Keywords
Last Name

Lee J. Quinton, PhD

TitleAssistant Professor
InstitutionBoston University School of Medicine
DepartmentMedicine
DivisionPulmonary, Allergy, Sleep & Critical Care Medicine
Address72 E. Concord St Housman (R)
Boston MA 02118
Phone(617) 638-6125
ORCID ORCID Icon0000-0003-1938-2507
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Graduate Medical Sciences

TitleAssistant Professor
InstitutionBoston University School of Medicine
DepartmentPathology & Laboratory Medicine

 Research Expertise & Professional Interests
My expertise lies in the areas of the biology of acute pulmonary inflammation and the innate immune response to microorganisms in the lung.

 NIH RePORTER Grants

Yr Title Project-Sub Proj Pubs
2014 The Biology of LIF During Pneumonia 5R01HL111449-03
2013 The Biology of LIF During Pneumonia 5R01HL111449-02
2012 The Biology of LIF During Pneumonia 1R01HL111449-01A1
2012 Lung-Liver Axis During Pneumonia 5R00HL092956-05 6
2011 Lung-Liver Axis During Pneumonia 5R00HL092956-04 6
2010 Lung-Liver Axis During Pneumonia 4R00HL092956-03 6
2009 Lung-Liver Axis During Pneumonia 5K99HL092956-02 2
2008 Lung-Liver Axis During Pneumonia 1K99HL092956-01 2


 Self-Described Keywords
  • cytokines
  • inflammation
  • pneumonia
  • pulmonary
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Hyatt LD, Wasserman GA, Rah YJ, Matsuura KY, Coleman FT, Hilliard KL, Pepper-Cunningham ZA, Ieong M, Stumpo DJ, Blackshear PJ, Quinton LJ, Mizgerd JP, Jones MR. Myeloid ZFP36L1 Does Not Regulate Inflammation or Host Defense in Mouse Models of Acute Bacterial Infection. PLoS One. 2014; 9(10):e109072.
    View in: PubMed
  2. Alfaro VY, Goldblatt DL, Valverde GR, Munsell MF, Quinton LJ, Walker AK, Dantzer R, Varadhachary A, Scott BL, Evans SE, Tuvim MJ, Dickey BF. Safety, tolerability, and biomarkers of the treatment of mice with aerosolized Toll-like receptor ligands. Front Pharmacol. 2014; 5:8.
    View in: PubMed
  3. Yamamoto K, Ahyi AN, Pepper-Cunningham ZA, Ferrari JD, Wilson AA, Jones MR, Quinton LJ, Mizgerd JP. Roles of Lung Epithelium in Neutrophil Recruitment during Pneumococcal Pneumonia. Am J Respir Cell Mol Biol. 2014 Feb; 50(2):253-62.
    View in: PubMed
  4. Ahyi AN, Quinton LJ, Jones MR, Ferrari JD, Pepper-Cunningham ZA, Mella JR, Remick DG, Mizgerd JP. Roles of STAT3 in protein secretion pathways during the acute-phase response. Infect Immun. 2013 May; 81(5):1644-53.
    View in: PubMed
  5. Jones MR, Blahna MT, Kozlowski E, Matsuura KY, Ferrari JD, Morris SA, Powers JT, Daley GQ, Quinton LJ, Mizgerd JP. Zcchc11 uridylates mature miRNAs to enhance neonatal IGF-1 expression, growth, and survival. PLoS Genet. 2012; 8(11):e1003105.
    View in: PubMed
  6. Quinton LJ. Evaluating the NET influence of inflammation on pneumonia biology. Am J Respir Crit Care Med. 2012 Nov 15; 186(10):943-4.
    View in: PubMed
  7. Yamamoto K, Ferrari JD, Cao Y, Ramirez MI, Jones MR, Quinton LJ, Mizgerd JP. Type I alveolar epithelial cells mount innate immune responses during pneumococcal pneumonia. J Immunol. 2012 Sep 1; 189(5):2450-9.
    View in: PubMed
  8. Quinton LJ, Mizgerd JP, Hilliard KL, Jones MR, Kwon CY, Allen E. Leukemia inhibitory factor signaling is required for lung protection during pneumonia. J Immunol. 2012 Jun 15; 188(12):6300-8.
    View in: PubMed
  9. Quinton LJ, Blahna MT, Jones MR, Allen E, Ferrari JD, Hilliard KL, Zhang X, Sabharwal V, Algül H, Akira S, Schmid RM, Pelton SI, Spira A, Mizgerd JP. Hepatocyte-specific mutation of both NF-?B RelA and STAT3 abrogates the acute phase response in mice. J Clin Invest. 2012 May 1; 122(5):1758-63.
    View in: PubMed
  10. Quinton LJ. GM-CSF: a double dose of protection during pneumonia. Am J Physiol Lung Cell Mol Physiol. 2012 Mar 1; 302(5):L445-6.
    View in: PubMed
  11. Blahna MT, Jones MR, Quinton LJ, Matsuura KY, Mizgerd JP. Terminal uridyltransferase enzyme Zcchc11 promotes cell proliferation independent of its uridyltransferase activity. J Biol Chem. 2011 Dec 9; 286(49):42381-9.
    View in: PubMed
  12. Zamjahn JB, Quinton LJ, Mack JC, Frevert CW, Nelson S, Bagby GJ. Differential flux of macrophage inflammatory protein-2 and cytokine-induced neutrophil chemoattractant from the lung after intrapulmonary delivery. Am J Physiol Lung Cell Mol Physiol. 2011 Oct; 301(4):L568-74.
    View in: PubMed
  13. Pittet LA, Quinton LJ, Yamamoto K, Robson BE, Ferrari JD, Algül H, Schmid RM, Mizgerd JP. Earliest innate immune responses require macrophage RelA during pneumococcal pneumonia. Am J Respir Cell Mol Biol. 2011 Sep; 45(3):573-81.
    View in: PubMed
  14. Quinton LJ, Mizgerd JP. NF-?B and STAT3 signaling hubs for lung innate immunity. Cell Tissue Res. 2011 Jan; 343(1):153-65.
    View in: PubMed
  15. Jones MR, Quinton LJ, Blahna MT, Neilson JR, Fu S, Ivanov AR, Wolf DA, Mizgerd JP. Zcchc11-dependent uridylation of microRNA directs cytokine expression. Nat Cell Biol. 2009 Sep; 11(9):1157-63.
    View in: PubMed
  16. Quinton LJ, Jones MR, Robson BE, Mizgerd JP. Mechanisms of the hepatic acute-phase response during bacterial pneumonia. Infect Immun. 2009 Jun; 77(6):2417-26.
    View in: PubMed
  17. Gamble L, Bagby GJ, Quinton LJ, Happel KI, Mizgerd JP, Zhang P, Nelson S. The systemic and pulmonary LPS binding protein response to intratracheal lipopolysaccharide. Shock. 2009 Feb; 31(2):212-7.
    View in: PubMed
  18. Quinton LJ, Jones MR, Robson BE, Simms BT, Whitsett JA, Mizgerd JP. Alveolar epithelial STAT3, IL-6 family cytokines, and host defense during Escherichia coli pneumonia. Am J Respir Cell Mol Biol. 2008 Jun; 38(6):699-706.
    View in: PubMed
  19. Happel KI, Rudner X, Quinton LJ, Movassaghi JL, Clark C, Odden AR, Zhang P, Bagby GJ, Nelson S, Shellito JE. Acute alcohol intoxication suppresses the pulmonary ELR-negative CXC chemokine response to lipopolysaccharide. Alcohol. 2007 Aug; 41(5):325-33.
    View in: PubMed
  20. Johnston RA, Mizgerd JP, Flynt L, Quinton LJ, Williams ES, Shore SA. Type I interleukin-1 receptor is required for pulmonary responses to subacute ozone exposure in mice. Am J Respir Cell Mol Biol. 2007 Oct; 37(4):477-84.
    View in: PubMed
  21. Quinton LJ, Jones MR, Simms BT, Kogan MS, Robson BE, Skerrett SJ, Mizgerd JP. Functions and regulation of NF-kappaB RelA during pneumococcal pneumonia. J Immunol. 2007 Feb 1; 178(3):1896-903.
    View in: PubMed
  22. Poonia B, Nelson S, Bagby GJ, Zhang P, Quniton L, Veazey RS. Chronic alcohol consumption results in higher simian immunodeficiency virus replication in mucosally inoculated rhesus macaques. AIDS Res Hum Retroviruses. 2006 Jun; 22(6):589-94.
    View in: PubMed
  23. Krishnamurthy VM, Quinton LJ, Estroff LA, Metallo SJ, Isaacs JM, Mizgerd JP, Whitesides GM. Promotion of opsonization by antibodies and phagocytosis of Gram-positive bacteria by a bifunctional polyacrylamide. Biomaterials. 2006 Jul; 27(19):3663-74.
    View in: PubMed
  24. Jones MR, Quinton LJ, Simms BT, Lupa MM, Kogan MS, Mizgerd JP. Roles of interleukin-6 in activation of STAT proteins and recruitment of neutrophils during Escherichia coli pneumonia. J Infect Dis. 2006 Feb 1; 193(3):360-9.
    View in: PubMed
  25. Happel KI, Dubin PJ, Zheng M, Ghilardi N, Lockhart C, Quinton LJ, Odden AR, Shellito JE, Bagby GJ, Nelson S, Kolls JK. Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae. J Exp Med. 2005 Sep 19; 202(6):761-9.
    View in: PubMed
  26. Quinton LJ, Nelson S, Zhang P, Happel KI, Gamble L, Bagby GJ. Effects of systemic and local CXC chemokine administration on the ethanol-induced suppression of pulmonary neutrophil recruitment. Alcohol Clin Exp Res. 2005 Jul; 29(7):1198-205.
    View in: PubMed
  27. Badewa AP, Quinton LJ, Shellito JE, Mason CM. Chemokine receptor 5 and its ligands in the immune response to murine tuberculosis. Tuberculosis (Edinb). 2005 May; 85(3):185-95.
    View in: PubMed
  28. Zhang P, Quinton LJ, Gamble L, Bagby GJ, Summer WR, Nelson S. The granulopoietic cytokine response and enhancement of granulopoiesis in mice during endotoxemia. Shock. 2005 Apr; 23(4):344-52.
    View in: PubMed
  29. Shahbazian LM, Quinton LJ, Bagby GJ, Nelson S, Wang G, Zhang P. Escherichia coli pneumonia enhances granulopoiesis and the mobilization of myeloid progenitor cells into the systemic circulation. Crit Care Med. 2004 Aug; 32(8):1740-6.
    View in: PubMed
  30. Quinton LJ, Nelson S, Zhang P, Boé DM, Happel KI, Pan W, Bagby GJ. Selective transport of cytokine-induced neutrophil chemoattractant from the lung to the blood facilitates pulmonary neutrophil recruitment. Am J Physiol Lung Cell Mol Physiol. 2004 Mar; 286(3):L465-72.
    View in: PubMed
  31. Boé DM, Nelson S, Zhang P, Quinton L, Bagby GJ. Alcohol-induced suppression of lung chemokine production and the host defense response to Streptococcus pneumoniae. Alcohol Clin Exp Res. 2003 Nov; 27(11):1838-45.
    View in: PubMed
  32. Happel KI, Zheng M, Young E, Quinton LJ, Lockhart E, Ramsay AJ, Shellito JE, Schurr JR, Bagby GJ, Nelson S, Kolls JK. Cutting edge: roles of Toll-like receptor 4 and IL-23 in IL-17 expression in response to Klebsiella pneumoniae infection. J Immunol. 2003 May 1; 170(9):4432-6.
    View in: PubMed
  33. Zhang P, Quinton LJ, Bagby GJ, Summer WR, Nelson S. Interferon-gamma enhances the pulmonary CXC chemokine response to intratracheal lipopolysaccharide challenge. J Infect Dis. 2003 Jan 1; 187(1):62-9.
    View in: PubMed
  34. Quinton LJ, Nelson S, Boé DM, Zhang P, Zhong Q, Kolls JK, Bagby GJ. The granulocyte colony-stimulating factor response after intrapulmonary and systemic bacterial challenges. J Infect Dis. 2002 May 15; 185(10):1476-82.
    View in: PubMed
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