Shannon Fisher, MD, PhD
Associate Professor
Boston University School of Medicine
Dept of Pharmacology & Experimental Therapeutics

MD, Johns Hopkins University School of Medicine
PhD, Johns Hopkins University School of Medicine



Dr. Fisher’s work has been instrumental in establishing the zebrafish as a model organism for the study of skeletal dysplasias, including her identical for a zebrafish model for Osteogenesis Imperfection and publication of the first osteoblast markers. She pioneered the use of zebrafish to analyze transcriptional and regulatory elements from the human genome, and has identified and studied dozens of enhancers associated with skeletal genes. Her most recent efforts are focused on skull development, an area of tremendous clinical relevance not well studied in zebrafish.


Screen for mutations affecting skull and suture formation In zebrafish
11/07/2015 - 05/31/2017 (PI)
NIH/National Institute of Dental & Craniofacial Research
5R01DE022955-05

Anatomical atlas and transgenic toolkit for late skull formation in zebrafish
10/01/2015 - 04/30/2017 (PI)
NIH/National Institute of Dental & Craniofacial Research
7U01DE024434-03




Yr Title Project-Sub Proj Pubs
2016 Screen for mutations affecting skull and suture formation in zebrafish 5R01DE022955-05
2016 Anatomical atlas and transgenic toolkit for late skull formation in zebrafish 5U01DE024434-04 2
2015 Screen for mutations affecting skull and suture formation in zebrafish 7R01DE022955-04
2015 Anatomical atlas and transgenic toolkit for late skull formation in zebrafish 5U01DE024434-02 2
2015 Anatomical atlas and transgenic toolkit for late skull formation in zebrafish 7U01DE024434-03 2
2014 Anatomical atlas and transgenic toolkit for late skull formation in zebrafish 1U01DE024434-01 2
2014 Screen for mutations affecting skull and suture formation in zebrafish 5R01DE022955-02
2013 Screen for mutations affecting skull and suture formation in zebrafish 1R01DE022955-01A1
2012 Cranial suture formation in the zebrafish 5R21DE021509-02 3
2011 Cranial suture formation in the zebrafish 1R21DE021509-01 3
Showing 10 of 21 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Brinkley JF, Fisher S, Harris MP, Holmes G, Hooper JE, Jabs EW, Jones KL, Kesselman C, Klein OD, Maas RL, Marazita ML, Selleri L, Spritz RA, van Bakel H, Visel A, Williams TJ, Wysocka J. The FaceBase Consortium: a comprehensive resource for craniofacial researchers. Development. 2016 Jul 15; 143(14):2677-88. PMID: 27287806; PMCID: PMC4958338; DOI: 10.1242/dev.135434;.
  2. Kague E, Roy P, Asselin G, Hu G, Simonet J, Stanley A, Albertson C, Fisher S. Osterix/Sp7 limits cranial bone initiation sites and is required for formation of sutures. Dev Biol. 2016 May 15; 413(2):160-72. PMID: 26992365; DOI: 10.1016/j.ydbio.2016.03.011;.
  3. Esteves FF, Springhorn A, Kague E, Taylor E, Pyrowolakis G, Fisher S, Bier E. BMPs regulate msx gene expression in the dorsal neuroectoderm of Drosophila and vertebrates by distinct mechanisms. PLoS Genet. 2014 Sep; 10(9):e1004625. PMID: 25210771; PMCID: PMC4161316; DOI: 10.1371/journal.pgen.1004625;.
  4. Costa AM, Pereira-Castro I, Ricardo E, Spencer F, Fisher S, da Costa LT. GRG5/AES interacts with T-cell factor 4 (TCF4) and downregulates Wnt signaling in human cells and zebrafish embryos. PLoS One. 2013; 8(7):e67694. PMID: 23840876; PMCID: PMC3698143; DOI: 10.1371/journal.pone.0067694;.
  5. Kague E, Gallagher M, Burke S, Parsons M, Franz-Odendaal T, Fisher S. Skeletogenic fate of zebrafish cranial and trunk neural crest. PLoS One. 2012; 7(11):e47394. PMID: 23155370; PMCID: PMC3498280; DOI: 10.1371/journal.pone.0047394;.
  6. Hu G, Codina M, Fisher S. Multiple enhancers associated with ACAN suggest highly redundant transcriptional regulation in cartilage. Matrix Biol. 2012 Jul; 31(6):328-37. PMID: 22820679; PMCID: PMC3508301; DOI: 10.1016/j.matbio.2012.06.001;.
  7. Maragh S, Miller RA, Bessling SL, McGaughey DM, Wessels MW, de Graaf B, Stone EA, Bertoli-Avella AM, Gearhart JD, Fisher S, McCallion AS. Identification of RNA binding motif proteins essential for cardiovascular development. BMC Dev Biol. 2011 Oct 19; 11:62. PMID: 22011202; PMCID: PMC3277282; DOI: 10.1186/1471-213X-11-62;.
  8. Hu G, Goll MG, Fisher S. FC31 integrase mediates efficient cassette exchange in the zebrafish germline. Dev Dyn. 2011 Sep; 240(9):2101-7. PMID: 21805532; PMCID: PMC3938014; DOI: 10.1002/dvdy.22699;.
  9. Knopf F, Hammond C, Chekuru A, Kurth T, Hans S, Weber CW, Mahatma G, Fisher S, Brand M, Schulte-Merker S, Weidinger G. Bone regenerates via dedifferentiation of osteoblasts in the zebrafish fin. Dev Cell. 2011 May 17; 20(5):713-24. PMID: 21571227; DOI: 10.1016/j.devcel.2011.04.014;.
  10. Kague E, Weber C, Fisher S. Mosaic zebrafish transgenesis for evaluating enhancer sequences. J Vis Exp. 2010 Jul 16; (41). PMID: 20679998; PMCID: PMC3156073; DOI: 10.3791/1722;.
Showing 10 of 30 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 30 publications over 18 distinct years, with a maximum of 3 publications in 2011

YearPublications
19892
19901
19911
19972
19991
20032
20042
20052
20062
20072
20081
20092
20101
20113
20122
20131
20141
20162
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72 E. Concord St Housman (R)
Boston MA 02118
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