Jinghua Yang, PhD
Research Associate Professor
Boston University School of Medicine
Dept of Surgery
General Surgery Section

PhD, Université de Montréal
MSc, Beijing University of Chemical Technology
Websites
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Our laboratory is pleased to provide facilities to investigators of Boston University Medical Campus and Boston VA Medical Center in clinic application of proteomics with expert, accurate, and collaborative interactions. These include i) Fluorescence-assistant Autoimmune Display (FaAD) to identify autoimmune responses against tumors, infectious diseases and autoimmune diseases, ii) Differential Gel Electrophoresis (DiGE) to identify differentially expressed proteins in blood/tissue samples, iii) Fluorescence-assistant Multi-dimensional HPLC (FaMD-HPLC) to differentially profile protein expression in patient biopsies, iv) LC-MALDI-TOF and nanoLC-Q-TOF (LC-MS/MS) for protein identification, protein profiling, and marker discovery, and v) Liquid protein array (xMAP from Luminex) to validate protein markers in patients.

We are studying the biological function of dsRNA and dsRNA-binding proteins. These include the dsRNA editing enzyme ADAR1, ADAR2 and ADAR3. ADAR1 is ubiquitously expressed particularly in immune organs; ADAR2 is found in all tissues but dominant in neuronal system; and ADAR3 is exclusively in the brain. Currently our interest is focused on the function of ADAR1 in viral infection/stress, and ADAR2 in traumatic stress.

Another focus of our laboratory is to identify the tumor specific complement activator (tsCA). This factor is found to activate human complement to kill different tumor cells in vitro.

VA Boston Healthcare System




Personnel Agreement for Research Services of Jinghua Yang
08/01/2017 - 12/30/2017 (PI)
VA Boston Healthcare System

Personnel Agreement for Research Services of Jinghua Yang
03/01/2016 - 06/30/2017 (PI)
VA Boston Healthcare System


Personnel Agreement for Research Services of Jinghua Yang
11/01/2012 - 12/31/2015 (PI)
VA Boston Healthcare System


Personnel Agreement for Research Services Jinghua Yang
04/01/2011 - 09/30/2011 (PI)
VA Boston Healthcare System


Personnel Agreement for research services of Yun Yang
06/01/2011 - 08/31/2011 (PI)
Boston VA Research Institute, Inc.


Role of RNA Editing by ADAR1 in Infection
11/01/2006 - 10/30/2010 (PI)
NIH/National Institute of Allergy & Infectious Diseases
5 K02 AI60701 06

The Mechanism and Function OF A-TO-1 RNA Editing
11/01/2006 - 07/31/2008 (PI)
NIH/National Institute of General Medical Sciences
7 R01 GM60426 06




Yr Title Project-Sub Proj Pubs
2008 Role of RNA Editing by ADAR1 in Infection 5K02AI060701-06 4
2007 Role of RNA Editing by ADAR1 in Infection 5K02AI060701-05 4
2006 Role of RNA Editing by ADAR1 in Infection 5K02AI060701-03 4
2006 Role of RNA Editing by ADAR1 in Infection 7K02AI060701-04 4
2005 Role of RNA Editing by ADAR1 in Infection 5K02AI060701-02 4
2004 Role of RNA Editing by ADAR1 in Infection 1K02AI060701-01 4
2004 THE MECHANISM AND FUNCTION OF A TO I RNA EDITING 7R01GM060426-06 8
2004 THE MECHANISM AND FUNCTION OF A TO I RNA EDITING 5R01GM060426-05 8
2003 THE MECHANISM AND FUNCTION OF A TO I RNA EDITING 5R01GM060426-04 8
2002 THE MECHANISM AND FUNCTION OF A TO I RNA EDITING 5R01GM060426-03 8
Showing 10 of 12 results. Show All Results
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

  1. Nie Y, Hammond GL, Yang JH. Double-stranded RNA deaminase ADAR1 increases host susceptibility to virus infection. J Virol. 2007 Jan; 81(2):917-23. PMID: 17079286; PMCID: PMC1797455; DOI: 10.1128/JVI.01527-06;.
  2. Nie Y, Ding L, Kao PN, Braun R, Yang JH. ADAR1 interacts with NF90 through double-stranded RNA and regulates NF90-mediated gene expression independently of RNA editing. Mol Cell Biol. 2005 Aug; 25(16):6956-63. PMID: 16055709; PMCID: PMC1190226; DOI: 10.1128/MCB.25.16.6956-6963.2005;.
  3. Xia S, Yang J, Su Y, Qian J, Ma E, Haddad GG. Identification of new targets of Drosophila pre-mRNA adenosine deaminase. Physiol Genomics. 2005 Jan 20; 20(2):195-202. PMID: 15522950; DOI: 10.1152/physiolgenomics.00093.2003;.
  4. Nie Y, Zhao Q, Su Y, Yang JH. Subcellular distribution of ADAR1 isoforms is synergistically determined by three nuclear discrimination signals and a regulatory motif. J Biol Chem. 2004 Mar 26; 279(13):13249-55. PMID: 14711814; DOI: 10.1074/jbc.M312753200;.
  5. Yang JH, Nie Y, Zhao Q, Su Y, Pypaert M, Su H, Rabinovici R. Intracellular localization of differentially regulated RNA-specific adenosine deaminase isoforms in inflammation. J Biol Chem. 2003 Nov 14; 278(46):45833-42. PMID: 12954622; DOI: 10.1074/jbc.M308612200;.
  6. Nie Y, Wu K, Yang J, Tian F, Li L, Chen B, Fan D. Induction of T lymphocytes specific to human gastric cancer using HLA-A matched allogeneic gastric tumor cells. J Immunother. 2003 Sep-Oct; 26(5):403-11. PMID: 12973029.
  7. Yang JH, Luo X, Nie Y, Su Y, Zhao Q, Kabir K, Zhang D, Rabinovici R. Widespread inosine-containing mRNA in lymphocytes regulated by ADAR1 in response to inflammation. Immunology. 2003 May; 109(1):15-23. PMID: 12709013; PMCID: PMC1782949.
  8. Wu J, Shi YQ, Wu KC, Zhang DX, Yang JH, Fan DM. Angiostatin up-regulation in gastric cancer cell SGC7901 inhibits tumorigenesis in nude mice. World J Gastroenterol. 2003 Jan; 9(1):59-64. PMID: 12508352; PMCID: PMC4728250.
  9. Rabinovici R, Zhang D, Su Y, Luo X, Zhao Q, Yang JH. MOB-1 and TNF-alpha interact to induce microvascular lung injury. Shock. 2002 Sep; 18(3):261-4. PMID: 12353928.
  10. Kabir K, Gelinas JP, Chen M, Chen D, Zhang D, Luo X, Yang JH, Carter D, Rabinovici R. Characterization of a murine model of endotoxin-induced acute lung injury. Shock. 2002 Apr; 17(4):300-3. PMID: 11954830.
Showing 10 of 18 results. Show More

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 18 publications over 13 distinct years, with a maximum of 4 publications in 2003

YearPublications
19901
19911
19921
19941
19951
19971
20001
20011
20022
20034
20042
20051
20061
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