Keywords
Last Name

Thomas M. Ruenger, MD

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentDermatology
DivisionDermatology (excluding Mohs Surgery)
Address609 Albany St (J Bldg)
Boston MA 02118
ORCID ORCID Icon0000-0001-8453-0276
Other Positions
TitleProfessor
InstitutionBoston University School of Medicine
DepartmentPathology & Laboratory Medicine

InstitutionRoger Williams Medical Center

 Self-Described Keywords
  • DNA repair
  • Extracellular matrix
  • mutagenesis
  • photobiology
  • photodermatology
  • phototherapy
  • scleroderma
  • wound healing
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Rünger TM. Mechanisms of Melanoma Promotion by Ultraviolet Radiation. J Invest Dermatol. 2016 Sep; 136(9):1751-2. PMID: 27542295.
    View in: PubMed
  2. Ruenger TM. The US-based Photomedicine Society. Photodermatol Photoimmunol Photomed. 2013 Dec; 29(6):289. PMID: 24580546.
    View in: PubMed
  3. Rünger TM. Much remains to be learned about how UVR induces mutations. J Invest Dermatol. 2013 Jul; 133(7):1717-9. PMID: 23760050.
    View in: PubMed
  4. Mardaryev AN, Meier N, Poterlowicz K, Sharov AA, Sharova TY, Ahmed MI, Rapisarda V, Lewis C, Fessing MY, Ruenger TM, Bhawan J, Werner S, Paus R, Botchkarev VA. Lhx2 differentially regulates Sox9, Tcf4 and Lgr5 in hair follicle stem cells to promote epidermal regeneration after injury. Development. 2011 Nov; 138(22):4843-52. PMID: 22028024.
    View in: PubMed
  5. Rünger TM, Farahvash B, Hatvani Z, Rees A. Comparison of DNA damage responses following equimutagenic doses of UVA and UVB: a less effective cell cycle arrest with UVA may render UVA-induced pyrimidine dimers more mutagenic than UVB-induced ones. Photochem Photobiol Sci. 2012 Jan; 11(1):207-15. PMID: 22005748.
    View in: PubMed
  6. Rünger TM, Adami S, Benhamou CL, Czerwinski E, Farrerons J, Kendler DL, Mindeholm L, Realdi G, Roux C, Smith V. Morphea-like skin reactions in patients treated with the cathepsin K inhibitor balicatib. J Am Acad Dermatol. 2012 Mar; 66(3):e89-96. PMID: 21571394.
    View in: PubMed
  7. Rünger TM. Is UV-induced mutation formation in melanocytes different from other skin cells? Pigment Cell Melanoma Res. 2011 Feb; 24(1):10-2. PMID: 21044273.
    View in: PubMed
  8. Rizzo JL, Dunn J, Rees A, Rünger TM. No formation of DNA double-strand breaks and no activation of recombination repair with UVA. J Invest Dermatol. 2011 May; 131(5):1139-48. PMID: 21150922.
    View in: PubMed
  9. Gan SD, Rünger TM. Dermal fibroblasts internalize elastin to lysosomes via the elastin-binding protein of the elastin-laminin receptor. J Dermatol Sci. 2011 Jan; 61(1):60-2. PMID: 21111579.
    View in: PubMed
  10. Lee MS, Yaar M, Eller MS, Rünger TM, Gao Y, Gilchrest BA. Telomeric DNA induces p53-dependent reactive oxygen species and protects against oxidative damage. J Dermatol Sci. 2009 Dec; 56(3):154-62. PMID: 19906512.
    View in: PubMed
  11. Codriansky KA, Quintanilla-Dieck MJ, Gan S, Keady M, Bhawan J, Rünger TM. Intracellular degradation of elastin by cathepsin K in skin fibroblasts--a possible role in photoaging. Photochem Photobiol. 2009 Nov-Dec; 85(6):1356-63. PMID: 19659918.
    View in: PubMed
  12. Quintanilla-Dieck MJ, Codriansky K, Keady M, Bhawan J, Rünger TM. Expression and regulation of cathepsin K in skin fibroblasts. Exp Dermatol. 2009 Jul; 18(7):596-602. PMID: 19469903.
    View in: PubMed
  13. Rünger TM. C-->T transition mutations are not solely UVB-signature mutations, because they are also generated by UVA. J Invest Dermatol. 2008 Sep; 128(9):2138-40. PMID: 18695684.
    View in: PubMed
  14. Quintanilla-Dieck MJ, Codriansky K, Keady M, Bhawan J, Rünger TM. Cathepsin K in melanoma invasion. J Invest Dermatol. 2008 Sep; 128(9):2281-8. PMID: 18368130.
    View in: PubMed
  15. Codriansky KA, Rünger TM, Bhawan J, Kantarci A, Kissin EY. Multicentric reticulohistiocytosis: a systemic osteoclastic disease? Arthritis Rheum. 2008 Mar 15; 59(3):444-8. PMID: 18311766.
    View in: PubMed
  16. Rünger TM, Kappes UP. Mechanisms of mutation formation with long-wave ultraviolet light (UVA). Photodermatol Photoimmunol Photomed. 2008 Feb; 24(1):2-10. PMID: 18201350.
    View in: PubMed
  17. Rünger TM. How different wavelengths of the ultraviolet spectrum contribute to skin carcinogenesis: the role of cellular damage responses. J Invest Dermatol. 2007 Sep; 127(9):2103-5. PMID: 17700622.
    View in: PubMed
  18. Perez-Maldonado A, Rünger TM, Krejci-Papa N. The 1,450-nm diode laser reduces sebum production in facial skin: a possible mode of action of its effectiveness for the treatment of acne vulgaris. Lasers Surg Med. 2007 Feb; 39(2):189-92. PMID: 17311272.
    View in: PubMed
  19. Bercht M, Flohr-Beckhaus C, Osterod M, Rünger TM, Radicella JP, Epe B. Is the repair of oxidative DNA base modifications inducible by a preceding DNA damage induction? DNA Repair (Amst). 2007 Mar 1; 6(3):367-73. PMID: 17197252.
    View in: PubMed
  20. Dunn J, Potter M, Rees A, Rünger TM. Activation of the Fanconi anemia/BRCA pathway and recombination repair in the cellular response to solar ultraviolet light. Cancer Res. 2006 Dec 1; 66(23):11140-7. PMID: 17145857.
    View in: PubMed
  21. Emmert S, Leibeling D, Rünger TM. Syndromes with genetic instability: model diseases for (skin) cancerogenesis. J Dtsch Dermatol Ges. 2006 Sep; 4(9):721-31. PMID: 16928240.
    View in: PubMed
  22. Rünger TM, Quintanilla-Dieck MJ, Bhawan J. Role of cathepsin K in the turnover of the dermal extracellular matrix during scar formation. J Invest Dermatol. 2007 Feb; 127(2):293-7. PMID: 16946716.
    View in: PubMed
  23. Kappes UP, Luo D, Potter M, Schulmeister K, Rünger TM. Short- and long-wave UV light (UVB and UVA) induce similar mutations in human skin cells. J Invest Dermatol. 2006 Mar; 126(3):667-75. PMID: 16374481.
    View in: PubMed
  24. Emmert S, Steinhoff M, Günzl HJ, Rünger TM. [Persistent plaque on the back and right upper arm. Latent syphilis (lues III) with tubero-ulcero-serpiginous plaque]. J Dtsch Dermatol Ges. 2006 Feb; 4(2):156-9. PMID: 16503944.
    View in: PubMed
  25. Kappes UP, Rünger TM. No major role for 7,8-dihydro-8-oxoguanine in ultraviolet light-induced mutagenesis. Radiat Res. 2005 Oct; 164(4 Pt 1):440-5. PMID: 16187746.
    View in: PubMed
  26. Rünger TM, Vergilis I, Sarkar P, DePinho RA, Sharpless NE. How disruption of cell cycle regulating genes might predispose to sun-induced skin cancer. Cell Cycle. 2005 May; 4(5):643-5. PMID: 15846097.
    View in: PubMed
  27. Leverkus M, Schwaaf A, Bröcker EB, Rünger TM. Recurrent hemolysis-associated pseudoerysipelas of the lower legs in a patient with congenital spherocytosis. J Am Acad Dermatol. 2004 Dec; 51(6):1019-23. PMID: 15583606.
    View in: PubMed
  28. Sarkar-Agrawal P, Vergilis I, Sharpless NE, DePinho RA, Rünger TM. Impaired processing of DNA photoproducts and ultraviolet hypermutability with loss of p16INK4a or p19ARF. J Natl Cancer Inst. 2004 Dec 1; 96(23):1790-3. PMID: 15572761.
    View in: PubMed
  29. Rünger TM, Kotas M, Poot M, Leverkus M, Epe B, Jeggo PA, Hellfritsch D. Reduced joining of DNA ends correlates with chromosomal instability in three melanoma cell lines. Tumour Biol. 2003 Mar-Apr; 24(2):100-8. PMID: 12853705.
    View in: PubMed
  30. Kim KJ, Chakrabarty I, Li GZ, Grösch S, Kaina B, Rünger TM. Modulation of base excision repair alters cellular sensitivity to UVA1 but not to UVB1. Photochem Photobiol. 2002 May; 75(5):507-12. PMID: 12017477.
    View in: PubMed
  31. Atzpodien J, Neuber K, Kamanabrou D, Fluck M, Bröcker EB, Neumann C, Rünger TM, Schuler G, von den Driesch P, Müller I, Paul E, Patzelt T, Reitz M. Combination chemotherapy with or without s.c. IL-2 and IFN-alpha: results of a prospectively randomized trial of the Cooperative Advanced Malignant Melanoma Chemoimmunotherapy Group (ACIMM). Br J Cancer. 2002 Jan 21; 86(2):179-84. PMID: 11870502.
    View in: PubMed
  32. Rünger TM, Möller K, Jung T, Dekant B. DNA damage formation, DNA repair, and survival after exposure of DNA repair-proficient and nucleotide excision repair-deficient human lymphoblasts to UVA1 and UVB. Int J Radiat Biol. 2000 Jun; 76(6):789-97. PMID: 10902733.
    View in: PubMed
  33. Jung T, Emmert S, Günzl HJ, Neumann C, Rünger TM. [Congenital manifestations of juvenile xanthogranuloma (large nodular form)]. Hautarzt. 2000 Jun; 51(6):423-6. PMID: 10907158.
    View in: PubMed
  34. Rünger TM, Emmert S, Schadendorf D, Diem C, Epe B, Hellfritsch D. Alterations of DNA repair in melanoma cell lines resistant to cisplatin, fotemustine, or etoposide. J Invest Dermatol. 2000 Jan; 114(1):34-9. PMID: 10620112.
    View in: PubMed
  35. Rünger TM. Role of UVA in the pathogenesis of melanoma and non-melanoma skin cancer. A short review. Photodermatol Photoimmunol Photomed. 1999 Dec; 15(6):212-6. PMID: 10599968.
    View in: PubMed
  36. Reich K, Brinck U, Letschert M, Blaschke V, Dames K, Braess J, Wörmann B, Rünger TM, Neumann C. Graft-versus-host disease-like immunophenotype and apoptotic keratinocyte death in paraneoplastic pemphigus. Br J Dermatol. 1999 Oct; 141(4):739-46. PMID: 10583130.
    View in: PubMed
  37. Junghans V, Rünger TM. Hypertriglyceridaemia following adjuvant interferon-alpha treatment in two patients with malignant melanoma. Br J Dermatol. 1999 Jan; 140(1):183-4. PMID: 10215802.
    View in: PubMed
  38. Terheyden P, Kämpgen E, Rünger TM, Bröcker EB, Becker JC. [Immunochemotherapy of metastatic uveal melanoma with interferon alfa-2b, interleukin-2 and fotemustine. Case reports and review of the literature]. Hautarzt. 1998 Oct; 49(10):770-3. PMID: 9857252.
    View in: PubMed
  39. Emmert S, Küster W, Schauder S, Neumann C, Rünger TM. [Erythrokeratodermia progressiva symmetrica Darier-Gottron with generalized expression]. Hautarzt. 1998 Aug; 49(8):666-71. PMID: 9759571.
    View in: PubMed
  40. Tzung TY, Rünger TM. Assessment of DNA damage induced by broadband and narrowband UVB in cultured lymphoblasts and keratinocytes using the comet assay. Photochem Photobiol. 1998 Jun; 67(6):647-50. PMID: 9648530.
    View in: PubMed
  41. Tzung TY, Rünger TM. Reduced joining of DNA double strand breaks with an abnormal mutation spectrum in rodent mutants of DNA-PKcs and Ku80. Int J Radiat Biol. 1998 May; 73(5):469-74. PMID: 9652803.
    View in: PubMed
  42. Czerny C, Eder E, Rünger TM. Genotoxicity and mutagenicity of the alpha, beta-unsaturated carbonyl compound crotonaldehyde (butenal) on a plasmid shuttle vector. Mutat Res. 1998 Mar; 407(2):125-34. PMID: 9637241.
    View in: PubMed
  43. Diem C, Rünger TM. A novel plasmid shuttle vector for the detection and analysis of microsatellite instability in cell lines. Mutat Res. 1998 Mar; 407(2):117-24. PMID: 9637240.
    View in: PubMed
  44. Soruri A, Fayyazi A, Gieseler R, Schlott T, Rünger TM, Neumann C, Peters JH. Specific autologous anti-melanoma T cell response in vitro using monocyte-derived dendritic cells. Immunobiology. 1998 Mar; 198(5):527-38. PMID: 9561371.
    View in: PubMed
  45. Tzung TY, Diem C, Rünger TM. Assessment of microsatellite instability in a cell line from a patient with xeroderma pigmentosum variant. Arch Dermatol Res. 1998 Mar; 290(3):109-12. PMID: 9558484.
    View in: PubMed
  46. Diem C, Rünger TM. Processing of three different types of DNA damage in cell lines of a cutaneous squamous cell carcinoma progression model. Carcinogenesis. 1997 Apr; 18(4):657-62. PMID: 9111196.
    View in: PubMed
  47. Liebetrau W, Rünger TM, Mehling BE, Poot M, Hoehn H. Mutagenic activity of ambient oxygen and mitomycin C in Fanconi's anaemia cells. Mutagenesis. 1997 Mar; 12(2):69-77. PMID: 9106246.
    View in: PubMed
  48. Rünger TM, Epe B, Möller K, Dekant B, Hellfritsch D. Repair of directly and indirectly UV-induced DNA lesions and of DNA double-strand breaks in cells from skin cancer-prone patients with the disorders dysplastic nevus syndrome or basal cell nevus syndrome. Recent Results Cancer Res. 1997; 143:337-51. PMID: 8912431.
    View in: PubMed
  49. Adam W, Andler S, Ballmaier D, Emmert S, Epe B, Grimm G, Mielke K, Möller M, Rünger TM, Saha-Möller CR, Schönberger A, Stopper H. Oxidative DNA damage induced by dioxetanes, photosensitizing ketones, and photo-fenton reagents. Recent Results Cancer Res. 1997; 143:21-34. PMID: 8912409.
    View in: PubMed
  50. Rünger TM, Bröcker EB. [Genetic factors in the development and progression of malignant melanoma]. Hautarzt. 1995 Jun; 46(6):394-9. PMID: 7642382.
    View in: PubMed
  51. Erhard H, Rünger TM, Kreienkamp M, Müller J, Müller-Hermelink HK, Bröcker EB. Atypical varicella-zoster virus infection in an immunocompromised patient: result of a virus-induced vasculitis. J Am Acad Dermatol. 1995 May; 32(5 Pt 2):908-11. PMID: 7722056.
    View in: PubMed
  52. Rünger TM, Lehmann P, Neumann NJ, Matthies C, Schauder S, Ortel B, Münzberger C, Hölzle E. [Recommendations for a photo-patch test standard series by the German speaking study group "Photopatch-Test"]. Hautarzt. 1995 Apr; 46(4):240-3. PMID: 7790188.
    View in: PubMed
  53. Emmert S, Epe B, Saha-Möller CR, Adam W, Rünger TM. Assessment of genotoxicity and mutagenicity of 1,2-dioxetanes in human cells using a plasmid shuttle vector. Photochem Photobiol. 1995 Feb; 61(2):136-41. PMID: 7899502.
    View in: PubMed
  54. Rünger TM. [DNA damage to the skin caused by ultraviolet irradiation. Development, significance, modification]. Med Klin (Munich). 1995 Jan 15; 90 Suppl 1:22-6. PMID: 7715580.
    View in: PubMed
  55. Rünger TM, Epe B, Möller K. Repair of ultraviolet B and singlet oxygen-induced DNA damage in xeroderma pigmentosum cells. J Invest Dermatol. 1995 Jan; 104(1):68-73. PMID: 7798643.
    View in: PubMed
  56. Rünger TM, Epe B, Möller K. Processing of directly and indirectly ultraviolet-induced DNA damage in human cells. Recent Results Cancer Res. 1995; 139:31-42. PMID: 7597299.
    View in: PubMed
  57. Rünger TM, Klein CE, Becker JC, Bröcker EB. The role of genetic instability, adhesion, cell motility, and immune escape mechanisms in melanoma progression. Curr Opin Oncol. 1994 Mar; 6(2):188-96. PMID: 7912108.
    View in: PubMed
  58. Rünger TM, Bauer C, Dekant B, Möller K, Sobotta P, Czerny C, Poot M, Martin GM. Hypermutable ligation of plasmid DNA ends in cells from patients with Werner syndrome. J Invest Dermatol. 1994 Jan; 102(1):45-8. PMID: 8288910.
    View in: PubMed
  59. Rünger TM, Sobotta P, Dekant B, Möller K, Bauer C, Kraemer KH. In-vivo assessment of DNA ligation efficiency and fidelity in cells from patients with Fanconi's anemia and other cancer-prone hereditary disorders. Toxicol Lett. 1993 Apr; 67(1-3):309-24. PMID: 8451768.
    View in: PubMed
  60. Rünger TM, Poot M, Kraemer KH. Abnormal processing of transfected plasmid DNA in cells from patients with ataxia telangiectasia. Mutat Res. 1992 Nov; 293(1):47-54. PMID: 1383810.
    View in: PubMed
  61. Poot M, Hoehn H, Rünger TM, Martin GM. Impaired S-phase transit of Werner syndrome cells expressed in lymphoblastoid cell lines. Exp Cell Res. 1992 Oct; 202(2):267-73. PMID: 1327851.
    View in: PubMed
  62. Pommier Y, Rünger TM, Kerrigan D, Kraemer KH. Relationship of DNA strand breakage produced by bromodeoxyuridine to topoisomerase II activity in Bloom-syndrome fibroblasts. Mutat Res. 1991 Mar; 254(2):185-90. PMID: 1848352.
    View in: PubMed
  63. Rünger TM, Kraemer KH. Joining of linear plasmid DNA is reduced and error-prone in Bloom's syndrome cells. EMBO J. 1989 May; 8(5):1419-25. PMID: 2767047.
    View in: PubMed
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