Maria Medalla, PhD
Assistant Professor
Boston University School of Medicine
Dept of Anatomy & Neurobiology

PhD, Boston University



Dr. Medalla’s work combines cellular in vitro electrophysiological methods with multi-scale anatomic techniques to understand the biophysical and synaptic properties of neurons within prefrontal cortical (PFC) networks in non-human primate and rodent animal models. Her expertise includes patch-clamp recording, pathway tract-tracing, multiple immunohistochemical labeling techniques for light and electron microscopy (EM), 3D serial EM, and confocal microscopy. The major goal of her work is to understand how distinct limbic, sensory and motor networks interact and are controlled by the PFC – the central executive of the brain. Her current focus is on the medial prefrontal anterior cingulate cortex (ACC) in rhesus monkeys, an area important for attention, emotions and context-to-action transformations, and is selectively disrupted in many affective disorders such as depression and anxiety disorders.

Graduate Faculty (Primary Mentor of Grad Students)
Boston University School of Medicine, Division of Graduate Medical Sciences




Physiology and Structure of Prefrontal Projections to Memory and Motor Circuits
09/23/2015 - 06/30/2017 (PI)
NIH/National Institute of Mental Health
5R00MH101234-04

Physiology and Structure of Prefrontal Projections to Memory and Motor Circuits
08/15/2013 - 07/31/2015 (PI)
NIH/National Institute of Mental Health
5K99MH101234-02



Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Hsu A, Luebke JI, Medalla M. Comparative ultrastructural features of excitatory synapses in the visual and frontal cortices of the adult mouse and monkey. J Comp Neurol. 2017 Jun 15; 525(9):2175-2191.View Related Profiles. PMID: 28256708; DOI: 10.1002/cne.24196;.
  2. Gilman JP, Medalla M, Luebke JI. Area-Specific Features of Pyramidal Neurons-a Comparative Study in Mouse and Rhesus Monkey. Cereb Cortex. 2017 Mar 01; 27(3):2078-2094.View Related Profiles. PMID: 26965903; DOI: 10.1093/cercor/bhw062;.
  3. Asai H, Ikezu S, Tsunoda S, Medalla M, Luebke J, Haydar T, Wolozin B, Butovsky O, Kügler S, Ikezu T. Depletion of microglia and inhibition of exosome synthesis halt tau propagation. Nat Neurosci. 2015 Nov; 18(11):1584-93.View Related Profiles. PMID: 26436904; PMCID: PMC4694577; DOI: 10.1038/nn.4132;.
  4. Tyler WA, Medalla M, Guillamon-Vivancos T, Luebke JI, Haydar TF. Neural precursor lineages specify distinct neocortical pyramidal neuron types. J Neurosci. 2015 Apr 15; 35(15):6142-52.View Related Profiles. PMID: 25878286; PMCID: PMC4397608; DOI: 10.1523/JNEUROSCI.0335-15.2015;.
  5. Medalla M, Luebke JI. Diversity of glutamatergic synaptic strength in lateral prefrontal versus primary visual cortices in the rhesus monkey. J Neurosci. 2015 Jan 7; 35(1):112-27.View Related Profiles. PMID: 25568107; PMCID: PMC4287137; DOI: 10.1523/JNEUROSCI.3426-14.2015;.
  6. Luebke JI, Medalla M, Amatrudo JM, Weaver CM, Crimins JL, Hunt B, Hof PR, Peters A. Age-related changes to layer 3 pyramidal cells in the rhesus monkey visual cortex. Cereb Cortex. 2015 Jun; 25(6):1454-68.View Related Profiles. PMID: 24323499; PMCID: PMC4428297; DOI: 10.1093/cercor/bht336;.
  7. Barbas H, Bunce JG, and Medalla M. In: Principles of Frontal Lobe Development. Stuss, DT, Knight RT, editors. Prefrontal Pathways that Control Attention. Oxford University Press. 2013; 31-48.
  8. Medalla M, Lera P, Feinberg M, Barbas H. Specificity in inhibitory systems associated with prefrontal pathways to temporal cortex in primates. Cereb Cortex. 2007 Sep; 17 Suppl 1:i136-50. PMID: 17725996; DOI: 10.1093/cercor/bhm068;.
  9. Medalla M, Barbas H. Diversity of laminar connections linking periarcuate and lateral intraparietal areas depends on cortical structure. Eur J Neurosci. 2006 Jan; 23(1):161-79. PMID: 16420426; DOI: 10.1111/j.1460-9568.2005.04522.x;.
  10. Barbas H, Medalla M, Alade O, Suski J, Zikopoulos B, Lera P. Relationship of prefrontal connections to inhibitory systems in superior temporal areas in the rhesus monkey. Cereb Cortex. 2005 Sep; 15(9):1356-70. PMID: 15635060; DOI: 10.1093/cercor/bhi018;.

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 10 publications over 6 distinct years, with a maximum of 3 publications in 2015

YearPublications
20051
20061
20071
20132
20153
20172
Contact for Mentoring:


72 E. Concord St Housman (R)
Boston MA 02118
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