Bjorn Reinhard, Dr. rer. nat.
Professor
Boston University College of Arts and Sciences
Dept of Chemistry

PhD, Technical University Munchen
MS, Technical University Munchen



Research in the Reinhard Lab focuses on new optical materials and their application to interrogate fundamental life processes. We are exploring the interface between nanotechnology and biological systems. For an overview of current research projects, please visit our group’s website. Recents techniques/materials developed in the Nano-Bio Interface Lab include:

Plasmon ruler RNase A cleavage assay: (A) The RNA plasmon rulers are bound to the surface of a glass flow chamber using a BSA (bovin serum albumin)-Biotin-NeutrAvidin surface chemistry. Upon addition of RNase A, the RNA tether is cleaved, and the dimer converted into a monomer. (B) Single RNA plasmon ruler cleavage trajectory (recorded at 96 Hz). (I) The plasmon ruler is first incubated in buffer containing spermidine at defined concentrations (0 -5 mM), (II) the buffer is exchanged with a 1 nM RNase A solution, causing (III) a strong drop in intensity upon RNA cleavage. Inset: Number of cleavage events for flushing with/without enzyme. ?tcl is defined as the time between enzyme addition and cleavage. For more information, refer to: L.R. Skewis & B.M. Reinhard, Nano Lett., 8, 214 (2008).

Plasmon Coupling Microscopy: Gold nanoparticle labeled surface receptors (left) and spectral signature (right) as function of interparticle distance. (a) For interparticle separations ? larger than the particle diameter D, the near-field interactions between the particles is small and the resonance wavelength ?res is that of an individual particle. (b) For interparticle separations ? < D the plasmons in the individual particles couple and the resonance wavelength ?res red-shifts with decreasing separation. This spectral shift is observable as an increase in the intensity ratio R = I580nm/I530nm.

Multiscale Nanoparticle Cluster Arrays (NCAs): SEM images from extracts of nanoparticle cluster arrays with varying diameters of e-beam defined binding size D = 50 nm (a), 80 nm (b), 100 nm (c), 130 nm (d), 200 nm (e). The SEM images confirm that through control of the diameter of the e-beam fabricated binding site the cluster size can be continuously varied. The enlargement of an individual cluster in (f) shows junctions and crevices between nearly touching particles constituting a high degree of roughness on the nanoscale.

The Reinhard group utilizes a variety of techniques including:
-Spectroscopy: Raman, SERS, Single Molecule Fluorescence, Plasmon
-Live Cell Imaging
-Nanofabrication
-Transmission Electron Microscopy
-Scanning Electron Microscopy
-Cell Culture Facility
-Fluorescence Plate Readers
-Nanoparticle Synthesis/Functionalization/Integration
-The Photonics Center
-Center of Nanoscience and Nanobiotechnology

Director
Boston University College of Arts and Sciences
Department of Nano-Bio Interface Laboratory




OP: Plasmonic Enhancement of Chiral Forces for Enantiomer Separation
09/01/2016 - 08/31/2019 (PI)
National Science Foundation
CHE-1609778

Plasmonically Enhanced Stimulated Coherent Spectroscopy
07/15/2016 - 06/30/2019 (Co-PI)
PI: Lawrence D. Ziegler, PhD
National Science Foundation
CHE-1609952

MRI Development of a Holographic Nanoscale Optics Instrument
08/15/2014 - 07/31/2017 (Co-PI)
National Science Foundation
DMR-1429437

Illuminating Dynamic Receptor Clustering in the Epidermal Growth Factor Receptor
05/01/2014 - 04/30/2017 (PI)
NIH/National Cancer Institute
5R01CA138509-08

Nanoplasmonic Metamaterial Filters
01/01/2016 - 12/31/2016 (PI)
EMD Millipore

Identification of Signals Required for the Establishment of HIV Infection and Latency
09/02/2015 - 08/31/2016 (PI)
Boston Medical Center Corporation NIH NIAID
1R56AI118682-01

New Optoplasmonic Materials for Next Generation Energy Systems
09/01/2013 - 08/31/2016 (PI)
Department of Energy
DE-SC0010679

Multiparametric Optical Microbe Sensing with Engineered Photonic-Plasmonic Nanostructures
08/15/2012 - 07/31/2015 (PI)
National Science Foundation
CBET-1159552

Elucidating Non-Virus Encoded HIV Capture Through Artificial Virus Nanoparticles
07/01/2013 - 06/30/2014 (PI)
NIH/National Institute of Allergy & Infectious Diseases
1R56AI104393-01A1

PHOTONICS RESEARCH AND TECHNOLOGY INSERTION
07/01/2006 - 06/30/2014 (SP Co-PI of Sub-Project / SP)
Department of Defense/ARL

Showing 10 of 12 results. Show All Results



Yr Title Project-Sub Proj Pubs
2016 Illuminating Dynamic Receptor Clustering in the Epidermal Growth Factor Receptor 5R01CA138509-08 29
2015 Illuminating Dynamic Receptor Clustering in the Epidermal Growth Factor Receptor 5R01CA138509-07 29
2014 Illuminating Dynamic Receptor Clustering in the Epidermal Growth Factor Receptor 2R01CA138509-06 29
2013 Elucidating Non-Virus Encoded HIV Capture through Artificial Virus Nanoparticles 1R56AI104393-01A1 1
2013 Illuminating Dynamic Receptor Clustering in the Epidermal Growth Factor Receptor 5R01CA138509-05 29
2012 Illuminating Dynamic Receptor Clustering in the Epidermal Growth Factor Receptor 5R01CA138509-04 29
2011 Illuminating Dynamic Receptor Clustering in the Epidermal Growth Factor Receptor 5R01CA138509-03 29
2010 Illuminating Dynamic Receptor Clustering in the Epidermal Growth Factor Receptor 5R01CA138509-02 29
2009 Illuminating Dynamic Receptor Clustering in the Epidermal Growth Factor Receptor 1R01CA138509-01 29
2009 Plasmon Coupling Microscopy for the in vivo Detection and Tracking of Cytoplasmic 5R21EB008822-02 6
Showing 10 of 11 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Kijewski SD, Akiyama H, Feizpour A, Miller CM, Ramirez NG, Reinhard BM, Gummuluru S. Access of HIV-2 to CD169-dependent dendritic cell-mediated trans infection pathway is attenuated. Virology. 2016 Oct; 497:328-36.View Related Profiles. PMID: 27521724; PMCID: PMC5026622; DOI: 10.1016/j.virol.2016.07.029;.
  2. Wu L, Xu F, Reinhard BM. Nanoconjugation prolongs endosomal signaling of the epidermal growth factor receptor and enhances apoptosis. Nanoscale. 2016 Jul 14; 8(28):13755-68. PMID: 27378391; DOI: 10.1039/c6nr02974d;.
  3. Alizadeh MH, Reinhard BM. Emergence of transverse spin in optical modes of semiconductor nanowires. Opt Express. 2016 Apr 18; 24(8):8471-9. PMID: 27137285; DOI: 10.1364/OE.24.008471;.
  4. Chen T, Reinhard BM. Assembling Color on the Nanoscale: Multichromatic Switchable Pixels from Plasmonic Atoms and Molecules. Adv Mater. 2016 May; 28(18):3522-7. PMID: 26990416; PMCID: PMC4939277; DOI: 10.1002/adma.201506179;.
  5. Ahn W, Zhao X, Hong Y, Reinhard BM. Low-Power Light Guiding and Localization in Optoplasmonic Chains Obtained by Directed Self-Assembly. Sci Rep. 2016 Mar 02; 6:22621. PMID: 26931149; PMCID: PMC4773872; DOI: 10.1038/srep22621;.
  6. Zhao X, Alizadeh MH, Reinhard BM. Harnessing Leaky Modes for Fluorescence Enhancement in Gold-Tipped Silicon Nanowires. J Phys Chem C Nanomater Interfaces. 2016 Sep 22; 120(37):20555-20562. PMID: 27795751.
  7. Lerch S, Reinhard BM. Quantum Plasmonics: Optical Monitoring of DNA-Mediated Charge Transfer in Plasmon Rulers. Adv Mater. 2016 Mar 09; 28(10):2030-6. PMID: 26789736; PMCID: PMC4783186; DOI: 10.1002/adma.201503885;.
  8. Xu F, Reiser M, Yu X, Gummuluru S, Wetzler L, Reinhard BM. Lipid-Mediated Targeting with Membrane-Wrapped Nanoparticles in the Presence of Corona Formation. ACS Nano. 2016 Jan 26; 10(1):1189-200.View Related Profiles. PMID: 26720275; PMCID: PMC4842014; DOI: 10.1021/acsnano.5b06501;.
  9. Lambert AW, Wong CK, Ozturk S, Papageorgis P, Raghunathan R, Alekseyev Y, Gower AC, Reinhard BM, Abdolmaleky HM, Thiagalingam S. Tumor Cell-Derived Periostin Regulates Cytokines That Maintain Breast Cancer Stem Cells. Mol Cancer Res. 2016 Jan; 14(1):103-13.View Related Profiles. PMID: 26507575; PMCID: PMC4715959; DOI: 10.1158/1541-7786.MCR-15-0079;.
  10. Chen T, Hong Y, Reinhard BM. Probing DNA Stiffness through Optical Fluctuation Analysis of Plasmon Rulers. Nano Lett. 2015 Aug 12; 15(8):5349-57. PMID: 26121062; PMCID: PMC4624404; DOI: 10.1021/acs.nanolett.5b01725;.
Showing 10 of 60 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 60 publications over 11 distinct years, with a maximum of 11 publications in 2011

YearPublications
20053
20072
20084
20094
20106
201111
20129
20134
20144
20155
20168
Contact for Mentoring:


590 Commonwealth Ave
Boston MA 02215
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(617) 353-6466 (fax)

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