Keywords
Last Name

Rachel Fearns, PhD

TitleAssociate Professor
InstitutionBoston University School of Medicine
DepartmentMicrobiology
Address72 E. Concord St Housman (R)
Boston MA 02118
Phone(617) 638-4034
ORCID ORCID Icon0000-0003-0783-7498
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Division of Graduate Medical Sciences

 Research Expertise & Professional Interests
Expertise in paramyxovirus genome transcription and replication mechanisms.

 Self-Described Keywords
  • mononegavirales
  • paramyxovirus
  • processing bodies
  • RNA dependent RNA polymerase
  • stress granules
  • transcription
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Munday DC, Wu W, Smith N, Fix J, Noton SL, Galloux M, Touzelet O, Armstrong SD, Dawson JM, Aljabr W, Easton AJ, Rameix-Welti MA, de Oliveira AP, Simabuco FM, Ventura AM, Hughes DJ, Barr JN, Fearns R, Digard P, Eléouët JF, Hiscox JA. Interactome analysis of the human respiratory syncytial virus RNA polymerase complex identifies protein chaperones as important cofactors that promote L-protein stability and RNA synthesis. J Virol. 2015 Jan 15; 89(2):917-30.
    View in: PubMed
  2. Persson BD, Jaffe AB, Fearns R, Danahay H. Respiratory syncytial virus can infect basal cells and alter human airway epithelial differentiation. PLoS One. 2014; 9(7):e102368.
    View in: PubMed
  3. Noton SL, Aljabr W, Hiscox JA, Matthews DA, Fearns R. Factors affecting de novo RNA synthesis and back-priming by the respiratory syncytial virus polymerase. Virology. 2014 Aug; 462-463:318-27.
    View in: PubMed
  4. Tremaglio CZ, Noton SL, Deflubé LR, Fearns R. Respiratory syncytial virus polymerase can initiate transcription from position 3 of the leader promoter. J Virol. 2013 Mar; 87(6):3196-207.
    View in: PubMed
  5. Collins PL, Fearns R, Graham BS. Respiratory syncytial virus: virology, reverse genetics, and pathogenesis of disease. Curr Top Microbiol Immunol. 2013; 372:3-38.
    View in: PubMed
  6. Noton SL, Deflubé LR, Tremaglio CZ, Fearns R. The respiratory syncytial virus polymerase has multiple RNA synthesis activities at the promoter. PLoS Pathog. 2012; 8(10):e1002980.
    View in: PubMed
  7. Noton SL, Fearns R. The first two nucleotides of the respiratory syncytial virus antigenome RNA replication product can be selected independently of the promoter terminus. RNA. 2011 Oct; 17(10):1895-906.
    View in: PubMed
  8. Hanley LL, McGivern DR, Teng MN, Djang R, Collins PL, Fearns R. Roles of the respiratory syncytial virus trailer region: effects of mutations on genome production and stress granule formation. Virology. 2010 Oct 25; 406(2):241-52.
    View in: PubMed
  9. Noton SL, Cowton VM, Zack CR, McGivern DR, Fearns R. Evidence that the polymerase of respiratory syncytial virus initiates RNA replication in a nontemplated fashion. Proc Natl Acad Sci U S A. 2010 Jun 1; 107(22):10226-31.
    View in: PubMed
  10. Barr JN, Fearns R. How RNA viruses maintain their genome integrity. J Gen Virol. 2010 Jun; 91(Pt 6):1373-87.
    View in: PubMed
  11. Dunn EF, Fearns R, Connor JH. Akt inhibitor Akt-IV blocks virus replication through an Akt-independent mechanism. J Virol. 2009 Nov; 83(22):11665-72.
    View in: PubMed
  12. Gallacher M, Brown SG, Hale BG, Fearns R, Olver RE, Randall RE, Wilson SM. Cation currents in human airway epithelial cells induced by infection with influenza A virus. J Physiol. 2009 Jul 1; 587(Pt 13):3159-73.
    View in: PubMed
  13. Cowton VM, McGivern DR, Fearns R. Unravelling the complexities of respiratory syncytial virus RNA synthesis. J Gen Virol. 2006 Jul; 87(Pt 7):1805-21.
    View in: PubMed
  14. Carlos TS, Fearns R, Randall RE. Interferon-induced alterations in the pattern of parainfluenza virus 5 transcription and protein synthesis and the induction of virus inclusion bodies. J Virol. 2005 Nov; 79(22):14112-21.
    View in: PubMed
  15. Cowton VM, Fearns R. Evidence that the respiratory syncytial virus polymerase is recruited to nucleotides 1 to 11 at the 3' end of the nucleocapsid and can scan to access internal signals. J Virol. 2005 Sep; 79(17):11311-22.
    View in: PubMed
  16. McGivern DR, Collins PL, Fearns R. Identification of internal sequences in the 3' leader region of human respiratory syncytial virus that enhance transcription and confer replication processivity. J Virol. 2005 Feb; 79(4):2449-60.
    View in: PubMed
  17. Fearns R, Peeples ME, Collins PL. Mapping the transcription and replication promoters of respiratory syncytial virus. J Virol. 2002 Feb; 76(4):1663-72.
    View in: PubMed
  18. Fearns R, Collins PL, Peeples ME. Functional analysis of the genomic and antigenomic promoters of human respiratory syncytial virus. J Virol. 2000 Jul; 74(13):6006-14.
    View in: PubMed
  19. Fearns R, Collins PL. Role of the M2-1 transcription antitermination protein of respiratory syncytial virus in sequential transcription. J Virol. 1999 Jul; 73(7):5852-64.
    View in: PubMed
  20. Collins PL, Whitehead SS, Bukreyev A, Fearns R, Teng MN, Juhasz K, Chanock RM, Murphy BR. Rational design of live-attenuated recombinant vaccine virus for human respiratory syncytial virus by reverse genetics. Adv Virus Res. 1999; 54:423-51.
    View in: PubMed
  21. Fearns R, Collins PL. Model for polymerase access to the overlapped L gene of respiratory syncytial virus. J Virol. 1999 Jan; 73(1):388-97.
    View in: PubMed
  22. Fearns R, Peeples ME, Collins PL. Increased expression of the N protein of respiratory syncytial virus stimulates minigenome replication but does not alter the balance between the synthesis of mRNA and antigenome. Virology. 1997 Sep 15; 236(1):188-201.
    View in: PubMed
  23. Kuo L, Fearns R, Collins PL. Analysis of the gene start and gene end signals of human respiratory syncytial virus: quasi-templated initiation at position 1 of the encoded mRNA. J Virol. 1997 Jul; 71(7):4944-53.
    View in: PubMed
  24. Kuo L, Fearns R, Collins PL. The structurally diverse intergenic regions of respiratory syncytial virus do not modulate sequential transcription by a dicistronic minigenome. J Virol. 1996 Sep; 70(9):6143-50.
    View in: PubMed
  25. Precious B, Young DF, Bermingham A, Fearns R, Ryan M, Randall RE. Inducible expression of the P, V, and NP genes of the paramyxovirus simian virus 5 in cell lines and an examination of NP-P and NP-V interactions. J Virol. 1995 Dec; 69(12):8001-10.
    View in: PubMed
  26. Fearns R, Young DF, Randall RE. Evidence that the paramyxovirus simian virus 5 can establish quiescent infections by remaining inactive in cytoplasmic inclusion bodies. J Gen Virol. 1994 Dec; 75 ( Pt 12):3525-39.
    View in: PubMed
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