Thomas L. Clarke, Ph.D
Assistant Professor
Boston University Chobanian & Avedisian School of Medicine
Pathology & Laboratory Medicine

PhD, University of Birmingham
BS, University of Exeter

Pronouns: he/him/his



Dr. Clarke studied Medical Science at the University of Exeter in the UK, which included a twelve-month research internship at Harvard Medical School. He then pursued a Ph.D. at the University of Birmingham in the laboratory of Dr. Clare Davies, working on understanding the importance of the arginine methyltransferase enzyme, PRMT5, in the DNA damage response (Clarke et al, Molecular Cell; 2017).

After his Ph.D., Dr. Clarke was awarded an EMBO Postdoctoral Fellowship and joined the laboratory of Dr. Johnathan Whetstine at Massachusetts General Hospital and Harvard Medical School, where he worked on elucidating the importance of chromatin dynamics and histone modifications for the regulation of extra chromosomal DNA amplifications (Clarke et al, Cancer Discovery; 2020). After the completion of his EMBO fellowship, Dr. Clarke joined the laboratory of Dr. Raul Mostoslavsky, Scientific Director of the Massachusetts General Hospital Cancer Center, to bridge his interests in chromatin dynamics, DNA damage repair and genome stability maintenance. Funded by fellowships from the Charles King Trust and Massachusetts General Hospital Fund for Medical Discovery, Dr. Clarke has been working to identify and characterize novel chromatin factors involved in DNA damage repair, linking these factors to the pathology of several cancers and human developmental syndromes (Clarke et al, in revision).

In the summer of 2022, Dr. Clarke became a junior faculty member at Harvard Medical School and The Massachusetts General Hospital Krantz Family Center for Cancer Research. In January 2024, funded by a National Institutes of Health K99/R00 career development award, Dr. Clarke joined the faculty at Boston University School of Medicine as an Assistant Professor to start his independent research laboratory.




Title


Yr Title Project-Sub Proj Pubs
2024 Identifying chromatin factors essential for DNA repair using a novel high-throughput screening methodology 4R00ES034443-03
2023 Identifying chromatin factors essential for DNA repair using a novel high-throughput screening methodology 5K99ES034443-02

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis       Copy PMIDs To Clipboard

  1. Clarke TL, Mostoslavsky R. DNA repair as a shared hallmark in cancer and ageing. Mol Oncol. 2022 Sep; 16(18):3352-3379. PMID: 35834102; PMCID: PMC9490147; DOI: 10.1002/1878-0261.13285;
     
  2. Martinez-Pastor B, Silveira GG, Clarke TL, Chung D, Gu Y, Cosentino C, Davidow LS, Mata G, Hassanieh S, Salsman J, Ciccia A, Bae N, Bedford MT, Megias D, Rubin LL, Efeyan A, Dellaire G, Mostoslavsky R. Assessing kinetics and recruitment of DNA repair factors using high content screens. Cell Rep. 2021 Dec 28; 37(13):110176. PMID: 34965416; PMCID: PMC8763642; DOI: 10.1016/j.celrep.2021.110176;
     
  3. Clarke TL, Mostoslavsky R. Resveratrol: Friend or Foe? Mol Cell. 2020 Sep 03; 79(5):705-707. PMID: 32888435; DOI: 10.1016/j.molcel.2020.08.008;
     
  4. Clarke TL, Tang R, Chakraborty D, Van Rechem C, Ji F, Mishra S, Ma A, Kaniskan HÜ, Jin J, Lawrence MS, Sadreyev RI, Whetstine JR. Histone Lysine Methylation Dynamics Control EGFR DNA Copy-Number Amplification. Cancer Discov. 2020 Feb; 10(2):306-325. PMID: 31776131; PMCID: PMC7271978; DOI: 10.1158/2159-8290.CD-19-0463;
     
  5. Mishra S, Van Rechem C, Pal S, Clarke TL, Chakraborty D, Mahan SD, Black JC, Murphy SE, Lawrence MS, Daniels DL, Whetstine JR. Cross-talk between Lysine-Modifying Enzymes Controls Site-Specific DNA Amplifications. Cell. 2018 Aug 09; 174(4):803-817.e16. PMID: 30057114; PMCID: PMC6212369; DOI: 10.1016/j.cell.2018.06.018;
     
  6. Chiang K, Zielinska AE, Shaaban AM, Sanchez-Bailon MP, Jarrold J, Clarke TL, Zhang J, Francis A, Jones LJ, Smith S, Barbash O, Guccione E, Farnie G, Smalley MJ, Davies CC. PRMT5 Is a Critical Regulator of Breast Cancer Stem Cell Function via Histone Methylation and FOXP1 Expression. Cell Rep. 2017 Dec 19; 21(12):3498-3513. PMID: 29262329; PMCID: PMC5746596; DOI: 10.1016/j.celrep.2017.11.096;
     
  7. Clarke TL, White DA, Osborne ME, Shaw AM, Smart NJ, Daniels IR. Predicting response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer with serum biomarkers. Ann R Coll Surg Engl. 2017 May; 99(5):373-377. PMID: 28462648; PMCID: PMC5449704; DOI: 10.1308/rcsann.2017.0030;
     
  8. Clarke TL, Sanchez-Bailon MP, Chiang K, Reynolds JJ, Herrero-Ruiz J, Bandeiras TM, Matias PM, Maslen SL, Skehel JM, Stewart GS, Davies CC. PRMT5-Dependent Methylation of the TIP60 Coactivator RUVBL1 Is a Key Regulator of Homologous Recombination. Mol Cell. 2017 Mar 02; 65(5):900-916.e7. PMID: 28238654; PMCID: PMC5344794; DOI: 10.1016/j.molcel.2017.01.019;
     
  9. Carneiro DG, Clarke T, Davies CC, Bailey D. Identifying novel protein interactions: Proteomic methods, optimisation approaches and data analysis pipelines. Methods. 2016 Feb 15; 95:46-54. PMID: 26320829; DOI: 10.1016/j.ymeth.2015.08.022;
     

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 9 publications over 7 distinct years, with a maximum of 3 publications in 2017

YearPublications
20151
20173
20181
20191
20201
20211
20221


2024 European Molecular Biology Organization (EMBO) : Evolution and diversity of the DNA damage response, Best Poster Prize
2023 Massachusetts General Hospital: Krantz Family Center for Cancer Research, Annual Retreat Poster Award
2023 Massachusetts General Hospital: Krantz Family Center for Cancer Research, Community Service Award
2022 National Institute of Environmental and Health Sciences (NIEHS): National Institutes of Health K99/R00 Pathway to Independence Award
2022 Executive Committee on Research, Massachusetts General Hospital: Fund for Medical Discovery Research Fellowship
2020 The Medical Foundation: Charles King Trust Postdoctoral Fellowship
2017 European Molecular Biology Organization: EMBO Postdoctoral Fellowship
2016 Federation of American Societies for Experimental Biology (FASEB): FASEB Conference Travel Award
2016 University of Birmingham: Best Doctoral Research Prize
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