402-8.
    View in: PubMed
  28. Lowry MH, McAllister BP, Jean JC, Brown LA, Hughey RP, Cruikshank WW, Amar S, Lucey EC, Braun K, Johnson P, Wight TN, Joyce-Brady M. Lung lining fluid glutathione attenuates IL-13-induced asthma. Am J Respir Cell Mol Biol. 2008 May; 38(5):509-16.
    View in: PubMed
  29. McFadden C, Morgan R, Rahangdale S, Green D, Yamasaki H, Center D, Cruikshank W. Preferential migration of T regulatory cells induced by IL-16. J Immunol. 2007 Nov 15; 179(10):6439-45.
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  30. Wang S, Diao H, Guan Q, Cruikshank WW, Delovitch TL, Jevnikar AM, Du C. Decreased renal ischemia-reperfusion injury by IL-16 inactivation. Kidney Int. 2008 Feb; 73(3):318-26.
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  31. Morgan RK, McAllister B, Cross L, Green DS, Kornfeld H, Center DM, Cruikshank WW. Histamine 4 receptor activation induces recruitment of FoxP3+ T cells and inhibits allergic asthma in a murine model. J Immunol. 2007 Jun 15; 178(12):8081-9.
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  32. Shreffler WG, Visness CM, Burger M, Cruikshank WW, Lederman HM, de la Morena M, Grindle K, Calatroni A, Sampson HA, Gern JE. Standardization and performance evaluation of mononuclear cell cytokine secretion assays in a multicenter study. BMC Immunol. 2006; 7:29.
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  33. Skundric DS, Cai J, Cruikshank WW, Gveric D. Production of IL-16 correlates with CD4+ Th1 inflammation and phosphorylation of axonal cytoskeleton in multiple sclerosis lesions. J Neuroinflammation. 2006; 3:13.
    View in: PubMed
  34. Rahangdale S, Morgan R, Heijens C, Ryan TC, Yamasaki H, Bentley E, Sullivan E, Center DM, Cruikshank WW. Chemokine receptor CXCR3 desensitization by IL-16/CD4 signaling is dependent on CCR5 and intact membrane cholesterol. J Immunol. 2006 Feb 15; 176(4):2337-45.
    View in: PubMed
  35. Gianoukakis AG, Douglas RS, King CS, Cruikshank WW, Smith TJ. Immunoglobulin G from patients with Graves' disease induces interleukin-16 and RANTES expression in cultured human thyrocytes: a putative mechanism for T-cell infiltration of the thyroid in autoimmune disease. Endocrinology. 2006 Apr; 147(4):1941-9.
    View in: PubMed
  36. Burkart KM, Barton SJ, Holloway JW, Yang IA, Cakebread JA, Cruikshank W, Little F, Jin X, Farrer LA, Clough JB, Keith TP, Holgate S, Center DM, O'Connor GT. Association of asthma with a functional promoter polymorphism in the IL16 gene. J Allergy Clin Immunol. 2006 Jan; 117(1):86-91.
    View in: PubMed
  37. Wilson KC, Cattel DJ, Wan Z, Rahangdale S, Ren F, Kornfeld H, Sullivan BA, Cruikshank WW, Center DM. Regulation of nuclear Prointerleukin-16 and p27(Kip1) in primary human T lymphocytes. Cell Immunol. 2005 Sep; 237(1):17-27.
    View in: PubMed
  38. Skundric DS, Zhou W, Cruikshank WW, Dai R. Increased levels of bioactive IL-16 correlate with disease activity during relapsing experimental autoimmune encephalomyelitis (EAE). J Autoimmun. 2005 Nov; 25(3):206-14.
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  39. Skundric DS, Dai R, Zakarian VL, Bessert D, Skoff RP, Cruikshank WW, Kurjakovic Z. Anti-IL-16 therapy reduces CD4+ T-cell infiltration and improves paralysis and histopathology of relapsing EAE. J Neurosci Res. 2005 Mar 1; 79(5):680-93.
    View in: PubMed
  40. Pritchard J, Tsui S, Horst N, Cruikshank WW, Smith TJ. Synovial fibroblasts from patients with rheumatoid arthritis, like fibroblasts from Graves' disease, express high levels of IL-16 when treated with Igs against insulin-like growth factor-1 receptor. J Immunol. 2004 Sep 1; 173(5):3564-9.
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  41. Little FF, Cruikshank WW. Interleukin-16 and peptide derivatives as immunomodulatory therapy in allergic lung disease. Expert Opin Biol Ther. 2004 Jun; 4(6):837-46.
    View in: PubMed
  42. Wilson KC, Center DM, Cruikshank WW. The effect of interleukin-16 and its precursor on T lymphocyte activation and growth. Growth Factors. 2004 Jun; 22(2):97-104.
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  43. Center DM, Cruikshank WW, Zhang Y. Nuclear pro-IL-16 regulation of T cell proliferation: p27(KIP1)-dependent G0/G1 arrest mediated by inhibition of Skp2 transcription. J Immunol. 2004 Feb 1; 172(3):1654-60.
    View in: PubMed
  44. Lynch EL, Little FF, Wilson KC, Center DM, Cruikshank WW. Immunomodulatory cytokines in asthmatic inflammation. Cytokine Growth Factor Rev. 2003 Dec; 14(6):489-502.
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  45. Lynch EA, Heijens CA, Horst NF, Center DM, Cruikshank WW. Cutting edge: IL-16/CD4 preferentially induces Th1 cell migration: requirement of CCR5. J Immunol. 2003 Nov 15; 171(10):4965-8.
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  46. Komata T, Cruikshank WW, Kelso A. Sustained linked stimulation via CD3 and CD4 is required for the IL-4-independent development of IL-4 synthesizing CD4+ T cells. Immunol Cell Biol. 2003 Aug; 81(4):283-8.
    View in: PubMed
  47. Gianoukakis AG, Martino LJ, Horst N, Cruikshank WW, Smith TJ. Cytokine-induced lymphocyte chemoattraction from cultured human thyrocytes: evidence for interleukin-16 and regulated upon activation, normal T cell expressed, and secreted expression. Endocrinology. 2003 Jul; 144(7):2856-64.
    View in: PubMed
  48. Pritchard J, Han R, Horst N, Cruikshank WW, Smith TJ. Immunoglobulin activation of T cell chemoattractant expression in fibroblasts from patients with Graves' disease is mediated through the insulin-like growth factor I receptor pathway. J Immunol. 2003 Jun 15; 170(12):6348-54.
    View in: PubMed
  49. Curiel-Lewandrowski C, Venna SS, Eller MS, Cruikshank W, Dougherty I, Cruz PD, Gilchrest BA. Inhibition of the elicitation phase of contact hypersensitivity by thymidine dinucleotides is in part mediated by increased expression of interleukin-10 in human keratinocytes. Exp Dermatol. 2003 Apr; 12(2):145-52.
    View in: PubMed
  50. Little FF, Lynch E, Fine G, Center DM, Cruikshank WW. Tumor necrosis factor-alpha-induced synthesis of interleukin-16 in airway epithelial cells: priming for serotonin stimulation. Am J Respir Cell Mol Biol. 2003 Mar; 28(3):354-62.
    View in: PubMed
  51. Little FF, de Bie J, van Oosterhout A, Kornfeld H, Center DM, Cruikshank WW. Immunomodulatory effect of interleukin-16 on allergic airway inflammation. Chest. 2003 Mar; 123(3 Suppl):431S-2S.
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  52. Wilson KC, Center DM, Cruikshank WW, Zhang Y. Binding of HTLV-1 tax oncoprotein to the precursor of interleukin-16, a T cell PDZ domain-containing protein. Virology. 2003 Feb 1; 306(1):60-7.
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  53. Wilson KC, Cruikshank WW, Center DM, Zhang Y. Prointerleukin-16 contains a functional CcN motif that regulates nuclear localization. Biochemistry. 2002 Dec 3; 41(48):14306-12.
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  54. Dent G, Hosking LA, Lordan JL, Steel MD, Cruikshank WW, Center DM, Ellis JH, Holgate ST, Davies DE, Djukanovic R. Differential roles of IL-16 and CD28/B7 costimulation in the generation of T-lymphocyte chemotactic activity in the bronchial mucosa of mild and moderate asthmatic individuals. J Allergy Clin Immunol. 2002 Dec; 110(6):906-14.
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  55. De Bie JJ, Jonker EH, Henricks PA, Hoevenaars J, Little FF, Cruikshank WW, Nijkamp FP, Van Oosterhout AJ. Exogenous interleukin-16 inhibits antigen-induced airway hyper-reactivity, eosinophilia and Th2-type cytokine production in mice. Clin Exp Allergy. 2002 Nov; 32(11):1651-8.
    View in: PubMed
  56. Gantner F, Sakai K, Tusche MW, Cruikshank WW, Center DM, Bacon KB. Histamine h(4) and h(2) receptors control histamine-induced interleukin-16 release from human CD8(+) T cells. J Pharmacol Exp Ther. 2002 Oct; 303(1):300-7.
    View in: PubMed
  57. Bandeira-Melo C, Sugiyama K, Woods LJ, Phoofolo M, Center DM, Cruikshank WW, Weller PF. IL-16 promotes leukotriene C(4) and IL-4 release from human eosinophils via CD4- and autocrine CCR3-chemokine-mediated signaling. J Immunol. 2002 May 1; 168(9):4756-63.
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  58. Pritchard J, Horst N, Cruikshank W, Smith TJ. Igs from patients with Graves' disease induce the expression of T cell chemoattractants in their fibroblasts. J Immunol. 2002 Jan 15; 168(2):942-50.
    View in: PubMed
  59. Little FF, Cruikshank WW, Center DM. Il-9 stimulates release of chemotactic factors from human bronchial epithelial cells. Am J Respir Cell Mol Biol. 2001 Sep; 25(3):347-52.
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  60. Ludwiczek O, Kaser A, Koch RO, Vogel W, Cruikshank WW, Tilg H. Activation of caspase-3 by interferon alpha causes interleukin-16 secretion but fails to modulate activation induced cell death. Eur Cytokine Netw. 2001 Jul-Sep; 12(3):478-86.
    View in: PubMed
  61. Center DM, Cruikshank WW, Parada NA, Ryan T, Theodore AC, Viglianti G, Lim KG, Weller PF. Measurement of interleukin 16. Curr Protoc Immunol. 2001 May; Chapter 6:Unit 6.23.
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  62. Kornfeld H, Cruikshank WW. Prospects for IL-16 in the treatment of AIDS. Expert Opin Biol Ther. 2001 May; 1(3):425-32.
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  63. Stoitzner P, Ratzinger G, Koch F, Janke K, Schöller T, Kaser A, Tilg H, Cruikshank WW, Fritsch P, Romani N. Interleukin-16 supports the migration of Langerhans cells, partly in a CD4-independent way. J Invest Dermatol. 2001 May; 116(5):641-9.
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  64. Pinsonneault S, El Bassam S, Mazer B, Cruikshank WW, Laberge S. IL-16 inhibits IL-5 production by antigen-stimulated T cells in atopic subjects. J Allergy Clin Immunol. 2001 Mar; 107(3):477-82.
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  65. Strohmeier GR, Walsh JH, Klings ES, Farber HW, Cruikshank WW, Center DM, Fenton MJ. Lipopolysaccharide binding protein potentiates airway reactivity in a murine model of allergic asthma. J Immunol. 2001 Feb 1; 166(3):2063-70.
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  66. Zhang Y, Kornfeld H, Cruikshank WW, Kim S, Reardon CC, Center DM. Nuclear translocation of the N-terminal prodomain of interleukin-16. J Biol Chem. 2001 Jan 12; 276(2):1299-303.
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  67. Van Drenth C, Jenkins A, Ledwich L, Ryan TC, Mashikian MV, Brazer W, Center DM, Cruikshank WW. Desensitization of CXC chemokine receptor 4, mediated by IL-16/CD4, is independent of p56lck enzymatic activity. J Immunol. 2000 Dec 1; 165(11):6356-63.
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  68. Kaser A, Dunzendorfer S, Offner FA, Ludwiczek O, Enrich B, Koch RO, Cruikshank WW, Wiedermann CJ, Tilg H. B lymphocyte-derived IL-16 attracts dendritic cells and Th cells. J Immunol. 2000 Sep 1; 165(5):2474-80.
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  69. Laberge S, Pinsonneault S, Varga EM, Till SJ, Nouri-Aria K, Jacobson M, Cruikshank WW, Center DM, Hamid Q, Durham SR. Increased expression of IL-16 immunoreactivity in bronchial mucosa after segmental allergen challenge in patients with asthma. J Allergy Clin Immunol. 2000 Aug; 106(2):293-301.
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  70. Krug N, Cruikshank WW, Tschernig T, Erpenbeck VJ, Balke K, Hohlfeld JM, Center DM, Fabel H. Interleukin 16 and T-cell chemoattractant activity in bronchoalveolar lavage 24 hours after allergen challenge in asthma. Am J Respir Crit Care Med. 2000 Jul; 162(1):105-11.
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  71. Center DM, Kornfeld H, Ryan TC, Cruikshank WW. Interleukin 16: implications for CD4 functions and HIV-1 progression. Immunol Today. 2000 Jun; 21(6):273-80.
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  72. Cruikshank WW, Kornfeld H, Center DM. Interleukin-16. J Leukoc Biol. 2000 Jun; 67(6):757-66.
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  73. Fujita T, Matsumoto Y, Hirai I, Ezoe K, Saito T, Yagihashi A, Torigoe T, Homma K, Takahashi S, Cruikshank WW, Jimbow K, Sato N. Immunosuppressive effect on T cell activation by interleukin- 16-cDNA-transfected human squamous cell line. Cell Immunol. 2000 May 25; 202(1):54-60.
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  74. Yoshimoto T, Wang CR, Yoneto T, Matsuzawa A, Cruikshank WW, Nariuchi H. Role of IL-16 in delayed-type hypersensitivity reaction. Blood. 2000 May 1; 95(9):2869-74.
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  75. Sciaky D, Brazer W, Center DM, Cruikshank WW, Smith TJ. Cultured human fibroblasts express constitutive IL-16 mRNA: cytokine induction of active IL-16 protein synthesis through a caspase-3-dependent mechanism. J Immunol. 2000 Apr 1; 164(7):3806-14.
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  76. Hidi R, Riches V, Al-Ali M, Cruikshank WW, Center DM, Holgate ST, Djukanovic R. Role of B7-CD28/CTLA-4 costimulation and NF-kappa B in allergen-induced T cell chemotaxis by IL-16 and RANTES. J Immunol. 2000 Jan 1; 164(1):412-8.
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  77. de Bie JJ, Henricks PA, Cruikshank WW, Hofman G, Nijkamp FP, van Oosterhout AJ. Effect of interleukin-16-blocking peptide on parameters of allergic asthma in a murine model. Eur J Pharmacol. 1999 Oct 27; 383(2):189-96.
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  78. Kaser A, Dunzendorfer S, Offner FA, Ryan T, Schwabegger A, Cruikshank WW, Wiedermann CJ, Tilg H. A role for IL-16 in the cross-talk between dendritic cells and T cells. J Immunol. 1999 Sep 15; 163(6):3232-8.
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  79. Yamasaki H, Ando M, Brazer W, Center DM, Cruikshank WW. Polarized type 1 cytokine profile in bronchoalveolar lavage T cells of patients with hypersensitivity pneumonitis. J Immunol. 1999 Sep 15; 163(6):3516-23.
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  80. Mashikian MV, Ryan TC, Seman A, Brazer W, Center DM, Cruikshank WW. Reciprocal desensitization of CCR5 and CD4 is mediated by IL-16 and macrophage-inflammatory protein-1 beta, respectively. J Immunol. 1999 Sep 15; 163(6):3123-30.
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  81. Nicoll J, Cruikshank WW, Brazer W, Liu Y, Center DM, Kornfeld H. Identification of domains in IL-16 critical for biological activity. J Immunol. 1999 Aug 15; 163(4):1827-32.
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  82. Liu Y, Cruikshank WW, O'Loughlin T, O'Reilly P, Center DM, Kornfeld H. Identification of a CD4 domain required for interleukin-16 binding and lymphocyte activation. J Biol Chem. 1999 Aug 13; 274(33):23387-95.
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  83. Wu DM, Zhang Y, Parada NA, Kornfeld H, Nicoll J, Center DM, Cruikshank WW. Processing and release of IL-16 from CD4+ but not CD8+ T cells is activation dependent. J Immunol. 1999 Feb 1; 162(3):1287-93.
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  84. Hofstra CL, Van Ark I, Savelkoul HF, Cruikshank WW, Nijkamp FP, Van Oosterhout AJ. Vbeta8+ T lymphocytes are essential in the regulation of airway hyperresponsiveness and bronchoalveolar eosinophilia but not in allergen-specific IgE in a murine model of allergic asthma. Clin Exp Allergy. 1998 Dec; 28(12):1571-80.
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  85. Lee ME, Adams JW, Villinger F, Brar SS, Meadows M, Bucur SZ, Lackey DA, Brice GT, Cruikshank WW, Ansari AA, Hillyer CD. Molecular cloning and expression of rhesus macaque and sooty mangabey interleukin 16: biologic activity and effect on simian immunodeficiency virus infection and/or replication. AIDS Res Hum Retroviruses. 1998 Oct 10; 14(15):1323-8.
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  86. Chupp GL, Wright EA, Wu D, Vallen-Mashikian M, Cruikshank WW, Center DM, Kornfeld H, Berman JS. Tissue and T cell distribution of precursor and mature IL-16. J Immunol. 1998 Sep 15; 161(6):3114-9.
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  87. Szabo P, Zhao K, Kirman I, Le Maoult J, Dyall R, Cruikshank W, Weksler ME. Maturation of B cell precursors is impaired in thymic-deprived nude and old mice. J Immunol. 1998 Sep 1; 161(5):2248-53.
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  88. De Bie JJ, Henricks PA, Cruikshank WW, Hofman G, Jonker EH, Nijkamp FP, Van Oosterhout AJ. Modulation of airway hyperresponsiveness and eosinophilia by selective histamine and 5-HT receptor antagonists in a mouse model of allergic asthma. Br J Pharmacol. 1998 Jul; 124(5):857-64.
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  89. Keane J, Nicoll J, Kim S, Wu DM, Cruikshank WW, Brazer W, Natke B, Zhang Y, Center DM, Kornfeld H. Conservation of structure and function between human and murine IL-16. J Immunol. 1998 Jun 15; 160(12):5945-54.
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  90. Mashikian MV, Tarpy RE, Saukkonen JJ, Lim KG, Fine GD, Cruikshank WW, Center DM. Identification of IL-16 as the lymphocyte chemotactic activity in the bronchoalveolar lavage fluid of histamine-challenged asthmatic patients. J Allergy Clin Immunol. 1998 Jun; 101(6 Pt 1):786-92.
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  91. Bostik P, Villinger F, Brice GT, Chikkala NF, Brar SS, Cruikshank WW, Adams JW, Hillyer CD, Ansari AA. Expression and in vitro evaluation of rhesus macaque wild type (wt) and modified CC chemokines. J Med Primatol. 1998 Apr-Jun; 27(2-3):113-20.
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  92. Hessel EM, Cruikshank WW, Van Ark I, De Bie JJ, Van Esch B, Hofman G, Nijkamp FP, Center DM, Van Oosterhout AJ. Involvement of IL-16 in the induction of airway hyper-responsiveness and up-regulation of IgE in a murine model of allergic asthma. J Immunol. 1998 Mar 15; 160(6):2998-3005.
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  93. Gochuico BR, Miranda KM, Hessel EM, De Bie JJ, Van Oosterhout AJ, Cruikshank WW, Fine A. Airway epithelial Fas ligand expression: potential role in modulating bronchial inflammation. Am J Physiol. 1998 Mar; 274(3 Pt 1):L444-9.
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