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PhD, Tufts University
MA, Washington University in St. Louis

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BU Research
NIH RePORTER Research

Regulation of Nitrogen Metabolism in Bacillus Subtilis
09/01/1994 - 06/30/2014 (PI)
NIH/National Institute of General Medical Sciences
5R01GM51127-16

Title

Yr	Title	Project-Sub Proj	Pubs
2012	Regulation of Nitrogen Metabolism in Bacillus subtilis	5R01GM051127-16	22
2011	Regulation of Nitrogen Metabolism in Bacillus subtilis	5R01GM051127-15	22
2010	Regulation of Nitrogen Metabolism in Bacillus subtilis	5R01GM051127-14	22
2009	Regulation of Nitrogen Metabolism in Bacillus subtilis	2R01GM051127-13A1	22
2006	Regulation of Nitrogen Metabolism in Bacillus subtilis	5R01GM051127-12	22
2005	Regulation of Nitrogen Metabolism in Bacillus subtilis	5R01GM051127-11	22
2004	Regulation of Nitrogen Metabolism in Bacillus subtilis	5R01GM051127-10	22
2003	Regulation of Nitrogen Metabolism in Bacillus subtilis	2R01GM051127-09	22
2002	REGULATION OF NITROGEN METABOLISM IN BACILLUS SUBTILIS	5R01GM051127-08	22
2001	REGULATION OF NITROGEN METABOLISM IN BACILLUS SUBTILIS	5R01GM051127-07	22

Showing 10 of 25 results. Show All Results

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Murray DS, Chinnam N, Tonthat NK, Whitfill T, Wray LV, Fisher SH, Schumacher MA. Structures of the Bacillus subtilis glutamine synthetase dodecamer reveal large intersubunit catalytic conformational changes linked to a unique feedback inhibition mechanism. J Biol Chem. 2013 Dec 13; 288(50):35801-11.View Related Profiles.

Wray, Lewis
Fisher, Susan

PMID: 24158439; PMCID: PMC3861631; DOI: 10.1074/jbc.M113.519496;

Wray LV, Fisher SH. Bacillus subtilis CodY operators contain overlapping CodY binding sites. J Bacteriol. 2011 Sep; 193(18):4841-8.View Related Profiles.

Wray, Lewis
Fisher, Susan

PMID: 21764931; PMCID: PMC3165709; DOI: 10.1128/JB.05258-11;

Wray LV, Fisher SH. Functional roles of the conserved Glu304 loop of Bacillus subtilis glutamine synthetase. J Bacteriol. 2010 Oct; 192(19):5018-25.View Related Profiles.

Wray, Lewis
Fisher, Susan

PMID: 20656908; PMCID: PMC2944536; DOI: 10.1128/JB.00509-10;

Fisher SH, Wray LV. Novel trans-Acting Bacillus subtilis glnA mutations that derepress glnRA expression. J Bacteriol. 2009 Apr; 191(8):2485-92.View Related Profiles.

Wray, Lewis
Fisher, Susan

PMID: 19233925; PMCID: PMC2668423; DOI: 10.1128/JB.01734-08;

Wray LV, Fisher SH. Bacillus subtilis GlnR contains an autoinhibitory C-terminal domain required for the interaction with glutamine synthetase. Mol Microbiol. 2008 Apr; 68(2):277-85.View Related Profiles.

Wray, Lewis
Fisher, Susan

PMID: 18331450; DOI: 10.1111/j.1365-2958.2008.06162.x;

Fisher SH, Wray LV. Bacillus subtilis glutamine synthetase regulates its own synthesis by acting as a chaperone to stabilize GlnR-DNA complexes. Proc Natl Acad Sci U S A. 2008 Jan 22; 105(3):1014-9.View Related Profiles.

Wray, Lewis
Fisher, Susan

PMID: 18195355; PMCID: PMC2242682; DOI: 10.1073/pnas.0709949105;

Wray LV, Fisher SH. Functional analysis of the carboxy-terminal region of Bacillus subtilis TnrA, a MerR family protein. J Bacteriol. 2007 Jan; 189(1):20-7.View Related Profiles.

Wray, Lewis
Fisher, Susan

PMID: 17085574; PMCID: PMC1797213

Fisher SH, Wray LV. Feedback-resistant mutations in Bacillus subtilis glutamine synthetase are clustered in the active site. J Bacteriol. 2006 Aug; 188(16):5966-74.View Related Profiles.

Wray, Lewis
Fisher, Susan

PMID: 16885465; PMCID: PMC1540052

Zalieckas JM, Wray LV, Fisher SH. Cross-regulation of the Bacillus subtilis glnRA and tnrA genes provides evidence for DNA binding site discrimination by GlnR and TnrA. J Bacteriol. 2006 Apr; 188(7):2578-85.View Related Profiles.

Wray, Lewis
Fisher, Susan

PMID: 16547045; PMCID: PMC1428417

Wray LV, Fisher SH. A feedback-resistant mutant of Bacillus subtilis glutamine synthetase with pleiotropic defects in nitrogen-regulated gene expression. J Biol Chem. 2005 Sep 30; 280(39):33298-304.View Related Profiles.

Wray, Lewis
Fisher, Susan

PMID: 16055443

Showing 10 of 50 results. Show More

Brandenburg JL, Wray LV, Beier L, Jarmer H, Saxild HH, Fisher SH. Roles of PucR, GlnR, and TnrA in regulating expression of the Bacillus subtilis ure P3 promoter. J Bacteriol. 2002 Nov; 184(21):6060-4.View Related Profiles.

Wray, Lewis
Fisher, Susan

PMID: 12374841; PMCID: PMC135401

Fisher SH, Wray LV. Mutations in the Bacillus subtilis glnRA operon that cause nitrogen source-dependent defects in regulation of TnrA activity. J Bacteriol. 2002 Aug; 184(16):4636-9.View Related Profiles.

Wray, Lewis
Fisher, Susan

PMID: 12142436; PMCID: PMC135256

Fisher SH, Brandenburg JL, Wray LV. Mutations in Bacillus subtilis glutamine synthetase that block its interaction with transcription factor TnrA. Mol Microbiol. 2002 Aug; 45(3):627-35.View Related Profiles.

Wray, Lewis
Fisher, Susan

PMID: 12139611

Fisher SH, Wray LV. Bacillus subtilis 168 contains two differentially regulated genes encoding L-asparaginase. J Bacteriol. 2002 Apr; 184(8):2148-54.View Related Profiles.

Wray, Lewis
Fisher, Susan

PMID: 11914346; PMCID: PMC134974

Wray LV, Zalieckas JM, Fisher SH. Bacillus subtilis glutamine synthetase controls gene expression through a protein-protein interaction with transcription factor TnrA. Cell. 2001 Nov 16; 107(4):427-35.View Related Profiles.

Wray, Lewis
Fisher, Susan

PMID: 11719184

Belitsky BR, Wray LV, Fisher SH, Bohannon DE, Sonenshein AL. Role of TnrA in nitrogen source-dependent repression of Bacillus subtilis glutamate synthase gene expression. J Bacteriol. 2000 Nov; 182(21):5939-47.View Related Profiles.

Wray, Lewis
Fisher, Susan

PMID: 11029411; PMCID: PMC94725

Wray LV, Zalieckas JM, Fisher SH. Purification and in vitro activities of the Bacillus subtilis TnrA transcription factor. J Mol Biol. 2000 Jun 30; 300(1):29-40.View Related Profiles.

Wray, Lewis
Fisher, Susan

PMID: 10864496

Zalieckas JM, Wray LV, Fisher SH. trans-acting factors affecting carbon catabolite repression of the hut operon in Bacillus subtilis. J Bacteriol. 1999 May; 181(9):2883-8.View Related Profiles.

Wray, Lewis
Fisher, Susan

PMID: 10217782; PMCID: PMC93733

Fisher SH. Regulation of nitrogen metabolism in Bacillus subtilis: vive la différence! Mol Microbiol. 1999 Apr; 32(2):223-32. PMID: 10231480

Zalieckas JM, Wray LV, Fisher SH. Expression of the Bacillus subtilis acsA gene: position and sequence context affect cre-mediated carbon catabolite repression. J Bacteriol. 1998 Dec; 180(24):6649-54.View Related Profiles.

Wray, Lewis
Fisher, Susan

PMID: 9852010; PMCID: PMC107769

Wray LV, Zalieckas JM, Ferson AE, Fisher SH. Mutational analysis of the TnrA-binding sites in the Bacillus subtilis nrgAB and gabP promoter regions. J Bacteriol. 1998 Jun; 180(11):2943-9.View Related Profiles.

Wray, Lewis
Fisher, Susan

PMID: 9603886; PMCID: PMC107263

Zalieckas JM, Wray LV, Ferson AE, Fisher SH. Transcription-repair coupling factor is involved in carbon catabolite repression of the Bacillus subtilis hut and gnt operons. Mol Microbiol. 1998 Mar; 27(5):1031-8.View Related Profiles.

Wray, Lewis
Fisher, Susan

PMID: 9535092

Wray LV, Ferson AE, Fisher SH. Expression of the Bacillus subtilis ureABC operon is controlled by multiple regulatory factors including CodY, GlnR, TnrA, and Spo0H. J Bacteriol. 1997 Sep; 179(17):5494-501.View Related Profiles.

Wray, Lewis
Fisher, Susan

PMID: 9287005; PMCID: PMC179421

Cruz-Ramos H, Glaser P, Wray LV, Fisher SH. The Bacillus subtilis ureABC operon. J Bacteriol. 1997 May; 179(10):3371-3.View Related Profiles.

Wray, Lewis
Fisher, Susan

PMID: 9150240; PMCID: PMC179123

Ferson AE, Wray LV, Fisher SH. Expression of the Bacillus subtilis gabP gene is regulated independently in response to nitrogen and amino acid availability. Mol Microbiol. 1996 Nov; 22(4):693-701.View Related Profiles.

Wray, Lewis
Fisher, Susan

PMID: 8951816

Wray LV, Ferson AE, Rohrer K, Fisher SH. TnrA, a transcription factor required for global nitrogen regulation in Bacillus subtilis. Proc Natl Acad Sci U S A. 1996 Aug 20; 93(17):8841-5.View Related Profiles.

Wray, Lewis
Fisher, Susan

PMID: 8799114; PMCID: PMC38555

Fisher SH, Rohrer K, Ferson AE. Role of CodY in regulation of the Bacillus subtilis hut operon. J Bacteriol. 1996 Jul; 178(13):3779-84. PMID: 8682780; PMCID: PMC232636

Wray LV, Fisher SH. Analysis of Bacillus subtilis hut operon expression indicates that histidine-dependent induction is mediated primarily by transcriptional antitermination and that amino acid repression is mediated by two mechanisms: regulation of transcription initiation and inhibition of histidine transport. J Bacteriol. 1994 Sep; 176(17):5466-73.View Related Profiles.

Wray, Lewis
Fisher, Susan

PMID: 8071225; PMCID: PMC196735

Fisher SH, Strauch MA, Atkinson MR, Wray LV. Modulation of Bacillus subtilis catabolite repression by transition state regulatory protein AbrB. J Bacteriol. 1994 Apr; 176(7):1903-12.View Related Profiles.

Wray, Lewis
Fisher, Susan

PMID: 8144456; PMCID: PMC205293

Wray LV, Pettengill FK, Fisher SH. Catabolite repression of the Bacillus subtilis hut operon requires a cis-acting site located downstream of the transcription initiation site. J Bacteriol. 1994 Apr; 176(7):1894-902.View Related Profiles.

Wray, Lewis
Fisher, Susan

PMID: 8144455; PMCID: PMC205292

Wray LV, Atkinson MR, Fisher SH. The nitrogen-regulated Bacillus subtilis nrgAB operon encodes a membrane protein and a protein highly similar to the Escherichia coli glnB-encoded PII protein. J Bacteriol. 1994 Jan; 176(1):108-14.View Related Profiles.

Wray, Lewis
Fisher, Susan

PMID: 8282685; PMCID: PMC205020

Wray LV, Fisher SH. The Streptomyces coelicolor glnR gene encodes a protein similar to other bacterial response regulators. Gene. 1993 Aug 16; 130(1):145-50.View Related Profiles.

Wray, Lewis
Fisher, Susan

PMID: 7688332

Atkinson MR, Wray LV, Fisher SH. Activation of the Bacillus subtilis hut operon at the onset of stationary growth phase in nutrient sporulation medium results primarily from the relief of amino acid repression of histidine transport. J Bacteriol. 1993 Jul; 175(14):4282-9.View Related Profiles.

Wray, Lewis
Fisher, Susan

PMID: 7687247; PMCID: PMC204867

Fisher SH. Glutamine synthesis in Streptomyces--a review. Gene. 1992 Jun 15; 115(1-2):13-7. PMID: 1612427

Wray LV, Atkinson MR, Fisher SH. Identification and cloning of the glnR locus, which is required for transcription of the glnA gene in Streptomyces coelicolor A3(2). J Bacteriol. 1991 Nov; 173(22):7351-60.View Related Profiles.

Wray, Lewis
Fisher, Susan

PMID: 1718946; PMCID: PMC209244

Fisher SH, Sonenshein AL. Control of carbon and nitrogen metabolism in Bacillus subtilis. Annu Rev Microbiol. 1991; 45:107-35. PMID: 1741612

Atkinson MR, Fisher SH. Identification of genes and gene products whose expression is activated during nitrogen-limited growth in Bacillus subtilis. J Bacteriol. 1991 Jan; 173(1):23-7. PMID: 1670935; PMCID: PMC207151

Atkinson MR, Wray LV, Fisher SH. Regulation of histidine and proline degradation enzymes by amino acid availability in Bacillus subtilis. J Bacteriol. 1990 Sep; 172(9):4758-65.View Related Profiles.

Wray, Lewis
Fisher, Susan

PMID: 2118500; PMCID: PMC213128

Fisher SH. Glutamate synthesis in Streptomyces coelicolor. J Bacteriol. 1989 May; 171(5):2372-7. PMID: 2708309; PMCID: PMC209910

Fisher SH, Wray LV. Regulation of glutamine synthetase in Streptomyces coelicolor. J Bacteriol. 1989 May; 171(5):2378-83.View Related Profiles.

Wray, Lewis
Fisher, Susan

PMID: 2468647; PMCID: PMC209911

Wray LV, Fisher SH. Cloning and nucleotide sequence of the Streptomyces coelicolor gene encoding glutamine synthetase. Gene. 1988 Nov 30; 71(2):247-56.View Related Profiles.

Wray, Lewis
Fisher, Susan

PMID: 2906310

Fisher SH, Bruton CJ, Chater KF. The glucose kinase gene of Streptomyces coelicolor and its use in selecting spontaneous deletions for desired regions of the genome. Mol Gen Genet. 1987 Jan; 206(1):35-44. PMID: 3033439

Schreier HJ, Fisher SH, Sonenshein AL. Regulation of expression from the glnA promoter of Bacillus subtilis requires the glnA gene product. Proc Natl Acad Sci U S A. 1985 May; 82(10):3375-9. PMID: 2860669; PMCID: PMC397778

Fisher SH, Rosenkrantz MS, Sonenshein AL. Glutamine synthetase gene of Bacillus subtilis. Gene. 1984 Dec; 32(3):427-38. PMID: 6152242

Fisher SH, Magasanik B. Synthesis of oxaloacetate in Bacillus subtilis mutants lacking the 2-ketoglutarate dehydrogenase enzymatic complex. J Bacteriol. 1984 Apr; 158(1):55-62. PMID: 6425269; PMCID: PMC215378

Fisher SH, Magasanik B. 2-Ketoglutarate and the regulation of aconitase and histidase formation in Bacillus subtilis. J Bacteriol. 1984 Apr; 158(1):379-82. PMID: 6143742; PMCID: PMC215431

Fisher SH, Magasanik B. Isolation of Bacillus subtilis mutants pleiotropically insensitive to glucose catabolite repression. J Bacteriol. 1984 Mar; 157(3):942-4. PMID: 6421803; PMCID: PMC215352

Fisher SH, Sonenshein AL. Bacillus subtilis glutamine synthetase mutants pleiotropically altered in glucose catabolite repression. J Bacteriol. 1984 Feb; 157(2):612-21. PMID: 6141156; PMCID: PMC215290

Fisher SH, Sonenshein AL. Glutamine-requiring mutants of Bacillus subtilis. Biochem Biophys Res Commun. 1977 Dec 7; 79(3):987-95. PMID: 23122

Sonenshein AL, Alexander HB, Rothstein DM, Fisher SH. Lipiarmycin-resistant ribonucleic acid polymerase mutants of Bacillus subtilis. J Bacteriol. 1977 Oct; 132(1):73-9. PMID: 410787; PMCID: PMC221828

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

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