Keywords
Last Name

Irina V. Zhdanova, MD, PhD

TitleProfessor
InstitutionBoston University School of Medicine
DepartmentAnatomy & Neurobiology
Address72 E. Concord St Housman (R)
Boston MA 02118
Phone(617) 638-8002
ORCID ORCID Icon0000-0002-8401-9571
Other Positions
TitleGraduate Faculty (Primary Mentor of Grad Students)
InstitutionBoston University School of Medicine, Division of Graduate Medical Sciences

 Research Expertise & Professional Interests
Research is focused on the role of the circadian system and sleep on the effects of drugs of abuse, aging, individual and social behavior, using non-human primates and zebrafish as models, within systems neuroscience approach.

 Self-Described Keywords
  • circadian system
  • drug abuse
  • physiology of behavior
  • sleep
  • metabolic profiles
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Riley E, Kopotiyenko K, Zhdanova I. Prenatal and acute cocaine exposure affects neural responses and habituation to visual stimuli. Front Neural Circuits. 2015; 9:41. PMID: 26379509.
    View in: PubMed
  2. Zhdanova IV, Rogers J, González-Martínez J, Farrer LA. The ticking clock of Cayo Santiago macaques and its implications for understanding human circadian rhythm disorders. Am J Primatol. 2016 Jan; 78(1):117-26. PMID: 25940511.
    View in: PubMed
  3. Hartsough EJ, Meyer RD, Chitalia V, Jiang Y, Marquez VE, Zhdanova IV, Weinberg J, Costello CE, Rahimi N. Lysine methylation promotes VEGFR-2 activation and angiogenesis. Sci Signal. 2013 Dec 3; 6(304):ra104. PMID: 24300896.
    View in: PubMed
  4. Akle V, Guelin E, Yu L, Brassard-Giordano H, Slack BE, Zhdanova IV. F-spondin/spon1b expression patterns in developing and adult zebrafish. PLoS One. 2012; 7(6):e37593. PMID: 22768035.
    View in: PubMed
  5. Zhdanova IV, Masuda K, Bozhokin SV, Rosene DL, González-Martínez J, Schettler S, Samorodnitsky E. Familial circadian rhythm disorder in the diurnal primate, Macaca mulatta. PLoS One. 2012; 7(3):e33327. PMID: 22413014.
    View in: PubMed
  6. Zhdanova IV, Masuda K, Quasarano-Kourkoulis C, Rosene DL, Killiany RJ, Wang S. Aging of intrinsic circadian rhythms and sleep in a diurnal nonhuman primate, Macaca mulatta. J Biol Rhythms. 2011 Apr; 26(2):149-59. PMID: 21454295.
    View in: PubMed
  7. Zhdanova IV. Sleep and its regulation in zebrafish. Rev Neurosci. 2011; 22(1):27-36. PMID: 21615259.
    View in: PubMed
  8. Masuda K, Zhdanova IV. Intrinsic activity rhythms in Macaca mulatta: their entrainment to light and melatonin. J Biol Rhythms. 2010 Oct; 25(5):361-71. PMID: 20876816.
    View in: PubMed
  9. Musson MC, Jepeal LI, Mabray PD, Zhdanova IV, Cardoso WV, Wolfe MM. Expression of glucose-dependent insulinotropic polypeptide in the zebrafish. Am J Physiol Regul Integr Comp Physiol. 2009 Dec; 297(6):R1803-12. PMID: 19793957.
    View in: PubMed
  10. Kishi S, Slack BE, Uchiyama J, Zhdanova IV. Zebrafish as a genetic model in biological and behavioral gerontology: where development meets aging in vertebrates--a mini-review. Gerontology. 2009; 55(4):430-41. PMID: 19654474.
    View in: PubMed
  11. Friedman L, Zeitzer JM, Kushida C, Zhdanova I, Noda A, Lee T, Schneider B, Guilleminault C, Sheikh J, Yesavage JA. Scheduled bright light for treatment of insomnia in older adults. J Am Geriatr Soc. 2009 Mar; 57(3):441-52. PMID: 19187411.
    View in: PubMed
  12. López Patiño MA, Yu L, Yamamoto BK, Zhdanova IV. Gender differences in zebrafish responses to cocaine withdrawal. Physiol Behav. 2008 Sep 3; 95(1-2):36-47. PMID: 18499199.
    View in: PubMed
  13. Zhdanova IV, Yu L, Lopez-Patino M, Shang E, Kishi S, Guelin E. Aging of the circadian system in zebrafish and the effects of melatonin on sleep and cognitive performance. Brain Res Bull. 2008 Mar 18; 75(2-4):433-41. PMID: 18331912.
    View in: PubMed
  14. Sack RL, Auckley D, Auger RR, Carskadon MA, Wright KP, Vitiello MV, Zhdanova IV. Circadian rhythm sleep disorders: part I, basic principles, shift work and jet lag disorders. An American Academy of Sleep Medicine review. Sleep. 2007 Nov; 30(11):1460-83. PMID: 18041480.
    View in: PubMed
  15. Sack RL, Auckley D, Auger RR, Carskadon MA, Wright KP, Vitiello MV, Zhdanova IV. Circadian rhythm sleep disorders: part II, advanced sleep phase disorder, delayed sleep phase disorder, free-running disorder, and irregular sleep-wake rhythm. An American Academy of Sleep Medicine review. Sleep. 2007 Nov; 30(11):1484-501. PMID: 18041481.
    View in: PubMed
  16. López-Patiño MA, Yu L, Cabral H, Zhdanova IV. Anxiogenic effects of cocaine withdrawal in zebrafish. Physiol Behav. 2008 Jan 28; 93(1-2):160-71. PMID: 17889042.
    View in: PubMed
  17. Shang EH, Zhdanova IV. The circadian system is a target and modulator of prenatal cocaine effects. PLoS One. 2007; 2(7):e587. PMID: 17622340.
    View in: PubMed
  18. Tsai SB, Tucci V, Uchiyama J, Fabian NJ, Lin MC, Bayliss PE, Neuberg DS, Zhdanova IV, Kishi S. Differential effects of genotoxic stress on both concurrent body growth and gradual senescence in the adult zebrafish. Aging Cell. 2007 Apr; 6(2):209-24. PMID: 17376146.
    View in: PubMed
  19. Yu L, Tucci V, Kishi S, Zhdanova IV. Cognitive aging in zebrafish. PLoS One. 2006; 1:e14. PMID: 17183640.
    View in: PubMed
  20. Zhdanova IV. Sleep in zebrafish. Zebrafish. 2006; 3(2):215-26. PMID: 18248262.
    View in: PubMed
  21. Karachentseva OV, Yartsev VN, Dvoretsky DP, Zhdanova IV. Melatonin-evoked potentiation of the juvenile rat tail artery neurogenic reactivity depends on degree of the change in the reactivity. Acta Physiol Scand. 2005 Oct; 185(2):99-107. PMID: 16168004.
    View in: PubMed
  22. Prada C, Udin SB, Wiechmann AF, Zhdanova IV. Stimulation of melatonin receptors decreases calcium levels in xenopus tectal cells by activating GABA(C) receptors. J Neurophysiol. 2005 Aug; 94(2):968-78. PMID: 15817645.
    View in: PubMed
  23. Zhdanova IV. Comment on 'Melatonin as a hypnotic: con'. Sleep Med Rev. 2005 Feb; 9(1):81; discussion 83-4. PMID: 15649742.
    View in: PubMed
  24. Zhdanova IV. Melatonin as a hypnotic: pro. Sleep Med Rev. 2005 Feb; 9(1):51-65. PMID: 15649738.
    View in: PubMed
  25. Brzezinski A, Vangel MG, Wurtman RJ, Norrie G, Zhdanova I, Ben-Shushan A, Ford I. Effects of exogenous melatonin on sleep: a meta-analysis. Sleep Med Rev. 2005 Feb; 9(1):41-50. PMID: 15649737.
    View in: PubMed
  26. Zhdanova IV. Advances in the management of insomnia. Expert Opin Pharmacother. 2004 Jul; 5(7):1573-9. PMID: 15212607.
    View in: PubMed
  27. Danilova N, Krupnik VE, Sugden D, Zhdanova IV. Melatonin stimulates cell proliferation in zebrafish embryo and accelerates its development. FASEB J. 2004 Apr; 18(6):751-3. PMID: 14766799.
    View in: PubMed
  28. Holmqvist B, Ellingsen B, Forsell J, Zhdanova I, Alm P. The early ontogeny of neuronal nitric oxide synthase systems in the zebrafish. J Exp Biol. 2004 Feb; 207(Pt 6):923-35. PMID: 14766951.
    View in: PubMed
  29. Zhdanova IV, Tucci V. Melatonin, Circadian Rhythms, and Sleep. Curr Treat Options Neurol. 2003 May; 5(3):225-229. PMID: 12670411.
    View in: PubMed
  30. Karachentseva OV, Iartsev VN, Dvoretskii DP, Zhdanova IV. [Effect of melatonin on neurogenic vasoreactivity: formation and modulation of the vessel response]. Ross Fiziol Zh Im I M Sechenova. 2003 Feb; 89(2):146-53. PMID: 12710184.
    View in: PubMed
  31. Zhdanova IV, Giorgetti M. Melatonin alters behavior and cAMP levels in nucleus accumbens induced by cocaine treatment. Brain Res. 2002 Nov 29; 956(2):323-31. PMID: 12445702.
    View in: PubMed
  32. Zhdanova IV, Geiger DA, Schwagerl AL, Leclair OU, Killiany R, Taylor JA, Rosene DL, Moss MB, Madras BK. Melatonin promotes sleep in three species of diurnal nonhuman primates. Physiol Behav. 2002 Apr 1; 75(4):523-9. PMID: 12062316.
    View in: PubMed
  33. Zhdanova IV, Tsvirenko SV, Barats SS, Smolenskaia OG, Volkova RF, Serezhenko TO. [Effect of fluvastain and its combination with aspirin and trental on hemostasis and microcirculation in atherosclerosis]. Ter Arkh. 2002; 74(8):9-12. PMID: 12360609.
    View in: PubMed
  34. Zhdanova IV, Wurtman RJ, Regan MM, Taylor JA, Shi JP, Leclair OU. Melatonin treatment for age-related insomnia. J Clin Endocrinol Metab. 2001 Oct; 86(10):4727-30. PMID: 11600532.
    View in: PubMed
  35. Zhdanova IV, Wang SY, Leclair OU, Danilova NP. Melatonin promotes sleep-like state in zebrafish. Brain Res. 2001 Jun 8; 903(1-2):263-8. PMID: 11382414.
    View in: PubMed
  36. Giorgetti M, Zhdanova IV. Chronic cocaine treatment induces dysregulation in the circadian pattern of rats' feeding behavior. Brain Res. 2000 Sep 22; 877(2):170-5. PMID: 10986329.
    View in: PubMed
  37. Zhdanova IV, Piotrovskaya VR. Melatonin treatment attenuates symptoms of acute nicotine withdrawal in humans. Pharmacol Biochem Behav. 2000 Sep; 67(1):131-5. PMID: 11113492.
    View in: PubMed
  38. Kayumov L, Zhdanova IV, Shapiro CM. Melatonin, sleep, and circadian rhythm disorders. Semin Clin Neuropsychiatry. 2000 Jan; 5(1):44-55. PMID: 10704537.
    View in: PubMed
  39. Zhdanova IV, Raz DJ. Effects of melatonin ingestion on cAMP and cGMP levels in human plasma. J Endocrinol. 1999 Dec; 163(3):457-62. PMID: 10588819.
    View in: PubMed
  40. Zhdanova IV, Simmons M, Marcus JN, Busza AC, Leclair OU, Taylor JA. Nocturnal increase in plasma cGMP levels in humans. J Biol Rhythms. 1999 Aug; 14(4):307-13. PMID: 10447311.
    View in: PubMed
  41. Zhdanova IV, Wurtman RJ, Wagstaff J. Effects of a low dose of melatonin on sleep in children with Angelman syndrome. J Pediatr Endocrinol Metab. 1999 Jan-Feb; 12(1):57-67. PMID: 10392349.
    View in: PubMed
  42. Zhdanova IV, Wurtman RJ, Balcioglu A, Kartashov AI, Lynch HJ. Endogenous melatonin levels and the fate of exogenous melatonin: age effects. J Gerontol A Biol Sci Med Sci. 1998 Jul; 53(4):B293-8. PMID: 18314560.
    View in: PubMed
  43. Zhdanova IV, Cantor ML, Leclair OU, Kartashov AI, Wurtman RJ. Behavioral effects of melatonin treatment in non-human primates. Sleep Res Online. 1998; 1(3):114-8. PMID: 11382867.
    View in: PubMed
  44. Zhdanova IV, Wurtman RJ. Efficacy of melatonin as a sleep-promoting agent. J Biol Rhythms. 1997 Dec; 12(6):644-50. PMID: 9406040.
    View in: PubMed
  45. Zhdanova IV, Lynch HJ, Wurtman RJ. Melatonin: a sleep-promoting hormone. Sleep. 1997 Oct; 20(10):899-907. PMID: 9415953.
    View in: PubMed
  46. Zhdanova IV, Wurtman RJ, Morabito C, Piotrovska VR, Lynch HJ. Effects of low oral doses of melatonin, given 2-4 hours before habitual bedtime, on sleep in normal young humans. Sleep. 1996 Jun; 19(5):423-31. PMID: 8843534.
    View in: PubMed
  47. Wurtman RJ, Zhdanova I. Improvement of sleep quality by melatonin. Lancet. 1995 Dec 2; 346(8988):1491. PMID: 7491013.
    View in: PubMed
  48. Silakov VL, Nikitin VS, Moiseeva LA, Losev SS, Perepelkin PD, Zhdanova IV. Influence of neuropeptides on the processes of higher nervous activity in primates. The action of cyclic analogs of enkephalins on the behavior of the lower monkeys. Neurosci Behav Physiol. 1995 Sep-Oct; 25(5):386-92. PMID: 8614479.
    View in: PubMed
  49. Zhdanova IV, Wurtman RJ, Lynch HJ, Ives JR, Dollins AB, Morabito C, Matheson JK, Schomer DL. Sleep-inducing effects of low doses of melatonin ingested in the evening. Clin Pharmacol Ther. 1995 May; 57(5):552-8. PMID: 7768078.
    View in: PubMed
  50. Silakov VL, Nikitin VS, Moiseeva LA, Losev SS, Perepelkin PD, Zhdanova IV. [The effect of neuropeptides on the processes of higher nervous activity in primates. The action of cyclic analogs of enkephalins on the behavior of lower monkeys]. Zh Vyssh Nerv Deiat Im I P Pavlova. 1994 Jul-Oct; 44(4-5):682-90. PMID: 7810210.
    View in: PubMed
  51. Dollins AB, Zhdanova IV, Wurtman RJ, Lynch HJ, Deng MH. Effect of inducing nocturnal serum melatonin concentrations in daytime on sleep, mood, body temperature, and performance. Proc Natl Acad Sci U S A. 1994 Mar 1; 91(5):1824-8. PMID: 8127888.
    View in: PubMed
  52. Zhdanova IV, Kordzadze RN, Pliashkevich IuG. [Changes in the emotionally conditioned behavior of rats under the influence of the hexapeptide fragment GLLDLK of the protein inhibitor of diazepam binding]. Biull Eksp Biol Med. 1991 Feb; 111(2):165-8. PMID: 1854959.
    View in: PubMed
  53. Zhdanova IV, Danilovskii MA, Tokarev AV. [Postural asymmetry in rats after unavoidable pain stimulation of different durations]. Zh Vyssh Nerv Deiat Im I P Pavlova. 1990 Sep-Oct; 40(5):974-8. PMID: 1964345.
    View in: PubMed
  54. Zhdanova IV, Tokarev AV. [The effect of the cerebrospinal fluid from patients with manic and depressive syndromes on the social hierarchical relationships in a group of rats]. Zh Vyssh Nerv Deiat Im I P Pavlova. 1990 May-Jun; 40(3):558-64. PMID: 2169163.
    View in: PubMed
  55. Zhdanova IV, Shipilova LS, Kireeva KN. [Relation between the hierarchical structure of the population and learning characteristics in random-bred albino rats and Dull Tryon rats]. Zh Vyssh Nerv Deiat Im I P Pavlova. 1987 Jul-Aug; 37(4):769-71. PMID: 3673270.
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  56. Vaido AI, Zhdanova IV, Shiriaeva NV. ["Emotional resonance" responses of rats with different levels of nervous system excitability]. Zh Vyssh Nerv Deiat Im I P Pavlova. 1987 May-Jun; 37(3):575-7. PMID: 3630396.
    View in: PubMed
  57. Khonicheva NM, Guliaeva NV, Zhdanova IV, Obidin AB, Dmitrieva IL. [Type of behavior and superoxide dismutase activity in the brain of rats (a comparison of 2 Tryon strains)]. Biull Eksp Biol Med. 1986 Dec; 102(12):643-5. PMID: 3801607.
    View in: PubMed
  58. Vartanian GA, Zhdanova IV, Petrov ES. [Specific neurohumoral activity of the cerebrospinal fluid of patients with manic-depressive psychosis]. Fiziol Cheloveka. 1986 Jan-Feb; 12(1):167-70. PMID: 2870946.
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  59. Vartanian GA, Zhdanova IV, Lebedev AA, Petrov ES. [Effect of the cerebrospinal fluid of manic-depressive psychosis patients on the self-stimulation reaction]. Fiziol Cheloveka. 1985 Nov-Dec; 11(6):980-3. PMID: 4076693.
    View in: PubMed
  60. Vartanyan GA, Zhdanova IV, Lebedev AA, Petrov ES. Effect of the CSF of patients with manic-depressive psychosis on the self-stimulation reaction. Hum Physiol. 1985 Nov-Dec; 11(6):404-6. PMID: 3837744.
    View in: PubMed
  61. Zhdanova IV. [Features of the reaction of the rat to intraventricular administration of the cerebrospinal fluid of patients with manic-depressive psychosis]. Zh Vyssh Nerv Deiat Im I P Pavlova. 1985 Jul-Aug; 35(4):770-4. PMID: 4050117.
    View in: PubMed
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