Jean-Pierre Roussarie | Profiles RNS

Jean-Pierre Roussarie PhD

Assistant Professor

Boston University Chobanian & Avedisian School of Medicine

Anatomy & Neurobiology

PhD, Pierre and Marie Curie University (Paris VI)
MS, Pierre and Marie Curie University (Paris VI)
BA, Ecole Poly Fed Du Lausanne

Pronouns: he/him/his

ORCID : 0000-0003-2644-6046

The lab is interested in deciphering the molecular events leading to neurodegeneration in Alzheimer’s disease. Like most neurodegenerative diseases, Alzheimer’s affects only very specific sets of neurons in its earliest stages. These neurons are located in the entorhinal cortex, a brain region indispensable for new memory formation. We think that understanding the particularities of these entorhinal cortex neurons will yield novel insights into the Alzheimer’s pathological processes. Eventually this will lead to the identification of new therapeutic targets to prevent neurodegeneration. In order to elucidate the properties of entorhinal neurons at single-cell resolution, we use a combination of mouse models, human postmortem tissue, novel in vitro culture protocols, and in silico modeling.

BU Research

Genomics analysis of the extreme vulnerability of transentorhinal cortex
09/01/2022 - 08/31/2025 (PI)
Alzheimer's Association

APOE Consortium: Modulation of Selective Neuronal Vulnerability in Alzheimer’s disease by ApoE
12/01/2022 - 06/30/2024 (PI)
Cure Alzheimer's Fund

APOE Consortium: Regulation by APOE of selective neuronal vulnerability to Alzheimer's disease
09/01/2021 - 11/30/2022 (PI)
Cure Alzheimer's Fund

Generation of Human iPSC-derived Entorhinal Cortex Neurons for Probing Selective Neuronal Vulnerability in Alzheimer's Disease
09/01/2021 - 08/31/2022 (PI)
NIH/National Institute on Aging
7RF1AG054564-02

Title

Yr	Title	Project-Sub Proj	Pubs

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

iCite Analysis Copy PMIDs To Clipboard

Rodriguez-Rodriguez P, Arroyo-Garcia LE, Tsagkogianni C, Li L, Wang W, Végvári Á, Salas-Allende I, Plautz Z, Cedazo-Minguez A, Sinha SC, Troyanskaya O, Flajolet M, Yao V, Roussarie JP. A cell autonomous regulator of neuronal excitability modulates tau in Alzheimer's disease vulnerable neurons. Brain. 2024 Mar 11. PMID: 38462574

Montalban E, Giralt A, Taing L, Nakamura Y, Pelosi A, Brown M, de Pins B, Valjent E, Martin M, Nairn AC, Greengard P, Flajolet M, Hervé D, Gambardella N, Roussarie JP, Girault JA. Operant Training for Highly Palatable Food Alters Translating Messenger RNA in Nucleus Accumbens D2 Neurons and Reveals a Modulatory Role of Ncdn. Biol Psychiatry. 2023 Aug 12. PMID: 37579933

Montalban E, Giralt A, Taing L, Nakamura Y, Pelosi A, Brown M, de Pins B, Valjent E, Martin M, Nairn AC, Greengard P, Flajolet M, Herv D, Gambardella N, Roussarie JP, Girault JA. Operant training for highly palatable food alters translating mRNA in nucleus accumbens D2 neurons and reveals a modulatory role of Neurochondrin. bioRxiv. 2023 Mar 09. PMID: 36945487; PMCID: PMC10028890; DOI: 10.1101/2023.03.07.531496;

Marion-Poll L, Roussarie JP, Taing L, Dard-Dascot C, Servant N, Jaszczyszyn Y, Jordi E, Mulugeta E, Hervé D, Bourc'his D, Greengard P, Thermes C, Girault JA. DNA methylation and hydroxymethylation characterize the identity of D1 and D2 striatal projection neurons. Commun Biol. 2022 Dec 01; 5(1):1321. PMID: 36456703; PMCID: PMC9715678; DOI: 10.1038/s42003-022-04269-w;

Montalban E, Giralt A, Taing L, Schut EHS, Supiot LF, Castell L, Nakamura Y, de Pins B, Pelosi A, Goutebroze L, Tuduri P, Wang W, Neiburga KD, Vestito L, Castel J, Luquet S, Nairn AC, Hervé D, Heintz N, Martin C, Greengard P, Valjent E, Meye FJ, Gambardella N, Roussarie JP, Girault JA. Translational profiling of mouse dopaminoceptive neurons reveals region-specific gene expression, exon usage, and striatal prostaglandin E2 modulatory effects. Mol Psychiatry. 2022 Apr; 27(4):2068-2079. PMID: 35177825; PMCID: PMC10009708; DOI: 10.1038/s41380-022-01439-4;

Roussarie JP, Rodriguez-Rodriguez P. Deciphering cell-type specific signal transduction in the brain: Challenges and promises. Adv Pharmacol. 2021; 90:145-171. PMID: 33706931

Roussarie JP, Yao V, Rodriguez-Rodriguez P, Oughtred R, Rust J, Plautz Z, Kasturia S, Albornoz C, Wang W, Schmidt EF, Dannenfelser R, Tadych A, Brichta L, Barnea-Cramer A, Heintz N, Hof PR, Heiman M, Dolinski K, Flajolet M, Troyanskaya OG, Greengard P. Selective Neuronal Vulnerability in Alzheimer's Disease: A Network-Based Analysis. Neuron. 2020 09 09; 107(5):821-835.e12. PMID: 32603655; PMCID: PMC7580783; DOI: 10.1016/j.neuron.2020.06.010;

Brichta L, Shin W, Jackson-Lewis V, Blesa J, Yap EL, Walker Z, Zhang J, Roussarie JP, Alvarez MJ, Califano A, Przedborski S, Greengard P. Identification of neurodegenerative factors using translatome-regulatory network analysis. Nat Neurosci. 2015 Sep; 18(9):1325-33. PMID: 26214373

Vidalain PO, Jacob Y, Hagemeijer MC, Jones LM, Neveu G, Roussarie JP, Rottier PJ, Tangy F, de Haan CA. A field-proven yeast two-hybrid protocol used to identify coronavirus-host protein-protein interactions. Methods Mol Biol. 2015; 1282:213-29. PMID: 25720483

Showing 10 of 14 results. Show More

Brahic M, Roussarie JP. Axon-myelin interactions during a viral infection of the central nervous system. PLoS Pathog. 2009 Sep; 5(9):e1000519. PMID: 19779566

Roussarie JP, Ruffié C, Edgar JM, Griffiths I, Brahic M. Axon myelin transfer of a non-enveloped virus. PLoS One. 2007 Dec 26; 2(12):e1331. PMID: 18159229

Roussarie JP, Ruffié C, Brahic M. The role of myelin in Theiler's virus persistence in the central nervous system. PLoS Pathog. 2007 Feb; 3(2):e23. PMID: 17305428

Mena I, Roussarie JP, Brahic M. Infection of macrophage primary cultures by persistent and nonpersistent strains of Theiler's virus: role of capsid and noncapsid viral determinants. J Virol. 2004 Dec; 78(23):13356-61. PMID: 15542687

This graph shows the total number of publications by year, by first, middle/unknown, or last author.

Bar chart showing 13 publications over 8 distinct years, with a maximum of 2 publications in 2007 and 2015 and 2020 and 2022 and 2023