Keywords
Last Name

Alice M. Wang, MD

TitleAssistant Professor
InstitutionBoston University School of Medicine
DepartmentPediatrics
DivisionNeonatology
Address771 Albany St
Boston MA 02118
Phone(617) 414-3697
ORCID ORCID Icon0000-0002-5153-0365
Other Positions
TitleActive Staff Privileges
InstitutionBoston Medical Center
DepartmentPediatrics

 Research Expertise & Professional Interests
As a neonatologist, I am focused on understanding how maternal and/or environmental factors can affect placental function and development to cause fetal and neonatal diseases such as fetal growth restriction (FGR) and neonatal abstinence syndrome. My work to date has focused on understanding the underlying molecular mechanisms for fetal growth restriction (FGR), with an emphasis on smoking-related fetal growth restriction. I am studying the effects of altered placental Wnt signaling and carbon monoxide exposure in the pathogenesis of fetal growth restriction, using cell-based assays, mouse models of pregnancy and clinical studies. The major goals of my work are to discern how environmental exposures and maternal disease can alter fundamental signaling pathways such as Wnt signaling in the placenta, and to identify and validate novel placental biomarkers of fetal/neonatal diseases that may also drive disease process.

 Self-Described Keywords
  • placental insufficiency, fetal growth restriction, preeclampsia, maternal cigarette smoking during pregnancy, maternal opioid use during pregnancy
 Publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Burke SD, Zsengellér ZK, Khankin EV, Lo AS, Rajakumar A, DuPont JJ, McCurley A, Moss ME, Zhang D, Clark CD, Wang A, Seely EW, Kang PM, Stillman IE, Jaffe IZ, Karumanchi SA. Soluble fms-like tyrosine kinase 1 promotes angiotensin II sensitivity in preeclampsia. J Clin Invest. 2016 Jul 01; 126(7):2561-74. PMID: 27270170.
    View in: PubMed
  2. Wang A, Zsengellér ZK, Hecht JL, Buccafusca R, Burke SD, Rajakumar A, Weingart E, Yu PB, Salahuddin S, Karumanchi SA. Excess placental secreted frizzled-related protein 1 in maternal smokers impairs fetal growth. J Clin Invest. 2015 Nov 2; 125(11):4021-5. PMID: 26413870.
    View in: PubMed
  3. Wang A, Karumanchi SA. Relaxin' with endothelial progenitor cells. Blood. 2012 Jan 12; 119(2):326-7. PMID: 22247520.
    View in: PubMed
  4. Wang A, Holston AM, Yu KF, Zhang J, Toporsian M, Karumanchi SA, Levine RJ. Circulating anti-angiogenic factors during hypertensive pregnancy and increased risk of respiratory distress syndrome in preterm neonates. J Matern Fetal Neonatal Med. 2012 Aug; 25(8):1447-52. PMID: 22097923.
    View in: PubMed
  5. Powe CE, Ecker J, Rana S, Wang A, Ankers E, Ye J, Levine RJ, Karumanchi SA, Thadhani R. Preeclampsia and the risk of large-for-gestational-age infants. Am J Obstet Gynecol. 2011 May; 204(5):425.e1-6. PMID: 21371687.
    View in: PubMed
  6. Wang A, Rana S, Karumanchi SA. Preeclampsia: the role of angiogenic factors in its pathogenesis. Physiology (Bethesda). 2009 Jun; 24:147-58. PMID: 19509125.
    View in: PubMed
  7. Rauh-Hain JA, Rana S, Tamez H, Wang A, Cohen B, Cohen A, Brown F, Ecker JL, Karumanchi SA, Thadhani R. Risk for developing gestational diabetes in women with twin pregnancies. J Matern Fetal Neonatal Med. 2009 Apr; 22(4):293-9. PMID: 19340713.
    View in: PubMed
  8. Ruppel KM, Willison D, Kataoka H, Wang A, Zheng YW, Cornelissen I, Yin L, Xu SM, Coughlin SR. Essential role for Galpha13 in endothelial cells during embryonic development. Proc Natl Acad Sci U S A. 2005 Jun 07; 102(23):8281-6. PMID: 15919816.
    View in: PubMed
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