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Last Name

Jinghua Yang, PhD

TitleResearch Associate Professor
InstitutionBoston University School of Medicine
DepartmentSurgery
DivisionGeneral Surgery
Address25 Buick St
Boston MA 02215
Phone(617) 638-8600
Other Positions
InstitutionVA Boston Healthcare System

 Research Expertise & Professional Interests
Our laboratory is pleased to provide facilities to investigators of Boston University Medical Campus and Boston VA Medical Center in clinic application of proteomics with expert, accurate, and collaborative interactions. These include i) Fluorescence-assistant Autoimmune Display (FaAD) to identify autoimmune responses against tumors, infectious diseases and autoimmune diseases, ii) Differential Gel Electrophoresis (DiGE) to identify differentially expressed proteins in blood/tissue samples, iii) Fluorescence-assistant Multi-dimensional HPLC (FaMD-HPLC) to differentially profile protein expression in patient biopsies, iv) LC-MALDI-TOF and nanoLC-Q-TOF (LC-MS/MS) for protein identification, protein profiling, and marker discovery, and v) Liquid protein array (xMAP from Luminex) to validate protein markers in patients.

We are studying the biological function of dsRNA and dsRNA-binding proteins. These include the dsRNA editing enzyme ADAR1, ADAR2 and ADAR3. ADAR1 is ubiquitously expressed particularly in immune organs; ADAR2 is found in all tissues but dominant in neuronal system; and ADAR3 is exclusively in the brain. Currently our interest is focused on the function of ADAR1 in viral infection/stress, and ADAR2 in traumatic stress.

Another focus of our laboratory is to identify the tumor specific complement activator (tsCA). This factor is found to activate human complement to kill different tumor cells in vitro.

 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Nie Y, Hammond GL, Yang JH. Double-stranded RNA deaminase ADAR1 increases host susceptibility to virus infection. J Virol. 2007 Jan; 81(2):917-23. PMID: 17079286.
    View in: PubMed
  2. Nie Y, Ding L, Kao PN, Braun R, Yang JH. ADAR1 interacts with NF90 through double-stranded RNA and regulates NF90-mediated gene expression independently of RNA editing. Mol Cell Biol. 2005 Aug; 25(16):6956-63. PMID: 16055709.
    View in: PubMed
  3. Xia S, Yang J, Su Y, Qian J, Ma E, Haddad GG. Identification of new targets of Drosophila pre-mRNA adenosine deaminase. Physiol Genomics. 2005 Jan 20; 20(2):195-202. PMID: 15522950.
    View in: PubMed
  4. Nie Y, Zhao Q, Su Y, Yang JH. Subcellular distribution of ADAR1 isoforms is synergistically determined by three nuclear discrimination signals and a regulatory motif. J Biol Chem. 2004 Mar 26; 279(13):13249-55. PMID: 14711814.
    View in: PubMed
  5. Yang JH, Nie Y, Zhao Q, Su Y, Pypaert M, Su H, Rabinovici R. Intracellular localization of differentially regulated RNA-specific adenosine deaminase isoforms in inflammation. J Biol Chem. 2003 Nov 14; 278(46):45833-42. PMID: 12954622.
    View in: PubMed
  6. Nie Y, Wu K, Yang J, Tian F, Li L, Chen B, Fan D. Induction of T lymphocytes specific to human gastric cancer using HLA-A matched allogeneic gastric tumor cells. J Immunother. 2003 Sep-Oct; 26(5):403-11. PMID: 12973029.
    View in: PubMed
  7. Yang JH, Luo X, Nie Y, Su Y, Zhao Q, Kabir K, Zhang D, Rabinovici R. Widespread inosine-containing mRNA in lymphocytes regulated by ADAR1 in response to inflammation. Immunology. 2003 May; 109(1):15-23. PMID: 12709013.
    View in: PubMed
  8. Wu J, Shi YQ, Wu KC, Zhang DX, Yang JH, Fan DM. Angiostatin up-regulation in gastric cancer cell SGC7901 inhibits tumorigenesis in nude mice. World J Gastroenterol. 2003 Jan; 9(1):59-64. PMID: 12508352.
    View in: PubMed
  9. Rabinovici R, Zhang D, Su Y, Luo X, Zhao Q, Yang JH. MOB-1 and TNF-alpha interact to induce microvascular lung injury. Shock. 2002 Sep; 18(3):261-4. PMID: 12353928.
    View in: PubMed
  10. Kabir K, Gelinas JP, Chen M, Chen D, Zhang D, Luo X, Yang JH, Carter D, Rabinovici R. Characterization of a murine model of endotoxin-induced acute lung injury. Shock. 2002 Apr; 17(4):300-3. PMID: 11954830.
    View in: PubMed
  11. Rabinovici R, Kabir K, Chen M, Su Y, Zhang D, Luo X, Yang JH. ADAR1 is involved in the development of microvascular lung injury. Circ Res. 2001 May 25; 88(10):1066-71. PMID: 11375277.
    View in: PubMed
  12. Li F, Yang J, Liu X, He P, Ji S, Wang J, Han J, Chen N, Yao L. Human glioma cell BT325 expresses a proteinase that converts human plasminogen to kringle 1-5-containing fragments. Biochem Biophys Res Commun. 2000 Nov 30; 278(3):821-5. PMID: 11095991.
    View in: PubMed
  13. Yang JH, Sklar P, Axel R, Maniatis T. Purification and characterization of a human RNA adenosine deaminase for glutamate receptor B pre-mRNA editing. Proc Natl Acad Sci U S A. 1997 Apr 29; 94(9):4354-9. PMID: 9113993.
    View in: PubMed
  14. Yang JH, Sklar P, Axel R, Maniatis T. Editing of glutamate receptor subunit B pre-mRNA in vitro by site-specific deamination of adenosine. Nature. 1995 Mar 2; 374(6517):77-81. PMID: 7870177.
    View in: PubMed
  15. Yang JH, Cedergren R, Nadal-Ginard B. Catalytic activity of an RNA domain derived from the U6-U4 RNA complex. Science. 1994 Jan 7; 263(5143):77-81. PMID: 8272868.
    View in: PubMed
  16. Yang JH, Usman N, Chartrand P, Cedergren R. Minimum ribonucleotide requirement for catalysis by the RNA hammerhead domain. Biochemistry. 1992 Jun 2; 31(21):5005-9. PMID: 1599926.
    View in: PubMed
  17. Perreault JP, Labuda D, Usman N, Yang JH, Cedergren R. Relationship between 2'-hydroxyls and magnesium binding in the hammerhead RNA domain: a model for ribozyme catalysis. Biochemistry. 1991 Apr 23; 30(16):4020-5. PMID: 1708285.
    View in: PubMed
  18. Yang JH, Perreault JP, Labuda D, Usman N, Cedergren R. Mixed DNA/RNA polymers are cleaved by the hammerhead ribozyme. Biochemistry. 1990 Dec 25; 29(51):11156-60. PMID: 1703011.
    View in: PubMed
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