Keywords
Last Name

Rachel Fearns, PhD

TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentMicrobiology
Address72 E. Concord St
Boston MA 02118
Phone(617) 638-4034
ORCID ORCID Icon0000-0003-0783-7498
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Graduate Medical Sciences

 Research Expertise & Professional Interests
Expertise in paramyxovirus genome transcription and replication mechanisms.

 Self-Described Keywords
  • mononegavirales
  • paramyxovirus
  • processing bodies
  • RNA dependent RNA polymerase
  • stress granules
  • transcription
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Tremaglio CZ, Noton SL, Deflubé LR, Fearns R. Respiratory syncytial virus polymerase can initiate transcription from position 3 of the leader promoter. J Virol. 2013 Mar; 87(6):3196-207.
    View in: PubMed
  2. Collins PL, Fearns R, Graham BS. Respiratory syncytial virus: virology, reverse genetics, and pathogenesis of disease. Curr Top Microbiol Immunol. 2013; 372:3-38.
    View in: PubMed
  3. Noton SL, Deflubé LR, Tremaglio CZ, Fearns R. The respiratory syncytial virus polymerase has multiple RNA synthesis activities at the promoter. PLoS Pathog. 2012; 8(10):e1002980.
    View in: PubMed
  4. Noton SL, Fearns R. The first two nucleotides of the respiratory syncytial virus antigenome RNA replication product can be selected independently of the promoter terminus. RNA. 2011 Oct; 17(10):1895-906.
    View in: PubMed
  5. Hanley LL, McGivern DR, Teng MN, Djang R, Collins PL, Fearns R. Roles of the respiratory syncytial virus trailer region: effects of mutations on genome production and stress granule formation. Virology. 2010 Oct 25; 406(2):241-52.
    View in: PubMed
  6. Noton SL, Cowton VM, Zack CR, McGivern DR, Fearns R. Evidence that the polymerase of respiratory syncytial virus initiates RNA replication in a nontemplated fashion. Proc Natl Acad Sci U S A. 2010 Jun 1; 107(22):10226-31.
    View in: PubMed
  7. Barr JN, Fearns R. How RNA viruses maintain their genome integrity. J Gen Virol. 2010 Jun; 91(Pt 6):1373-87.
    View in: PubMed
  8. Dunn EF, Fearns R, Connor JH. Akt inhibitor Akt-IV blocks virus replication through an Akt-independent mechanism. J Virol. 2009 Nov; 83(22):11665-72.
    View in: PubMed
  9. Gallacher M, Brown SG, Hale BG, Fearns R, Olver RE, Randall RE, Wilson SM. Cation currents in human airway epithelial cells induced by infection with influenza A virus. J Physiol. 2009 Jul 1; 587(Pt 13):3159-73.
    View in: PubMed
  10. Cowton VM, McGivern DR, Fearns R. Unravelling the complexities of respiratory syncytial virus RNA synthesis. J Gen Virol. 2006 Jul; 87(Pt 7):1805-21.
    View in: PubMed
  11. Carlos TS, Fearns R, Randall RE. Interferon-induced alterations in the pattern of parainfluenza virus 5 transcription and protein synthesis and the induction of virus inclusion bodies. J Virol. 2005 Nov; 79(22):14112-21.
    View in: PubMed
  12. Cowton VM, Fearns R. Evidence that the respiratory syncytial virus polymerase is recruited to nucleotides 1 to 11 at the 3' end of the nucleocapsid and can scan to access internal signals. J Virol. 2005 Sep; 79(17):11311-22.
    View in: PubMed
  13. McGivern DR, Collins PL, Fearns R. Identification of internal sequences in the 3' leader region of human respiratory syncytial virus that enhance transcription and confer replication processivity. J Virol. 2005 Feb; 79(4):2449-60.
    View in: PubMed
  14. Fearns R, Peeples ME, Collins PL. Mapping the transcription and replication promoters of respiratory syncytial virus. J Virol. 2002 Feb; 76(4):1663-72.
    View in: PubMed
  15. Fearns R, Collins PL, Peeples ME. Functional analysis of the genomic and antigenomic promoters of human respiratory syncytial virus. J Virol. 2000 Jul; 74(13):6006-14.
    View in: PubMed
  16. Fearns R, Collins PL. Role of the M2-1 transcription antitermination protein of respiratory syncytial virus in sequential transcription. J Virol. 1999 Jul; 73(7):5852-64.
    View in: PubMed
  17. Collins PL, Whitehead SS, Bukreyev A, Fearns R, Teng MN, Juhasz K, Chanock RM, Murphy BR. Rational design of live-attenuated recombinant vaccine virus for human respiratory syncytial virus by reverse genetics. Adv Virus Res. 1999; 54:423-51.
    View in: PubMed
  18. Fearns R, Collins PL. Model for polymerase access to the overlapped L gene of respiratory syncytial virus. J Virol. 1999 Jan; 73(1):388-97.
    View in: PubMed
  19. Fearns R, Peeples ME, Collins PL. Increased expression of the N protein of respiratory syncytial virus stimulates minigenome replication but does not alter the balance between the synthesis of mRNA and antigenome. Virology. 1997 Sep 15; 236(1):188-201.
    View in: PubMed
  20. Kuo L, Fearns R, Collins PL. Analysis of the gene start and gene end signals of human respiratory syncytial virus: quasi-templated initiation at position 1 of the encoded mRNA. J Virol. 1997 Jul; 71(7):4944-53.
    View in: PubMed
  21. Kuo L, Fearns R, Collins PL. The structurally diverse intergenic regions of respiratory syncytial virus do not modulate sequential transcription by a dicistronic minigenome. J Virol. 1996 Sep; 70(9):6143-50.
    View in: PubMed
  22. Precious B, Young DF, Bermingham A, Fearns R, Ryan M, Randall RE. Inducible expression of the P, V, and NP genes of the paramyxovirus simian virus 5 in cell lines and an examination of NP-P and NP-V interactions. J Virol. 1995 Dec; 69(12):8001-10.
    View in: PubMed
  23. Fearns R, Young DF, Randall RE. Evidence that the paramyxovirus simian virus 5 can establish quiescent infections by remaining inactive in cytoplasmic inclusion bodies. J Gen Virol. 1994 Dec; 75 ( Pt 12):3525-39.
    View in: PubMed
Rachel's Networks
Click the "See All" links for more information and interactive visualizations!
Concepts
_
BU Co-Authors
_
Similar BU People
_
Same Department