Toby Chai | Profiles RNS

Toby C. Chai, MD

Richard K. Babayan, MD Professor

Boston University Chobanian & Avedisian School of Medicine

Urology

MD, Indiana University School of Medicine
MA, Yale University
BA, Johns Hopkins University

Websites

	LinkedIn
	BMC Urology
	Boston Medical Center Provider Profile
	ResearchGate

ORCID : 0000-0002-1119-546X

Toby C. Chai, MD, is Chief of Urology at Boston Medical Center, and Professor and Chair of the Department of Urology at Chobanian and Avedisian School of Medicine. He also serves as President of Boston University Medical Center Urologists, Inc.

Dr. Chai was previously Professor of Urology and Obstetrics, Gynecology, and Reproductive Sciences at Yale University School of Medicine. He served as Vice Chair of Research in the Department of Urology and Co-Director of the Female Pelvic Medicine and Reconstructive Surgery Program at Yale New Haven Hospital.

Dr. Chai completed his medical degree at Indiana University School of Medicine, his urology residency at University of Michigan Medical Center, and a fellowship at University of Virginia. Prior to joining Yale, he held the John D. Young Professorship in Urology at the University of Maryland School of Medicine.

Dr. Chai has been PI on NIH R01, P20 and U01 grants. He has published 150 papers, reviews, and medical texts. He serves on the editorial board of the American Journal of Physiology - Renal, and is Co-Editor-in-Chief of Bladder and Associate Editor for Journal of Urology. His peers have recognized his significant contributions to the field by honoring him with the American Urological Association’s Victor A. Politano Award for outstanding work in treatment of urinary incontinence and innovations in bladder research and the Society of Urodynamics, Female Pelvic Medicine & Urogenital Reconstruction’s Distinguished Service Award for outstanding contributions to urodynamics, female urology and voiding dysfunction, and exemplary service to the Society.

Chair
Boston University Chobanian & Avedisian School of Medicine
Urology

Chief
Boston Medical Center
Urology

President
Boston University Medical Center Urologists, Inc.

BMC Research

Enhancing Urologic Clinic Accessibility for Spinal Cord Injured Patients
10/31/2020 - 10/30/2021 (PI)
Craig H. Neilsen Foundation

Title

Yr	Title	Project-Sub Proj	Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Donohoo N, Orlando A, Chai TC. Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) is Imprecise-Time to Cleave into IC and BPS as Separate Conditions. J Urol. 2024 Apr 05; 101097JU0000000000003953. PMID: 38578287

Assel M, Chai TC. When Is Using a Prediction Model Better Than No Model to Inform Clinical Decision Making? J Urol. 2022 09; 208(3):530-533. PMID: 35748649

Chai TC. RE: Intraoperative Evaluation of Urinary Tract Injuries at the Time of Pelvic Surgery: A Systematic Review. Female Pelvic Med Reconstr Surg. 2021 07 01; 27(7):e605. PMID: 33411453

Zhu K, Hill WG, Li F, Shi B, Chai TC. Urine and Tissue Bacterial Loads Correlate With Voiding Behaviors in a Murine Urinary Tract Infection Model. Urology. 2021 08; 154:344.e1-344.e7. PMID: 34010680

Powell T, Staib L, Liu B, Bhatia S, Chai T, Ayyagari R. Voiding and Storage Domain-Specific Symptom Score Outcomes After Prostate Artery Embolization for Lower Urinary Tract Symptoms and Urinary Retention. Urology. 2021 10; 156:216-224.View Related Profiles.

Ayyagari, Rajasekhara
Chai, Toby

PMID: 33961894

Biebel MG, Pate WR, Chai TC. Transurethral resection of prostatic abscess. Can J Urol. 2021 04; 28(2):10638-10642. PMID: 33872565

Li Y, Liu Y, Gao Z, Zhang L, Chen L, Wu Z, Liu Q, Wang S, Zhou N, Chai TC, Shi B. Single-cell transcriptomes of mouse bladder urothelium uncover novel cell type markers and urothelial differentiation characteristics. Cell Prolif. 2021 Apr; 54(4):e13007. PMID: 33538002; PMCID: PMC8016651; DOI: 10.1111/cpr.13007;

Zhu K, Hill WG, Li F, Shi B, Chai TC. Early Increased Urinary IL-2 and IL-10 Levels Were Associated With Development of Chronic UTI in a Murine Model. Urology. 2020 07; 141:188.e1-188.e6. PMID: 32201154

Rovner E, Chai TC, Jacobs S, Christ G, Andersson KE, Efros M, Nitti V, Davies K, McCullough AR, Melman A. Evaluating the safety and potential activity of URO-902 (hMaxi-K) gene transfer by intravesical instillation or direct injection into the bladder wall in female participants with idiopathic (non-neurogenic) overactive bladder syndrome and detrusor overactivity from two double-blind, imbalanced, placebo-controlled randomized phase 1 trials. Neurourol Urodyn. 2020 02; 39(2):744-753. PMID: 31945197; PMCID: PMC7028015; DOI: 10.1002/nau.24272;

Ayyagari R, Powell T, Staib L, Chapiro J, Raja A, Bhatia S, Chai T, Schoenberger S, Devito R. Prostatic Artery Embolization Using 100-300-µm Trisacryl Gelatin Microspheres to Treat Lower Urinary Tract Symptoms Attributable to Benign Prostatic Hyperplasia: A Single-Center Outcomes Analysis with Medium-Term Follow-up. J Vasc Interv Radiol. 2020 Jan; 31(1):99-107.View Related Profiles.

Ayyagari, Rajasekhara
Chai, Toby

PMID: 31771896

Showing 10 of 146 results. Show More

Ackerman AL, Chai TC. The Bladder is Not Sterile: an Update on the Urinary Microbiome. Curr Bladder Dysfunct Rep. 2019; 14(4):331-341. PMID: 32612735; PMCID: PMC7328282; DOI: 10.1007/s11884-019-00543-6;

Ayyagari R, Powell T, Staib L, Chapiro J, Perez-Lozada JC, Bhatia S, Chai T, Schoenberger S, Devito R. Prostatic Artery Embolization in Nonindex Benign Prostatic Hyperplasia Patients: Single-center Outcomes for Urinary Retention and Gross Prostatic Hematuria. Urology. 2020 Feb; 136:212-217.View Related Profiles.

Ayyagari, Rajasekhara
Chai, Toby

PMID: 31734349

Anger J, Lee U, Ackerman AL, Chou R, Chughtai B, Clemens JQ, Hickling D, Kapoor A, Kenton KS, Kaufman MR, Rondanina MA, Stapleton A, Stothers L, Chai TC. Recurrent Uncomplicated Urinary Tract Infections in Women: AUA/CUA/SUFU Guideline. J Urol. 2019 08; 202(2):282-289. PMID: 31042112

Wu Z, Li Y, Liu Q, Liu Y, Chen L, Zhao H, Guo H, Zhu K, Zhou N, Chai TC, Shi B. Pyroptosis engagement and bladder urothelial cell-derived exosomes recruit mast cells and induce barrier dysfunction of bladder urothelium after uropathogenic E. coli infection. Am J Physiol Cell Physiol. 2019 09 01; 317(3):C544-C555. PMID: 31241987

Lu M, Zhu K, Schulam PG, Chai TC. A non-enzymatic method for dissection of mouse bladder urothelial tissue. Nat Protoc. 2019 04; 14(4):1280-1292. PMID: 30894693; DOI: 10.1038/s41596-019-0142-x;

Yeh J, Lu M, Alvarez-Lugo L, Chai TC. Bladder urothelial BK channel activity is a critical mediator for innate immune response in urinary tract infection pathogenesis. Am J Physiol Renal Physiol. 2019 04 01; 316(4):F617-F623. PMID: 30648906; DOI: 10.1152/ajprenal.00554.2018;

Abelson B, Sun D, Que L, Nebel RA, Baker D, Popiel P, Amundsen CL, Chai T, Close C, DiSanto M, Fraser MO, Kielb SJ, Kuchel G, Mueller ER, Palmer MH, Parker-Autry C, Wolfe AJ, Damaser MS. Sex differences in lower urinary tract biology and physiology. Biol Sex Differ. 2018 10 22; 9(1):45. PMID: 30343668; PMCID: PMC6196569; DOI: 10.1186/s13293-018-0204-8;

Zhao H, Wei Y, Wang J, Chai T. Isolation and expression analysis of cadmium-induced genes from Cd/Mn hyperaccumulator Phytolacca americana in response to high Cd exposure. Plant Biol (Stuttg). 2019 Jan; 21(1):15-24. PMID: 30183121

Acevedo-Alvarez M, Yeh J, Alvarez-Lugo L, Lu M, Sukumar N, Hill WG, Chai TC. Mouse urothelial genes associated with voiding behavior changes after ovariectomy and bladder lipopolysaccharide exposure. Neurourol Urodyn. 2018 11; 37(8):2398-2405. PMID: 29682797; DOI: 10.1002/nau.23592;

Lu M, Li JR, Alvarez-Lugo L, Li Y, Yu S, Li X, Shi B, Chai TC. Lipopolysaccharide stimulates BK channel activity in bladder umbrella cells. Am J Physiol Cell Physiol. 2018 06 01; 314(6):C643-C653. PMID: 29466671; DOI: 10.1152/ajpcell.00339.2017;

Chai TC, Kudze T. New therapeutic directions to treat underactive bladder. Investig Clin Urol. 2017 12; 58(Suppl 2):S99-S106. PMID: 29279882; PMCID: PMC5740036; DOI: 10.4111/icu.2017.58.S2.S99;

Lee H, Koh BH, Peri LE, Corrigan RD, Lee HT, George NE, Bhetwal BP, Xie Y, Perrino BA, Chai TC, Sanders KM, Koh SD. Premature contractions of the bladder are suppressed by interactions between TRPV4 and SK3 channels in murine detrusor PDGFRa+ cells. Sci Rep. 2017 09 25; 7(1):12245. PMID: 28947806; PMCID: PMC5613012; DOI: 10.1038/s41598-017-12561-7;

Chai TC. Re: Incontinence Medication Response Relates to the Female Urinary Microbiota. Eur Urol. 2017 11; 72(5):854. PMID: 28648367; DOI: 10.1016/j.eururo.2017.06.014;

Chai TC. Mesh Sling Removals: Why, When, How and Consequences. J Urol. 2017 09; 198(3):496-497. PMID: 28641082; DOI: 10.1016/j.juro.2017.06.063;

Chai TC, Asfaw TS, Baker JE, Clarkson B, Coleman P, Hoffstetter S, Konkel K, Lavender M, Nair S, Norton J, Subak L, Visco A, Star RA, Bavendam T. Future Directions of Research and Care for Urinary Incontinence: Findings from the National Institute of Diabetes and Digestive and Kidney Diseases Summit on Urinary Incontinence Clinical Research in Women. J Urol. 2017 07; 198(1):22-29. PMID: 28286067; DOI: 10.1016/j.juro.2016.10.133;

Chai TC. Caloric Restriction and Aging Bladder Dysfunction. J Urol. 2016 11; 196(5):1339. PMID: 27520084; DOI: 10.1016/j.juro.2016.08.013;

Li Y, Lu M, Alvarez-Lugo L, Chen G, Chai TC. Granulocyte-macrophage colony-stimulating factor (GM-CSF) is released by female mouse bladder urothelial cells and expressed by the urothelium as an early response to lipopolysaccharides (LPS). Neurourol Urodyn. 2017 Apr; 36(4):1020-1025. PMID: 27337494; DOI: 10.1002/nau.23057;

Losada L, Amundsen CL, Ashton-Miller J, Chai T, Close C, Damaser M, DiSanto M, Dmochowski R, Fraser MO, Kielb SJ, Kuchel G, Mueller ER, Parker-Autry C, Wolfe AJ, Mallampalli MP. Expert Panel Recommendations on Lower Urinary Tract Health of Women Across Their Life Span. J Womens Health (Larchmt). 2016 11; 25(11):1086-1096. PMID: 27285829; PMCID: PMC5116700; DOI: 10.1089/jwh.2016.5895;

Chai TC, Moalli PA, Richter HE, Lake AG, Kim HY, Nager CW, Sirls LT, Brubaker L, Kusek JW. Preoperative Urodynamic Parameters (Valsalva Leak Point Pressure and Maximum Urethral Closure Pressure), Urinary Collagen and Plasma Vitamin D Levels as Predictors of Mid Urethral Sling Surgery Outcome. J Urol. 2016 Sep; 196(3):819-23. PMID: 27113967; DOI: 10.1016/j.juro.2016.03.177;

Chai TC, Russo A, Yu S, Lu M. Mucosal signaling in the bladder. Auton Neurosci. 2016 10; 200:49-56. PMID: 26422993; DOI: 10.1016/j.autneu.2015.08.009;

Chai TC. Continence and micturition: physiological mechanisms under behavioral control. Am J Physiol Renal Physiol. 2015 Jul 01; 309(1):F33-4. PMID: 25972511; DOI: 10.1152/ajprenal.00193.2015;

Chao J, Chai TC. The future of research in female pelvic medicine. Curr Urol Rep. 2015 Feb; 16(2):2. PMID: 25604652; DOI: 10.1007/s11934-014-0474-6;

Norton PA, Nager CW, Brubaker L, Lemack GE, Sirls LT, Holley R, Chai TC, Kraus SR, Zyczynski H, Smith B, Stoddard A. The cost of preoperative urodynamics: A secondary analysis of the ValUE trial. Neurourol Urodyn. 2016 Jan; 35(1):81-4. PMID: 25327775; PMCID: PMC4517975; DOI: 10.1002/nau.22684;

Chai TC, Davis R, Hawes LN, Twaddell WS. Ectopic ureter presenting as anterior wall vaginal prolapse. Female Pelvic Med Reconstr Surg. 2014 Jul-Aug; 20(4):237-9. PMID: 24978091; DOI: 10.1097/SPV.0000000000000082;

Keay SK, Birder LA, Chai TC. Evidence for bladder urothelial pathophysiology in functional bladder disorders. Biomed Res Int. 2014; 2014:865463. PMID: 24900993; PMCID: PMC4034482; DOI: 10.1155/2014/865463;

Subak LL, Goode PS, Brubaker L, Kusek JW, Schembri M, Lukacz ES, Kraus SR, Chai TC, Norton P, Tennstedt SL. Urinary incontinence management costs are reduced following Burch or sling surgery for stress incontinence. Am J Obstet Gynecol. 2014 Aug; 211(2):171.e1-7.View Related Profiles.

Year	Publications
1993	1
1995	2
1996	2
1997	1
1998	3
1999	2
2000	5
2001	6
2002	5
2003	6
2004	4
2005	3
2006	3
2007	7
2008	8
2009	12
2010	10
2011	13
2012	12
2013	5
2014	4
2015	3
2016	4
2017	5
2018	4
2019	7
2020	2
2021	5
2022	1
2024	1