Keywords
Last Name

Douglas Keene, MD, MPH

TitleInstructor
InstitutionBoston University School of Medicine
DepartmentFamily Medicine
Address
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Corallo D, Schiavinato A, Bizzotto D, Milanetto M, Guljelmovic M, Keene DR, Sengle G, Braghetta P, Bonaldo P. EMILIN3, an extracellular matrix molecule with restricted distribution in skin. Exp Dermatol. 2016 Nov 28. PMID: 27892605.
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  2. Siprashvili Z, Nguyen NT, Gorell ES, Loutit K, Khuu P, Furukawa LK, Lorenz HP, Leung TH, Keene DR, Rieger KE, Khavari P, Lane AT, Tang JY, Marinkovich MP. Safety and Wound Outcomes Following Genetically Corrected Autologous Epidermal Grafts in Patients With Recessive Dystrophic Epidermolysis Bullosa. JAMA. 2016 Nov 01; 316(17):1808-1817. PMID: 27802546.
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  3. Sakai LY, Keene DR, Renard M, De Backer J. FBN1: The disease-causing gene for Marfan syndrome and other genetic disorders. Gene. 2016 Oct 10; 591(1):279-91. PMID: 27437668.
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  4. Schiavinato A, Keene DR, Wohl AP, Corallo D, Colombatti A, Wagener R, Paulsson M, Bonaldo P, Sengle G. Targeting of EMILIN-1 and EMILIN-2 to Fibrillin Microfibrils Facilitates their Incorporation into the Extracellular Matrix. J Invest Dermatol. 2016 Jun; 136(6):1150-60. PMID: 26945878.
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  5. Iwasaki A, Sakai K, Moriya K, Sasaki T, Keene DR, Akhtar R, Miyazono T, Yasumura S, Watanabe M, Morishita S, Sakai T. Molecular Mechanism Responsible for Fibronectin-controlled Alterations in Matrix Stiffness in Advanced Chronic Liver Fibrogenesis. J Biol Chem. 2016 Jan 01; 291(1):72-88. PMID: 26553870.
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  6. Hou Y, Guey LT, Wu T, Gao R, Cogan J, Wang X, Hong E, Ning WV, Keene D, Liu N, Huang Y, Kaftan C, Tangarone B, Quinones-Garcia I, Uitto J, Francone OL, Woodley DT, Chen M. Intravenously Administered Recombinant Human Type VII Collagen Derived from Chinese Hamster Ovary Cells Reverses the Disease Phenotype in Recessive Dystrophic Epidermolysis Bullosa Mice. J Invest Dermatol. 2015 Dec; 135(12):3060-7. PMID: 26203639.
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  7. Sengle G, Carlberg V, Tufa SF, Charbonneau NL, Smaldone S, Carlson EJ, Ramirez F, Keene DR, Sakai LY. Abnormal Activation of BMP Signaling Causes Myopathy in Fbn2 Null Mice. PLoS Genet. 2015 Jun; 11(6):e1005340. PMID: 26114882.
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  8. Huang AH, Riordan TJ, Pryce B, Weibel JL, Watson SS, Long F, Lefebvre V, Harfe BD, Stadler HS, Akiyama H, Tufa SF, Keene DR, Schweitzer R. Musculoskeletal integration at the wrist underlies the modular development of limb tendons. Development. 2015 Jul 15; 142(14):2431-41. PMID: 26062940.
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  9. Keene DR. A review of color blindness for microscopists: guidelines and tools for accommodating and coping with color vision deficiency. Microsc Microanal. 2015 Apr; 21(2):279-89. PMID: 25739321.
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  10. Melo SP, Lisowski L, Bashkirova E, Zhen HH, Chu K, Keene DR, Marinkovich MP, Kay MA, Oro AE. Somatic correction of junctional epidermolysis bullosa by a highly recombinogenic AAV variant. Mol Ther. 2014 Apr; 22(4):725-33. PMID: 24390279.
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  11. Keene DR, Tufa SF, Wong MH, Smith NR, Sakai LY, Horton WA. Correlation of the same fields imaged in the TEM, confocal, LM, and microCT by image registration: from specimen preparation to displaying a final composite image. Methods Cell Biol. 2014; 124:391-417. PMID: 25287851.
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  12. Tolar J, McGrath JA, Xia L, Riddle MJ, Lees CJ, Eide C, Keene DR, Liu L, Osborn MJ, Lund TC, Blazar BR, Wagner JE. Patient-specific naturally gene-reverted induced pluripotent stem cells in recessive dystrophic epidermolysis bullosa. J Invest Dermatol. 2014 May; 134(5):1246-54. PMID: 24317394.
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  13. Richardson RJ, Gebauer JM, Zhang JL, Kobbe B, Keene DR, Karlsen KR, Richetti S, Wohl AP, Sengle G, Neiss WF, Paulsson M, Hammerschmidt M, Wagener R. AMACO is a component of the basement membrane-associated Fraser complex. J Invest Dermatol. 2014 May; 134(5):1313-22. PMID: 24232570.
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  14. Woodley DT, Cogan J, Wang X, Hou Y, Haghighian C, Kudo G, Keene DR, Chen M. De novo anti-type VII collagen antibodies in patients with recessive dystrophic epidermolysis bullosa. J Invest Dermatol. 2014 Apr; 134(4):1138-40. PMID: 24213372.
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  15. Pokidysheva E, Zientek KD, Ishikawa Y, Mizuno K, Vranka JA, Montgomery NT, Keene DR, Kawaguchi T, Okuyama K, Bächinger HP. Posttranslational modifications in type I collagen from different tissues extracted from wild type and prolyl 3-hydroxylase 1 null mice. J Biol Chem. 2013 Aug 23; 288(34):24742-52. PMID: 23861401.
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  16. Barkauskas CE, Cronce MJ, Rackley CR, Bowie EJ, Keene DR, Stripp BR, Randell SH, Noble PW, Hogan BL. Type 2 alveolar cells are stem cells in adult lung. J Clin Invest. 2013 Jul; 123(7):3025-36. PMID: 23921127.
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  17. Wang X, Ghasri P, Amir M, Hwang B, Hou Y, Khalili M, Khilili M, Lin A, Keene D, Uitto J, Woodley DT, Chen M. Topical application of recombinant type VII collagen incorporates into the dermal-epidermal junction and promotes wound closure. Mol Ther. 2013 Jul; 21(7):1335-44. PMID: 23670575.
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  18. Sengle G, Tufa SF, Sakai LY, Zulliger MA, Keene DR. A correlative method for imaging identical regions of samples by micro-CT, light microscopy, and electron microscopy: imaging adipose tissue in a model system. J Histochem Cytochem. 2013 Apr; 61(4):263-71. PMID: 23264636.
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  19. Adair-Kirk TL, Griffin GL, Meyer MJ, Kelley DG, Miner JH, Keene DR, Marinkovich MP, Ruppert JM, Uitto J, Senior RM. Keratinocyte-targeted expression of human laminin ?2 rescues skin blistering and early lethality of laminin ?2 deficient mice. PLoS One. 2012; 7(9):e45546. PMID: 23029085.
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  20. Tolar J, Xia L, Lees CJ, Riddle M, McElroy A, Keene DR, Lund TC, Osborn MJ, Marinkovich MP, Blazar BR, Wagner JE. Keratinocytes from induced pluripotent stem cells in junctional epidermolysis bullosa. J Invest Dermatol. 2013 Feb; 133(2):562-5. PMID: 22931927.
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  21. Shung CY, Ota S, Zhou ZQ, Keene DR, Hurlin PJ. Disruption of a Sox9-ß-catenin circuit by mutant Fgfr3 in thanatophoric dysplasia type II. Hum Mol Genet. 2012 Nov 1; 21(21):4628-44. PMID: 22843502.
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  22. Agarwal P, Zwolanek D, Keene DR, Schulz JN, Blumbach K, Heinegård D, Zaucke F, Paulsson M, Krieg T, Koch M, Eckes B. Collagen XII and XIV, new partners of cartilage oligomeric matrix protein in the skin extracellular matrix suprastructure. J Biol Chem. 2012 Jun 29; 287(27):22549-59. PMID: 22573329.
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  23. Ishikawa Y, Vranka JA, Boudko SP, Pokidysheva E, Mizuno K, Zientek K, Keene DR, Rashmir-Raven AM, Nagata K, Winand NJ, Bächinger HP. Mutation in cyclophilin B that causes hyperelastosis cutis in American Quarter Horse does not affect peptidylprolyl cis-trans isomerase activity but shows altered cyclophilin B-protein interactions and affects collagen folding. J Biol Chem. 2012 Jun 22; 287(26):22253-65. PMID: 22556420.
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  24. Sengle G, Tsutsui K, Keene DR, Tufa SF, Carlson EJ, Charbonneau NL, Ono RN, Sasaki T, Wirtz MK, Samples JR, Fessler LI, Fessler JH, Sekiguchi K, Hayflick SJ, Sakai LY. Microenvironmental regulation by fibrillin-1. PLoS Genet. 2012 Jan; 8(1):e1002425. PMID: 22242013.
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  25. Maeda T, Sakabe T, Sunaga A, Sakai K, Rivera AL, Keene DR, Sasaki T, Stavnezer E, Iannotti J, Schweitzer R, Ilic D, Baskaran H, Sakai T. Conversion of mechanical force into TGF-ß-mediated biochemical signals. Curr Biol. 2011 Jun 7; 21(11):933-41. PMID: 21600772.
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  26. Zhou ZQ, Shung CY, Ota S, Akiyama H, Keene DR, Hurlin PJ. Sequential and coordinated actions of c-Myc and N-Myc control appendicular skeletal development. PLoS One. 2011; 6(4):e18795. PMID: 21494559.
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  27. Kutz WE, Wang LW, Bader HL, Majors AK, Iwata K, Traboulsi EI, Sakai LY, Keene DR, Apte SS. ADAMTS10 protein interacts with fibrillin-1 and promotes its deposition in extracellular matrix of cultured fibroblasts. J Biol Chem. 2011 May 13; 286(19):17156-67. PMID: 21402694.
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  28. Moriya K, Bae E, Honda K, Sakai K, Sakaguchi T, Tsujimoto I, Kamisoyama H, Keene DR, Sasaki T, Sakai T. A fibronectin-independent mechanism of collagen fibrillogenesis in adult liver remodeling. Gastroenterology. 2011 May; 140(5):1653-63. PMID: 21320502.
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  29. McCarty OJ, Conley RB, Shentu W, Tormoen GW, Zha D, Xie A, Qi Y, Zhao Y, Carr C, Belcik T, Keene DR, de Groot PG, Lindner JR. Molecular imaging of activated von Willebrand factor to detect high-risk atherosclerotic phenotype. JACC Cardiovasc Imaging. 2010 Sep; 3(9):947-55. PMID: 20846630.
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  30. Wagner JE, Ishida-Yamamoto A, McGrath JA, Hordinsky M, Keene DR, Woodley DT, Chen M, Riddle MJ, Osborn MJ, Lund T, Dolan M, Blazar BR, Tolar J. Bone marrow transplantation for recessive dystrophic epidermolysis bullosa. N Engl J Med. 2010 Aug 12; 363(7):629-39. PMID: 20818854.
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  31. Liu W, Watson SS, Lan Y, Keene DR, Ovitt CE, Liu H, Schweitzer R, Jiang R. The atypical homeodomain transcription factor Mohawk controls tendon morphogenesis. Mol Cell Biol. 2010 Oct; 30(20):4797-807. PMID: 20696843.
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  32. Patel TR, Morris GA, Zwolanek D, Keene DR, Li J, Harding SE, Koch M, Stetefeld J. Nano-structure of the laminin ?-1 short arm reveals an extended and curved multidomain assembly. Matrix Biol. 2010 Sep; 29(7):565-72. PMID: 20688161.
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  33. Charbonneau NL, Carlson EJ, Tufa S, Sengle G, Manalo EC, Carlberg VM, Ramirez F, Keene DR, Sakai LY. In vivo studies of mutant fibrillin-1 microfibrils. J Biol Chem. 2010 Aug 06; 285(32):24943-55. PMID: 20529844.
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  34. Baldridge D, Lennington J, Weis M, Homan EP, Jiang MM, Munivez E, Keene DR, Hogue WR, Pyott S, Byers PH, Krakow D, Cohn DH, Eyre DR, Lee B, Morello R. Generalized connective tissue disease in Crtap-/- mouse. PLoS One. 2010 May 11; 5(5):e10560. PMID: 20485499.
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  35. Charbonneau NL, Jordan CD, Keene DR, Lee-Arteaga S, Dietz HC, Rifkin DB, Ramirez F, Sakai LY. Microfibril structure masks fibrillin-2 in postnatal tissues. J Biol Chem. 2010 Jun 25; 285(26):20242-51. PMID: 20404337.
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  36. Sakai N, Waterman EA, Nguyen NT, Keene DR, Marinkovich MP. Observations of skin grafts derived from keratinocytes expressing selectively engineered mutant laminin-332 molecules. J Invest Dermatol. 2010 Aug; 130(8):2147-50. PMID: 20393483.
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  37. Vranka JA, Pokidysheva E, Hayashi L, Zientek K, Mizuno K, Ishikawa Y, Maddox K, Tufa S, Keene DR, Klein R, Bächinger HP. Prolyl 3-hydroxylase 1 null mice display abnormalities in fibrillar collagen-rich tissues such as tendons, skin, and bones. J Biol Chem. 2010 May 28; 285(22):17253-62. PMID: 20363744.
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  38. Loeys BL, Gerber EE, Riegert-Johnson D, Iqbal S, Whiteman P, McConnell V, Chillakuri CR, Macaya D, Coucke PJ, De Paepe A, Judge DP, Wigley F, Davis EC, Mardon HJ, Handford P, Keene DR, Sakai LY, Dietz HC. Mutations in fibrillin-1 cause congenital scleroderma: stiff skin syndrome. Sci Transl Med. 2010 Mar 17; 2(23):23ra20. PMID: 20375004.
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  39. Keene DR, Tufa SF. Transmission electron microscopy of cartilage and bone. Methods Cell Biol. 2010; 96:443-73. PMID: 20869534.
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  40. Tsutsui K, Manabe R, Yamada T, Nakano I, Oguri Y, Keene DR, Sengle G, Sakai LY, Sekiguchi K. ADAMTSL-6 is a novel extracellular matrix protein that binds to fibrillin-1 and promotes fibrillin-1 fibril formation. J Biol Chem. 2010 Feb 12; 285(7):4870-82. PMID: 19940141.
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  41. Nuka S, Zhou W, Henry SP, Gendron CM, Schultz JB, Shinomura T, Johnson J, Wang Y, Keene DR, Ramírez-Solis R, Behringer RR, Young MF, Höök M. Phenotypic characterization of epiphycan-deficient and epiphycan/biglycan double-deficient mice. Osteoarthritis Cartilage. 2010 Jan; 18(1):88-96. PMID: 19932218.
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  42. Gebauer JM, Keene DR, Olsen BR, Sorokin LM, Paulsson M, Wagener R. Mouse AMACO, a kidney and skin basement membrane associated molecule that mediates RGD-dependent cell attachment. Matrix Biol. 2009 Oct; 28(8):456-62. PMID: 19651211.
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  43. Remington J, Wang X, Hou Y, Zhou H, Burnett J, Muirhead T, Uitto J, Keene DR, Woodley DT, Chen M. Injection of recombinant human type VII collagen corrects the disease phenotype in a murine model of dystrophic epidermolysis bullosa. Mol Ther. 2009 Jan; 17(1):26-33. PMID: 19018253.
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  44. Caswell CC, Barczyk M, Keene DR, Lukomska E, Gullberg DE, Lukomski S. Identification of the first prokaryotic collagen sequence motif that mediates binding to human collagen receptors, integrins alpha2beta1 and alpha11beta1. J Biol Chem. 2008 Dec 26; 283(52):36168-75. PMID: 18990704.
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  45. Bader HL, Keene DR, Charvet B, Veit G, Driever W, Koch M, Ruggiero F. Zebrafish collagen XII is present in embryonic connective tissue sheaths (fascia) and basement membranes. Matrix Biol. 2009 Jan; 28(1):32-43. PMID: 18983916.
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  46. Keene DR, Tufa SF, Lunstrum GP, Holden P, Horton WA. Confocal/TEM overlay microscopy: a simple method for correlating confocal and electron microscopy of cells expressing GFP/YFP fusion proteins. Microsc Microanal. 2008 Aug; 14(4):342-8. PMID: 18598569.
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  47. Shaut CA, Keene DR, Sorensen LK, Li DY, Stadler HS. HOXA13 Is essential for placental vascular patterning and labyrinth endothelial specification. PLoS Genet. 2008 May 16; 4(5):e1000073. PMID: 18483557.
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  48. Ohno-Jinno A, Isogai Z, Yoneda M, Kasai K, Miyaishi O, Inoue Y, Kataoka T, Zhao JS, Li H, Takeyama M, Keene DR, Sakai LY, Kimata K, Iwaki M, Zako M. Versican and fibrillin-1 form a major hyaluronan-binding complex in the ciliary body. Invest Ophthalmol Vis Sci. 2008 Jul; 49(7):2870-7. PMID: 18390636.
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  49. Sengle G, Charbonneau NL, Ono RN, Sasaki T, Alvarez J, Keene DR, Bächinger HP, Sakai LY. Targeting of bone morphogenetic protein growth factor complexes to fibrillin. J Biol Chem. 2008 May 16; 283(20):13874-88. PMID: 18339631.
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  50. Caswell CC, Han R, Hovis KM, Ciborowski P, Keene DR, Marconi RT, Lukomski S. The Scl1 protein of M6-type group A Streptococcus binds the human complement regulatory protein, factor H, and inhibits the alternative pathway of complement. Mol Microbiol. 2008 Feb; 67(3):584-96. PMID: 18093091.
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  51. Russell BH, Vasan R, Keene DR, Koehler TM, Xu Y. Potential dissemination of Bacillus anthracis utilizing human lung epithelial cells. Cell Microbiol. 2008 Apr; 10(4):945-57. PMID: 18067609.
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  52. Murchison ND, Price BA, Conner DA, Keene DR, Olson EN, Tabin CJ, Schweitzer R. Regulation of tendon differentiation by scleraxis distinguishes force-transmitting tendons from muscle-anchoring tendons. Development. 2007 Jul; 134(14):2697-708. PMID: 17567668.
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  53. Russell BH, Vasan R, Keene DR, Xu Y. Bacillus anthracis internalization by human fibroblasts and epithelial cells. Cell Microbiol. 2007 May; 9(5):1262-74. PMID: 17474904.
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  54. Cabral WA, Makareeva E, Letocha AD, Scribanu N, Fertala A, Steplewski A, Keene DR, Persikov AV, Leikin S, Marini JC. Y-position cysteine substitution in type I collagen (alpha1(I) R888C/p.R1066C) is associated with osteogenesis imperfecta/Ehlers-Danlos syndrome phenotype. Hum Mutat. 2007 Apr; 28(4):396-405. PMID: 17206620.
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  55. Ota S, Zhou ZQ, Keene DR, Knoepfler P, Hurlin PJ. Activities of N-Myc in the developing limb link control of skeletal size with digit separation. Development. 2007 Apr; 134(8):1583-92. PMID: 17360777.
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  56. Kobayashi N, Kostka G, Garbe JH, Keene DR, Bächinger HP, Hanisch FG, Markova D, Tsuda T, Timpl R, Chu ML, Sasaki T. A comparative analysis of the fibulin protein family. Biochemical characterization, binding interactions, and tissue localization. J Biol Chem. 2007 Apr 20; 282(16):11805-16. PMID: 17324935.
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  57. Maertens B, Hopkins D, Franzke CW, Keene DR, Bruckner-Tuderman L, Greenspan DS, Koch M. Cleavage and oligomerization of gliomedin, a transmembrane collagen required for node of ranvier formation. J Biol Chem. 2007 Apr 6; 282(14):10647-59. PMID: 17293346.
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  58. Guarnieri D, Battista S, Borzacchiello A, Mayol L, De Rosa E, Keene DR, Muscariello L, Barbarisi A, Netti PA. Effects of fibronectin and laminin on structural, mechanical and transport properties of 3D collageneous network. J Mater Sci Mater Med. 2007 Feb; 18(2):245-53. PMID: 17323155.
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  59. Woodley DT, Remington J, Huang Y, Hou Y, Li W, Keene DR, Chen M. Intravenously injected human fibroblasts home to skin wounds, deliver type VII collagen, and promote wound healing. Mol Ther. 2007 Mar; 15(3):628-35. PMID: 17245357.
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  60. Weirich C, Keene DR, Kirsch K, Heil M, Neumann E, Dinser R. Expression of PSACH-associated mutant COMP in tendon fibroblasts leads to increased apoptotic cell death irrespective of the secretory characteristics of mutant COMP. Matrix Biol. 2007 May; 26(4):314-23. PMID: 17307347.
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  61. Brandt-Bohne U, Keene DR, White FA, Koch M. MEGF9: a novel transmembrane protein with a strong and developmentally regulated expression in the nervous system. Biochem J. 2007 Jan 15; 401(2):447-57. PMID: 16981854.
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  62. Sonnylal S, Denton CP, Zheng B, Keene DR, He R, Adams HP, Vanpelt CS, Geng YJ, Deng JM, Behringer RR, de Crombrugghe B. Postnatal induction of transforming growth factor beta signaling in fibroblasts of mice recapitulates clinical, histologic, and biochemical features of scleroderma. Arthritis Rheum. 2007 Jan; 56(1):334-44. PMID: 17195237.
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  63. Kuo CL, Isogai Z, Keene DR, Hazeki N, Ono RN, Sengle G, Bächinger HP, Sakai LY. Effects of fibrillin-1 degradation on microfibril ultrastructure. J Biol Chem. 2007 Feb 9; 282(6):4007-20. PMID: 17158461.
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  64. Veit G, Hansen U, Keene DR, Bruckner P, Chiquet-Ehrismann R, Chiquet M, Koch M. Collagen XII interacts with avian tenascin-X through its NC3 domain. J Biol Chem. 2006 Sep 15; 281(37):27461-70. PMID: 16861231.
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  65. Goldoni S, Iozzo RA, Kay P, Campbell S, McQuillan A, Agnew C, Zhu JX, Keene DR, Reed CC, Iozzo RV. A soluble ectodomain of LRIG1 inhibits cancer cell growth by attenuating basal and ligand-dependent EGFR activity. Oncogene. 2007 Jan 18; 26(3):368-81. PMID: 16847455.
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  66. Han R, Caswell CC, Lukomska E, Keene DR, Pawlowski M, Bujnicki JM, Kim JK, Lukomski S. Binding of the low-density lipoprotein by streptococcal collagen-like protein Scl1 of Streptococcus pyogenes. Mol Microbiol. 2006 Jul; 61(2):351-67. PMID: 16856940.
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  67. Woodley DT, Ram R, Doostan A, Bandyopadhyay P, Huang Y, Remington J, Hou Y, Keene DR, Liu Z, Chen M. Induction of epidermolysis bullosa acquisita in mice by passive transfer of autoantibodies from patients. J Invest Dermatol. 2006 Jun; 126(6):1323-30. PMID: 16543893.
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  68. Carvalho HF, Felisbino SL, Keene DR, Vogel KG. Identification, content, and distribution of type VI collagen in bovine tendons. Cell Tissue Res. 2006 Aug; 325(2):315-24. PMID: 16568302.
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  69. Han R, Zwiefka A, Caswell CC, Xu Y, Keene DR, Lukomska E, Zhao Z, Höök M, Lukomski S. Assessment of prokaryotic collagen-like sequences derived from streptococcal Scl1 and Scl2 proteins as a source of recombinant GXY polymers. Appl Microbiol Biotechnol. 2006 Aug; 72(1):109-15. PMID: 16552563.
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  70. Carta L, Pereira L, Arteaga-Solis E, Lee-Arteaga SY, Lenart B, Starcher B, Merkel CA, Sukoyan M, Kerkis A, Hazeki N, Keene DR, Sakai LY, Ramirez F. Fibrillins 1 and 2 perform partially overlapping functions during aortic development. J Biol Chem. 2006 Mar 24; 281(12):8016-23. PMID: 16407178.
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  71. Zong Y, Xu Y, Liang X, Keene DR, Höök A, Gurusiddappa S, Höök M, Narayana SV. A 'Collagen Hug' model for Staphylococcus aureus CNA binding to collagen. EMBO J. 2005 Dec 21; 24(24):4224-36. PMID: 16362049.
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  72. Veit G, Kobbe B, Keene DR, Paulsson M, Koch M, Wagener R. Collagen XXVIII, a novel von Willebrand factor A domain-containing protein with many imperfections in the collagenous domain. J Biol Chem. 2006 Feb 10; 281(6):3494-504. PMID: 16330543.
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  73. Battista S, Guarnieri D, Borselli C, Zeppetelli S, Borzacchiello A, Mayol L, Gerbasio D, Keene DR, Ambrosio L, Netti PA. The effect of matrix composition of 3D constructs on embryonic stem cell differentiation. Biomaterials. 2005 Nov; 26(31):6194-207. PMID: 15921736.
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  74. Kim JK, Xu Y, Xu X, Keene DR, Gurusiddappa S, Liang X, Wary KK, Höök M. A novel binding site in collagen type III for integrins alpha1beta1 and alpha2beta1. J Biol Chem. 2005 Sep 16; 280(37):32512-20. PMID: 16043429.
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  75. Gregory KE, Ono RN, Charbonneau NL, Kuo CL, Keene DR, Bächinger HP, Sakai LY. The prodomain of BMP-7 targets the BMP-7 complex to the extracellular matrix. J Biol Chem. 2005 Jul 29; 280(30):27970-80. PMID: 15929982.
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  76. Poon CJ, Plaas AH, Keene DR, McQuillan DJ, Last K, Fosang AJ. N-linked keratan sulfate in the aggrecan interglobular domain potentiates aggrecanase activity. J Biol Chem. 2005 Jun 24; 280(25):23615-21. PMID: 15849197.
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  77. Holden P, Keene DR, Lunstrum GP, Bächinger HP, Horton WA. Secretion of cartilage oligomeric matrix protein is affected by the signal peptide. J Biol Chem. 2005 Apr 29; 280(17):17172-9. PMID: 15749701.
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  78. Humtsoe JO, Kim JK, Xu Y, Keene DR, Höök M, Lukomski S, Wary KK. A streptococcal collagen-like protein interacts with the alpha2beta1 integrin and induces intracellular signaling. J Biol Chem. 2005 Apr 8; 280(14):13848-57. PMID: 15647274.
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  79. Woodley DT, Keene DR, Atha T, Huang Y, Ram R, Kasahara N, Chen M. Intradermal injection of lentiviral vectors corrects regenerated human dystrophic epidermolysis bullosa skin tissue in vivo. Mol Ther. 2004 Aug; 10(2):318-26. PMID: 15294178.
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  80. Judge DP, Biery NJ, Keene DR, Geubtner J, Myers L, Huso DL, Sakai LY, Dietz HC. Evidence for a critical contribution of haploinsufficiency in the complex pathogenesis of Marfan syndrome. J Clin Invest. 2004 Jul; 114(2):172-81. PMID: 15254584.
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  81. Woodley DT, Keene DR, Atha T, Huang Y, Lipman K, Li W, Chen M. Injection of recombinant human type VII collagen restores collagen function in dystrophic epidermolysis bullosa. Nat Med. 2004 Jul; 10(7):693-5. PMID: 15195089.
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  82. Koch M, Schulze J, Hansen U, Ashwodt T, Keene DR, Brunken WJ, Burgeson RE, Bruckner P, Bruckner-Tuderman L. A novel marker of tissue junctions, collagen XXII. J Biol Chem. 2004 May 21; 279(21):22514-21. PMID: 15016833.
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  83. Charbonneau NL, Ono RN, Corson GM, Keene DR, Sakai LY. Fine tuning of growth factor signals depends on fibrillin microfibril networks. Birth Defects Res C Embryo Today. 2004 Mar; 72(1):37-50. PMID: 15054903.
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  84. Corson GM, Charbonneau NL, Keene DR, Sakai LY. Differential expression of fibrillin-3 adds to microfibril variety in human and avian, but not rodent, connective tissues. Genomics. 2004 Mar; 83(3):461-72. PMID: 14962672.
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  85. Marneros AG, Keene DR, Hansen U, Fukai N, Moulton K, Goletz PL, Moiseyev G, Pawlyk BS, Halfter W, Dong S, Shibata M, Li T, Crouch RK, Bruckner P, Olsen BR. Collagen XVIII/endostatin is essential for vision and retinal pigment epithelial function. EMBO J. 2004 Jan 14; 23(1):89-99. PMID: 14685281.
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  86. Woodley DT, Krueger GG, Jorgensen CM, Fairley JA, Atha T, Huang Y, Chan L, Keene DR, Chen M. Normal and gene-corrected dystrophic epidermolysis bullosa fibroblasts alone can produce type VII collagen at the basement membrane zone. J Invest Dermatol. 2003 Nov; 121(5):1021-8. PMID: 14708601.
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  87. Pappano WN, Steiglitz BM, Scott IC, Keene DR, Greenspan DS. Use of Bmp1/Tll1 doubly homozygous null mice and proteomics to identify and validate in vivo substrates of bone morphogenetic protein 1/tolloid-like metalloproteinases. Mol Cell Biol. 2003 Jul; 23(13):4428-38. PMID: 12808086.
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  88. Ortiz-Urda S, Lin Q, Yant SR, Keene D, Kay MA, Khavari PA. Sustainable correction of junctional epidermolysis bullosa via transposon-mediated nonviral gene transfer. Gene Ther. 2003 Jul; 10(13):1099-104. PMID: 12808440.
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  89. Ortiz-Urda S, Thyagarajan B, Keene DR, Lin Q, Calos MP, Khavari PA. PhiC31 integrase-mediated nonviral genetic correction of junctional epidermolysis bullosa. Hum Gene Ther. 2003 Jun 10; 14(9):923-8. PMID: 12828862.
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  90. Li J, Tzu J, Chen Y, Zhang YP, Nguyen NT, Gao J, Bradley M, Keene DR, Oro AE, Miner JH, Marinkovich MP. Laminin-10 is crucial for hair morphogenesis. EMBO J. 2003 May 15; 22(10):2400-10. PMID: 12743034.
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  91. Ortiz-Urda S, Lin Q, Green CL, Keene DR, Marinkovich MP, Khavari PA. Injection of genetically engineered fibroblasts corrects regenerated human epidermolysis bullosa skin tissue. J Clin Invest. 2003 Jan; 111(2):251-5. PMID: 12531881.
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  92. Veitch DP, Nokelainen P, McGowan KA, Nguyen TT, Nguyen NE, Stephenson R, Pappano WN, Keene DR, Spong SM, Greenspan DS, Findell PR, Marinkovich MP. Mammalian tolloid metalloproteinase, and not matrix metalloprotease 2 or membrane type 1 metalloprotease, processes laminin-5 in keratinocytes and skin. J Biol Chem. 2003 May 2; 278(18):15661-8. PMID: 12473650.
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  93. Chen M, Kasahara N, Keene DR, Chan L, Hoeffler WK, Finlay D, Barcova M, Cannon PM, Mazurek C, Woodley DT. Restoration of type VII collagen expression and function in dystrophic epidermolysis bullosa. Nat Genet. 2002 Dec; 32(4):670-5. PMID: 12426566.
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  94. Isogai Z, Ono RN, Ushiro S, Keene DR, Chen Y, Mazzieri R, Charbonneau NL, Reinhardt DP, Rifkin DB, Sakai LY. Latent transforming growth factor beta-binding protein 1 interacts with fibrillin and is a microfibril-associated protein. J Biol Chem. 2003 Jan 24; 278(4):2750-7. PMID: 12429738.
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  95. Charbonneau NL, Dzamba BJ, Ono RN, Keene DR, Corson GM, Reinhardt DP, Sakai LY. Fibrillins can co-assemble in fibrils, but fibrillin fibril composition displays cell-specific differences. J Biol Chem. 2003 Jan 24; 278(4):2740-9. PMID: 12429739.
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  96. Steiglitz BM, Keene DR, Greenspan DS. PCOLCE2 encodes a functional procollagen C-proteinase enhancer (PCPE2) that is a collagen-binding protein differing in distribution of expression and post-translational modification from the previously described PCPE1. J Biol Chem. 2002 Dec 20; 277(51):49820-30. PMID: 12393877.
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  97. Ortiz-Urda S, Thyagarajan B, Keene DR, Lin Q, Fang M, Calos MP, Khavari PA. Stable nonviral genetic correction of inherited human skin disease. Nat Med. 2002 Oct; 8(10):1166-70. PMID: 12244305.
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  98. Rattenholl A, Pappano WN, Koch M, Keene DR, Kadler KE, Sasaki T, Timpl R, Burgeson RE, Greenspan DS, Bruckner-Tuderman L. Proteinases of the bone morphogenetic protein-1 family convert procollagen VII to mature anchoring fibril collagen. J Biol Chem. 2002 Jul 19; 277(29):26372-8. PMID: 11986329.
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  99. Xu Y, Keene DR, Bujnicki JM, Höök M, Lukomski S. Streptococcal Scl1 and Scl2 proteins form collagen-like triple helices. J Biol Chem. 2002 Jul 26; 277(30):27312-8. PMID: 11976327.
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  100. Fukai N, Eklund L, Marneros AG, Oh SP, Keene DR, Tamarkin L, Niemelä M, Ilves M, Li E, Pihlajaniemi T, Olsen BR. Lack of collagen XVIII/endostatin results in eye abnormalities. EMBO J. 2002 Apr 2; 21(7):1535-44. PMID: 11927538.
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  101. Hirohata S, Wang LW, Miyagi M, Yan L, Seldin MF, Keene DR, Crabb JW, Apte SS. Punctin, a novel ADAMTS-like molecule, ADAMTSL-1, in extracellular matrix. J Biol Chem. 2002 Apr 5; 277(14):12182-9. PMID: 11805097.
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  102. Gaiser KG, Maddox BK, Bann JG, Boswell BA, Keene DR, Garofalo S, Horton WA. Y-position collagen II mutation disrupts cartilage formation and skeletal development in a transgenic mouse model of spondyloepiphyseal dysplasia. J Bone Miner Res. 2002 Jan; 17(1):39-47. PMID: 11771668.
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  103. Møller T, Franch T, Højrup P, Keene DR, Bächinger HP, Brennan RG, Valentin-Hansen P. Hfq: a bacterial Sm-like protein that mediates RNA-RNA interaction. Mol Cell. 2002 Jan; 9(1):23-30. PMID: 11804583.
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  104. Dzamba BJ, Keene DR, Isogai Z, Charbonneau NL, Karaman-Jurukovska N, Simon M, Sakai LY. Assembly of epithelial cell fibrillins. J Invest Dermatol. 2001 Dec; 117(6):1612-20. PMID: 11886530.
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  105. Isogai Z, Aspberg A, Keene DR, Ono RN, Reinhardt DP, Sakai LY. Versican interacts with fibrillin-1 and links extracellular microfibrils to other connective tissue networks. J Biol Chem. 2002 Feb 8; 277(6):4565-72. PMID: 11726670.
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  106. Vranka J, Mokashi A, Keene DR, Tufa S, Corson G, Sussman M, Horton WA, Maddox K, Sakai L, Bächinger HP. Selective intracellular retention of extracellular matrix proteins and chaperones associated with pseudoachondroplasia. Matrix Biol. 2001 Nov; 20(7):439-50. PMID: 11691584.
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  107. Gregory KE, Keene DR, Tufa SF, Lunstrum GP, Morris NP. Developmental distribution of collagen type XII in cartilage: association with articular cartilage and the growth plate. J Bone Miner Res. 2001 Nov; 16(11):2005-16. PMID: 11697796.
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  108. Chen M, Keene DR, Costa FK, Tahk SH, Woodley DT. The carboxyl terminus of type VII collagen mediates antiparallel dimer formation and constitutes a new antigenic epitope for epidermolysis Bullosa acquisita autoantibodies. J Biol Chem. 2001 Jun 15; 276(24):21649-55. PMID: 11274208.
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  109. Fitzgerald J, Mörgelin M, Selan C, Wiberg C, Keene DR, Lamandé SR, Bateman JF. The N-terminal N5 subdomain of the alpha 3(VI) chain is important for collagen VI microfibril formation. J Biol Chem. 2001 Jan 5; 276(1):187-93. PMID: 11027693.
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  110. Xu Y, Gurusiddappa S, Rich RL, Owens RT, Keene DR, Mayne R, Höök A, Höök M. Multiple binding sites in collagen type I for the integrins alpha1beta1 and alpha2beta1. J Biol Chem. 2000 Dec 15; 275(50):38981-9. PMID: 10986291.
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  111. Koch M, Murrell JR, Hunter DD, Olson PF, Jin W, Keene DR, Brunken WJ, Burgeson RE. A novel member of the netrin family, beta-netrin, shares homology with the beta chain of laminin: identification, expression, and functional characterization. J Cell Biol. 2000 Oct 16; 151(2):221-34. PMID: 11038171.
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  112. Gayraud B, Keene DR, Sakai LY, Ramirez F. New insights into the assembly of extracellular microfibrils from the analysis of the fibrillin 1 mutation in the tight skin mouse. J Cell Biol. 2000 Aug 7; 150(3):667-80. PMID: 10931876.
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  113. Amano S, Scott IC, Takahara K, Koch M, Champliaud MF, Gerecke DR, Keene DR, Hudson DL, Nishiyama T, Lee S, Greenspan DS, Burgeson RE. Bone morphogenetic protein 1 is an extracellular processing enzyme of the laminin 5 gamma 2 chain. J Biol Chem. 2000 Jul 28; 275(30):22728-35. PMID: 10806203.
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  114. Keene DR, San Antonio JD, Mayne R, McQuillan DJ, Sarris G, Santoro SA, Iozzo RV. Decorin binds near the C terminus of type I collagen. J Biol Chem. 2000 Jul 21; 275(29):21801-4. PMID: 10823816.
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  115. Morris NP, Oxford JT, Davies GB, Smoody BF, Keene DR. Developmentally regulated alternative splicing of the alpha1(XI) collagen chain: spatial and temporal segregation of isoforms in the cartilage of fetal rat long bones. J Histochem Cytochem. 2000 Jun; 48(6):725-41. PMID: 10820146.
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  116. Maddox BK, Mokashi A, Keene DR, Bächinger HP. A cartilage oligomeric matrix protein mutation associated with pseudoachondroplasia changes the structural and functional properties of the type 3 domain. J Biol Chem. 2000 Apr 14; 275(15):11412-7. PMID: 10753957.
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  117. Dallas SL, Keene DR, Bruder SP, Saharinen J, Sakai LY, Mundy GR, Bonewald LF. Role of the latent transforming growth factor beta binding protein 1 in fibrillin-containing microfibrils in bone cells in vitro and in vivo. J Bone Miner Res. 2000 Jan; 15(1):68-81. PMID: 10646116.
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  118. Raff ML, Craigen WJ, Smith LT, Keene DR, Byers PH. Partial COL1A2 gene duplication produces features of osteogenesis imperfecta and Ehlers-Danlos syndrome type VII. Hum Genet. 2000 Jan; 106(1):19-28. PMID: 10982177.
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  119. Trotter JA, Lyons-Levy G, Chino K, Koob TJ, Keene DR, Atkinson MA. Collagen fibril aggregation-inhibitor from sea cucumber dermis. Matrix Biol. 1999 Dec; 18(6):569-78. PMID: 10607918.
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  120. Zhu Y, Oganesian A, Keene DR, Sandell LJ. Type IIA procollagen containing the cysteine-rich amino propeptide is deposited in the extracellular matrix of prechondrogenic tissue and binds to TGF-beta1 and BMP-2. J Cell Biol. 1999 Mar 8; 144(5):1069-80. PMID: 10085302.
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  121. Lunstrum GP, Keene DR, Weksler NB, Cho YJ, Cornwall M, Horton WA. Chondrocyte differentiation in a rat mesenchymal cell line. J Histochem Cytochem. 1999 Jan; 47(1):1-6. PMID: 9857207.
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  122. Forlino A, Keene DR, Schmidt K, Marini JC. An alpha2(I) glycine to aspartate substitution is responsible for the presence of a kink in type I collagen in a lethal case of osteogenesis imperfecta. Matrix Biol. 1998 Dec; 17(8-9):575-84. PMID: 9923651.
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  123. Keene DR, Ridgway CC, Iozzo RV. Type VI microfilaments interact with a specific region of banded collagen fibrils in skin. J Histochem Cytochem. 1998 Feb; 46(2):215-20. PMID: 9446828.
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  124. Maddox BK, Keene DR, Sakai LY, Charbonneau NL, Morris NP, Ridgway CC, Boswell BA, Sussman MD, Horton WA, Bächinger HP, Hecht JT. The fate of cartilage oligomeric matrix protein is determined by the cell type in the case of a novel mutation in pseudoachondroplasia. J Biol Chem. 1997 Dec 5; 272(49):30993-7. PMID: 9388247.
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  125. Kuo HJ, Maslen CL, Keene DR, Glanville RW. Type VI collagen anchors endothelial basement membranes by interacting with type IV collagen. J Biol Chem. 1997 Oct 17; 272(42):26522-9. PMID: 9334230.
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  126. Pereira L, Andrikopoulos K, Tian J, Lee SY, Keene DR, Ono R, Reinhardt DP, Sakai LY, Biery NJ, Bunton T, Dietz HC, Ramirez F. Targetting of the gene encoding fibrillin-1 recapitulates the vascular aspect of Marfan syndrome. Nat Genet. 1997 Oct; 17(2):218-22. PMID: 9326947.
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  127. Keene DR, Marinkovich MP, Sakai LY. Immunodissection of the connective tissue matrix in human skin. Microsc Res Tech. 1997 Aug 15; 38(4):394-406. PMID: 9297689.
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  128. Rousselle P, Keene DR, Ruggiero F, Champliaud MF, Rest M, Burgeson RE. Laminin 5 binds the NC-1 domain of type VII collagen. J Cell Biol. 1997 Aug 11; 138(3):719-28. PMID: 9245798.
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  129. Keene DR, Jordan CD, Reinhardt DP, Ridgway CC, Ono RN, Corson GM, Fairhurst M, Sussman MD, Memoli VA, Sakai LY. Fibrillin-1 in human cartilage: developmental expression and formation of special banded fibers. J Histochem Cytochem. 1997 Aug; 45(8):1069-82. PMID: 9267468.
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  130. Maddox BK, Garofalo S, Keene DR, Smith C, Horton WA. Type II collagen pro-alpha-chains containing a Gly574Ser mutation are not incorporated into the cartilage matrix of transgenic mice. Matrix Biol. 1997 Aug; 16(3):93-103. PMID: 9314159.
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  131. Reinhardt DP, Mechling DE, Boswell BA, Keene DR, Sakai LY, Bächinger HP. Calcium determines the shape of fibrillin. J Biol Chem. 1997 Mar 14; 272(11):7368-73. PMID: 9054436.
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  132. Maddox BK, Garofalo S, Smith C, Keene DR, Horton WA. Skeletal development in transgenic mice expressing a mutation at Gly574Ser of type II collagen. Dev Dyn. 1997 Feb; 208(2):170-7. PMID: 9022054.
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  133. Reinhardt DP, Sasaki T, Dzamba BJ, Keene DR, Chu ML, Göhring W, Timpl R, Sakai LY. Fibrillin-1 and fibulin-2 interact and are colocalized in some tissues. J Biol Chem. 1996 Aug 9; 271(32):19489-96. PMID: 8702639.
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  134. Ballo R, Viljoen D, Machado M, Keene D, Horton W, Fredlund V, Jacobs M, Martell R, Beighton P, Ramesar R. Mseleni joint disease--a molecular genetic approach to defining the aetiology. S Afr Med J. 1996 Aug; 86(8):956-8. PMID: 8823421.
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  135. Takagi Y, Nomizu M, Gullberg D, MacKrell AJ, Keene DR, Yamada Y, Fessler JH. Conserved neuron promoting activity in Drosophila and vertebrate laminin alpha1. J Biol Chem. 1996 Jul 26; 271(30):18074-81. PMID: 8663504.
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  136. Trotter JA, Lyons-Levy G, Luna D, Koob TJ, Keene DR, Atkinson MA. Stiparin: a glycoprotein from sea cucumber dermis that aggregates collagen fibrils. Matrix Biol. 1996 Jul; 15(2):99-110. PMID: 8837011.
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  137. Mechling DE, Gambee JE, Morris NP, Sakai LY, Keene DR, Mayne R, Bächinger HP. Type IX collagen NC1 domain peptides can trimerize in vitro without forming a triple helix. J Biol Chem. 1996 Jun 7; 271(23):13781-5. PMID: 8662808.
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  138. Reinhardt DP, Keene DR, Corson GM, Pöschl E, Bächinger HP, Gambee JE, Sakai LY. Fibrillin-1: organization in microfibrils and structural properties. J Mol Biol. 1996 Apr 26; 258(1):104-16. PMID: 8613981.
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  139. Marinkovich MP, Taylor TB, Keene DR, Burgeson RE, Zone JJ. LAD-1, the linear IgA bullous dermatosis autoantigen, is a novel 120-kDa anchoring filament protein synthesized by epidermal cells. J Invest Dermatol. 1996 Apr; 106(4):734-8. PMID: 8618013.
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  140. Champliaud MF, Lunstrum GP, Rousselle P, Nishiyama T, Keene DR, Burgeson RE. Human amnion contains a novel laminin variant, laminin 7, which like laminin 6, covalently associates with laminin 5 to promote stable epithelial-stromal attachment. J Cell Biol. 1996 Mar; 132(6):1189-98. PMID: 8601594.
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  141. Keene DR, Oxford JT, Morris NP. Ultrastructural localization of collagen types II, IX, and XI in the growth plate of human rib and fetal bovine epiphyseal cartilage: type XI collagen is restricted to thin fibrils. J Histochem Cytochem. 1995 Oct; 43(10):967-79. PMID: 7560887.
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  142. Kuo HJ, Keene DR, Glanville RW. The macromolecular structure of type-VI collagen. Formation and stability of filaments. Eur J Biochem. 1995 Sep 1; 232(2):364-72. PMID: 7556183.
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  143. Roark EF, Keene DR, Haudenschild CC, Godyna S, Little CD, Argraves WS. The association of human fibulin-1 with elastic fibers: an immunohistological, ultrastructural, and RNA study. J Histochem Cytochem. 1995 Apr; 43(4):401-11. PMID: 7534784.
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  144. Scheffer IE, Bhatia KP, Lopes-Cendes I, Fish DR, Marsden CD, Andermann E, Andermann F, Desbiens R, Keene D, Cendes F, et al. Autosomal dominant nocturnal frontal lobe epilepsy. A distinctive clinical disorder. Brain. 1995 Feb; 118 ( Pt 1):61-73. PMID: 7895015.
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  145. Andrikopoulos K, Liu X, Keene DR, Jaenisch R, Ramirez F. Targeted mutation in the col5a2 gene reveals a regulatory role for type V collagen during matrix assembly. Nat Genet. 1995 Jan; 9(1):31-6. PMID: 7704020.
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  146. Rosati R, Horan GS, Pinero GJ, Garofalo S, Keene DR, Horton WA, Vuorio E, de Crombrugghe B, Behringer RR. Normal long bone growth and development in type X collagen-null mice. Nat Genet. 1994 Oct; 8(2):129-35. PMID: 7842010.
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  147. Nelson RE, Fessler LI, Takagi Y, Blumberg B, Keene DR, Olson PF, Parker CG, Fessler JH. Peroxidasin: a novel enzyme-matrix protein of Drosophila development. EMBO J. 1994 Aug 1; 13(15):3438-47. PMID: 8062820.
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  148. Sakai LY, Keene DR. Fibrillin: monomers and microfibrils. Methods Enzymol. 1994; 245:29-52. PMID: 7760739.
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  149. Marinkovich MP, Verrando P, Keene DR, Meneguzzi G, Lunstrum GP, Ortonne JP, Burgeson RE. Basement membrane proteins kalinin and nicein are structurally and immunologically identical. Lab Invest. 1993 Sep; 69(3):295-9. PMID: 8377472.
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  150. Marinkovich MP, Keene DR, Rimberg CS, Burgeson RE. Cellular origin of the dermal-epidermal basement membrane. Dev Dyn. 1993 Aug; 197(4):255-67. PMID: 8292823.
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  151. Keene DR, McDonald K. The ultrastructure of the connective tissue matrix of skin and cartilage after high-pressure freezing and freeze-substitution. J Histochem Cytochem. 1993 Aug; 41(8):1141-53. PMID: 8331280.
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  152. Marinkovich MP, Lunstrum GP, Keene DR, Burgeson RE. The dermal-epidermal junction of human skin contains a novel laminin variant. J Cell Biol. 1992 Nov; 119(3):695-703. PMID: 1383241.
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  153. Lunstrum GP, McDonough AM, Marinkovich MP, Keene DR, Morris NP, Burgeson RE. Identification and partial purification of a large, variant form of type XII collagen. J Biol Chem. 1992 Oct 5; 267(28):20087-92. PMID: 1400326.
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  154. Watt SL, Lunstrum GP, McDonough AM, Keene DR, Burgeson RE, Morris NP. Characterization of collagen types XII and XIV from fetal bovine cartilage. J Biol Chem. 1992 Oct 5; 267(28):20093-9. PMID: 1400327.
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  155. Hori H, Keene DR, Sakai LY, Wirtz MK, Bächinger HP, Godfrey M, Hollister DW. Repeated helical epitopes of defined amino acid sequence in human type III collagen identified by monoclonal antibodies. Mol Immunol. 1992 Jun; 29(6):759-70. PMID: 1376414.
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  156. Wang H, Paul R, Burgeson RE, Keene DR, Kabat D. Plasma membrane receptors for ecotropic murine retroviruses require a limiting accessory factor. J Virol. 1991 Dec; 65(12):6468-77. PMID: 1942243.
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  157. Sakai LY, Keene DR, Glanville RW, Bächinger HP. Purification and partial characterization of fibrillin, a cysteine-rich structural component of connective tissue microfibrils. J Biol Chem. 1991 Aug 5; 266(22):14763-70. PMID: 1860873.
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  158. Rousselle P, Lunstrum GP, Keene DR, Burgeson RE. Kalinin: an epithelium-specific basement membrane adhesion molecule that is a component of anchoring filaments. J Cell Biol. 1991 Aug; 114(3):567-76. PMID: 1860885.
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  159. Lunstrum GP, Morris NP, McDonough AM, Keene DR, Burgeson RE. Identification and partial characterization of two type XII-like collagen molecules. J Cell Biol. 1991 May; 113(4):963-9. PMID: 2026655.
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  160. Keene DR, Lunstrum GP, Morris NP, Stoddard DW, Burgeson RE. Two type XII-like collagens localize to the surface of banded collagen fibrils. J Cell Biol. 1991 May; 113(4):971-8. PMID: 2026656.
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  161. Keene DR, Maddox BK, Kuo HJ, Sakai LY, Glanville RW. Extraction of extendable beaded structures and their identification as fibrillin-containing extracellular matrix microfibrils. J Histochem Cytochem. 1991 Apr; 39(4):441-9. PMID: 2005373.
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  162. Keene DR, Sakai LY, Burgeson RE. Human bone contains type III collagen, type VI collagen, and fibrillin: type III collagen is present on specific fibers that may mediate attachment of tendons, ligaments, and periosteum to calcified bone cortex. J Histochem Cytochem. 1991 Jan; 39(1):59-69. PMID: 1983874.
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  163. Bächinger HP, Morris NP, Lunstrum GP, Keene DR, Rosenbaum LM, Compton LA, Burgeson RE. The relationship of the biophysical and biochemical characteristics of type VII collagen to the function of anchoring fibrils. J Biol Chem. 1990 Jun 15; 265(17):10095-101. PMID: 2112541.
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  164. Wirtz MK, Keene DR, Hori H, Glanville RW, Steinmann B, Rao VH, Hollister DW. In vivo and in vitro noncovalent association of excised alpha 1 (I) amino-terminal propeptides with mutant pN alpha 2(I) collagen chains in native mutant collagen in a case of Ehlers-Danlos syndrome, type VII. J Biol Chem. 1990 Apr 15; 265(11):6312-7. PMID: 2318855.
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  165. Burgeson RE, Lunstrum GP, Rokosova B, Rimberg CS, Rosenbaum LM, Keene DR. The structure and function of type VII collagen. Ann N Y Acad Sci. 1990; 580:32-43. PMID: 2186694.
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  166. Maddox BK, Sakai LY, Keene DR, Glanville RW. Connective tissue microfibrils. Isolation and characterization of three large pepsin-resistant domains of fibrillin. J Biol Chem. 1989 Dec 15; 264(35):21381-5. PMID: 2512293.
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  167. Kuo HJ, Keene DR, Glanville RW. Orientation of type VI collagen monomers in molecular aggregates. Biochemistry. 1989 May 2; 28(9):3757-62. PMID: 2502170.
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  168. Godfrey M, Keene DR, Blank E, Hori H, Sakai LY, Sherwin LA, Hollister DW. Type II achondrogenesis-hypochondrogenesis: morphologic and immunohistopathologic studies. Am J Hum Genet. 1988 Dec; 43(6):894-903. PMID: 3057886.
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  169. Keene DR, Engvall E, Glanville RW. Ultrastructure of type VI collagen in human skin and cartilage suggests an anchoring function for this filamentous network. J Cell Biol. 1988 Nov; 107(5):1995-2006. PMID: 3182942.
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  170. Foster JA, Rich CB, Horrigan S, Miller M, Dadd CA, Baule V, Keene DR. Synthesis of soluble and insoluble elastins in cultures of chick aortic cells. Lab Invest. 1988 Jun; 58(6):667-73. PMID: 3379914.
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  171. Keene DR, Sakai LY, Bächinger HP, Burgeson RE. Type III collagen can be present on banded collagen fibrils regardless of fibril diameter. J Cell Biol. 1987 Nov; 105(5):2393-402. PMID: 2445760.
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  172. Lunstrum GP, Kuo HJ, Rosenbaum LM, Keene DR, Glanville RW, Sakai LY, Burgeson RE. Anchoring fibrils contain the carboxyl-terminal globular domain of type VII procollagen, but lack the amino-terminal globular domain. J Biol Chem. 1987 Oct 5; 262(28):13706-12. PMID: 2443495.
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  173. Keene DR, Sakai LY, Burgeson RE, Bächinger HP. Direct visualization of IgM antibodies bound to tissue antigens using a monoclonal anti-type III collagen IgM as a model system. J Histochem Cytochem. 1987 Mar; 35(3):311-8. PMID: 3546481.
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  174. Keene DR, Sakai LY, Lunstrum GP, Morris NP, Burgeson RE. Type VII collagen forms an extended network of anchoring fibrils. J Cell Biol. 1987 Mar; 104(3):611-21. PMID: 3818794.
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  175. Campagnone R, Regan J, Rich CB, Miller M, Keene DR, Sakai L, Foster JA. Pulmonary fibroblasts: a model system for studying elastin synthesis. Lab Invest. 1987 Feb; 56(2):224-30. PMID: 3807319.
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  176. Sakai LY, Keene DR, Engvall E. Fibrillin, a new 350-kD glycoprotein, is a component of extracellular microfibrils. J Cell Biol. 1986 Dec; 103(6 Pt 1):2499-509. PMID: 3536967.
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  177. Sakai LY, Keene DR, Morris NP, Burgeson RE. Type VII collagen is a major structural component of anchoring fibrils. J Cell Biol. 1986 Oct; 103(4):1577-86. PMID: 3771648.
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  178. Lunstrum GP, Sakai LY, Keene DR, Morris NP, Burgeson RE. Large complex globular domains of type VII procollagen contribute to the structure of anchoring fibrils. J Biol Chem. 1986 Jul 5; 261(19):9042-8. PMID: 3013874.
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  179. Morris NP, Keene DR, Glanville RW, Bentz H, Burgeson RE. The tissue form of type VII collagen is an antiparallel dimer. J Biol Chem. 1986 Apr 25; 261(12):5638-44. PMID: 3082888.
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  180. Burgeson RE, Morris NP, Murray LW, Duncan KG, Keene DR, Sakai LY. The structure of type VII collagen. Ann N Y Acad Sci. 1985; 460:47-57. PMID: 3868959.
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